• kinase
  • Among his most notable contributions are the discovery and study of the enzyme PI-3-kinase, now known to be important to understanding cancer and diabetes mellitus. (wikipedia.org)
  • structures
  • We have solved the high-resolution structures of 3 HLA A2-restricted phosphopeptides associated with tumor immunity and compared them with the structures of their nonphosphorylated counterparts. (pnas.org)
  • To study the intrinsic link between the deregulated signaling cascade present in many cancers and the ability of antigen processing to alert CTLs to such molecular events, we have investigated the structural and biophysical properties and structures of 3 HLA A2 phosphopeptide complexes derived from cell division cycle (CDC) 25b, β-catenin, and insulin receptor substrate (IRS) 2 and have compared them with the structures of their nonphosphorylated counterparts. (pnas.org)
  • insights
  • These findings provide insights into the mode of phosphopeptide presentation by HLA as well as providing a platform for the rational design of a generation of posttranslationally modified tumor vaccines. (pnas.org)
  • tissues
  • However, the mechanisms of the hormonal-regulation of SIK2 in liver remain controversial, with much of the data based on the studies in non-hepatic tissues/cells. (bl.uk)
  • calcium
  • NMR Spectroscopy and mass spectroscopic studies of a novel calcium, phosphate and fluoride delivery vehicle-the multiphosphorylated peptide αs2-Casein(59-79) complexed with amorphous calcium fluoride phosphate. (edu.au)
  • Unfolded phosphopeptides are believed to sequester ACP nanoclusters, and form stable complexes in other biofluids such as urine and blood serum, thus preventing deposition of insoluble calcium phosphates and calcification of soft tissue. (wikipedia.org)
  • Amorphous calcium phosphate in combination with casein phosphopeptide has been used as a dental treatment to treat incipient dental decay. (wikipedia.org)
  • Production
  • To test this hypothesis, highly selective pan SIK inhibitors (HG-9-91-01 and KIN112) were characterised and used to study the importance of SIKs activity in hepatic glucose production employing mouse primary hepatocytes. (bl.uk)
  • gene
  • A genome-wide association study identified RNF213 as the first gene associated to Moyamoya disease. (wikipedia.org)
  • cancer
  • These studies were designed to determine whether ritonavir inhibits breast cancer in vitro and in vivo and, if so, how. (aacrjournals.org)
  • Ritonavir effects on breast cancer cell growth were studied in the estrogen receptor (ER)-positive lines MCF7 and T47D and in the ER-negative lines MDA-MB-436 and MDA-MB-231. (aacrjournals.org)
  • water
  • Recent studies suggest that water fluoridation, particularly in industrialized nations, may be unnecessary because topical fluorides (such as in toothpaste) are widely used, and caries rates have become low. (wikipedia.org)
  • addition
  • In addition, HLA A2-restricted tumor-specific phosphopeptides are immunogenic, and cytotoxic T lymphocytes (CTLs) that distinguish between phosphorylated and native peptides can be generated in HLA A2 transgenic mice ( , 9 ). (pnas.org)
  • The addition of suitable phosphopeptides prevents precipitation. (wikipedia.org)
  • Design
  • In one study design, cells are exposed to SILAC labelling and then stimulated by a specific growth factor. (wikipedia.org)
  • activity
  • Publications] Ando, S.: 'Alterations in tyrosine phosphatase activity during proliferation of Lewis lung carcinoma-derived cells,studied with synthetic phosphopeptides as substrates. (nii.ac.jp)