• The aim of the present study was to investigate if time since schizophrenia diagnosis, body mass index (BMI), sex, metabolic syndrome, alcohol use, smoking, alanine transaminase (ALT), and body fat percentage (as measured by bioelectrical impedance) were associated with HS, determined by computed tomography (CT), in a population of patients diagnosed with schizophrenia. (aau.dk)
  • The aim of the present study was to investigate if time since schizophrenia diagnosis, body mass index (BMI), sex, metabolic syndrome, alcohol use, smoking, alanine transaminase (ALT), and body fat percentage (as measured by bioelectrical impedance) were associated with HS, determined by computed tomography (CT), in a population of patients diagnosed with schizophrenia.METHODS: Moderate to severe HS (40 CT Hounsfield units as threshold) was determined utilizing non-contrast enhanced CT. (aau.dk)
  • [ 2 ] Schizophrenia is more common in men, and the diagnosis is made at a younger age in males. (medscape.com)
  • Because of the variability of symptom expression, diagnostic requirements of chronicity, and lack of pathognomonic features, an ED diagnosis of schizophrenia should be made cautiously. (medscape.com)
  • As a diagnosis-by-exclusion, schizophrenia must be distinguished from the numerous psychiatric and organic disorders that also can lead to psychotic disturbances in thinking and behavior. (medscape.com)
  • Hearing voices is so common in schizophrenia that it is often used as a " principal indicator " of a schizophrenia diagnosis. (medicalnewstoday.com)
  • An innovative strategy that analyzes specific regions of the genome offers the possibility of early diagnosis of schizophrenia, reports a team led by researchers at Baylor College of Medicine. (bcm.edu)
  • This leads to another diagnosis, bipolar or schizophrenia, and other drugs. (madinamerica.com)
  • 80 patients having diagnosis of schizophrenia according to ICD-10 are assigned to treatment with olanzapine (N=20), risperidone (N=20) and haloperidol (N=40). (who.int)
  • Because of the variability of symptom expression, diagnostic requirements of chronicity, and lack of pathognomonic features, an ED diagnosis of schizophrenia should be provisional at best. (medscape.com)
  • While the primary diagnosis of schizophrenia rarely is made de novo in the ED, several historical features can be helpful in distinguishing the illness from the many medical and psychiatric conditions that can mimic it. (medscape.com)
  • In July, an international consortium of schizophrenia researchers, mounting what it calls the largest biological experiment in the history of psychiatry, reported 108 regions in the genome associated with schizophrenia. (discovermagazine.com)
  • In a recent study published in the journal Scientific Reports , a group of researchers investigated the influence of ketamine, a N-Methyl-D-Aspartate (NMDA) receptor antagonist, on mentalizing deficits and associated neural responses, providing insights into glutamate's role in schizophrenia's social cognition impairments. (news-medical.net)
  • In the present study, researchers delved into the effects of ketamine on symptoms of schizophrenia and mentalizing, the ability to understand others' mental states. (news-medical.net)
  • Researchers have previously shown that genetic variation in the NDE1 gene and the related DISC1 network increases risk for schizophrenia in a Finnish family cohort. (helsinki.fi)
  • The researchers found that people with major depressive disorder, bipolar disorder and schizophrenia all showed a shift in tryptophan metabolism from serotonin to the kynurenine pathway. (nature.com)
  • Researchers are seeking volunteers of African ancestry, without schizophrenia or bipolar disorder, for a study. (jhu.edu)
  • A new study by researchers at the David Geffen School of Medicine at UCLA and colleagues at the University of Southern California describes some of the strategies people with schizophrenia have used to overcome the disorder and function successfully in their careers. (uclahealth.org)
  • The researchers conducted up to three interviews each with 10 men and 10 women with schizophrenia from the Los Angeles area. (uclahealth.org)
  • In imaging studies, UCLA researchers found that the brains of people with schizophrenia are less sensitive to social rewards, such as the positive feelings that can come from social interactions with people, than they are to so-called nonsocial rewards, such as money or objects. (uclahealth.org)
  • To study the brain's response to different stimuli, researchers recruited 27 people with clinically stable schizophrenia and 25 healthy individuals. (uclahealth.org)
  • The findings provide additional evidence of disrupted social rewards processing in people with schizophrenia, researchers say. (uclahealth.org)
  • To study the brain's response to stimuli, researchers had participants play a computerized version of a slot machine, or "one-armed bandit. (uclahealth.org)
  • To this end, in a first-of-its-kind study, researchers from Okayama University, Japan, conducted a randomized trial to assess the benefits of interventions for early cancer screening in patients with schizophrenia. (ascopost.com)
  • Researchers have identified many genes they believe to be potential candidates, in mutated form, as contributors to schizophrenia-not any one gene acting alone, but rather interacting with other genes and with environmental triggers. (bbrfoundation.org)
  • Using powerful sequencing technology, the researchers identified a particular mutation occurring in 14 out of 17 families studied. (bbrfoundation.org)
  • To do so, researchers will use genetically engineered animal models to see if the mutation that was identified translates, in the animals, into behavioral problems that are analogous to problems seen in people with schizophrenia. (bbrfoundation.org)
  • Psychiatry researchers Akira Sawa (Director of The Johns Hopkins Schizophrenia Center)and Thomas Sedlak have found that glutamate in broccoli sprouts may improve chemical imbalances in people with schizophrenia. (hopkinsmedicine.org)
  • The findings from this study identified 10 mg of samidorphan as the daily dose to further assess the mitigation of olanzapine-induced weight gain, and they support the continued development of olanzapine plus samidorphan in a phase 3 program," the researchers concluded. (psychnews.org)
  • Many previous studies have analyzed methylation profiles in blood samples with the goal of identifying epigenetic differences between individuals with schizophrenia, the researchers explained. (bcm.edu)
  • UCLA researchers have found that people with schizophrenia were able to more accurately determine whether two auditory tones matched or differed, after receiving a type of electrical brain stimulation. (ucla.edu)
  • In 12 people with schizophrenia, researchers applied tDCS via electrodes on the scalp to the auditory cortex, the part of the brain that processes auditory information. (ucla.edu)
  • Researchers obtained what they call an "unprecedently large" set of GWAS samples, including schizophrenia (53,386 patients and 77,258 controls) and various CVD risk factors. (medscape.com)
  • In a different study, in which researchers systematically analyzed mutations identical to those found in patients with Darier disease, mutant SERCA2 protein aggregates were found to cause stress to the endoplasmic reticulum, subsequently inducing cell apoptosis. (medscape.com)
  • As part of the international Stanley Global Neuropsychiatric Genomics Initiative, the researchers launched the Finnish SUPER (Finnish Study on Genetic Mechanisms of Psychotic Disorders), which aims to recruit 10,000 patients who have major psychiatric disorders by the end of 2018. (medscape.com)
  • The researchers performed home sleep studies with polysomnography in 30 schizophrenia patients who were being treated with clozapine . (medscape.com)
  • Twin studies of psychiatric disorders such as schizophrenia and autism spectrum disorder have employed epidemiological approaches that determine heritability by comparing the concordance rate between monozygotic twins (MZs) and dizygotic twins. (springer.com)
  • Recently, biological studies based on molecular methods are now being increasingly applied to examine the differences between MZs discordance for psychiatric disorders to unravel their possible causes. (springer.com)
  • As a result, twin studies of psychiatric disorders are greatly contributing to the elucidation of genetic and environmental factors in the etiology of psychiatric conditions. (springer.com)
  • In recent years, studies on the differences between genomic and epigenomic characteristics of MZs have led to the development of new approaches for elucidating the etiology of psychiatric disorders (Liang et al. (springer.com)
  • Psychosis is a major feature of schizophrenia, as it is in several other psychiatric disorders. (medscape.com)
  • Method: Callosal size and shape were determined using high-resolution magnetic resonance imaging on 76 patients with first-episode schizophrenia-spectrum disorders, 86 patients with established schizophrenia and 55 healthy participants. (monash.edu)
  • A total of 97 subjects participated, including matched groups of healthy controls, subjects with a marijuana use disorder, schizophrenia subjects with no history of substance use disorders, and schizophrenia subjects with a marijuana use disorder. (futurity.org)
  • This outcome on average however is worse than for other psychotic and otherwise psychiatric disorders though a moderate number of people with schizophrenia were seen to remit and remain well, some of these without need for maintenance medication. (wikipedia.org)
  • The Johns Hopkins Schizophrenia Center strives to provide the finest possible clinical care for individuals with schizophrenia, schizoaffective disorders and related conditions as well as support for their families. (hopkinsmedicine.org)
  • Our extensive research efforts are driven by that same passion to find the causes of schizophrenia and related disorders and to develop treatments to improve the lives of patients everywhere. (hopkinsmedicine.org)
  • Few studies have compared this burden among caregivers of patients with eating disorders and other mental illnesses. (biomedcentral.com)
  • The objective of this study was to compare caregiver consequences in eating disorders (ED) with caregiver consequences in depression and schizophrenia, assessed with the same instrument, the Involvement Evaluation Questionnaire (IEQ). (biomedcentral.com)
  • The burden of caregiving is higher among caregivers of patients with eating disorders patients than among caregivers of patients with depression or schizophrenia. (biomedcentral.com)
  • Other studies on the consequences of providing care for patients with affective disorders also suggest that the relatives of these patients experience considerable distress, sometimes strikingly similar to those in schizophrenia [ 17 - 19 ]. (biomedcentral.com)
  • The results were presented at the ECNP conference - held in Paris, France - and will be published at a later date in Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders . (medicalnewstoday.com)
  • Davies, E.J. "Developmental aspects of schizophrenia and related disorders: possible implications for treatment strategies. (medicinenet.com)
  • Schizophrenia is a severe brain disorder with clinical manifestations that may include hallucinations, delusions, and thought and movement disorders. (cdc.gov)
  • The study was led by Linn Rødevand, PhD, Norwegian Center for Mental Disorders Research, Division of Mental Health and Addiction , Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Norway, and colleagues. (medscape.com)
  • Treatment with antipsychotics can cause metabolic side effects leading to medical disorders among the patients suffering from schizophrenia. (who.int)
  • Schizophrenia is one of several psychiatric disorders for which psychosis is a major feature. (medscape.com)
  • Prepulse inhibition (PPI) is a widely investigated behavior to study the mechanisms of disorders such as anxiety, schizophrenia, and bipolar mania. (lu.se)
  • Schizophrenia and affective disorders : biology and drug treatment / edited by Arthur Rifkin. (who.int)
  • FLORENCE, Italy - A large proportion of schizophrenia patients suffer from a range of sleep disturbances - a finding that shines a light on an underexamined area in major psychiatric disorders. (medscape.com)
  • These patients were more likely to suffer from substance abuse, depression, schizophrenia, and paralytic disorders compared to the reference cases. (cdc.gov)
  • Schizophrenia is a relatively common but genetically complex disorder, making the identification of susceptibility genes formidable. (nih.gov)
  • Thomas Insel, director of the National Institute of Mental Health, describes schizophrenia as polygenic, meaning that genes probably act in networks to produce it. (discovermagazine.com)
  • A similar study in rats revealed that approximately the same sample size was required for rat brain mRNA expression studies.The mRNA levels of several genes were studied in 55 schizophrenia and 55 control prefrontal brain autopsies, using a novel and more powerful statistical analysis. (avhandlingar.se)
  • Environmental factors interacting with different combinations of genes may cause schizophrenia, according to Dr. Gejman. (northwestern.edu)
  • This conclusion is based on its presence in the genes of a Canadian study population of 24 families where multiple individuals had been diagnosed with schizophrenia. (sciencedaily.com)
  • There is an extensive genetic overlap between schizophrenia and smoking, but there are also schizophrenia genes that may protect against obesity , illustrating the bidirectional effects of shared loci across cardiovascular disease (CVD) risk factors, results of new research suggest. (medscape.com)
  • Aims: To study the effects on glucose and lipid metabolism with the use of atypical and typical antipsychotics in the treatment of schizophrenia Methods: The present study is a 12 weeks open label prospective study of antipsychotic drugs olanzapine, risperidone and haloperidol in patients with schizophrenia. (who.int)
  • Go to Schizoaffective Disorder , Childhood-Onset Schizophrenia , and Schizophreniform Disorder for complete information on these topics. (medscape.com)
  • Research shows that people with schizophrenia or schizoaffective disorder have a better quality of life when their family members tend to be more supportive and less critical of them. (medicinenet.com)
  • The team found that 30% of patients aged 18 to 40 years who had schizophrenia or schizoaffective disorder reported sleeping more than 10 hours a day. (medscape.com)
  • Living Outside Mental Illness demonstrates the importance of listening to what people diagnosed with schizophrenia themselves have to say about their struggle, and shows the dramatic effect this approach can have on clinical practice and social policy. (google.com)
  • The dissemination of this intervention into routine clinical practice may help bridge the gap between early detection of cancer and mortality across people with schizophrenia and the general population," Dr. Fujiwara noted. (ascopost.com)
  • In several clinical guidelines for schizophrenia, long-term use of anticholinergic drugs is not recommended. (frontiersin.org)
  • A clinical study using strict recovery criteria (concurrent remission of positive and negative symptoms and adequate social and vocational functioning continuously for two years) found a recovery rate of 14% within the first five years. (wikipedia.org)
  • A 5-year community study found that 62% showed overall improvement on a composite measure of clinical and functional outcomes. (wikipedia.org)
  • A clinical study that took into account concurrent remission of positive and negative symptoms, and adequate social and vocational functioning continuously for two years, found a recovery rate of 14% within the first five years. (wikipedia.org)
  • As described in the journal Neuron on Feb. 22, 2012, a small clinical study conducted at the San Francisco VA Medical Center (SFVAMC) and the University of California, San Francisco (UCSF), tested the digital exercises as a new therapy for schizophrenia. (ucsf.edu)
  • Antipsychotic-induced weight gain generally has a rapid onset and can occur in the first few weeks of treatment-an effect that was seen in all treatment groups during the first two weeks of this study," wrote lead author William Martin, M.D., senior director of clinical development at Alkermes, manufacturer of samidorphan. (psychnews.org)
  • Since millions of people with schizophrenia live in betel-chewing regions, an increased understanding of the interaction between betel chewing and schizophrenia should benefit clinical treatment. (cambridge.org)
  • The study was supported by the Veterans Administration Desert Pacific Veterans Integrated Service Network 22 Mental Illness Research, Education and Clinical Center. (ucla.edu)
  • The new results "shed light" on biological pathways associated with comorbidity between CVD and schizophrenia, said the authors, adding future work could provide insights into mechanisms underlying the comorbidity and could facilitate development of antipsychotics with lower metabolic side effects, which could help prevent comorbid CVD, "thereby helping to mitigate a major clinical and health care problem. (medscape.com)
  • This study aimed to evaluate the informed consent process, therapeutic misconception and motivation for participation among Egyptians participating in clinical trials. (who.int)
  • In a cross-sectional qualitative pilot study 103 participants in 10 clinical trials responded to a questionnaire. (who.int)
  • The DISC-IV was originally developed for use in large-scale epidemiological surveys of children and adolescents, but is now also being used in many clinical studies, screening projects, and service settings. (cdc.gov)
  • Scientists wanted to find out if tDCS - which comes in two active varieties, anodal or cathodal - could boost auditory processing in people with schizophrenia. (ucla.edu)
  • There is a widespread misunderstanding that individuals with schizophrenia are violent and dangerous, often homeless, and beyond help,'' Cohen said. (uclahealth.org)
  • Schizophrenia is associated with immune abnormalities and increased mortality from infectious diseases. (psychiatrist.com)
  • Conversely, in people with schizophrenia, abnormalities in how the brain processes social rewards likely contribute to human interaction problems. (uclahealth.org)
  • Several studies have also reported P300 abnormalities in schizophrenia in visual tasks, but these findings are inconsistent. (harvard.edu)
  • The marijuana-related brain abnormalities are correlated with a poor working memory performance and look similar to schizophrenia-related brain abnormalities, the study shows. (futurity.org)
  • This is the first study to target key brain regions in the deep subcortical gray matter of chronic marijuana users with structural MRI and to correlate abnormalities in these regions with an impaired working memory. (futurity.org)
  • The study links the chronic use of marijuana to these concerning brain abnormalities that appear to last for at least a few years after people stop using it," says lead study author Matthew Smith, an assistant research professor in psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine. (futurity.org)
  • During 2009-2011, an estimated 382,000 emergency department (ED) visits related to schizophrenia occurred each year among adults aged 18-64 years, with an overall ED visit rate of 20.1 per 10,000 adults. (medscape.com)
  • A new NCHS report describes the rate and characteristics of emergency department (ED) visits related to schizophrenia among adults aged 18-64. (cdc.gov)
  • The overall rate for ED visits related to schizophrenia for men (26.5 per 10,000) was approximately double the rate for women (13.8 per 10,000). (cdc.gov)
  • Public insurance (Medicaid, Medicare, or dual Medicare and Medicaid) was used more frequently at ED visits related to schizophrenia compared with ED visits not related to schizophrenia. (cdc.gov)
  • In DNA from blood samples, the team identified epigenetic markers, a profile of methyl chemical groups in the DNA, that differ between people diagnosed with schizophrenia and people without the disease and developed a model that would assess an individual's probability of having the condition. (bcm.edu)
  • abstract = "Background: The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness. (monash.edu)
  • ABSTRACT Few studies have explored the informed consent process among research participants in developing countries. (who.int)
  • The University of Bonn initiated a study, recruiting 387 individuals through online platforms. (news-medical.net)
  • Eligibility for the study, determined through questionnaires, on-site interviews, and drug and pregnancy tests, led to 85 qualified individuals, of whom 70 participants, with an average age of 24 years, engaged in the Magnetic Resonance Imaging (MRI)segment. (news-medical.net)
  • Now the same family cohort with close to a thousand affected individuals has been studied further. (helsinki.fi)
  • We demonstrated that compared with healthy individuals, people with schizophrenia had higher levels of glucose in the blood. (iflscience.com)
  • We demonstrated higher levels of insulin, and increased levels of insulin resistance in individuals with early schizophrenia. (iflscience.com)
  • To the best of our knowledge, no previous studies have addressed how individuals with schizophrenia who also met some definition of recovery manage the symptoms of their disease," said Amy Cohen, an associate research psychologist in the department of psychiatry and biobehavioral sciences at the Geffen School and the study's first author. (uclahealth.org)
  • The bulk of treatments for schizophrenia were developed from observations of individuals who are quite ill or hospitalized, rather than patients who have achieved a level of recovery," Cohen said. (uclahealth.org)
  • However, when comparing machines that gave payouts of human smiling faces, the level of activity in the brain was much lower in people with schizophrenia than in healthy individuals. (uclahealth.org)
  • The brains of individuals with schizophrenia were less reactive to social rewards. (uclahealth.org)
  • The purpose of this study was to compare the effects of three different physical exercise programs on the symptomatology, body composition, physical activity, physical fitness, and quality of life of individuals with schizophrenia. (nature.com)
  • We concluded that 3 weekly sessions of a moderate to vigorous progressive exercise program for 16 weeks improved the symptomatology of individuals with schizophrenia in all three groups, with no differences between them. (nature.com)
  • Thus, schizophrenia does not typically "breed true" - there are few very large pedigrees where schizophrenia appears across multiple individuals in the absence of some other neuropsychiatric conditions in the family. (wiringthebrain.com)
  • Importantly, the Walss-Bass team has recently shown that in brains from individuals with schizophrenia the neuregulin-1 protein is not properly cut. (bbrfoundation.org)
  • Previous studies have evaluated the effects of marijuana on the cortex, and few have directly compared chronic marijuana use in otherwise healthy individuals and individuals with schizophrenia. (futurity.org)
  • The younger the individuals were when they started chronically using marijuana, the more abnormally their brain regions were shaped, the study reports. (futurity.org)
  • Numerous international studies have demonstrated favorable long-term outcomes for around half of those diagnosed with schizophrenia, with substantial variation between individuals and regions. (wikipedia.org)
  • These results echo the increased expression of NOS1AP that has been observed in postmortem brain samples from individuals with schizophrenia. (sciencedaily.com)
  • The collection includes samples drawn from large populations of Asian, Caucasian, African American and Hispanic individuals with schizophrenia. (sciencedaily.com)
  • This, together with the fact that DNA methylation at CoRSIVs is established very early in life, indicates that the epigenetic differences we identified between schizophrenia patients and healthy individuals were there before the disease was diagnosed, suggesting they may contribute to the condition. (bcm.edu)
  • Three distinct phenotypes of offenders with schizophrenia have been identified: individuals with a childhood onset of conduct disorder who display antisocial and aggressive behaviour both before and after schizophrenia onset, individuals with no history of conduct problems who begin engaging in aggressive behaviour at the onset of illness, and individuals who engage in a severe physical assault after many years of illness. (researchgate.net)
  • Individuals with schizophrenia have more than twice the rate of death than those without the disorder. (medicinenet.com)
  • the authors noted individuals with schizophrenia are more nicotine dependent than the general population, and they experience greater reinforcing effects of nicotine and worse withdrawal symptoms during abstinence than the general population. (medscape.com)
  • 34 healthy individuals (mean age = 32.50, male = 21, female = 13) and 30 subjects with schizophrenia (mean age = 33.07, male = 19, female = 11) underwent a blood draw and T1-weighted magnetic resonance imaging . (bvsalud.org)
  • Methods used in the study are limited by uncertainties in translating genetic loci to causal variants, which restricts the biological interpretation of the shared genetic variants. (medscape.com)
  • The methods used to assess the conditions have changed during the pandemic as the amount of literature and types of studies increased. (cdc.gov)
  • METHODS: The study sample consisted of 3552 students aged 13-19 years from Piotrkowski district. (who.int)
  • Methods: For this retrospective study, patients injured as a result of contact with law enforcement personnel were identified using ICD-9 external cause of injury codes from medical record databases of patients treated in all hospitals and trauma units in Illinois between 2000 and 2009. (cdc.gov)
  • In a prevalence study conducted from January 2010 to April 2012 at Georgia Health Sciences University Medical Center, Augusta, we recruited 136 adult subjects (mean age = 42.8 years): 57 inpatients with an acute relapse of DSM-IV schizophrenia, 40 stable outpatients with DSM-IV schizophrenia, and 39 healthy controls from the community. (psychiatrist.com)
  • This study was based on a cohort of 118 stable outpatients with schizophrenia. (elsevier.es)
  • Our study examined whether diabetes risk is already raised in people at the onset of schizophrenia - before they've started taking antipsychotic drugs or when they've only just started taking them. (iflscience.com)
  • These findings are a wake-up call that we need to rethink the link between diabetes and schizophrenia and start prevention right from the onset of schizophrenia. (iflscience.com)
  • The onset of schizophrenia is insidious in approximately one half of all patients. (medscape.com)
  • For instance, methylation patterns in blood can be affected by factors such as smoking and taking antipsychotic medications, both of which are common in schizophrenia patients. (bcm.edu)
  • However, women with schizophrenia tend to have milder symptoms initially, and progress to more severe symptoms as they age. (wikipedia.org)
  • Women with schizophrenia are thought to be more likely to suffer from complications during their pregnancies , at delivery and during their children's newborn period. (medicinenet.com)
  • Schizophrenia is widely considered the most severe and disabling of the mental illnesses. (google.com)
  • Lead study author Masaki Fujiwara, MD , commented, "Although municipalities have been approaching populations to participate in cancer screening, mortality rates remain high among people with severe mental illnesses. (ascopost.com)
  • Schizophrenia is a severe, chronic psychotic disorder. (medscape.com)
  • Men with schizophrenia tend to have more severe symptoms in the initial stage of the disorder, but gradually improve as they age. (wikipedia.org)
  • DeVylder, J.E. "Prevention of schizophrenia and severe mental illness. (medicinenet.com)
  • We investigated the characteristics of the use of anticholinergics in patients with schizophrenia by considering psychotropic prescription patterns and differences among hospitals. (frontiersin.org)
  • The journal is oriented to the study of mental illnesses, their pathological processes, and their psychosocial consequences and aims to disseminate scientific advances in all fields related to illness and mental health. (elsevier.es)
  • Aims: To investigate the size and shape of the corpus callosum in a large sample of people with first-episode and established schizophrenia. (monash.edu)
  • The aims of this study were to compare smoking topography characteristics of usual-brand and very low nicotine content (VLNC) cigarettes in SS and control smokers without psychiatric illness (CS), and to determine whether nicotine replacement reversed any changes in topography produced by VLNC cigarettes. (who.int)
  • However, other larger mutations (copy number variations) in this area have been found world-wide in people with schizophrenia, autism spectrum disorder and intellectual disability, implying a potential broader role for this micro-RNA, William Hennah explains. (helsinki.fi)
  • In psychiatry, there is a much higher concordance rate for schizophrenia (SCZ) and autism spectrum disorder (ASD) in MZs versus DZs (Hilker et al. (springer.com)
  • People with schizophrenia who completed 80 hours of intensive, computerized cognitive training exercises were better able to perform complex tasks that required them to distinguish their internal thoughts from reality. (ucsf.edu)
  • We predicted that in order to improve complex cognitive functions in neuropsychiatric illness, we must target impairments in lower-level perceptual processes, as well as higher-order working-memory and social cognitive processes," said Srikantan Nagarajan , PhD, a professor of radiology and biomedical imaging at UCSF and a senior author of the study. (ucsf.edu)
  • It is a complex cognitive function that is impaired in schizophrenia. (ucsf.edu)
  • Then, 16 of the 31 patients with schizophrenia were randomly assigned to complete 80 hours of computerized training composed of auditory, visual and social cognitive exercises that included programs designed by the Posit Science Corporation. (ucsf.edu)
  • Genome-wide association studies (GWAS) have detected several loci associated with CVD risk factors, including body mass index (BMI), waist-to-hip ratio, type 2 diabetes , lipids , and blood pressure, with increasing evidence suggesting genetic overlap between such risk factors and schizophrenia. (medscape.com)
  • There was a pattern of mixed effect directions among loci jointly associated with schizophrenia and lipids, blood pressure, type 2 diabetes, waist-to-hip ratio, and coronary artery disease , which may reflect variation in genetic susceptibility to CVD across subgroups of schizophrenia. (medscape.com)
  • Conclusion and recommendation In this study, the social domain was recorded as having the lowest mean score, which may indicate that patients with schizophrenia could need better psychosocial support. (bmj.com)
  • One such study examines the genetics of schizophrenia . (bbrfoundation.org)
  • Dr. Gejman holds one of the largest National Institute of Mental Health (NIMH) genetic grants awarded to a psychiatrist in the United States and directs the largest NIMH effort for the study of genetics of schizophrenia. (northwestern.edu)
  • Schizophrenia is a devastating disease that affects about 1% of the world's population," said corresponding author Dr. Robert A. Waterland professor of pediatrics - nutrition at the USDA/ARS Children's Nutrition Research Center at Baylor and of molecular and human genetics. (bcm.edu)
  • Cytokines are produced during stress or infections, which are environmental threats that are believed may trigger schizophrenia symptoms in genetically susceptible people. (bbrfoundation.org)
  • These results are interesting because the "hypoglutamatergic hypothesis" for pathophysiology of schizophrenia has been articulated since the early eighties. (nih.gov)
  • The results of this study were recently published in the Royal Society journal Open Biology . (helsinki.fi)
  • These results remained statistically significant even when we restricted our analysis to studies where people with schizophrenia were matched to healthy controls with regards their diet, the amount of exercise they engaged in and their ethnic background. (iflscience.com)
  • This suggests that our results were not wholly driven by differences in lifestyle factors or ethnicity between the two groups, and may therefore point towards a direct role for schizophrenia in increasing risk of diabetes. (iflscience.com)
  • The results also highlight the potential importance of monitoring for comorbid UTI in acutely relapsed patients with schizophrenia. (psychiatrist.com)
  • RESULTS: In the present study, 145 patients diagnosed with schizophrenia (mean age 42.2 years (SD ± 13.8)) were included, with 88 (60.7%) being male. (aau.dk)
  • The association between the explanatory variables and outcome of HS was assessed using multivariable logistic regression.RESULTS: In the present study, 145 patients diagnosed with schizophrenia (mean age 42.2 years (SD ± 13.8)) were included, with 88 (60.7%) being male. (aau.dk)
  • Nevertheless, the results support a role for monoaminergic synapses in schizophrenia. (avhandlingar.se)
  • These results suggest that visual P300 is affected already at the prodromal stage and could be a marker of the prodromal phase of schizophrenia. (harvard.edu)
  • Because the study results examined one point in time, a longitudinal study is needed to definitively show if marijuana is responsible for the brain changes and memory impairment. (futurity.org)
  • Results may help mental health clinics when considering ways to improve social and thinking skills in people with schizophrenia. (pcori.org)
  • The combination of the antipsychotic olanzapine and samidorphan, an experimental agent that acts on opioid receptors in the brain, results in significantly lower weight gain than olanzapine plus placebo in patients with schizophrenia, according to a report in AJP in Advance . (psychnews.org)
  • The findings suggest that risk factors for HS are similar in both the general population and in patients with schizophrenia. (aau.dk)
  • These findings suggest that patients with schizophrenia can participate in cancer screening to the same extent as the general population, albeit with some assistance. (ascopost.com)
  • 1 Department of Schizophrenia Research, Tokyo Institute of Psychiatry. (nih.gov)
  • The consortium's broad-scale analyses included 35 research groups that have integrated genetic samples from a total of 150,000 subjects - 37,000 of whom have schizophrenia and 113,000 healthy controls. (discovermagazine.com)
  • Further research is essential due to antipsychotics' limited efficacy and the uncharted territory regarding ketamine's effects on mentalizing in schizophrenia. (news-medical.net)
  • 2017 ). The current paper focuses on epidemiological and molecular genetic research studies in MZs with the purpose of unravelling useful insights on factors that can lead to SCZ and ASD. (springer.com)
  • The 5000 randomised controlled trials (RCTs) in the Cochrane Schizophrenia Group's database affords an opportunity to research for variables related to the differences between nations of their output of schizophrenia trials. (biomedcentral.com)
  • A study-based register affords an opportunity for research. (biomedcentral.com)
  • Heavy marijuana use as a teenager may cause changes in brain structure that resemble schizophrenia, new research shows. (futurity.org)
  • Chronic use of marijuana may contribute to changes in brain structure that are associated with having schizophrenia, the research shows. (futurity.org)
  • We have assembled here in the Schizophrenia Center a broad and deep pool of expertise in the Hopkins tradition that integrates patient care, research, and public health. (hopkinsmedicine.org)
  • We collaborate across divisions, departments, institutions and patients and families who participate in our research studies to expand our knowledge of schizophrenia and related conditions. (hopkinsmedicine.org)
  • The research team is working with 19 mental health clinics in New England to recruit 378 people with schizophrenia. (pcori.org)
  • This study builds on earlier research into the specific parts of the brain responsible for hearing voices. (medicalnewstoday.com)
  • Schizophrenia Research. (madinamerica.com)
  • Betel nut alkaloids include potent muscarinic cholinomimetics: recent research suggests that these agents may be therapeutic in schizophrenia. (cambridge.org)
  • The study received support from the Research Council of Norway, Norwegian Health Association, South-East Norway Regional Health Authority, and the European Union. (medscape.com)
  • The findings were presented here at the Schizophrenia International Research Society (SIRS) 2018 Biennial Meeting. (medscape.com)
  • This hypothesis has been supported both by pharmacological evidence that administration of NMDA-type glutamate receptor antagonists induces schizophrenia-like symptoms and by neurophysiological studies. (nih.gov)
  • Studies utilizing NMDA-receptor antagonists like ketamine, known for creating narcotic and psychotomimetic effects, aim to understand schizophrenia-related glutamate signaling deficiencies. (news-medical.net)
  • Therefore, in this study, we measured the P300 component as well as the P1/N1 in a visual oddball paradigm in prodromal subjects and first episode schizophrenia patients, and compared them with those of healthy controls. (harvard.edu)
  • Visual P300 and P1/N1 were obtained from prodromal (PRO, n = 23), first episode schizophrenia patients (SZ, n = 17), and healthy control subjects (HC, n = 31), who silently counted infrequent target stimuli ("X") amid standard stimuli ("Y") presented on the screen while 64-channel EEG was recorded. (harvard.edu)
  • In the study, the brains of 31 patients with schizophrenia and 15 healthy people used for comparison were scanned using functional magnetic resonance imaging (fMRI) while they performed a reality-monitoring task. (ucsf.edu)
  • In a study that included more than 5000 psychiatric patients and 8000 healthy control persons, investigators found that among schizophrenia patients, particularly those aged 18 to 40 years, rates of sleep disturbances were much higher than in the general population. (medscape.com)
  • The population is the number of people, and, with a lifetime prevalence of 1% for schizophrenia, it represents the numbers of people with the illness who live in the country. (biomedcentral.com)
  • Describe the prevalence, phases and complications-including oral complications-of schizophrenia. (dimensionsofdentalhygiene.com)
  • The aim of the study was to investigate the prevalence and factors associated with ever and continued e-cigarette use among the secondary and high school students from a socially disadvantaged rural area in Poland. (who.int)
  • Although the variants we studied are common to many populations, their specific biological consequences associated with schizophrenia and gene expression changes may be unique to this Finnish family cohort. (helsinki.fi)
  • ATSDR also convened a panel of epidemiologists with experience in military and occupational cohort studies to provide recommendations on future studies. (cdc.gov)
  • The proposed mortality study would evaluate all causes of death occurring in the cohort of Marines and naval personnel who began active duty on or after June 1975 and who were assigned to the base anytime during the period June 1975- December 1985. (cdc.gov)
  • Prediction of working disability in schizophrenia : a 5-year prospective study of a representative cohort of first-admissions / Antti Pakaslahti. (who.int)
  • The risk of schizophrenia to someone who carries one of these markers is increased by as little as one-tenth of a percent. (discovermagazine.com)
  • A recent study focusing on familial schizophrenia in Finland demonstrates that genetic variation in a known risk gene called NDE1 can affect both gene expression levels and medication usage of psychoactive drugs used to treat major mental illnesses. (helsinki.fi)
  • According to the researches, the role of the DISC1 network as a schizophrenia risk factor seems to be restricted to specific populations and families. (helsinki.fi)
  • However, our latest study found that the risk of developing diabetes in people with schizophrenia remains high even when we take these factors into account. (iflscience.com)
  • We pooled data from multiple studies that examined evidence of diabetic risk in blood samples from people with early schizophrenia prescribed little or no antipsychotic medication. (iflscience.com)
  • For example, premature birth and low birth weight are recognised as risk factors for the development of both schizophrenia and diabetes later in life. (iflscience.com)
  • It is possible that the stress associated with developing schizophrenia, which sees levels of cortisol rise, may also contribute to higher diabetic risk. (iflscience.com)
  • Recent studies predicting signs of suicide risk from social media using artificial intelli. (psychiatrist.com)
  • OBJECTIVE: With hepatic steatosis (HS) being an established risk factor for CVD in the general population, it may also be a predictor of CVD in patients with schizophrenia. (aau.dk)
  • It has been observed that deficit and non-deficit schizophrenia (SCZ-D and SCZ-ND) might be characterized by different risk factors. (elsevier.es)
  • Therefore, the present study aimed to assess as to whether previously reported risk factors of schizophrenia are specifically associated with SCZ-D and SCZ-ND. (elsevier.es)
  • They add that regular smokers of cannabis are at increased risk of developing schizophrenia by two to three times. (mednews.com)
  • Patients with schizophrenia have a higher risk of death when compared to the general population. (medscape.com)
  • The rates of smoking for people with schizophrenia is as high as four times that of the general population, contributing to people with schizophrenia increased risk of excess mortality, heart and lung diseases, and even diabetes. (wikipedia.org)
  • Geneticists have identified a specific DNA change that is likely to increase risk for developing schizophrenia in some people. (sciencedaily.com)
  • They not only suggest the possibility of predicting risk of schizophrenia early in life, but also outline a new approach that may be applicable to other diseases. (bcm.edu)
  • There is now robust evidence that schizophrenia is associated with an increased risk of violence. (researchgate.net)
  • People with schizophrenia are at increased risk, as compared to the general population, to be convicted for violent crimes because they are more likely to engage in aggressive behaviour towards others. (researchgate.net)
  • Mental health services need to assess the risk of violence among patients with schizophrenia and provide treatments that directly target antisocial and aggressive behaviour. (researchgate.net)
  • Using MiXeR, the study showed that several genetic variants underlying schizophrenia also influence CVD phenotypes, particularly risk factors of smoking and BMI. (medscape.com)
  • this is in line with evidence of low BMI being a risk factor for schizophrenia, although obesity is more common in people with schizophrenia. (medscape.com)
  • The aim of this study is to identify comorbid risk factors and describe acute outcomes of medically treated traumatic injuries occurring as a result of contact with law enforcement personnel. (cdc.gov)
  • Another study in England showed that the risk bi city (Shiekh Khalifa Medical City, Al Mafraq Hospital, of a completed suicide in the year following the attempt and Al Rahba Hospital). (who.int)
  • Since the epigenetic status differs in each tissue type, in addition to the DNA from the peripheral blood, studies using DNA from nerve cells induced from postmortem brains or induced pluripotent stem cells are being carried out. (springer.com)
  • The good news from the study was that many of the variants associated with the disorder made biological sense. (discovermagazine.com)
  • This argument is often trotted out in discussions of the genetic architecture of schizophrenia, which centre on the question of whether it is caused by rare, single mutations in most cases or whether it is due to unfortunate combinations of thousands of common variants segregating in the population. (wiringthebrain.com)
  • However, progress in genetic studies on schizophrenia during the past ten years has revealed several replicated linkage loci, which span over multiple chromosomal regions. (nih.gov)
  • Here, we introduce the overview of recent progress in genetic studies that converge to depict the hypothesis of glutamatergic hypofunction in schizophrenia. (nih.gov)
  • The unprecedentedly large sample allows a glimpse of the genetic basis of the disease that smaller, earlier studies didn't have the statistical power to see. (discovermagazine.com)
  • The basis for these studies is that MZs share 100% of their genetic information. (springer.com)
  • Why have genetic linkage studies of schizophrenia failed? (wiringthebrain.com)
  • It is true that many genetic linkage studies have been performed to look for mutations that are segregating with schizophrenia across multiple affected members in families. (wiringthebrain.com)
  • This depends very much on the details of how these studies were carried out, their underlying assumptions, their specific findings and the real genetic architecture of the disorder. (wiringthebrain.com)
  • The idea of genetic linkage studies is that if you have a disease segregating in a particular family, you can use neutral genetic markers across the genome to look at the inheritance of different segments of chromosomes through the pedigree and track which ones co-segregate with the disease. (wiringthebrain.com)
  • Yeah, they are actually discussing now what is the likely genetic link for predisposition for schizophrenia and type II diabetes. (madinamerica.com)
  • The role of glutamatergic NMDA receptors in these deficits is undetermined despite ketamine studies indicating potential links. (news-medical.net)
  • P300 deficits in schizophrenia patients are well established, especially in the auditory modality. (harvard.edu)
  • The neurobiology of social dysfunction in schizophrenia is unknown, but smell identification deficits (SIDs) exist in schizophrenia, and olfaction is related to social affiliation in other mammals. (nih.gov)
  • Combined ECT and neuroleptic therapy in treatment-refractory schizophrenia: prediction of outcome. (medicinenet.com)
  • Schizophrenia is a chronic psychotic disorder, either persistent or episodic, whose hallmark features may include delusions, hallucinations, disturbed thinking processes, flattening of affect, and abnormal behaviors. (medscape.com)
  • One study using the Involvement Evaluation Questionnaire-EU Version (IEQ-EU) showed that the consequences of caring for an individual with depression or schizophrenia were comparable [ 11 ]. (biomedcentral.com)
  • Depression and schizophrenia : a contribution on their chemical pathologies / H. M. van Praag. (who.int)
  • Until recently, gene scans were unsuccessful in turning up links to schizophrenia. (discovermagazine.com)
  • The serotonin receptor 2C gene (HTR2C) showed a significant 1.5-fold decrease in the patients as compared to controls, and the monoamine oxidase B gene (MAOB) a 1.2-fold increase.The mechanism behind the decrease of HTR2C mRNA levels was investigated by studying the correlation of drug treatment and HTR2C promoter polymorphisms to the HTR2C expression levels. (avhandlingar.se)
  • Consuelo Walss-Bass, Ph.D. and colleagues have sequenced the neuregulin-1 gene in members of the Costa Rican community who have schizophrenia. (bbrfoundation.org)
  • The gene in question, NOS1AP, previously known as CAPON, is one which Brzustowicz has been studying for six years. (sciencedaily.com)
  • The new analytical technique quantifies the statistical evidence for association, in this case between the altered gene and schizophrenia. (sciencedaily.com)
  • Schizophrenia is not a single-gene disorder, and there are environmental factors that are also important. (sciencedaily.com)
  • Approximately 1 percent of the general population has schizophrenia but not all of those with the illness will have this altered gene. (sciencedaily.com)
  • Brzustowicz estimates that the frequency of the altered gene in people with schizophrenia is going to be higher than the average in the general population. (sciencedaily.com)
  • CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy. (medicinenet.com)
  • Of the 15 marijuana smokers who had schizophrenia in the study, 90 percent started heavily using the drug before they developed the mental disorder. (futurity.org)
  • However, smokers with schizophrenia (SS) may be prone to changing their smoking topography in efforts to compensate for the reduction in nicotine content. (who.int)
  • Possible complications for schizophrenia range from more medical conditions (morbidity) or shortened life span (mortality) to negative impacts on their family members as well. (medicinenet.com)
  • These cancers could be evaluated in a mortality study and in a cancer incidence study. (cdc.gov)
  • The study's participants, who were administered ketamine, exhibited significantly more schizophrenia-related symptoms than the control group across various factors, except for hostility symptoms. (news-medical.net)
  • Prior studies have shown that half to two-thirds of people with schizophrenia will significantly improve or fully recover, enabling them to live fulfilling and productive lives. (uclahealth.org)
  • Betel chewers with schizophrenia scored significantly lower on the positive ( P =0.001) and negative ( P =0.002) sub-scales of the PANSS than did non-chewers. (cambridge.org)
  • This makes it challenging to assess whether epigenetic changes contribute to diseases involving the brain, like schizophrenia. (bcm.edu)
  • They proposed that studying CoRSIVs is a novel way to uncover epigenetic causes of disease. (bcm.edu)
  • The study was published in the Journal of Neural Transmission. (ucla.edu)
  • When comparing machines that gave dollar-bill payouts, levels of activity in the brain were similar in people with and without schizophrenia. (uclahealth.org)
  • Teens who were heavy marijuana users-smoking it daily for about three years-had abnormal changes in their brain structures related to working memory and performed poorly on memory tasks, a new study shows. (futurity.org)
  • Few studies have examined marijuana's effect on the deep regions in the brain-the 'subcortical gray matter' below the noodle-shaped cortex. (futurity.org)
  • The medial prefrontal cortex is a critical higher-order brain region that supports successful reality-monitoring processes," said Karuna Subramaniam, the study's first author, who worked directly with the patients in the study and analyzed their data. (ucsf.edu)
  • A new study confirms the brain region involved in generating the"voices" that occur in schizophrenia. (medicalnewstoday.com)
  • GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD-67), is associated with childhood onset schizophrenia and cortical gray matter volume loss. (medicinenet.com)