• A well-known example of a lipid kinase is phosphoinositide 3-kinase which is implicated in a number of cancers, mainly through alterations to its catalytic subunit - PIK3CA. (horizondiscovery.com)
  • Serine/Threonine Kinases (STKs), cAMP-dependent protein kinase (PKA) subfamily, PRKX-like kinases, catalytic (c) subunit. (umbc.edu)
  • All six receptors belong to the G protein-coupled receptor (GPCR) superfamily which initiates intracellular signalling cascades via four G protein classes differentiated by their α subunit type: Gαs, Gαi/o, Gαq/11, Gα12/13. (smpdb.ca)
  • The binding of LPA to an LPAR allosterically activates the heterotrimeric G protein by exchanging GDP for GTP at the G protein's alpha subunit. (smpdb.ca)
  • STK16 is serine/threonine kinase 16 which constitute the catalytic subunit of a multisubunit kinase. (signalchem.com)
  • The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
  • DYRKs are named after their characteristic dual-specificity, as they auto-phosphorylate a conserved tyrosine in their activation loop, but phosphorylate substrates on serine and threonine residues 2 . (nature.com)
  • Finally, the C-terminus of HIPK1-3 comprises a region rich in serine, glutamine, and alanine (SQA) residues, which is involved in the interaction with different co-factors 14 . (nature.com)
  • can phosphorylate substrate proteins on serine, threonine, tyrosines or histidine residues. (horizondiscovery.com)
  • STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
  • 2022 ) predicts human DBNDD1 - with a short stretch of helical propensity between residues L77 and S95 - entirely as an IDP. (springer.com)
  • PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. (umbc.edu)
  • Based on their ability to phosphorylate either tyrosine or serine and threonine residues, they are classified into two main families. (parsianpharma.com)
  • is a kinase enzyme , in particular a protein kinase , that phosphorylates the OH group of the amino-acid residues serine or threonine , which have similar side chains. (cloudfront.net)
  • While serine/threonine kinases all phosphorylate serine or threonine residues in their substrates, they select specific residues to phosphorylate on the basis of residues that flank the phosphoacceptor site, which together comprise the consensus sequence . (cloudfront.net)
  • Since the consensus sequence residues of a target substrate only make contact with several key amino acids within the catalytic cleft of the kinase (usually through hydrophobic forces and ionic bonds ), a kinase is usually not specific to a single substrate, but instead can phosphorylate a whole 'substrate family' which share common recognition sequences. (cloudfront.net)
  • This domain occurred 395 times on human genes ( 899 proteins). (umbc.edu)
  • In contrast to the human genome that contains two genes, plant GSKs are encoded by a multigene family. (biomedcentral.com)
  • This domain occurred 438 times on human genes ( 989 proteins). (umbc.edu)
  • The human genome consists of 90 tyrosine kinase genes, which 58 are receptor types that are classified into 20 subfamilies, the other 32 tyrosine kinase genes are the non-receptor types that are classified into 10 subfamilies. (parsianpharma.com)
  • Such radiations include genes involved in spermatogenesis, chemosensation, Wnt signaling and FGF receptor-like kinases. (wormbook.org)
  • Protein kinases constitute one of the largest and most important of protein families, accounting for ~2% of genes in a variety of eukaryotic genomes. (wormbook.org)
  • We identified 438 protein kinase genes, including 20 atypical kinases, and an additional 25 kinase fragments or pseudogenes. (wormbook.org)
  • While the catalytic domain of these kinases is highly conserved , the sequence variation that is observed in the kinome (the subset of genes in the genome that encode kinases) provides for recognition of distinct substrates. (cloudfront.net)
  • Consequently, while Smad protein are intrinsically transcriptional activators, the transcriptional end result of buy BV-6 their focus on genes often depends upon the transcriptional companions connected with Smads [24]. (molecularcircuit.com)
  • Members of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types and, to date, the cloning of seven mammalian PKC genes encoding eight distinct isoforms has been reported. (bgu.ac.il)
  • Degenerate oligonucleotide primers corresponding to conserved sequence motifs, which distinguish the PKC family from other protein kinases, were employed in polymerase chain reactions (PCR) to amplify partial core sequences of putative PKC genes from a human peripheral blood lymphocyte-derived cDNA library. (bgu.ac.il)
  • Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
  • SMAD MifaMurtide proteins will be the major substrates of TGF-β1 receptors [19] whereas we previously discovered that TGF-β1 up-regulated CTGF manifestation had not been via SMAD pathways in rabbit corneal wound curing [14]. (bio2009.org)
  • Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
  • Types include those acting directly as membrane-bound receptors ( Receptor protein serine/threonine kinase ) and intracellular kinases participating in Signal transduction . (cloudfront.net)
  • Human homologs of the AKT8 oncogenic protein were identified in 1987.By 1995 it had been found that Akt kinases function as mitogen-activated kinases downstream from cell surface receptors that activate phosphoinositide 3-kinase . (cloudfront.net)
  • In human beings, three isoforms of TGF-have been explained, TGF-ligands is definitely transduced through cell surface area recaptor complexes of two unique types of transmembrane serine-threonine kinases, the sort I and type II receptors. (molecularcircuit.com)
  • Seven type I receptors (Activin-recaptor like kinases, ALKs, 1C7) and five type II receptors are known in vertebrates. (molecularcircuit.com)
  • The EGF-CFC family has been identified in all chordate species and consists of Cripto-1 (CR-1) and Cryptic that perform an obligatory role as co-receptors for the TGF beta subfamily of proteins, Nodal/GDF1/GDF3 and that regulate gastrulation, germ layer formation and left-right axis determination. (grantome.com)
  • Nodal binding to cripto-1 functions through the ALK4 and Act-R-IIB Activin/TGF beta class of serine-threonine kinase receptors to activate a canonical Smad2 and Smad3 intracellular signaling pathway through dimerization with Smad4. (grantome.com)
  • Protein kinases are one of the largest and most influential of gene families: constituting some 2% of the proteome, they regulate almost all biochemical pathways and may phosphorylate up to 30% of the proteome. (wormbook.org)
  • The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
  • The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). (umbc.edu)
  • Glioblastoma (GBM), a very aggressive and incurable tumor, often results from constitutive activation of EGFR (epidermal growth factor receptor) and of phosphoinositide 3-kinase (PI3K). (sdbonline.org)
  • PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (nih.gov)
  • Thus, the two substrates of this enzyme are ATP and a protein , whereas its two products are ADP and phosphoprotein . (cloudfront.net)
  • Adding further complexity to this picture is the fact that both kinases and phosphatases can function in signaling networks where multiple kinases and phosphatases contribute to the outcome of a pathway. (rupress.org)
  • One technique of microorganisms which has lately attracted particular curiosity is the capability to acquire web host fluid-phase go with regulatory protein of the choice pathway. (abic2004.org)
  • Both central individual fluid-phase go with regulators of the choice pathway are FHL-1/reconectin and aspect H. Both protein are related structurally, and their transcripts are produced by alternative digesting of the nuclear RNA transcript, LY2811376 which comes from a single human being gene (11, 47). (abic2004.org)
  • Extracellular signal-regulated kinase (ERK) JNK and p38 pathway constitute three main subfamilies of MAPK pathways [21]. (bio2009.org)
  • 2. Ohta, S. et.al: A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway. (signalchem.com)
  • Within the cDNA, open reading frames (ORF) were defined encoding proteins of 367 and 358 amino acids respectively, as well as conserved kinase domains typical of the superfamily of Ser/Thr kinases. (elsevierpure.com)
  • The TGF-superfamily contains a lot more than 30 proteins ligands split into subfamilies predicated on series similarity and function. (molecularcircuit.com)
  • Users from the TGF-superfamily are TGF-is secreted like a latent precursor: After secretion the pro-domain (latency connected proteins, LAP) binds and inactivate the ligand, permitting its association with inhibitory latent TGF binding protein (LTBPs) that focus on the complicated towards the ECM where in fact the latent TGF-is sequestered. (molecularcircuit.com)
  • The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. (thermofisher.com)
  • Kinases are a large family of enzymes with over 500 encoded in the human genome and all share a highly conserved kinase domain. (horizondiscovery.com)
  • Mitogen-activated protein kinases such as RAF kinases involved in the MAPK signaling pathways and cyclin dependent kinases (CDKs) involved in cell cycle regulation are prime examples of pathways implicated in cancers. (horizondiscovery.com)
  • Furthermore to SMAD proteins the mitogen-activated proteins kinase (MAPK) MifaMurtide pathways had been involved with TGF-β1 signaling [20]. (bio2009.org)
  • MAPK pathways certainly are a category of serine-threonine proteins kinases that are triggered in response to a number of extra mobile stimuli. (bio2009.org)
  • We were able to demonstrate that CR-1 can also activate Nodal and ALK4-independent signaling pathways by binding to glypican-1 and by subsequently activating c-src, MAPK, PI-3 kinase and Akt which are critical for CR-1 in stimulating EMT. (grantome.com)
  • Through extensive biochemical and genetic analysis, we now know that pathways are not simply switched on with kinases and off with phosphatases. (rupress.org)
  • In humans and animals, GSK-3/SGG are key regulators of a broad range of signaling pathways and their dysregulation responsible for a number of diseases or developmental abnormalities, both aspects abundantly documented in the literature. (biomedcentral.com)
  • Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. (umbc.edu)
  • By phosphorylating substrate proteins, kinases modify the activity, location and affinities of up to 30% of all cellular proteins, and direct most cellular processes, particularly in signal transduction and co-ordination of complex pathways. (wormbook.org)
  • Many of these pathways are highly conserved, and 53 distinct kinase functions and subfamilies appear to have been conserved between yeasts, nematodes, insects and vertebrates, with a further 91 subfamilies of kinases being seen throughout metazoan genomes. (wormbook.org)
  • Recently, a book arm of TGF-signaling continues to be discovered where ALK5 activates the R-Smads, Smad1/5, resulting in TGF-can on the other hand activate the R-Smads, Smad1/5/8 via the Tcan also activate Smad-independent signaling pathways through the connection and association with option mediator protein [30]. (molecularcircuit.com)
  • TP53RK belongs to a small subfamily of atypical protein kinases. (rockland.com)
  • The remaining atypical protein kinases (aPK) belong to several families, some of which have structural, but not sequence similarity to ePKs. (wormbook.org)
  • They are divided into three subfamilies: conventional (or classical), novel, and atypical based on their second messenger requirements. (cloudfront.net)
  • LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. (thermofisher.com)
  • The human trabecular meshwork cells were treated with t BHP for 1 or 2 h with or without pretreatment of SB203580, an inhibitor of MAP kinase homologs. (molvis.org)
  • Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). (umbc.edu)
  • Kinases are deeply conserved in evolution, and the worm has family homologs for over 80% of the human kinome. (wormbook.org)
  • Nematodes share 153 subfamilies with human, providing close homologs for 81% (419/518) of all human kinases. (wormbook.org)
  • A large group of enzymes that speeding up protein phosphorylation and controlling multiple signaling incidents are titled as Protein tyrosine kinases, which represents a complicated system and is wrapped up by of 518 members. (parsianpharma.com)
  • In enzymology , the term serine/threonine protein kinase describes a class of enzymes in the family of transferases , that transfer phosphates to the oxygen atom of a serine or threonine side chain in proteins . (cloudfront.net)
  • PKCθ displays the highest homology to PKCδ, lacks the Ca 2+ -binding C2 domain and, thus, belongs to the subfamily of Ca 2+ - independent PKC enzymes which also includes the δ, ε, ζ, and η isoforms. (bgu.ac.il)
  • Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the PCTK1 gene. (wikipedia.org)
  • This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) domains. (assaysolution.com)
  • Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
  • The systematic name of this enzyme class is ATP:protein phosphotransferase (non-specific) . (cloudfront.net)
  • These were formerly included in EC number '2.7.1.37', which was a general EC number for any enzyme that phosphorylates proteins while converting ATP to ADP (i.e. (cloudfront.net)
  • A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
  • This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. (origene.com)
  • In addition, TSKS, the human homologue of a putative substrate of TSSK 1 and 2, was cloned. (elsevierpure.com)
  • Included within this ~2.7-kilobase pair cDNA is an open reading frame of 2,118 nucleotides encoding a putative 82-kDa protein. (bgu.ac.il)
  • The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. (antibodypedia.com)
  • This assay has high sensitivity and excellent specificity for detection of Human Total Akt1. (assaysolution.com)
  • Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
  • HIPKs belong to the CMGC group of serine/threonine kinases and are part of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. (nature.com)
  • The human and mouse homologues of TSSK 1 and TSSK 2, together with TSSK 3 and SSTK/FKSG82, constitute a kinase subfamily closely related to the calmodulin kinases and SNF/nim 1 kinase subfamilies. (elsevierpure.com)
  • The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. (wikipedia.org)
  • Mitogen-activated protein kinases (MAPKs) comprise a large family of proteins activated by a wide range of proinflammatory cytokines and environmental stress. (molvis.org)
  • Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)
  • The DYRK family has been characterized in organisms from yeast to humans and can be divided into five subfamilies, class I DYRKs, class II DYRKs, YAKs, HIPKs, and PRP4s 1 . (nature.com)
  • Within the HIPK family, HIPK1 and HIPK2 are the most closely related members, sharing about 93% sequence identity in their kinase domains, while HIPK3 is slightly less conserved with 87% identity. (nature.com)
  • The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. (abic2004.org)
  • Two members of the human testis-specific serine/threonine (Ser/Thr) kinase family, TSSK 1 and TSSK 2, were cloned and sequenced from a human testis adaptor-ligated cDNA library using a PCR strategy. (elsevierpure.com)
  • Antibodies against recombinant TSSK 2 demonstrated that a member of the TSSK family was present in human testis and localized to the equatorial segment of ejaculated human sperm. (elsevierpure.com)
  • The finding of a TSSK family member in mature sperm suggests that this family of kinases might play a role in sperm function. (elsevierpure.com)
  • The dysbindin (dystrobrevin-binding protein) protein family is a group of evolutionarily related proteins of moderate size (Mw 13-45 kDa) in higher Eukaryotes. (springer.com)
  • Unlike other dysbindin family proteins, DBNDD1 isoforms are probably non-classical secretory proteins (Talbot et al. (springer.com)
  • Launch Proteins kinase C (EC 2.7.11.13), known as PKC also, is a family group of serine/threonine kinases that play an integral function in the legislation of varied cellular procedures, including cell proliferation, apoptosis, and differentiation.1,2 In individuals, at least 11 different PKC polypeptides have already been identified. (nibbp2p.org)
  • DnaJ heat shock protein family (Hsp40). (gsea-msigdb.org)
  • is actually a family of protein kinases consisting of ~10 isozymes . (cloudfront.net)
  • form part of the MAPKK Kinase family and are activated by growth factors. (cloudfront.net)
  • CAMK2β belongs to the serine/threonine protein kinase family and to the type II multifunctional Ca(2+)/calmodulin-dependent protein kinase subfamily. (signalchem.com)
  • The deduced primary structure contains consensus sequences characteristic of protein kinase catalytic domains and, based on its amino acid sequence and domain structure, is a member of the PKC family. (bgu.ac.il)
  • Our laboratory studies the the EGF-CFC family and their role in the development of the mouse mammary gland and in the initiation and progression of mouse and human breast cancer. (grantome.com)
  • also alpha -PAK and p65-PAK) is both a cytoplasmic and nuclear 58-60 kDa member of PAK group I, STE20 subfamily, STE Ser/Thr protein kinase family of molecules. (rndsystems.com)
  • No significant cross-reactivity or interference between Human Total Akt1 and analogues was observed. (assaysolution.com)
  • Full length human recombinant protein of human AKT2 (NP_001617) produced in HEK293T cell. (origene.com)
  • Overexpression of AKT2 contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. (nsjbio.com)
  • AKT2 is a general protein kinase capable of phophorylating several known proteins. (nsjbio.com)
  • A portion of amino acids 452-481 from the human protein was used as the immunogen for this AKT2 antibody. (nsjbio.com)
  • The protein level of phospho-p38 was measured using western blot analysis. (molvis.org)
  • TP53RK Protein is suitable for use in Western Blot. (rockland.com)
  • MATERIALS AND METHODS: Real-Time PCR (RT-PCR) and Western Blot were adopted to detect the mRNA and protein expression levels of calcium channel regulatory molecules. (bvsalud.org)
  • Glycogen synthase kinase 3 (GSK-3) / SHAGGY kinase (SGG) are multifunctional non receptor serine/threonine kinases. (biomedcentral.com)
  • In accordance with the close relationship between HIPKs and other DYRK subfamily members, DYRK1A, a class I DYRK member, shares a sequence identity with HIPK3 of 38% within the catalytic domain. (nature.com)
  • 2009 ). The designated dysbindin paralogs show very limited sequence homology which raised the question whether DBNDD1 and DBNDD2 are dysbindin-like proteins or proteins that share a less conserved domain with DTNBP1 in the context of otherwise unrelated sequences (Ghiani and Dell'Angelica 2011 ). (springer.com)
  • As an outcome human DBNDD1 revealed a high sequence identity to dysbindin domain-containing proteins from other Hominidae (e.g. (springer.com)
  • Proteins with high sequence identity to human DBNDD1 can also be found in evolutionarily more distant species (e.g. (springer.com)
  • Peptide sequence around phosphorylation site of threonine 200 (M-K-T(p)-V-C) derived from human CaMKIV. (genetex.com)
  • Most protein kinases share a common ePK (eukaryotic protein kinase) catalytic domain, and can be identified by sequence similarity with Blast or profile hidden Markov models (HMMs). (wormbook.org)
  • The classification is based on sequence similarity within the kinase domain, the presence of additional domains, known biological functions, and conservation across divergent genomes. (wormbook.org)
  • The complete cDNA sequence was determined by anchored PCR cloning and sequencing the entire coding sequence, using cDNA derived from a human leukemic T cell line (Jurkat). (bgu.ac.il)
  • Synthetic peptide within Human p38 aa 150-250 (internal sequence). (abcam.com)
  • Over aa 128-242, human PAK1 shares 96% aa sequence identity with mouse PAK1. (rndsystems.com)
  • Many kinases are inhibited by a pseudosubstrate that binds to the kinase like a real substrate but lacks the amino acid to be phosphorylated. (cloudfront.net)
  • This study reports that LKB1 binds to Phosphoinositide-dependent kinase (PDK1) by a conserved binding motif. (sdbonline.org)
  • Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. (umbc.edu)
  • This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
  • Further study on the mechanisms of p38MAPK in human TM cell apoptosis may help to illuminate the pathogenesis of POAG. (molvis.org)
  • In summary, homozygous mutation leads to B-cell hyperproliferation and faulty apoptosis with consequent lymphocyte autoantibody and deposition creation in human beings, and disrupts organic killer cell function. (nibbp2p.org)
  • Serine/threonine kinases play a role in the regulation of cell proliferation, programmed cell death ( apoptosis ), cell differentiation, and embryonic development. (cloudfront.net)
  • 1. Ligos, J. M. et.al: Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases. (signalchem.com)
  • Similar to the mouse, tissue expression by northern and dot blot analysis revealed that human TSSK 1 and 2 messages are expressed exclusively in the testis. (elsevierpure.com)
  • Expression of CR-1 was found to correlate with LRH-1 expression in a tissue microarray of human breast tumors and this correlation in LRH-1 and CR-1 expression occurs more frequently in HER+ and in triple negative breast tumors ( HER-, ER- and PR-) as compared to more differentiated Luminal A and Luminal B breast tumors. (grantome.com)
  • Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and. (bindingdb.org)
  • Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) tyr kinases. (umbc.edu)
  • C-terminally adjacent to the HID follows a proline, glutamate, serine, and threonine (PEST)-rich domain, mediating proteasomal degradation of these kinases. (nature.com)
  • It phosphorylates and activates several downstream kinases, including AMP-dependent kinase, AMPK . (sdbonline.org)
  • This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)
  • Recombinant full-length human TP53RK was expressed by baculovirus in Sf9 insect cells using an N-Terminal Glutathione-S-Transferase fusion protein. (rockland.com)
  • Recombinant full-length human CAMK2beta was expressed by baculovirus in Sf9 cells using an N-terminal His tag. (signalchem.com)
  • The dysbindin domain-containing protein 1 (DBNDD1) is a conserved protein among higher eukaryotes whose structure and function are poorly investigated so far. (springer.com)
  • Human dysbindin domain-containing protein 1 (DBNDD1) is encoded by the gene DBNDD1 at chromosome locus 16q24.3. (springer.com)
  • Dysbindin domain-containing protein 1 (DBNDD1) is conserved in different species. (springer.com)
  • Their amino acid sequences suggest that they are mainly cytosolic or nuclear proteins partly associating with membranes (Talbot et al. (springer.com)
  • 2021 ). The human DBNDD1 isoforms 1 (UniProtKB: Q9H9R9-1) and 2 (UniProtKB: Q9H9R9-2) differ only in the N-terminal region where 20 amino acids are additional in isoform 2. (springer.com)
  • Human PAK1 is 545 amino acids (aa) in length. (rndsystems.com)
  • PAK1 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line using Goat Anti-Human PAK1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7495) at 15 µg/mL for 3 hours at room temperature. (rndsystems.com)
  • Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
  • To fully understand this complex and essential regulatory process, the kinases and phosphatases mediating the changes in cellular phosphorylation must be identified and characterized. (rupress.org)
  • Due to their vital functions in cellular activities and the pathological effects on cell behavior, these recent years the main focus of researches has been directed towards cancer-associated tyrosine kinases. (parsianpharma.com)
  • Since kinases perform such a variety of distinct basic cellular functions, it is not surprising to see that 53 subfamilies and functions are present in all four kinomes ( Figure 1 ). (wormbook.org)
  • Protein phosphorylation in particular plays a significant role in a wide range of cellular processes and is a very important posttranslational modification . (cloudfront.net)
  • The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) plays an important role in cellular resistance to alkylating agents. (aacrjournals.org)
  • A cellular DNA-repair protein, namely O 6 -methylguanine-DNA methyltransferase (MGMT) protein, reverses alkylation at the O 6 position of guanine, thereby inhibiting the lethal cross-linking and bringing about resistance to alkylating agents ( 2, 3 ). (aacrjournals.org)
  • The master kinase LKB1 is a key regulator of several cellular processes, including cell proliferation, cell polarity and cellular metabolism. (sdbonline.org)