These randomized controlled trials (RCTs) compared treatment with famotidine against no famotidine among ambulatory persons with COVID-19 and persons hospitalized with severe COVID-19. (parasiteswithoutborders.com)
Among hospitalized patients with severe COVID- 19, the IDSA panel suggests against famotidine for the treatment of COVID-19. (parasiteswithoutborders.com)
Lopinavir6
In this study, 78 percent of the 440 patients in the REYATAZ /r arm met the primary endpoint of achieving undetectable viral load (defined as HIV-1 RNA less than 50 copies/mL) at 48 weeks, compared with 76 percent of the 443 patients in the lopinavir/r arm. (salesandmarketingnetwork.com)
CASTLE is the first large-scale, open-label, randomized study designed to demonstrate the non-inferiority of REYATAZ /r to lopinavir/r in previously untreated HIV-1 infected adult patients. (salesandmarketingnetwork.com)
REYATAZ /r arm and seven percent of patients in the lopinavir/r arm required initiation of lipid-lowering therapy in the study. (salesandmarketingnetwork.com)
Nine percent of patients in the REYATAZ /r arm and thirteen percent of patients in the lopinavir/r arm discontinued the study therapy before week 48. (salesandmarketingnetwork.com)
Four hundred and forty patients were randomized to receive REYATAZ 300 mg and ritonavir 100 mg once daily and 443 patients were randomized to receive lopinavir 400 mg and ritonavir 100 mg twice daily, each in combination with a once-daily, fixed- dose combination of emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg. (salesandmarketingnetwork.com)
In the study, 74 percent of the 223 patients with high baseline viral load (greater than or equal to 100,000 copies/mL) in the once-daily REYATAZ (atazanavir sulfate)/r arm achieved undetectable viral load at 48 weeks, vs. 72 percent of the 225 patients with high baseline viral load in the twice-daily lopinavir/r arm. (salesandmarketingnetwork.com)
Cohort study1
This cohort study included ≥18 years-old individuals with underlying conditions associated with an immunocompromised state and diagnosed with COVID-19 between February-2020 and January-2021 at Karolinska University Hospital, Stockholm. (parasiteswithoutborders.com)
Multicentre1
TANGO is a phase III, randomised, open-label, active-controlled, multicentre, parallel-group study comparing dolutegravir plus lamivudine once daily against continuation of a ≥3-drug tenofovir alafenamide (TAF)-based regimen over 48-weeks in HIV-1 infected, antiretroviral treatment-experienced, virally suppressed subjects. (gsk.com)
Ambulatory3
This section includes updated remarks for the existing recommendation on the use of nirmatrelvir/ritonavir for ambulatory patients with mild-to-moderate COVID-19 at high risk for progression to severe disease. (idsociety.org)
among ambulatory patients with mild-to-moderate COVID-19, the IDSA panel suggests against famotidine for the treatment of COVID-19 (Conditional recommendation, low certainty of evidence). (parasiteswithoutborders.com)
The national estimates produced from these studies describe the utilization of hospital ambulatory medical care services in the United States. (cdc.gov)
Dose2
The GEMINI 1 & 2 phase III studies compared a 2DR of dolutegravir plus lamivudine to a 3-drug regimen of dolutegravir plus the fixed-dose tablet tenofovir/emtricitabine (TDF/FTC). (gsk.com)
SOF: 0.5GS-331007: 2515% Of dose excreted in urineSingle dose administration of [14C] SOF or [14C] VEL in mass balance studies. (drugcentral.org)
Inhibitors3
In drug combination studies of delavirdine with zidovudine, didanosine, zalcitabine, lamivudine, interferon-α, and protease inhibitors, additive to synergistic anti-HIV-1 activity was observed in cell culture. (drugs.com)
In treatment-naïve patients, the clinical study data on use of raltegravir are limited to use in combination with two nucleotide reverse transcriptase inhibitors (NRTIs) (emtricitabine and tenofovir disoproxil fumarate). (medthority.com)
Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation. (rtrn.net)
Trials1
Still under study: Two oral antivirals, Pfizer's PF-07321332, which began Phase 2-3 trials in July in combination with ritonavir, and masitinib , which is still in preclinical testing. (stethoscopeonrome.com)
DAKLINZA is indicated for use with sofosbuvir, with or without ribavirin, for the treatment of patients with chronic hepatitis C virus (HCV) genotype 1 or genotype 3 infection [see DOSAGE AND ADMINISTRATION and Clinical Studies ]. (rxlist.com)
Sustained virologic response (SVR12) rates are reduced in HCV genotype 3-infected patients with cirrhosis receiving DAKLINZA in combination with sofosbuvir for 12 weeks [see Clinical Studies ]. (rxlist.com)
The optimal duration of DAKLINZA and sofosbuvir with or without ribavirin has not been established for HCV genotype 3 patients with cirrhosis or for HCV genotype 1 patients with Child-Pugh C cirrhosis [see Clinical Studies ]. (rxlist.com)
Unfortunately scientists fixated early on hydroxychloroquine, largely due to French celebrity microbiologist Didier Raoult's dreadful research (e.g. the abstract of this study neglects to mention that 4 of the 20 patients who received the drug, vs. none of 16 controls, wound up in the ICU or dead). (stethoscopeonrome.com)
Fluvoxamine, an SSRI antidepressant, after very preliminary positive results last November, seems in a larger study to cut hospital recourse in high-risk patients by 30% . (stethoscopeonrome.com)
The CASTLE study provides important additional data to inform the use of a once-daily regimen including REYATAZ and ritonavir in antiretroviral-naive HIV-infected patients," said Jean-Michel Molina, M.D., Hopital Saint Louis, Paris, France. (salesandmarketingnetwork.com)
The international, multi-center, open-label, 96-week CASTLE study randomized 883 treatment-naive patients infected with HIV-1. (salesandmarketingnetwork.com)
The primary endpoint for the study was the proportion of patients with viral load of less than 50 copies/mL at 48 weeks. (salesandmarketingnetwork.com)
Main reasons for non-availability of paediatric-specific formulations are non-availability of clinical data on paediatric patients, clinical studies conducted mostly with adult patients, the small number of patients in the paediatric age group, varying age groups of paediatric patients, and business focus on the larger population of adult patients [ 5 ]. (ijpsonline.com)
Efficacy2
The efficacy analyses of this study suggested that the sustained improvements in sleep and daytime functioning with daridorexant 50 mg support its use for long-term treatment of insomnia disorder, without concerns. (wikipedia.org)
The BRIGHTE study is a two-cohort (randomised and non-randomised), phase III clinical trial evaluating the safety and efficacy of the HIV-1 attachment inhibitor fostemsavir in heavily treatment-experienced adults with HIV-1 infection. (gsk.com)
Risk2
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. (drugs.com)
Animal studies indicate an increased risk for unborn babies if Nerlynx is taken by pregnant women, including abortions, death, or abnormalities. (rxwiki.com)
Induction of Cellular Senescence in Rat Vaginal Fibroblasts and Treatment With Senolytics: An in Vitro Model for the Study of Pelvic Organ Prolapse. (ouhsc.edu)
Phase II evaluation of dasatinib in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. (ouhsc.edu)
Phase1
Week 48 pooled analysis of the phase III ATLAS and FLAIR studies, as well as patient-reported views and outcomes from both studies, will be presented at IAS 2019. (gsk.com)
Outcomes1
The study was aimed to determine the association between pre-infection use of immunosuppressant drugs with COVID-19 outcomes within one month. (parasiteswithoutborders.com)
Clinical1
Additional studies are needed to correlate viral culture positivity with confirmed transmission and to validate the utility of clinical antigen testing for defining optimal isolation periods. (parasiteswithoutborders.com)
Combination1
In a separate study, an average of 86-fold increase in the zidovudine susceptibility of patient isolates (n = 24) was observed after 24 weeks of combination therapy with RESCRIPTOR and zidovudine. (drugs.com)
Mass2
As the study reported that age, lean body weight, fat mass, and alkaline phosphatase influence exposure to a limited extent, that is, less than 20% difference from a typical subject. (wikipedia.org)
Data from the CASTLE study were presented for the first time at the 15th Conference on Retroviruses and Opportunistic Infections (CROI) this week in Boston, Mass. (salesandmarketingnetwork.com)
Effectiveness1
This means that Health Canada has approved this medication to be marketed based on promising evidence of effectiveness, but additional results of studies are needed to verify its effectiveness. (medbroadcast.com)
Show2
Studies of Adderall and Adderall XR show that the drugs improve attention and focus, and reduce impulsive behaviors. (medicalnewstoday.com)
Studies show that Epclusa is effective for treating hepatitis C virus. (fixhepc.com)
Time2
Time to symptom resolution was shorter in the famotidine group (mean difference [MD] -0.9 days, 95% CI: -1.44, -0.36), as was length of hospital stay (MD -1.7 days, 95% CI: -2.77, -1.13), although due to lack of blinding these estimates remain less certain (low CoE). (parasiteswithoutborders.com)
We performed this study to determine the start time in Favipiravir's covid pneumonia. (c19early.org)
Data1
Ivermectin has been more or less debunked in a Cochrane review , and some ongoing studies might stop now that a major article has been withdrawn for data fabrication . (stethoscopeonrome.com)
Oral1
The chewable tablets and the granules for oral suspension have not been studied in HIV-infected adolescents (12 to 18 years) or adults. (medicines.org.uk)