Mucous membrane pemphigoid is a rare chronic autoimmune subepithelial blistering disease characterized by erosive lesions of the mucous membranes and skin. (wikipedia.org)
Brunsting-Perry cicatricial pemphigoid is a rare variant of mucous membrane pemphigoid involving the scalp and the neck without mucosal involvement. (wikipedia.org)
In mucous membrane pemphigoid, the autoimmune reaction occurs in the skin, specifically at the level of the basement membrane, which connects the lower skin layer (dermis) to the upper skin layer (epidermis) and keeps it attached to the body. (wikipedia.org)
Mucous membrane pemphigoid (MMP), also known as cicatricial pemphigoid, refers to a group of rare chronic autoimmune blistering diseases that predominately affect the mucous membranes, including the conjunctiva, and occasionally the skin. (medscape.com)
Ocular manifestations of cicatricial pemphigoid (mucous membrane pemphigoid) include symblepharon, demonstrated in this photograph by the tethering of the lower lid to the cornea. (medscape.com)
Classification of mucous membrane pemphigoid patients has been difficult because some patients with other autoimmune blistering diseases, including bullous pemphigoid (BP), epidermolysis bullosa acquisita (EBA),and anti-p200 pemphigoid, may have mucosal involvement. (medscape.com)
By direct immunofluorescence (DIF) study, antibodies bound in a linear band at the epidermal-dermal junction have been found in patients with mucous membrane pemphigoid (MMP), as depicted below. (medscape.com)
Different epithelial membrane zone components have been recognized by antibodies in patients with mucous membrane pemphigoid, including BP antigens 1 and 2 (BP230 and BP180), laminin-332, laminin-311, type VII collagen, b4 integrin subunit, and antigens with unknown identities (a 45-kd protein, uncein, a 168-kd epithelial protein, and a 120-kd epithelial protein). (medscape.com)
Patients with mucous membrane pemphigoid react with epitopes on BP180 distinct from those associated with BP and linear IgA bullous dermatosis, particularly the C-terminal of the protein. (medscape.com)
Laminin-332 contains disulfide-linked alpha, beta, and gamma chains, of which the alpha subunit is the major site of mucous membrane pemphigoid reactivity. (medscape.com)
A group of autoimmune blistering diseases affecting primarily the mucous membranes is termed mucous membrane pemphigoid (MMP) (also termed cicatricial pemphigoid). (medscape.com)
Whereas the pemphigus subset of diseases is mediated by autoantibodies that target the extracellular skin components that link one epidermal cell to another, the pemphigoid subset is mediated by autoantibodies that target the extracellular skin components that link the skinbasement membrane components either to the lowermost layer of epidermal cells or to the dermal components. (medscape.com)
Thorough examination by consulting physicians experienced in mucous membrane pemphigoid (cicatricial pemphigoid) is recommended for some patients with oral lesions that also can have genital mucosal involvement. (medscape.com)
A spontaneous canine model of mucous membrane (cicatricial) pemphigoid, an autoimmune blistering disease affecting mucosae and mucocutaneous junctions. (medscape.com)
Mucous Membrane Pemphigoid (MMP) is an autoimmune subepithelial blistering disorder usually affecting older individuals. (bvsalud.org)
The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators. (bvsalud.org)
Mucous membrane pemphigoid (MMP) is a heterogeneous group of chronic autoimmune subepithelial blistering diseases. (btitrainingcenter.com)
Although future research is necessary to confirm these observations, PRGF could be a useful adjuvant for the management of extensive mucous membrane pemphigoid oral lesions. (btitrainingcenter.com)
Mucous membrane pemphigoid is the designation given to a heterogeneous group of rare chronic autoimmune disorders that tend to cause waxing and waning bullous lesions of the mucous membranes, often with subsequent scarring and morbidity. (msdmanuals.com)
Synonyms of mucous membrane pemphigoid that are no longer used include cicatricial pemphigoid, ocular cicatricial pemphigoid, and benign mucous membrane pemphigoid. (msdmanuals.com)
Пемфігоїд слизової оболонки ока Ocular mucous membrane pemphigoid is a chronic, bilateral, progressive scarring and shrinkage of the conjunctiva with opacification of the cornea. (msdmanuals.com)
Mucous membrane pemphigoid (MMP) is characterized by subepithelial lesions caused by autoantibodies against molecules of epithelial basement membranes. (msdmanuals.com)
Mucous membrane pemphigoid progresses slowly, rarely remits spontaneously, and often responds incompletely to treatment. (msdmanuals.com)
Mucous membrane pemphigoid (MMP) comprises a heterogenous group of autoimmune subepithelial bullous diseases very frequently having oral involvement. (ncl.ac.uk)
Laminin-332 polypeptides are targeted by auto-antibodies in human patients with mucous membrane (cicatricial) pemphigoid or, more rarely, subepidermal vesicular diseases that resemble epidermolysis bullosa acquisita (EBA) or bullous pemphigoid (BP). (morulaivf.com)
The names 'acquired junctional epidermolysis bullosa', 'anti-laminin-332 mucous membrane pemphigoid (MMP)' and 'mixed auto-immune subepidermal blistering dermatosis' are proposed for dogs with clinical signs reminiscent of EBA, MMP or BP respectively. (morulaivf.com)
Autoimmune etiologies including ocular rosacea with meibomian gland disease , atopic disease, and most commonly, ocular cicatricial pemphigoid (OCP) , part of the mucous membrane pemphigoid (MMP) spectrum of disorders, [4] have been implicated in active, progressive cicatrizing conjunctivitis. (eyewiki.org)
Other non-classical clinical presentations include an inflammatory bullous pemphigoid-like eruption a mucous membrane pemphigoid-like eruption and an IgA bullous dermatosis-like disease. (globalgenes.org)
Cicatricial1
Scarring of the mucous membranes is common, hence the designation cicatricial, which can lead to decreased vision, blindness, and supraglottic stenosis with hoarseness or airway obstruction. (medscape.com)
Including the conjunctiva1
The pathologic process of OCP , the most common autoimmune cause of cicatrizing conjunctivitis, is mediated by genetic susceptibility [4] for autoantibody formation against basement membrane glycoproteins of mucosal membranes, including the conjunctiva, esophagus, and larynx. (eyewiki.org)
Lichen Planus1
Lichen planus (LP) is a chronic inflammatory and immune mediated disease that affects the skin, nails, hair, and mucous membranes. (hindawi.com)
Lesions1
These techniques also aid in the diagnosis and therapy of subepithelial lesions localized to the muscularis mucosa or submucosa. (elsevierpure.com)
Diseases3
These observations establish laminin-332 as a novel basement membrane antigen in dogs with autoimmune blistering diseases with variable clinical phenotypes. (morulaivf.com)
Immune disturbance as well as destruction of basal epidermal cells and base membrane by GVHD may result in the induction of autoimmune blistering diseases with unusual clinical and laboratory manifestations. (morulaivf.com)
Modulating the cytokine network in thickening of the basement membrane underlying the respiratory diseases such as asthma, with expected airway epithelium. (cdc.gov)
Basement membrane zone2
Hereditary junctional epidermolysis bullosa (JEB) is a recessive inherited blistering disorder of the skin and mucous membrane in which tissue separation occurs within the lamina lucida (i.e. under the basal plasma membrane of the basal keratinocytes and above the basement membrane) of the basement membrane zone (BMZ) at the dermal-epidermal junction [ 1 ]. (biomedcentral.com)
A rare chronic incurable sub epithelial autoimmune bullous disease characterized by the presence of tissue bound autoantibodies against type VII collagen within the basement membrane zone of the dermal-epidermal junction of stratified squamous epithelia. (globalgenes.org)
Conjunctiva1
The conjunctiva is a translucent mucous menbrane that covers the inner surface of the eyelids and extends to the limbus on the surface of the globe. (bmj.com)
Systemic1
3] Later, the term EM minor was proposed to differentiate the more mild cutaneous disease (as described by von Hebra) from a more severe form that may involve mucous membranes and systemic symptoms, which at that time was referred to as EM major. (jcadonline.com)
Chronic3
A significant correlation was found between the number of epithelial or submucosal cells expressing TGF- β in both asthma and chronic bronchitis and basement membrane thickness and fibroblast number. (atsjournals.org)
Asthma is a chronic inflammatory disease associated with remodeling of the airways ( 1 ) as shown by subepithelial fibrosis ( 2 ) and by the activation of fibroblasts and myofibroblasts ( 3 ). (atsjournals.org)
Chronic inflammatory condition of the pharynx characterized by hypertrophy of mucosa, seromucinous glands, subepithelial lymphoid follicles and even the muscular coat of the pharynx. (medchrome.com)
Amniotic membrane3
A lamellar keratectomy, corneal patch graft, amniotic membrane were applied. (bascompalmerlearn.org)
Preop and post-op-month 1, with amniotic membrane dissolved. (bascompalmerlearn.org)
Ulcerative vernal keratitis require surgical treatment in the form of debridement, superficial keratectomy, excimer laser therapeutic keratectomy, as well as amniotic membrane transplantation to enhance re-epithelialisation. (drcremers.com)
Immunofluorescence1
Direct immunofluorescence revealed a linear deposition of IgG on the base membrane zone. (morulaivf.com)
Mucosa1
Jul 27, 2017 the mucosa is a mucussecreting lubricating membrane that lines the digestive tract, including the colon and the rectum. (web.app)
In this connection, Kingsley ('24) found that the true gland of the nictitating membrane of the cat and rabbit is a regressive structure and that this bears a close relation to the lymphoid tissue present. (edu.au)
ABSTRACT1
Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, Abstract hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. (cdc.gov)
Hypertrophy1
A patient with acquired corneal subepithelial hypertrophy (ACSH) following history of penetrating keratoplasty. (bascompalmerlearn.org)
Antibodies2
When the condition is active, the basement membrane is dissolved by the antibodies produced, and areas of skin lift away at the base, causing hard blisters which scar if they burst. (wikipedia.org)
The results indicate that emission from dental light curing units can affect the oral mucous membrane and may reduce its functional abilities. (who.int)
Conclusions The age-related changes of conjunctivas included decreasing densities of DCs as well as the degeneration of subepithelial structures. (bmj.com)
Inflammation1
Erythema nodosum en, is an inflammatory condition characterized by inflammation of the fat cells under the skin, resulting in tender red nodules or lumps that are usually seen on both shins. (web.app)
Skin1
Erythema marginatum is a type of erythema redness of the skin or mucous membranes involving pink rings on the torso and inner surfaces of the limbs which come and go for as long as several months. (web.app)
Severe1
More severe cases can also affect areas of mucous membrane elsewhere in the body, such as the sinuses, genitals, anus, and cornea. (wikipedia.org)
Some Patients Suffer From Dry Eye As A Result Of Medications Such As Antibiotics, Antihistamines, Diuretics, And Anti-Diarrheals, Which Can Dry Up The Mucous Membranes. (indiahealthtour.com)
Group1
The diameters of subepithelial fibres in each group were measured as well. (bmj.com)
Junction1
Some authors suggest mild trauma as the causative agent in angina bullosa hemorrhagica to break the epithelial-connective-tissue junction, causing bleeding of superficial capillaries and resulting in the formation of a subepithelial hemorrhagic bullae. (medscape.com)
It plays a critical role in keeping the integrity of the ocular surface, serving as the source of the tear mucous layer 1 and assisting the immunity system. (bmj.com)