AdhesionInflammatoryPolymorphismsIntegrinsInnateExtravasationEndotheliumAcuteChemokinesCapillariesCytokinesPeripheral blood leukocytesRecruitmentInflammationMacrophagesImmunePlatelet activationEsophagealPolymorphonuclearCD11bExposureStimulationTransplantationActivationCountsHumanLeukopeniaBloodCellsCyclesReceptorConcentrationProteinsDiseasesPatientsSignificantReleaseFormationResponseControlCell
Adhesion8
- It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. (wikipedia.org)
- CD11b, as an integrin molecule on the surface of leukocytes, plays an important role in cell migration, adhesion, and transmigration across blood vessels, because it can bind to components of extracellular matrix and intracellular adhesion molecules (ICAMs) on the endothelial surface. (wikipedia.org)
- Once activated, CD11b can bind its ligands with high affinity, e.g., binding of ICAM-1 or ICAM-2 molecules on endothelium and subsequent adhesion. (wikipedia.org)
- Subsequent ICAM-1 and VCAM-1 mediated adhesion leads to extravasation of the leukocyte through the blood vessel wall into the extracellular matrix tissue. (rndsystems.com)
- Activated by cytokines and chemokines, leukocytes and endothelial cells express distinct adhesion molecules on their cell surfaces [ 9 ]. (biomedcentral.com)
- These adhesion molecules enable the deceleration of blood cells on the endothelial layer in order to enable subsequent diapedesis. (biomedcentral.com)
- A large body of evidence now implicates increased leukocyte-endothelial cell adhesion as a key early event in the development of diabetic retinopathy. (diabetesjournals.org)
- We recently reported that raised activity of the glycosylating enzyme core 2 β 1,6- N -acetylglucosaminyltransferase (GlcNAc-T) through protein kinase C (PKC)β2-dependent phosphorylation plays a fundamental role in increased leukocyte-endothelial cell adhesion and capillary occlusion in retinopathy. (diabetesjournals.org)
Inflammatory8
- We and others have discovered factors that control the recruitment of inflammatory leukocytes to the peritoneal mesentery in response to pristane [ 9 , 10 ]. (hindawi.com)
- The migration of inflammatory leukocytes, including dendritic cells, neutrophils, and macrophages, to the peritoneal mesentery has been shown to be promoted in LAT −/− (lack mature T cells) mice but inhibited in μ MT (lack mature B cells) mice during the pristane-induced immune response [ 10 ]. (hindawi.com)
- However, little is known about how hypoxia affects the ability of microglia, resident CNS macrophages, to respond to subsequent inflammatory challenges that are often present during neurodegenerative processes. (frontiersin.org)
- Despite the common co-occurrence of Hx with neural disease, few studies have investigated how pre-exposure to Hx changes the long-term ability of resident CNS macrophages/microglia to respond to a subsequent inflammatory insult, such as pathogen exposure or a sterile inflammatory stimulus. (frontiersin.org)
- This report reviews the emerging literature describing a novel class of proteolytic targets, leukocyte chemoattractants, and, in particular, chemerin, a dendritic cell and macrophage chemoattractant activated by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. (nih.gov)
- The activated leukocytes can mediate a variety of immune and inflammatory responses through their binding and subsequent activation of specific receptors on the cell surface (Napier et al . (scialert.net)
- These results showed a reduced capacity of circulating leukocytes to produce inflammatory proteins in response to a secondary stimulus following a metal-rich particulate matter pulmonary exposure and provide mechanistic insight into epidemiological and experimental evidence illustrating immunosuppression following welding fume exposure. (cdc.gov)
- An environmental trigger is thought to evoke an inflammatory response and subsequent hyperproliferation of keratinocytes. (merckmanuals.com)
Polymorphisms3
- We examined the relationships of human leukocyte antigen (HLA) and related polymorphisms to glioblastoma multiforme in adult Caucasians (non-Hispanic Whites) from the San Francisco Bay area. (aacrjournals.org)
- The binding profile of SARS-CoV-2 with human leukocyte antigen polymorphisms reveals critical alleles involved in immune evasion. (bvsalud.org)
- The binding affinity of human leukocyte antigen (HLA) polymorphisms to SARS-CoV-2 might be related to immune escape, but the mechanisms remained unclear. (bvsalud.org)
Integrins1
- The second chain of αMβ2 is the common integrin β2 subunit known as CD18, and integrin αMβ2 thus belongs to the β2 subfamily (or leukocyte) integrins. (wikipedia.org)
Innate3
- αMβ2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells and subsets of T and B cells. (wikipedia.org)
- Mounting evidence demonstrates that live attenuated vaccines provide nonspecific protection against lethal infections unrelated to the target pathogen of the vaccine by inducing trained nonspecific innate immune cells for improved host responses against subsequent infections. (scitechdaily.com)
- Live attenuated vaccines induce nonspecific effects representing "trained innate immunity" by training leukocyte (immune system cells) precursors in the bone marrow to function more effectively against broader infectious insults. (scitechdaily.com)
Extravasation2
- The extravasation of leukocytes from the vascular bed into surrounding tissues and organs is part of the host defense mechanisms against invading pathogens. (biomedcentral.com)
- In the first phase of the extravasation process, selectins such as L-selectin on leukocytes and E- and P-selectin on endothelial cells lead to a loose connection that permits tethering and rolling of leukocytes on the endothelium under hydrodynamic shear [ 10 ]. (biomedcentral.com)
Endothelium1
- This interaction permits leukocytes to roll along the vascular endothelium. (rndsystems.com)
Acute2
- As a visiting scientist at the University in Bergen in Norway, Dr. Warren developed a number of new assays, including a unique method for the determination of the levels of cytotoxic nucleotide accumulation into the leukocyte DNA of acute lymphocytic leukemia patients receiving 6-mercaptopurine maintenance therapy. (aacc.org)
- Acute leukopenia, with almost total absence of granular leukocytes, leukoblastic groups and lymphoid tissue in the bone marrow, was reported in the case of a 36-year-old chemist who had worked with radium for 14 years (Reitter and Martland 1926). (cdc.gov)
Chemokines1
- Chemokines are a family of small peptides that act as chemoattractants and activators of specific types of leukocytes. (scialert.net)
Capillaries2
- The exact pathogenic mechanism by which capillary nonperfusion, as demonstrated by fluorescein angiography, occurs is still unclear, but recent experimental animal studies ( 3 - 5 ) demonstrate that increased leukocyte entrapment in retinal capillaries of diabetic rats is an early event associated with areas of capillary nonperfusion and the development of endothelial cell damage. (diabetesjournals.org)
- Retention of leukocytes in capillaries: role of cell size and deformability. (concordia.ca)
Cytokines1
- The high numbers of leukocytes remaining in a unit of pRBCs during the storage process can fragment, deteriorate, and release cytokines, and they have been implicated as a cause of reactions to a current and subsequent blood transfusions in some transfusion recipients. (utmb.edu)
Peripheral blood leukocytes2
- Oncolytic vesicular stomatitis virus (VSV) can be delivered intravenously to target primary and metastatic lesions, but the interaction between human peripheral blood leukocytes (PBLs) and VSV remains poorly understood. (karger.com)
- Human peripheral blood leukocytes (PMN) are induced to release lysosomal enzymes by the calcium ionophore A23187 in the presence but not the absence of extracellular Ca++. (rupress.org)
Recruitment4
- However, it remains unknown how leukocyte recruitment is regulated. (hindawi.com)
- Pristane-induced chronic inflammation has been characterized by the continuous recruitment of leukocytes, including lymphocytes, neutrophils, and macrophages, to the peritoneal cavity and the spleen [ 6 - 8 ]. (hindawi.com)
- This process is important for leukocyte recruitment into the site of inflammation. (wikipedia.org)
- As chemoattractants are critical for both systemic leukocyte positioning by triggering integrin activation and subsequent recruitment from circulation, and local intratissue leukocyte positioning via chemotaxis, modulation of attractant activities by proteases may have profound effects on the immune response. (nih.gov)
Inflammation4
- Chronic inflammation is associated with an increased number of leukocytes in the spleen, which are then redirected to the site of inflammation. (hindawi.com)
- E-Selectin mediates the initial attachment of circulating leukocytes to the blood vessel wall during inflammation. (rndsystems.com)
- Proteolytic cascades trigger blood clotting, fibrinolysis, and complement activation, while proteases released upon leukocyte degranulation are integral to the processes of inflammation and immunity. (nih.gov)
- Furthermore, in a moue model of arterial inflammation we found that P-selectin is responsible for a significant part of the platelet-leukocyte interactions. (avhandlingar.se)
Macrophages1
- Polymorphonuclear leukocytes and macrophages release elastases, which could damage elastic fibers with subsequent phagocytosis. (medscape.com)
Immune1
- Subsequent structural predictions identified 10 active binding sites in these HLA proteins that may promote immune evasion . (bvsalud.org)
Platelet activation2
- We could conclude that prasugrel inhibits several markers of platelet activation and the formation of platelet-leukocyte aggregates more efficiently than clopidogrel. (avhandlingar.se)
- Subsequent studies recognized the Rigel compound R406 to block platelet activation by the HIT IC via FcgRIIa [69]. (immune-source.com)
Esophageal6
- We hypothesize that leukocyte telomere length might be able to predict future risk of cancer and examined this in a cohort of patients with Barrett's esophagus, who are at increased risk of esophageal adenocarcinoma and thus were enrolled in a long-term cancer surveillance program. (aacrjournals.org)
- Leukocyte telomere length hazard ratios (HR) for risk of esophageal adenocarcinoma were calculated using multivariate Cox models. (aacrjournals.org)
- Ku YN, Chao SC, Lai MW, Kong MS, Chen SY (2015) Hypermetabolism Correlated with Subsequent Stricture Formation in Esophageal Caustic Burn Injury in Children. (omicsonline.org)
- Hypermetabolism is commonly found and correlated to subsequent esophageal stricture after caustic burn injury in children. (omicsonline.org)
- Corrosive ingestion is one of the emergent events in children causing immediate esophageal damage and even subsequent esophageal stricture [ 1 , 2 ]. (omicsonline.org)
- It is a challenge for the pediatrician to identify the risk factors for developing subsequent esophageal stricture. (omicsonline.org)
Polymorphonuclear1
- Microfilaments and microtubules in calcium ionophore-induced secretion of lysosomal enzymes from human polymorphonuclear leukocytes. (rupress.org)
CD11b3
- CD11b also modulates other functions of leukocytes, e.g. oxidative burst, apoptosis, binding of fibrinogen etc. (wikipedia.org)
- On circulating leukocytes, CD11b is expressed in a closed conformation. (wikipedia.org)
- To conclude, CD11b signalling negatively regulates leukocyte activation after TLR stimulation. (wikipedia.org)
Exposure4
- Dr. Ruqia Mir, Neurology Consultant and Sub-Investigator in PHOMS study at the Abu Dhabi Stem Cells Centre, said: "This innovative procedure used in our study, ECP, involves the treatment of a patient's autologous leukocytes with a photoactivatable drug, followed by exposure to UVA light and subsequent reinfusion into the patient. (emirates247.com)
- Plication was prevented by cytochalasin B or reversed by subsequent exposure to an endocytic stimulus such as zymosan. (rupress.org)
- Reduced responsiveness of circulating leukocytes following metal-rich particulate matter exposure. (cdc.gov)
- The aim of this study was to evaluate the molecular changes and responsiveness of circulating leukocytes following welding fume exposure. (cdc.gov)
Stimulation2
- The switch into an active conformation follows quickly after the stimulation of toll-like receptors (TLR) of the leukocytes. (wikipedia.org)
- Ex vivo stimulation with LPS of circulating leukocytes showed reduced production of CCL4, CXCL2, CXCL10 and TNF alpha protein in MMAW-SS treated rats. (cdc.gov)
Transplantation1
- Plerixafor injection is indicated in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells (HSCs) to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) or multiple myeloma (MM). (fresenius-kabi.com)
Activation1
- Despite clearing a fraction of small PS-exposing MV CVVH does not eliminate larger MV. Concurrently, CVVH induces the release of CD31+/CD4− MV that indicate leukocyte activation during hemofilter passage in septic patients. (springeropen.com)
Counts1
- Units that underwent leukoreduction had substantially lower leukocyte and platelet counts than nonleukoreduced units. (avma.org)
Human1
- Family history is common, and certain genes and human leukocyte antigens (Cw6, B13, B17) are associated with psoriasis. (merckmanuals.com)
Leukopenia1
- Minimally, the researchers requested hematological determinations to assess leukopenia (=5000 leukocytes) and hypertransaminasemia of =150 U/L, a number over three times the GOT and GPT normal values according to age and sex. (who.int)
Blood2
- Leukocyte-reduced red blood cells are prepared using special filters and have special indications. (utmb.edu)
- Blood was collected and analyzed for differential changes by flow cytometry and gene expression changes by microarray and subsequent pathway analysis. (cdc.gov)
Cells3
- The boy's cerebrospinal fluid (CSF) contained glucose at 2.5 mmol/L, protein at 0.88 g/L, and 125 leukocytes/μL (100% lymph cells). (cdc.gov)
- Plerixafor may cause mobilization of leukemic cells and subsequent contamination of the apheresis product. (fresenius-kabi.com)
- Leukocyte-platelet-rich plasma (L-PRP) is a bloodderived portion composed of high concentrations of platelets and white cells, and it has been applied as autogenous biomaterial in bone repair 13 . (bvsalud.org)
Cycles2
Receptor1
- In a subsequent study we could correlate decreased response to clopidogrel to increased protein expression of the P2Y12 receptor in patients with coronary artery disease. (avhandlingar.se)
Concentration1
- Plasma NMH concentration increased immediately after leukoreduction but did not change significantly during the subsequent 28 days of storage, nor did it differ between units that did and did not undergo leukoreduction. (avma.org)
Proteins1
- Subsequent projects on drug metabolism led him to establish methodologies for the efficient expression of recombinant proteins. (aacc.org)
Diseases1
- Purpose: Leukocyte telomere length has gained attention as a marker of oxidative damage and age-related diseases, including cancer. (aacrjournals.org)
Patients2
- Leukoreduced RBCs still contain enough leukocytes capable of producing transfusion-associated graft versus host disease (TAGVHD) in susceptible patients. (utmb.edu)
- The patients' subsequent and nuclear magnetic resonance im- ultrasonography and a computerized recovery was uneventful and she was aging can also be helpful. (who.int)
Significant2
- In spina bifida children, leukocyte esterase testing can be used to exclude significant bacteriuria at home, while dip slide tests have no added value to diagnose or exclude significant bacteriuria. (biomedcentral.com)
- A significant increase in presumably mostly leukocyte-derived CD31+/CD41− MV (1.32 (1.09-1.93)-fold [median (25th-75th quartiles)], p = 0.021) was observed post- to prefilter, whereas platelet-derived MV as well as AnnexinV-binding MV were unaltered. (springeropen.com)
Release1
- Researchers who wish to cite entries in their publications should always cite the accession number to ensure that readers can find the relevant data in a subsequent release. (lu.se)
Formation1
- The application of corticosteroid should be carefully evaluated for its impact on hypermetabolism, risky for subsequent stricture formation. (omicsonline.org)
Response1
- One of the sentinel features of atherosclerosis is endothelial cell dysfunction that manifests itself in a variety of ways including poor nitric oxide production, poor vasodilatory response, and increased adhesiveness to leukocytes ( 1 ). (diabetesjournals.org)
Control1
- Subsequent control was performed with annual CT. (who.int)
Cell1
- Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)