Study skeletal muscle cells. Medical search. Frequent questions

Skeletal muscle fibers release proteins called myokines in the blood during physical activity. (medicalnewstoday.com)
These molecules that can suppress cancer cell growth include myokines, which are cytokines and other proteins secreted by the skeletal muscle fibers during physical activity. (medicalnewstoday.com)
This work will eventually help us understand why certain types of muscle fibers are more susceptible to muscular dystrophy. (seattlechildrens.org)
Certain muscular dystrophies preferentially affect either fast or slow twitch muscle fibers. (seattlechildrens.org)
In human and mouse models of Duchenne Muscular Dystrophy (DMD), fast muscle fibers are more susceptible to damage than slow fibers. (seattlechildrens.org)
The newly identified stem cells are found within populations of satellite cells located between muscle fibers and the surrounding connective tissue that are responsible for the repair and maintenance of skeletal muscles, said Professor Bradley Olwin of CU-Boulder's molecular, cellular and developmental biology department. (phys.org)
When muscle fibers are stressed or traumatized, satellite cells divide to make more specialized muscle cells and repair the muscle, said Olwin. (phys.org)
Although injected cells will repair the muscle fibers, maintaining the muscle fibers requires additional cell injections. (phys.org)
Initiated by neural impulses and subsequent calcium release, skeletal muscle fibers contract (actively generate force) as a result of repetitive power strokes of acto-myosin cross-bridges. (frontiersin.org)
RACK1 was expressed transiently in the skeletal muscle of post-natal mice, being abundant in the early phase of muscle growth and almost disappearing in adult mature fibers. (sdbonline.org)
After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)

This calls for dietary interventions and other strategies to improve muscle progenitor cell proliferation and lower oxidative stress that could aid muscle regeneration during aging. (ibtimes.com)
The human muscle progenitor cell or hMPC is responsible for skeletal muscle regeneration. (ibtimes.com)
Currently, research on dietary interventions to support skeletal muscle regeneration in humans is limited. (ibtimes.com)
Focusing on muscle progenitor cells, which contribute to muscle formation before birth, and muscle stem cells, which contribute to muscle formation after birth and to regeneration from injury throughout life, the group mapped out how the cells' gene networks - which genes are active and inactive - change as the cells mature. (scienceblog.com)
Cell therapy using adipose-derived stromal cells (ADSC) is an intensively developing approach to promote angiogenesis and regeneration. (biomedcentral.com)
The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
A collaboration between researchers in the Department of Biomedical Engineering and the College of Medicine at Texas A&M University identifies the crucial role of minerals in regulating gene expression, thus controlling the number of proteins that a cell should make, thereby encouraging tissue regeneration and redefining cellular identity. (sciencedaily.com)
The main interest of Dr. Darabi's lab is to use pluripotent stem cells for skeletal muscle regeneration in muscular dystrophies and muscle injuries. (uh.edu)
Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)
Collectively, this study provides the first evidence that transient levels of the evolutionarily conserved factor RACK1 are critical for adult SC activation and proper skeletal muscle regeneration, favoring the efficient progression of SC from a committed to a fully differentiated state. (sdbonline.org)
Our team is working on the molecular and cellular actors involved in human muscle regeneration , in muscle ageing and in muscular dystrophies including oculopharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). (institut-myologie.org)
More precisely we are working on RNA metabolism , muscle regeneration , muscle stem cells , and fibrosis , with the final aim of developing innovative therapeutic approaches. (institut-myologie.org)

Seeking understand the decline in function of tissues in organisms, researchers from the Stem Cells and Development unit at Institut Pasteur made a discovery on the still unknown mechanisms of the epigenetic clock in stem cells. (pasteur.fr)
It should be noted that epigenetic clocks based on DNA methylation are constructed from data from multiple tissues from a mixture of different cell types. (pasteur.fr)
Skeletal and cardiac muscle tissues were also significantly affected. (wikipedia.org)
The significance of programmed cell death is not well established in post mitotic tissues, such as skeletal muscle. (cdc.gov)
However, the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects, which has led to new research exploring the effects of vitamin D on a variety of tissues, especially in the skeletal muscle. (hindawi.com)
The involvement of miRNAs in cancer research emerged from studies demonstrating their aberrant expression in neoplastic tissues. (genengnews.com)
The study , published May 11 in the peer-reviewed journal Cell Stem Cell, identified various cell types present in skeletal muscle tissues, from early embryonic development all the way to adulthood. (scienceblog.com)
Leveraging the power of this technology and the Plath lab's bioinformatics expertise, the group identified the genetic signatures of various cell types from human tissues and pluripotent stem cells. (scienceblog.com)
Basement membrane (BM) is a sheet-like extracellular matrix that underlies most tissues and acts as a barrier to invading cells. (duke.edu)
This research shows how satellite cells can maintain their populations within injured tissues," said Olwin. (phys.org)
One of the major findings of this study is that minerals such as silicon, magnesium and lithium are involved in inducing endochondral ossification, a process by which stem cells are transformed into soft and hard tissues such as cartilage and bone in young humans. (sciencedaily.com)
Although some studies exist, there is still limited information regarding histone modifications in human tissues linked to metabolic diseases. (lu.se)
PCB methyl sulphones and related compounds: Identification of target cells and tissues in different species. (cdc.gov)

Physical exercise can modulate the circulating levels of growth factors, hormones, and cytokines, a class of proteins that can modulate inflammation levels, that are involved in sustaining the growth of cancer cells. (medicalnewstoday.com)
The RYR1 and CACNA1S genes provide instructions for making proteins that play essential roles in muscles used for movement ( skeletal muscles ). (medlineplus.gov)
The proteins produced from the RYR1 and CACNA1S genes are involved in the movement of calcium ions within muscle cells. (medlineplus.gov)
In conclusion, it appears that apoptotic signaling contributes to training-induced hypertrophy in skeletal muscle of young animals, by down regulation of pro- and up regulation of anti-apoptotic proteins. (cdc.gov)
[ 2 ] Skeletal muscle has a complex structure, composed of intricately organized proteins arranged in a specific manner to allow for muscle contraction. (medscape.com)
Exercise promotes the formation of intracellular junctions in skeletal muscle between stacks of sarcoplasmic reticulum (SR) cisternae and extensions of transverse-tubules (TT) that increase co-localization of proteins required for store-operated Ca 2+ entry (SOCE). (elifesciences.org)
Delivery of CS allows transplantation of cells along with matrix proteins to facilitate engraftment. (biomedcentral.com)
The team found that the chemical interferes with the signals between proteins which enable muscles to function. (nyhealthinsurer.com)
Their review of nearly 100 scientific studies concluded that some seaweed proteins work just like the bioactive peptides in milk products to reduce blood pressure, almost like the popular ACE inhibitor drugs. (spiritualityhealth.com)
Studies previously conducted show that HS negatively affects the skeletal muscle growth and development by changing its effects on myogenic regulatory factors, insulin growth factor-1, and heat-shock proteins. (frontiersin.org)
Researchers at the Francis Crick Institute and UCL have shown that hundreds of proteins and mRNA molecules are found in the wrong place in nerve cells affected by Motor Neuron Disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS). (news-medical.net)
These signaling pathways are responsible for instructing the cells to take on specific functions, such as converting into another type of cells or starting the healing process by secreting tissue-specific proteins known as extracellular matrix. (sciencedaily.com)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)

A diet with blueberries might improve muscle growth and repair, finds a new study which revealed that the low-calorie dark blue colored berries might improve one's potential for preservation and recovery of skeletal muscle mass. (ibtimes.com)
In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)

Determine how different modalities of exercise influence skeletal muscle splicing. (lu.se)

Muscle stem cell from young mouse stained with the transcription factor Pax7 and in contact with the muscle fibre through the extracellular matrix protein M-Cadherin. (pasteur.fr)
Stem cell numbers usually decline during aging thereby confounding results when total cell populations are surveyed. (pasteur.fr)
This discovery on ageing underscores the importance of basic research in understanding the mechanisms that regulate stem cell properties and function to pave the way for future development of innovative diagnostic or therapeutic strategies. (pasteur.fr)
Despite extensive studies, their stem cell character remains largely undefined. (nih.gov)
Using pulse-chase labelling with BrdU to mark the putative stem cell niche, we identify a subpopulation of label-retaining satellite cells during growth and after injury. (nih.gov)
The cosegregation of 'immortal' template DNA strands and their link with the asymmetry apparatus has important implications for stem cell biology and cancer. (nih.gov)
An interdisciplinary team of researchers at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA has developed a first-of-its-kind roadmap of how human skeletal muscle develops, including the formation of muscle stem cells. (scienceblog.com)
Muscle loss due to aging or disease is often the result of dysfunctional muscle stem cells," said April Pyle, senior author of the paper and a member of the Broad Stem Cell Research Center. (scienceblog.com)
For the pluripotent stem cell-derived muscle cells, the group evaluated cells created using their own unique method and the methods of several other groups. (scienceblog.com)
The Pyle lab collaborated with the lab of Kathrin Plath, a UCLA professor of biological chemistry and member of the Broad Stem Cell Research Center, to conduct high-throughput droplet-based single-cell RNA sequencing of all of the samples. (scienceblog.com)
This enabled the group to match the genetic signatures found in the pluripotent stem cell-derived muscle cells with their corresponding locations on the map of human muscle development. (scienceblog.com)
The group found that pluripotent stem cell-derived muscle cells produced by all the methods they tried resembled muscle progenitor cells at an early developmental state and did not align to adult muscle stem cells. (scienceblog.com)
A University of Colorado at Boulder research team has identified a type of skeletal muscle stem cell that contributes to the repair of damaged muscles in mice, which could have important implications in the treatment of injured, diseased or aging muscle tissue in humans, including the ravages of muscular dystrophy. (phys.org)
The stem cell population identified by the CU team within the satellite cells -- dubbed "satellite-SP" cells -- were shown to renew the satellite cell population after injection into injured muscle cells, contributing to recovery of muscle tissue in the laboratory mice. (phys.org)
A paper on the subject was published in the March 5 issue of the journal Cell Stem Cell . (phys.org)
As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
These nanoparticles are known specifically as nanosilicates, and with them, the team is able to determine the role of minerals in regulating gene expression profiles to direct stem cell differentiation. (sciencedaily.com)
Our study is one of the first studies to utilize unbiased transcriptome-wide sequencing to determine how mineral ions can direct stem cell fate. (sciencedaily.com)
These include generation of knock-in reporter stem cell lines to study myogenic differentiation, CRISPR/Cas9 gene targeting methods to correct mutated genes in muscular dystrophies, and using bioscaffolds, seeded with stem cells, to treat skeletal muscle injuries. (uh.edu)
Wu J, Matthias N, Lo J, Ortiz-Vitali JL, Shieh AW, Wang SH, Darabi R . A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors. (uh.edu)
Stem Cell Res. (uh.edu)
Wu J, Hunt SD, Matthias N, Servián-Morilla E, Lo J, Jafar-Nejad H, Paradas C, Darabi R . Generation of an induced pluripotent stem cell line (CSCRMi001-A) from a patient with a new type of limb-girdle muscular dystrophy (LGMD) due to a missense mutation in POGLUT1 (Rumi). (uh.edu)
Matthias N, Hunt SD, Wu J, Darabi R . Skeletal muscle perfusion and stem cell delivery in muscle disorders using intra-femoral artery canulation in mice. (uh.edu)
Skoglund G, Lainé J, Darabi R , Fournier E, Perlingeiro R, Tabti N. Physiological and ultrastructural features of human induced pluripotent and embryonic stem cell-derived skeletal myocytes in vitro. (uh.edu)
Assessment of the myogenic stem cell compartment following transplantation of pax3/pax7-induced embryonic stem cell-derived progenitors. (uh.edu)

We have validated a microfluidic microphysiological system (MPS) that demonstrates electrically stimulated contraction of human-engineered muscle myobundles derived from muscle biopsies from older, sedentary (OS) adults compared to those derived from young, athletic (YA) adults as a model of age-related muscle disfunction. (selectbiosciences.com)
These studies involve taking skeletal muscle biopsies. (lu.se)
From the biopsies, muscle stem cells (satellite cells) are isolated and later used for preclinical measurements. (lu.se)
Our exercise studies include muscle biopsies and skeletal muscle satellite cells. (lu.se)

By examining the transcriptome and epigenome of individual muscle stem cells simultaneously, we found that DNA transcribes* more chaotically in older muscle stem cells compared to those in younger mice. (pasteur.fr)
This matrix protein is decreased in muscle stem cells in old mice thereby destabilising contact with the fibre. (pasteur.fr)
We hypothesize that either small changes in cell composition during ageing may affect the epigenetic age of a tissue, or that our epigenetic clocks for mice need further refinement" says Shahragim Tajbakhsh. (pasteur.fr)
The functional benefits of exercise on SOCE, constitutive Ca 2+ entry and muscle force production were lost in mice with muscle-specific loss of Orai1 function. (elifesciences.org)
Mouse ADSC (mADSC) isolated from C57 male mice were expanded for CS formation (10 6 cells per CS). (biomedcentral.com)
The chemical also affects muscle function in fish and mice. (nyhealthinsurer.com)
The team also studied triclosan's effects on fish and mice. (nyhealthinsurer.com)
During the last several years, his lab has developed novel methods for multi-lineage differentiation of pluripotent stem cells for cell therapy in mice models of muscular dystrophies and injuries. (uh.edu)

The Journal of Cell Biology. (wikipedia.org)
The focus of the Skeletal Muscle Biology & Cell Death Laboratory is to study the biochemical and molecular mechanisms regulating autophagy and apoptosis in skeletal muscle. (uwaterloo.ca)
This experiment will allow us to study the effects of microgravity on muscle cell biology. (adventistworld.org)
Co-authors on the study included the MCD biology department's Kathleen Tanaka, John Hall and Andrew Troy, as well as Dawn Cornelison from the University of Missouri and Susan Majka from the University of Colorado Denver. (phys.org)
New research offers clues about the biology of cells in the spinal cord that die off in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. (news-medical.net)
We contribute with expertise and resources in molecular genetics and muscle biology. (lu.se)

The researchers explained that increased levels of omega-3 fatty acids in the cells of the skeletal muscles improved insulin sensitivity. (spiritualityhealth.com)
APM-1 can increase insulin sensitivity of skeletal muscle. (prospecbio.com)
Encouraging preclinical results suggest that β3-AR agonists could also improve obesity-related metabolic disease by increasing brown adipose tissue (BAT) thermogenesis, white adipose tissue (WAT) lipolysis, and insulin sensitivity.METHODS We treated 14 healthy women of diverse ethnicities (27.5 ± 1.1 years of age, BMI of 25.4 ± 1.2 kg/m2) with 100 mg mirabegron (Myrbetriq extended-release tablet, Astellas Pharma) for 4 weeks in an open-label study. (jci.org)
0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). (jci.org)

Plectin has been revealed to localize to the desmosomes and in vitro studies have shown that it can form bridges between the desmosome protein, desmoplakin and intermediate filaments. (wikipedia.org)
In vitro studies have shown that the active form of vitamin D, calcitriol, acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation. (hindawi.com)

A new study explains how a single bout of high-intensity exercise can boost tumor-suppressing mechanisms even in advanced prostate cancer. (medicalnewstoday.com)
We are investigating the mechanisms of skeletal muscle fiber-type differentiation. (seattlechildrens.org)
One focus of our lab is understanding the mechanisms behind how skeletal muscle cells differentiate into a specific muscle fiber type, either fast twitch or slow twitch. (seattlechildrens.org)
This research helps us understand the genetic risk factors related to fatal diseases of the heart muscle and the mechanisms underlying the disease, and offers new tools for their prevention. (news-medical.net)
A marginal benefit has been observed in many preclinical studies, however it is also a challenge to understand the mechanisms of these benefits. (escardio.org)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
In another study, we established the molecular mechanisms of the anabolic action of formoterol. (wada-ama.org)
Two newly discovered mechanisms of heart cells may result in a better understanding of cardiovascular disease and lead to new treatment options that prevent damage. (pharmacytimes.com)
The authors of a study published by Cell Reports discovered that these biological mechanisms may prevent damage to the network of mitochondrial circuits that provide energy to the cells. (pharmacytimes.com)
These cell lines are shared in collaboration with many international teams, either to study physiological or pathophysiological mechanisms, or to test innovative therapeutic approaches. (institut-myologie.org)
Furthermore, the authors expanded the study by conducting in vitro experiments on human skeletal muscle cells to understand the biochemical mechanisms regulating the effect of simvastatin on irisin expression. (medscape.com)

Significant loss of muscle mass may occur in cachexia and sarcopenia, which are major causes of mortality and disability. (mdpi.com)
Vitamin D is known to be effective for the prevention of muscle atrophy, such as age-related sarcopenia. (nih.gov)
The roadmap is critical for researchers who aim to develop muscle stem cells in the lab that can be used in regenerative cell therapies for devastating muscle diseases, including muscular dystrophies, and sarcopenia, the age-related loss of muscle mass and strength. (scienceblog.com)
The findings from the spaceflight will be important because the research can also be applied to finding treatments for age-related muscle loss, known as sarcopenia, institute officials said. (adventistworld.org)

CS with underlying muscle was stained for apoptosis, proliferation, monocytes and blood vessels. (biomedcentral.com)
Statin treatment leads to increased oxidative stress in the skeletal muscle cells and leads to upregulation of apoptosis. (medscape.com)

PROJECT DESCRIPTION / ABSTRACT Declines in muscle quality and impaired metabolism are major contributing factors to cardiovascular disease morbidity and mortality. (nih.gov)

Study on culture, identification and differentiation of primary rat skeletal muscle satellite cells]. (bvsalud.org)
To establish the isolation, culture and identification methods of primary rat skeletal muscle satellite cells (SMSC) and observe its characterization of differentiation in vitro . (bvsalud.org)
Myogenesis of these cells was induced in differentiation medium and the mRNA expressions of myogenic differentiation gene (MyoD) and Myogenin were determined by Real-time polymerase chain reaction ( PCR ). (bvsalud.org)
Skeletal muscle satellite cells with high purity and strong differentiation ability can be obtained by means of tissue block culture method . (bvsalud.org)
Furthermore, we demonstrate that the asymmetric cell-fate determinant Numb segregates selectively to one daughter cell during mitosis and before differentiation, suggesting that Numb is associated with self-renewal. (nih.gov)
A goal of this project is to test a fundamental hypothesis: that factors that promote slow muscle differentiation will ameliorate the effects of DMD. (seattlechildrens.org)
We take advantage of zebrafish models to address whether factors that regulate fiber-type differentiation enhance or suppress the zebrafish dmd muscle degeneration phenotype. (seattlechildrens.org)
The proposed studies seek to fill this knowledge gap by investigating the hypothesis that arsenic impairs muscle progenitor cell function and differentiation to promote declines in muscle quality and composition, as well as disrupt communication of healthy muscle metabolism with systemic organs. (nih.gov)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
6- Differentiation of iPSCs into cardiomyocytes and endothelial cells for disease modeling and screening. (uh.edu)

Thus, vitamin D may prevent muscle atrophy via the FOXO1-mediated pathway in muscle cells. (nih.gov)
Obestatin signalling counteracts glucocorticoid-induced skeletal muscle atrophy via NEDD4/KLF15 axis. (institut-myologie.org)

They then investigated how the serum would affect muscle progenitor cell function by calculating the cell number, capacity to manage oxidative stress, etc. (ibtimes.com)
These negative effects are of particular importance in sports events where performance depends on endurance and muscle oxidative capacity. (wada-ama.org)

This preliminary study of muscle progenitor cell function paves the way for future studies to develop clinical interventions," EurekAlert quoted the study's lead author Anna Thalacker-Mercer, Ph.D. (ibtimes.com)
More than 3 decades ago, the clinical observation that patients with rickets and osteomalacia displayed proximal myopathy suggested a direct link between hypovitaminosis D and muscle function [ 7 ]. (hindawi.com)
In this review, we will specifically address the effect of vitamin D on skeletal muscles and its clinical implications, especially frailty and the risk of fall. (hindawi.com)
The company will now pursue dose and mechanistic studies as well as identify suitable biomarkers for clinical applications. (genengnews.com)
The DNA markers associated with the disease found in the study may be a step toward a genetic test, but it is important to confirm its clinical significance before such tests are offered. (news-medical.net)
Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
Details of published experimental and clinical studies about the renal safety of GH in the order of study type (first experimental and after that clinical) and publication year are summarized in the Table. (tattoorockparlour.com)
The appropriate therapy for neurogenic bladder and a successful treatment outcome are predicated upon an accurate diagnosis through a careful medical and voiding history, together with a variety of clinical examinations, including urodynamics and selective radiographic imaging studies. (medscape.com)

Myokines help muscles communicate with other organs and are known to have a beneficial impact on metabolism. (medicalnewstoday.com)
[ 8 ] Glucocorticoid excess may lead to muscle weakness via inhibition of protein synthesis, increased protein catabolism and altered carbohydrate metabolism. (medscape.com)
Based on a dataset encompassing more than 500 Dobermanns, the disease was associated with two nearby genomic loci, where changes were identified in genes that affect the functioning, energy metabolism and structure of the heart muscle. (news-medical.net)
Muscle cells from research-study participants at Florida Hospital's Translational Research Institute for Metabolism and Diabetes (TRI) will be blasting off toward the International Space Station in mid-November 2018 as part of an experiment to examine the effects of a weightless environment on muscle health. (adventistworld.org)
The term anabolic steroids refers to testosterone derivatives that cause nitrogen retention and positive protein metabolism, thereby leading to increased protein synthesis and buy Clenbuterol from Europe muscle mass, and that are used either clinically or by athletes for their anabolic properties. (tattoorockparlour.com)
Our research unit is interested in learning how genetic variation influences skeletal muscle function and whole-body metabolism. (lu.se)
Our research interest is to understand how genetic variation influences skeletal muscle function and whole-body metabolism. (lu.se)

Skeletal muscle satellite cells were obtained by tissue block culture method in combination with pre-plating techniques , and the purity of these cells was detected by both immunocytochemistry and fluorescence activated cell sorter (FACS) with Pax7 as marker of SMSC. (bvsalud.org)
Cells crawled out from the edge of tissue blocks after 1 week of culture . (bvsalud.org)
This paper provides a step-by-step protocol describing how to handle the tissue, conduct the imaging, and use stereological methods to obtain unbiased and quantitative data on fiber type-specific subcellular glycogen distribution in skeletal muscle. (jove.com)
However, vitamin D action in skeletal muscle tissue and muscle cells is largely unknown. (nih.gov)
Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)
So we set out to generate this map as a reference that our lab and others can use to compare the genetic signatures of the cells we are creating to those of real human skeletal muscle tissue. (scienceblog.com)
The group obtained 21 samples of human skeletal muscle tissue from their UCLA collaborators and from colleagues at the University of Southern California and the University of Tübingen in Germany. (scienceblog.com)
In addition to pinning down the true maturity of the lab-produced cells, this analysis also provided details about the other cell types present in skeletal muscle tissue across development and in populations derived from human pluripotent stem cells. (scienceblog.com)
The hope is this new method will allow us to repair damaged or diseased skeletal muscle tissue. (phys.org)
In healthy skeletal muscle tissue, the population of satellite cells is constantly maintained, leading the CU-Boulder team to believe that at least some of the satellite cell population in the mouse study included stem cells. (phys.org)
For the study, the researchers injected 2,500 satellite-SP cells into a population of satellite cells within injured mouse muscle tissue. (phys.org)
They found that 75 percent of the satellite cells that reproduced were derived from the previous satellite-SP cells injected into the tissue. (phys.org)
This research paves the way for future studies to identify the role of specific minerals, as well as how they can be assembled to design the next generation of mineral medicine to heal damaged tissue. (sciencedaily.com)
Such a high dose of growth factors results in a range of complications, including uncontrolled tissue formation, inflammation and tumorigenesis, the production or formation of tumor cells. (sciencedaily.com)
The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)

One of the implications of the study is that all people with cancer should try to complete a bout of high intensity exercise most if not every day of the week to dose their body with the anticancer factors produced by their skeletal muscles," he told us. (medicalnewstoday.com)
There is strong evidence that the chemical can impair muscle function, and the scientists are concerned about its implications to human health and the environment. (nyhealthinsurer.com)
The study has significant implications for veterinary medicine, providing a basis for developing a new genetic test for early diagnostics and breeding. (news-medical.net)
We discuss implications of our model approach for enhancing muscle models in general, as well as a few aspects regarding the significance of phosphate kinetics as one contributor to muscle fatigue. (frontiersin.org)
We hope that this research will lead to a new understanding of skeletal muscle function with implications primarily for human health, but also provide answers to fundamental evolutionary questions. (lu.se)

The number and thickness of fused and striatal myofibers and contraction magnitude are increased in the OS group and begin to resemble the YA phenotype indicating the cells retain their donor phenotype and respond to external stimuli by triggering protein synthesis. (selectbiosciences.com)
[ 2 ] Contraction of a muscle fiber is initiated by the action of the axon that innervates it, which is then transmitted to the inside of the muscle fiber by a structure called the transverse tubular system that results in the release of calcium from the endoplasmic reticulum. (medscape.com)
[ 2 ] This calcium then leads to muscle contraction through a series of downstream events in an ATP-dependent process. (medscape.com)
Future missions will also contain a camera and additional electronics to monitor muscle contraction. (adventistworld.org)
Myoblasts retain skeletal muscle properties and couple only sporadically to resident cardiomyocytes precluding synchronized contraction as mechanism of benefit (8). (escardio.org)
In fast-twitch muscles, the slowing of the time course of skeletal muscle contraction and relaxation during force generation induced by clenbuterol treatment could be considered as a negative effect, contrasting the anabolic effect. (wada-ama.org)

We knew that the muscle cells we were making in the lab were not as functional as the fully matured muscle stem cells found in humans," said Haibin Xi, first author of the new paper and an assistant project scientist in Pyle's lab. (scienceblog.com)
Your germicidal soap might contain triclosan , an effective antimicrobial agent that may also cause muscle impairment in humans. (nyhealthinsurer.com)
Researchers from the University of Helsinki and the Folkhälsan Research Center, together with their international partners, have identified the genetic background of dilated cardiomyopathy, a disease that enlarges the heart muscle, in dogs and humans. (news-medical.net)
The identical genetic background suggests that, to a degree, similar problems with the functioning of the heart muscle lead to dilated cardiomyopathy in both humans and dogs. (news-medical.net)
We use translational approaches and regularly conduct focused intervention studies in humans. (lu.se)

Although normally a cytoplasmic protein, plectin is expressed on the cell membrane in pancreatic ductal adenocarcinoma (PDAC) and can therefore be used to target PDAC cells. (wikipedia.org)
and (5) pancreatic islands of Langerhans dysfunction (as in diabetic muscle infarction). (medscape.com)
In pancreatic beta-cells, the K ATP channel regulates the secretion of insulin by sensing a change in the blood glucose level and thus maintains glucose homeostasis. (go.jp)

Adrenal disorders associated with skeletal muscle dysfunction include primary adrenal insufficiency, glucocorticoid excess, and hyperaldosteronism. (medscape.com)
Adrenal hormone excess or deficiency secondary to pituitary disorders may also be associated with skeletal muscle dysfunction. (medscape.com)
The Maves lab investigates skeletal muscle and heart development, with the goal of making discoveries that lead to new treatments for muscular dystrophy and heart disorders. (seattlechildrens.org)
This map identifies the precise gene networks present in muscle progenitor and stem cells across development, which is essential to developing methods to generate these cells in a dish to treat muscle disorders. (scienceblog.com)
Spinal muscular atrophies include several types of hereditary disorders characterized by skeletal muscle wasting due to progressive degeneration of anterior horn cells in the spinal cord and of motor nuclei in the brain stem. (msdmanuals.com)

Moreover, we found delivery of mADSC as CS to be superior to equivalent dose of suspended cells in terms of perfusion and angiogenesis. (biomedcentral.com)

These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)
Injection of myoblasts into infarcted myocardium has been shown to augment systolic and diastolic functions in experimental animal studies (7). (escardio.org)

Stem cells are distinguished by their ability to renew themselves through cell division and differentiate into specialized cell types. (phys.org)
Therefore, in collaboration with W. Wright, we have developed an approach for the immortalisation of human muscle precursors that allows them to retain their ability to differentiate: this has enabled the generation of immortal cell lines derived from patient cells. (institut-myologie.org)

Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. (wikipedia.org)
The Singh Laboratory, managed by Singh, leverages high-throughput functional assays and perturbations to dissect the functional regulatory programs in mammalian cells. (sciencedaily.com)

In a follow-up study published in Prostate Cancer and Prostatic Diseases , the same researchers have now shown that serum samples collected immediately after a single bout of physical exercise from exercise-trained advanced prostate cancer patients also showed elevated myokine levels and enhanced tumor suppressive effects than before exercise. (medicalnewstoday.com)
Using NSAIDs and hormonal birth control together increased the overall risk of blood clots in women in the study, but the researchers stressed that the overall risk is still low. (livescience.com)
Researchers in Pyle's lab and others around the world already have the capacity to generate skeletal muscle cells from human pluripotent stem cells - cells that have the ability to self-renew and to develop into any cell type in the body. (scienceblog.com)
To create this resource, the group gathered highly specific data about two different groups of skeletal muscle cells: those from the human body, ranging from the fifth week of embryonic development to middle age, and those derived from human pluripotent stem cells the researchers generated in the lab. (scienceblog.com)
This technology enables researchers to identify the gene networks present in a single cell and can process thousands of cells at the same time. (scienceblog.com)
Researchers studied how triclosan affects human cardiac and skeletal muscles in the laboratory. (nyhealthinsurer.com)
Because the cells have a limited lifespan, researchers have only a brief window of time to study the effects of weightlessness, Malany said. (adventistworld.org)

However, it remains unclear if dietary interventions impact the function of these cells. (ibtimes.com)
Recent studies suggest that physical exercise can help improve the quality of life and physical function of cancer patients. (medicalnewstoday.com)
A myopathy is defined as an abnormality of the structure or function of skeletal muscle. (medscape.com)
Although endocrinopathies lead to alterations in cellular function and metabolic disturbances that can result in skeletal muscle dysfunction, the exact pathogenesis remains incompletely understood. (medscape.com)
Hypovitaminosis D is consistently associated with decrease in muscle function and performance and increase in disability. (hindawi.com)
In October 2014, we performed a comprehensive literature search in the bibliographic database "Pubmed," looking at studies discussing the following topics: "hypovitaminosis D and physical performance: observational studies," "can vitamin D supplementation improve muscle function? (hindawi.com)
These results indicate that TT association with SR-stacks enhances Orai1-dependent SOCE to optimize Ca 2+ dynamics and muscle contractile function during acute exercise. (elifesciences.org)
Thus, SOCE plays an important role in both normal muscle development/function and muscle disease. (elifesciences.org)
Reductions of cardiac muscle function and grip strength were noted by as much as 25 and 18 percent respectively. (nyhealthinsurer.com)
The vasculature has a crucial function in normal physiology, enabling the transport of oxygen and nutrients to cells throughout the body. (duke.edu)
This project, which constitutes a follow-up from a previous work funded by WADA, aims at widening our understanding of the effects of 󤠀2-agonists on muscle function, cognitive function and exercise performance. (wada-ama.org)
These findings could improve the understanding of heart and skeletal muscle function in conditions such as heart disease, mitochondrial disease, and muscular dystrophy. (pharmacytimes.com)
Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. (jci.org)
This study demonstrated that the Receptor for Activated C-Kinase 1 (RACK1) is important in SC function. (sdbonline.org)
This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)

Strikingly, some of these cells display selective template-DNA strand segregation during mitosis in the muscle fibre in vivo, as well as in culture independent of their niche, indicating that genomic DNA strands are nonequivalent. (nih.gov)
Develop, test, and implement a new method for skeletal muscle fibre typing. (lu.se)

The current standard of care is corticosteroid treatment, which delays the progression of muscle dysfunction but also has serious side effects. (seattlechildrens.org)

They next developed computational methods to focus on muscle progenitor and stem cells and mapped out their gene networks associated with every developmental stage. (scienceblog.com)
These cells could play an essential role in muscle cell maturation and could be critical to improving methods to generate and support muscle stem cells in a dish. (scienceblog.com)
We found that some methods to generate muscle cells in a dish also produce unique cell types that likely support the muscle cells," said Pyle, who is also a member of the UCLA Jonsson Comprehensive Cancer Center. (scienceblog.com)
Combining interdisciplinary techniques and biomedical engineering and genomics methods, the lead authors of this study, doctoral students Anna Brokesh and Lauren Cross, identify and characterize significant genes that are turned "on" and activated by different signaling pathways due to treatment with minerals. (sciencedaily.com)
The printing methods can be used to fabricate various types of suspended microfluidic devices to perform single-cell biopsy and biophysical characterization of single-cells. (tudelft.nl)

Attenuate hepatic lipogenesis and gluconeogenesis, regulate NO production in endothelial cells, inhibit proliferation of smooth muscle cells and prevent lipid accumulation of macrophage cells. (prospecbio.com)

These results suggest that regular exercise could help suppress tumor cell proliferation in patients with advanced prostate cancer, and each additional bout of exercise could potentially further enhance this tumor-suppressive effect. (medicalnewstoday.com)
Consistent with this, studies have shown that serum collected immediately after a bout of exercise from patients with breast or colon cancer can inhibit the proliferation of cultured cancer cells. (medicalnewstoday.com)

Embryonic development occurs with precisely timed morphogenetic cell movements directed by complex gene regulation. (duke.edu)
HEK293 (Human embryonic kidney cell line). (prospecbio.com)

Aging and spaceflight share similar physiological effects on muscle atrophy and effective countermeasures are needed for both Earth and Space applications. (selectbiosciences.com)
The measure of glycogen content in single cells and subcellular organizations is important because in most cell types, single cells adapt differently to changing physiological conditions and diseases. (jove.com)
In living organisms, if the temperature exceeds the normal range (thermo-neutral zone), it disturbs the normal physiological functioning and induces cell injury. (frontiersin.org)
Since the discovery of the K ATP channel in 1983, numerous studies have revealed its physiological functions. (go.jp)

For this reason, the team of Shahragim Tajbakhsh from Institut Pasteur, in collaboration with the team of Wolf Reik at the Babraham (UK) tried to decipher the relationships between epigenetic regulation of DNA and ageing muscle stem cells. (pasteur.fr)
The first part of the study was focused on understanding the regulation of irisin levels based on multiple baseline parameters, such as lipoprotein(a) and cholesterol levels. (medscape.com)

Moreover, it is not clear whether apoptotic signaling contributes to training-induced skeletal muscle hypertrophy. (cdc.gov)
Loss of lean body mass and muscle vitality not only impairs mobility, but also contributes to worsening of a large range of systemic disease outcomes. (nih.gov)

The IAL aims to synergise the expertise in muscle and neuromuscular diseases of French teams and the expertise in immunology and inflammation of the Brazilian teams . (institut-myologie.org)
Myasthenia gravis (MG) is a relatively rare acquired, autoimmune disorder caused by an antibody-mediated blockade of neuromuscular transmission resulting in skeletal muscle weakness and rapid muscle fatigue. (medscape.com)
The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
[ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
Myasthenia gravis (MG) is a relatively rare autoimmune disorder in which antibodies form against acetylcholine nicotinic postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)

Expression of vinculin in muscle cells was strikingly down-regulated. (wikipedia.org)
We previously found that a transcription factor, FOXO1 gene expression, was induced in various muscle atrophy conditions causing muscle atrophy by upregulating atrophy-related genes, including atrogin 1 (ubiquitin ligase) and cathepsin L (lysosomal proteinase). (nih.gov)
According to Dr. Marcusson, an important aspect of these studies was the demonstration of miR-21 knockdown using genome-wide mRNA expression studies. (genengnews.com)
Cells' therapeutic potential can be also increased by expression of proangiogenic factors by viral transduction. (biomedcentral.com)
The team will study the gene expression changes in the cells sent to space compared to the cells that remained on earth. (adventistworld.org)
We also reported that clenbuterol regulates negatively the expression of myostatin a master regulatory factor of muscle mass. (wada-ama.org)
In this study, they analyzed whole transcriptomic sequencing (RNA-seq) data to evaluate the effect of nanosilicates and ionic dissolution products on the gene expression profiles of stem cells. (sciencedaily.com)
Derivation of Skeletal Myogenic Precursors from Human Pluripotent Stem Cells Using Conditional Expression of PAX7. (uh.edu)

Using BV system and sodium butyrate treatment we expressed human VEGF165 in mADSC (production of VEGF165 reached ≈ 25-27 ng/ml/10 5 cells) and optimized conditions to ensure cells' viability after transduction. (biomedcentral.com)
It was found that GSOs reversed GLU-induced reductions in cell viability and the LDH release rate, and rescued ROS accumulation. (sdbonline.org)
Studying that specific nucleus, by removing it from the cell, perform transcriptomics on it and determining the cell viability after the nucleus removal, can provide important information about FSHD. (tudelft.nl)
Mitochondrial antioxidants reverse the effects of simvastatin-induced reduction of cell viability and irisin release. (medscape.com)

This study is the first to examine skeletal muscle-secreted molecules (myokines) in patients with metastatic castrate-resistant prostate cancer (mCRPC).This work supports an acute myokine response to exercise in patients with advanced cancer and that the serum of these patients after acute exercise has a growth-suppressive effect. (medicalnewstoday.com)

However, until now, they had no way of determining where these cells fall on the continuum of human development. (scienceblog.com)
A study published in the Proceedings of the National Academy of Sciences has found that triclosan interferes with human muscle contractions at the cellular level. (nyhealthinsurer.com)
These findings provide strong evidence that the chemical is of concern to both human and environmental health," said study author Isaac Pessah. (nyhealthinsurer.com)
The study revealed that these same risk genes cause heart muscle disease in human patients. (news-medical.net)
Trimeric form of Adiponectin Human trimeric form was expressed in HEK293 cells. (prospecbio.com)
Our results indicate that clenbuterol-induced hypertrophy can involve the recruitment of reserve cells in human skeletal muscle. (wada-ama.org)
This engineering research group is led by Dr. Akhilesh Gaharwar, associate professor of biomedical engineering and Presidential Impact Fellow, in collaboration with Dr. Irtisha Singh, assistant professor in the Department of Molecular and Cellular Medicine at Texas A&M and the co-corresponding author of the study where a new class of mineral-based nanoparticles has been introduced to direct human stem cells toward bone cells. (sciencedaily.com)
Wu J, Hunt SD, Xue H, Liu Y, Darabi R . Generation and Validation of PAX7 Reporter Lines from Human iPS Cells Using CRISPR/Cas9 Technology. (uh.edu)
Wu J, Hunt SD, Xue H, Liu Y, Darabi R . Generation and Characterization of a MYF5 Reporter Human iPS Cell Line Using CRISPR/Cas9 Mediated Homologous Recombination. (uh.edu)
This activity, developed with the full support of the AFM as well as the Dutch Duchenne Parent Project NL (DPP-NL) and the Jain Foundation, has resulted in the creation of a platform for the immortalisation of human cells. (institut-myologie.org)

Spinal muscular atrophy type 4 (late-onset) can be recessive, dominant, or X-linked, with adult onset (age 30 to 60 years) and slow progression of primarily proximal muscle weakness and wasting. (msdmanuals.com)

When the RYR1 channel is active, it releases calcium ions from storage into the fluid-filled space inside muscle cells. (medlineplus.gov)
The resulting increase in calcium ion concentration inside the cells stimulates muscles to contract. (medlineplus.gov)
As a result, abnormally large amounts of calcium ions are released from storage within muscle cells. (medlineplus.gov)
The abnormal increase in calcium ion concentration within muscle cells activates processes that generate heat (leading to increased body temperature) and produce excess acid (leading to acidosis). (medlineplus.gov)
An overabundance of calcium ions also causes skeletal muscles to contract, which leads to muscle rigidity. (medlineplus.gov)
A putative transmembrane receptor may be responsible for nongenomic effects leading to rapid influx of calcium within muscle cells. (hindawi.com)
On the basis of bio-chemical kinetics, we present a model of muscle fiber exhaustion based on hydrolytic ATP-ADP-P i dynamics, which are assumed to be length- and calcium activity-dependent. (frontiersin.org)

A new method of equine muscle cell research might be more welfare-friendly than in vivo studies. (thehorse.com)
Muscle glucose uptake and signaling were measured ex vivo in fetal ( n = 5-8/group) and juvenile ( n = 8/group) offspring. (diabetesjournals.org)

Amyotrophic Lateral Sclerosis (ALS) and Other Motor Neuron Diseases (MNDs) Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei. (msdmanuals.com)

In cardiac muscle and skeletal muscle, plectin is localized to specialized entities known as Z-discs. (wikipedia.org)
Loss of muscle mass and frailty are prevalent in many chronic diseases such as chronic obstructive pulmonary disease, cardiac insufficiency, cancer, and chronic kidney disease (CKD) [ 6 ]. (hindawi.com)

However, mutations in prostate cancer cells can lead to the development of resistance to androgen deprivation therapy. (medicalnewstoday.com)
Duchenne muscular dystrophy (DMD) is a muscle wasting disease caused by mutations in the DMD gene, which encodes dystrophin. (seattlechildrens.org)

We recently identified novel epigenetic small molecules that improve muscle degeneration in DMD zebrafish ( https://doi.org/10.1186/s13395-020-00251-4 ). (seattlechildrens.org)

We are using zebrafish and mouse models to study the functions of factors such as Pbx homeodomain transcription factors and how they control muscle fiber-type development. (seattlechildrens.org)
Recent studies, including work from our lab, now create an opportunity to directly test whether fiber-type modulation is a viable therapeutic approach for muscular dystrophies. (seattlechildrens.org)
We are also working to identify new epigenetic factors that regulate muscle fiber type. (seattlechildrens.org)
We expect that this project will identify genetic and epigenetic regulators of muscle fiber-type identities that confer susceptibility or resistance to muscular dystrophy. (seattlechildrens.org)
This project is aimed at an ultimate goal of manipulating skeletal muscle fiber type as a treatment for muscular dystrophy. (seattlechildrens.org)

In this study, we found that vitamin D inhibited FOXO1-mediated transcriptional activity in a reporter gene assay. (nih.gov)
The disease has been studied from various angles for decades without significant gene discoveries. (news-medical.net)

In muscle, plectin binds to the periphery of Z-discs, and along with the intermediate filament protein desmin, may form lateral linkages among neighboring Z-discs. (wikipedia.org)
The animals were sacrificed 24 hours following the last exposure and the tibialis anterior (TA) muscles were removed for protein analysis. (cdc.gov)
Additionally, the level of pro-apoptotic AIF protein, which is thought to play a role in caspase independent signaling, was significantly decreased (p=0.046) by 51.7% in experimental as compared to control muscles. (cdc.gov)
In a new study, stopping skeletal-muscle cancer cells from making a specific protein forced them to turn into healthy muscle cells. (livescience.com)
In muscular dystrophy, the loss of a protein called dystrophin causes the muscle to literally tear itself apart, a process that cannot be repaired without cell-based intervention. (phys.org)
In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell. (news-medical.net)
These results also suggest the coupling of RACK1 to muscle unfolded protein response during SC activation. (sdbonline.org)
The booming popularity of protein and collagen exemplifies this quest "to safeguard your 'frame'-protein for muscles that support bones, and collagen for cartilage support," Ray noted. (nutraceuticalsworld.com)

They then compared the genetic signatures of cells from both sources. (scienceblog.com)
Reciprocally, we also found that the genetic deletion of myostatin renders satellite cells refractory to the hypertrophic effect of clenbuterol. (wada-ama.org)
The disease is caused by a genetic error in 1/1000 - 1/200 of the nuclei in a multinucleated skeletal muscle cell. (tudelft.nl)

Previous research has shown that blood taken from patients with advanced prostate cancer who followed a high-intensity exercise program for a few months could suppress the growth of cultured tumor cells. (medicalnewstoday.com)
Preclinical studies suggest that these myokines can suppress the growth of tumor cells. (medicalnewstoday.com)
Previous research has shown that serum from advanced prostate cancer patients who followed a supervised high-intensity exercise program (HIIT) for 6 months showed elevated myokine levels and a greater ability to suppress the growth of tumor cells. (medicalnewstoday.com)
Cell invasion is a crucial step of tumor metastasis , finding new regulators of which offers potential drug targets for cancer therapy. (sdbonline.org)

Commonly, muscle fatigue, i.e., the decline of the generable force level over time, is differentiated between central fatigue , i.e., the inability of the neural network to provide sufficient stimulation, and peripheral fatigue , i.e., the inability of the muscle cells to provide energy through metabolic activities (cf. (frontiersin.org)
Risk Factors and Metabolic Syndrome Among Adults in India: A We searched databases PubMed Central, EMBASE, MEDLINE, Systematic Review and Meta-Analysis of Observational Studies. (cdc.gov)
Several studies have explored the effect of anthropometric risk ing central obesity, atherogenic dyslipidemia (ie, low high-density factors on metabolic syndrome. (cdc.gov)

After purification by pre-plating techniques , more than 97.6% of the cells expressed Pax7, a unique marker of satellite cells . (bvsalud.org)
Satellite cells assure postnatal skeletal muscle growth and repair. (nih.gov)
This damage is repaired by satellite cells that can undergo a finite number of cell divisions. (wada-ama.org)
From a sport viewpoint, it predicts that any benefits of clenbuterol treatment are likely to impose any extra stress on the satellite cells and this method could risk the regenerative capacity in the long term. (wada-ama.org)

[ 3 ] muscle weakness is also a common manifestation of chronic Addison disease . (medscape.com)
Glucocorticoid excess caused by Cushing's syndrome, Cushing's disease, ectopic adrenocorticotropic hormone (ACTH) production, and exogenous glucocorticoid administration are all associated with muscle weakness and atrophy, with predominant proximal muscle involvement. (medscape.com)
Hyperaldosteronism caused by pituitary or ectopic overproduction of ACTH, adrenal tumors, or exogenous corticosteroid administration has been associated with muscle weakness that is attributed to the associated hypokalemia. (medscape.com)
Children have flaccid muscle weakness and fasciculations, which may be hard to see in young children. (msdmanuals.com)

Anatomy54

Organisms19

Diseases13

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes54

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Health Care1

Fibers11

Regeneration12

Tissues13

Proteins13

Recovery of skeletal muscle2

Influence skeletal muscle1

Stem cell30

Biopsies4

Mice8

Biology6

Insulin sensitivity4

Vitro studies2

Mechanisms11

Sarcopenia4

Apoptosis2

Abstract1

Differentiation10

Atrophy via2

Oxidative2

Clinical10

Metabolism7

Tissue16

Implications5

Contraction6

Humans5

Pancreatic3

Disorders5

Perfusion1

Myoblasts3

Differentiate2

Mammalian cells2

Researchers7

Function15

Fibre2

Dysfunction1

METHODS5

Endothelial1

Proliferation2

Embryonic2

Physiological4

Regulation2

Contributes2

Neuromuscular5

Expression8

Viability4

Patients with metastatic1

Human10

Adult1

Calcium7

Vivo2

Bulbar1

Cardiac2

Mutations2

Degeneration1

Fiber5

Gene2

Protein8

Genetic3

Tumor4

Metabolic3

Satellite cells4

Weakness4