Study models genetic. Medical search. Frequent questions

Increasingly, logistic regression methods for genetic association studies of binary phenotypes must be able to accommodate data sparsity, which arises from unbalanced case-control ratios and/or rare genetic variants. (karger.com)
Results from genome-wide association studies (GWAS) on DGE show that most quantitative traits in livestock are highly polygenic and that variants tend to be associated with more than one trait [ 4 ]. (springer.com)
We investigate protein-altering variants in ANGPTL4 among 58,124 participants in the DiscovEHR human genetics study, with follow-up studies in 82,766 T2D cases and 498,761 controls. (nature.com)
In this study, we examine the association of genetic variants that abolish ANGPTL4 function with fasting glucose, oral glucose tolerance, and risk for type 2 diabetes in 58,124 individuals of European ancestry sampled from a large US health care population, and in 13 additional datasets comprising 82,766 type 2 diabetes cases and 498,761 controls. (nature.com)
We also evaluate the functional consequences of rare and novel genetic variants identified by exome sequencing, as well as the effect of Angptl4 deletion on insulin sensitivity and glucose homeostasis. (nature.com)
Various genetic variants have been identified as risk factors for DA in association studies. (cdc.gov)
Of the models we examined, the metapopulation model, in which HIV-1 evolves within an individual as a large collection of small subpopulations subject to frequent migration, extinction, and recolonization, was most consistent with the observed levels of genetic variation and the average frequencies of those variants. (bioone.org)
The two-stage design is often adopted in genome-wide association studies (GWASs) to search for genetic variants underlying susceptibility for complex diseases. (biomedcentral.com)
Besides age and smoking, genetic variants from several gene loci have reproducibly been associated with this condition and likely explain a large proportion of disease. (uni-wuerzburg.de)
Here, we developed a genetic risk score (GRS) for AMD based on 13 risk variants from eight gene loci. (uni-wuerzburg.de)
There have been significant advances in the genetic epidemiology of lung function, but the causal genetic variants and causal genes, and the mechanisms by which they influence lung function, chronic obstructive pulmonary disease (COPD) and other respiratory diseases remain incompletely understood. (nottingham.ac.uk)
Pharmacogenomic testing, which uses a blood, saliva, or buccal swab sample, could help identify genetic variants involved in drug metabolism and response as well as guide prescribing and reduce adverse effects, the authors write. (medscape.com)
We used the statistical methods the bivariate causal mixture model (MiXeR) and the conditional/conjunctional false discovery rate (pleioFDR) to quantify genome-wide overlap and to identify shared genetic variants. (plos.org)
Depression shared 68% of genetic variants with body mass index and 14% and with systolic blood pressure. (plos.org)
Further analyses identified shared genetic variants found in metabolism of alpha-linolenic pathway for type 2 diabetes. (plos.org)

The same quantitative trait loci were identified with all models. (springer.com)
Interactions of associated loci were identified for MGR selection in trees with complex genetic backgrounds. (frontiersin.org)
The cost efficient two-stage design is often used in genome-wide association studies (GWASs) in searching for genetic loci underlying the susceptibility for complex diseases. (biomedcentral.com)
Numerous obesity loci have been identified using genome-wide association studies. (lu.se)
A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. (lu.se)
article{8ec093ff-a22c-4f74-83bb-2d1330edc6c6, abstract = {{Numerous obesity loci have been identified using genome-wide association studies. (lu.se)
The main goal of the first project is to understand the role of natural and sexual selection in the evolution and maintenance of genetic variation at loci coding for melanin-based colour traits by combining disciplines of behavioural ecology, genetics and population genetics. (unil.ch)
We used the bivariate causal mixture model (MiXeR) to quantify genome-wide polygenic overlap and the conditional/conjunctional false discovery rate (pleioFDR) method to identify shared loci, based on genome-wide association study summary statistics on depression (n = 450,619), coronary artery disease (n = 502,713) and nine cardiovascular risk factors (n = 204,402-776,078). (plos.org)
Genetic loci were functionally annotated using FUnctional Mapping and Annotation (FUMA). (plos.org)
Genome-wide association studies have identified more than 100 genetic loci for SLE susceptibility across populations, with most of the genetic risk shared across borders and ethnicities. (medscape.com)

The new mouse model, known as Ts66Yah, has a minichromosome with over a hundred genes from mouse chromosome 16 attached to the centromere region of mouse chromosome 17. (nih.gov)
Scientists often use different strains of mice as animal models to study human diseases because most genes in humans have similar counterparts in mice. (nih.gov)
Importantly, the previous mouse model's genome contains 45 extra genes that are irrelevant to human Down syndrome, a byproduct of how the model was developed. (nih.gov)
The previous mouse model has an additional region of mouse chromosome 17 that contains 45 extra genes not found on human chromosome 21. (nih.gov)
To create an enhanced mouse model of Down syndrome, researchers at the University of Strasbourg, France, removed these extra 45 genes using CRISPR gene-editing technology. (nih.gov)
Dr. Bianchi's group then compared the two mouse models and found that the extra 45 genes in the previous mouse model were affecting brain development and contributed to more severe difficulties with motor skills, communication and memory. (nih.gov)
There are considerable effects of these extra genes on mouse brain development and behavior," said Faycal Guedj, Ph.D., staff scientist in NHGRI's Center for Precision Health Research and first author of the study. (nih.gov)
What was previously thought as the best mouse model of Down syndrome has traits derived from genes that are not relevant to human chromosome 21. (nih.gov)
A hidden Markov model for haplotype inference for present-absent data of clustered genes using identified haplotypes and haplotype patterns by: KUI eZHANG, et al. (uitm.edu.my)
However, more recent studies suggest that multiple genes, perhaps up to 40, contribute to this trait. (medlineplus.gov)
Studies suggest that at least some of these genes help determine the overall right-left asymmetry of the body starting in the earliest stages of development. (medlineplus.gov)
This study evaluated the association of the Nrf2 and HO-1 genes polymorphisms with vitiligo susceptibility. (nih.gov)
In this case-control study of 1136 Han Chinese vitiligo patients and 1200 controls, Nrf2 (rs35652124 and rs6721961) and HO-1 (rs2071746) genes were genotyped by PCR-restriction fragment length polymorphism analysis. (nih.gov)
Ciliopathies are a highly heterogeneous disease group, continually expanding with the discovery of new genes and availability of genetic diagnostics. (asn-online.org)
Recent studies in humans and in genetic mouse models have identified Slitrks Sitagliptin as candidate genes for neuropsychiatric disorders. (ecologicalsgardens.com)
A new study published in Science indicates that cocaine sensitization -- which is linked to addiction -- might be associated with circadian genes, the genes that set the biological clock. (sciencedaily.com)
This study opens up the field of drug studies to thinking how a totally unexpected set of genes functions in response to drugs," says Jay Hirsh, professor of biology at U.Va. and senior author of the report. (sciencedaily.com)
Now the largest-ever genetic analysis of people being treated with checkpoint inhibitors has found that certain genes people are born with (called germline genes) may play a critical role. (mskcc.org)
The use of various strains in studies of genes and age related or noise related hearing loss was described. (cdc.gov)
A genome-wide study in a northern European population replicated the association of SLE with susceptibility genes related to B-cell receptor pathway signaling, as well as confirmed the association of SLE with genes at the interferon regulatory factor 5 (IRF5)-TNPO3 locus. (medscape.com)

The differences in susceptibility to noise induced hearing loss (NIHL) which may be attributed to genetic factors were discussed. (cdc.gov)
Priya Duggal, PhD, Associate Professor, Johns Hopkins Bloomberg School of Public Health, will discuss her research on host genetic susceptibility to infectious disease, focusing on AFM. (cdc.gov)

In this study we comprehensively assess the shared genetic basis of impaired lung function and lung cancer risk by conducting genome-wide association analyses in the UK Biobank cohort to identify genetic determinants of three pulmonary phenotypes, forced expiratory volume in 1s (FEV 1 ), forced vital capacity (FVC), and FEV 1 /FVC. (nature.com)
We examine the genetic correlation between pulmonary function phenotypes and lung cancer, followed by Mendelian randomization (MR) using novel genetic instruments to formally test the causal relevance of impaired pulmonary function, using the largest available dataset of 29,266 lung cancer cases and 56,450 controls from the OncoArray lung cancer collaboration 16 . (nature.com)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
that carry as much genetic variation as the entire human population, making them ideal for studying the wide-ranging characteristics (or phenotypes, in scientific parlance) of aging. (jax.org)
The model included unique patient characteristics, such as metabolizer phenotypes, and followed the experience of patients through diagnosis, treatment, and recurrence. (medscape.com)
The genetic relationship between depression and these cardiovascular phenotypes is not known. (plos.org)

2014) studied the differences between two sub-populations of India, the Indo-European-speaking Gujaratis (labelled as North Indians) and the Dravidian-speaking Tamils (labelled as South Indians), and found that one of the most apparent differences between them is in skin complexion, with North Indians being much fairer, which points to gene flow from Europe to North India. (wikipedia.org)
Among Indian populations, the largest genetic distance is between Gujaratis and the tribal Irulas. (wikipedia.org)
This work demonstrates the successful translation and deployment of molecular genetic knowledge into specific MAS tools that can be easily applied in a selection or breeding program to efficiently screen MGR against WPBR in Alberta limber pine populations. (frontiersin.org)
However, compared to this potential, populations of HIV-1 within individuals exhibit little genetic variation. (bioone.org)
An extensive literature documenting physiological and ecological diversity make Daphnia an ideal model to study the genetic architecture of phenotypic variation in natural populations and the evolution of genome structure/function relationships in aquatic environments. (biomedcentral.com)
The Qinghai-like Clade 2.2 virus was found to possess a high genetic relationship with viruses isolated from other countries on the migratory flyway of wild birds 4 , suggesting that the migration of wild birds played an important role in circulating H5N1 HPAIV viruses between the different avian populations. (nature.com)
I am a wildlife ecologist and field veterinarian, most recently working on modelling the impact of canine distemper (CDV) on wild tiger populations to understand the contribution of domestic and wild carnivores to the CDV reservoir. (gla.ac.uk)
In natural populations, local mate selection and dispersal create correlations between geographic location and genetic variation - each individual's genome is a mosaic of material inherited from recent ancestors that are usually geographically nearby. (elifesciences.org)
These populations originated from the latitudinal extremes of the species's range, where we had previously demonstrated significant differences in memory and brain morphology in a multi-population study. (researchgate.net)
The JAX Genetic Diversity Initiative is a strategic effort to increase the awareness and availability of diversity mouse populations and associated tools across the research community. (jax.org)
These populations are powering a revolution in model organism research that will enable major advancements in the understanding of complex genetic traits. (jax.org)

This study was conducted to characterize Alberta limber pine seed families for WPBR resistance and to develop reliable molecular tools for marker-assisted selection (MAS). (frontiersin.org)
The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. (okstate.edu)
Molecular, genetic and cellular mechanisms underlying Asthma & Chronic Obstructive Pulmonary Disease. (nottingham.ac.uk)
The work laid the foundation for the current studies elaborating the possible molecular bases for cocaine addiction in people, including other recently published findings in the current online issue of Current Biology, ( http://www.biomednet.com/library/abstract/JCUB.bb9p35 ) that implicate tyramine, one of the body's naturally occurring molecules, as the likely perpetrator of cocaine sensitization in fruit flies. (sciencedaily.com)
This molecular model shows a T cell receptor and an HLA-A white blood cell antigen bound to part of a virus. (mskcc.org)
Based on the results of that study, the molecular techniques to test these samples, government included beta-thalassaemia but accurate characterization of the molec- screening laboratory tests in the compulso- ular abnormality depends upon knowledge ry package of medical tests for all couples of the abnormal genetic forms, or thalas- prior to marriage [ 8 ]. (who.int)

I am interested in mathematical modelling of infectious diseases. (gla.ac.uk)

Mühlenbein, H., Schlierkamp-Voosen, D.: Predictive models for the breeder genetic algorithm: I. continuous parameter optimization. (springer.com)
In this study it was determined whether host genetic risk factors improve the predictive abilities of an existing model regarding hearing loss after childhood BM. (biomedcentral.com)

Our study aimed at identifying SNPs associated with DGE and IGE for survival time, and comparing results from models that analyse survival time and repeated binomial survival. (springer.com)
Approximately 30,000 single nucleotide polymorphisms (SNPs) were included in the genome-wide association study (GWAS), using a linear mixed model for survival time, a linear mixed model and a generalized linear mixed model for repeated binomial survival (0/1). (springer.com)
Backwards elimination was used to determine phenotypic and genetic variance explained by SNPs. (springer.com)
These SNPs explained 1 to 6% of the phenotypic variance and 9 to 44% of the total genetic variance. (springer.com)
6 ] conducted an association study using 1022 single nucleotide polymorphisms (SNPs) and identified 81 SNPs that were associated with IGE for plumage condition in laying hens. (springer.com)
In this workshop, we will focus firstly on the website tools and criteria of selection of SNPs polymorphism that will be used on the study. (edu.sa)
Since in most cases there is no evidence suggesting that the additive risk model is most appropriate for the underlying disease model, especially in the typical GWASs where we most likely evaluate only the tagging SNPs, but not the causal SNPs directly. (biomedcentral.com)
Addition of TLR9 -1237 SNPs and the combination of TLR2 + 2477 and TLR4 + 896 SNPs improved the clinical prediction model, but not significantly (increase of AUC's from 0.856 to 0.861 and from 0.856 to 0.875 ( p = 0.570 and 0.335, respectively). (biomedcentral.com)
Future studies should evaluate whether more combinations of SNPs in larger cohorts has an additional value to the existing prediction model for post meningitis hearing loss. (biomedcentral.com)

Two-stage GWAS analysis process used to detect infection-associated Streptococcus pneumoniae k-mers in study of disease-associated Streptococcus pneumoniae genetic variation. (cdc.gov)
Beyond GWAS—Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19? (mdpi.com)
The consortia that we based our study on (the original GWASs) have GWAS summary statistics available. (plos.org)

Harik, G.R.: Learning gene linkage to efficiently solve problems of bounded difficulty using genetic algorithms. (springer.com)
Syswerda, G.: Uniform crossover in genetic algorithms. (springer.com)
Sastry, K.: Evaluation-relaxation schemes for genetic and evolutionary algorithms. (springer.com)
RESULTS: In our work we explored direction by applying poisoning techniques to contaminate data and then applying genetic algorithms to extract the non-poisoned content from the poisoned content that can generate a good response when paraphrased. (eai.eu)
Hands-on genetic algorithms with Python: applying genetic algorithms to solve real-world deep learning and artificial intelligence problems. (eai.eu)
In this study, we propose a forecasting method integrating Genetic algorithms (GA) and Autoregressive Moving Average (ARMA) method to take advantages of the unique strength of ARMA and genetic algorithms model. (itu.edu.tr)

This enormous capability to generate genetic variation allows for escape from immune surveillance and antiviral therapy. (bioone.org)
This discrepancy between the known mutation rate of HIV-1 and the average level of genetic variation in the env gene observed in vivo is reflected in comparisons of the actual numbers of productively infected cells, estimated as 10 7 , and the effective population size, estimated as 10 3 . (bioone.org)
Age itself is the largest risk factor for diseases and disability among the elderly," says Nadia Rosenthal, Ph.D., F.Med.Sci Investigates the role of genetic variation and the immune system in tissue repair, focusing on cardiovascular and skeletal muscle disease Nadia Rosenthal , scientific director of The Jackson Laboratory's mammalian genetics campus in Bar Harbor, Maine. (jax.org)

Functional studies in Angptl4 -deficient mice confirm improved insulin sensitivity and glucose homeostasis. (nature.com)
genetic deficiencies in BDNF or TrkB (KO mice) (Baquet et al. (ecologicalsgardens.com)
The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice. (bvsalud.org)

The new mouse model shows milder cognitive traits compared to a previously studied Down syndrome mouse model. (nih.gov)
Scientists found that the new mouse model, known as Ts66Yah, had memory difficulties and behavior traits, but the symptoms were not as severe as seen with the previous mouse model. (nih.gov)
The availability of genomic information has increased our understanding of complex traits, but studies have mainly focussed on DGE. (springer.com)
Daphnia is a versatile model system to investigate fundamental mechanisms of inheritance and development, cellular function, physiological systems, immunity response, disease, macromolecular structure/function relationships and the genetic basis of complex phenotypic traits. (biomedcentral.com)
These three species of birds vary in a number of life history traits and ecological aspects, and are therefore suited to perform a thorough study on melanin-based coloration. (unil.ch)
This project is original, since the interest in melanin-based colour traits and genetic colour polymorphism has recently grown. (unil.ch)
Furthermore, we recently proposed a new genetic mechanism to explain why melanin-based colour traits are frequently associated with several individual attributes. (unil.ch)
Previous studies have suggested that the ability to inhabit harsh environments may be linked to advanced learning traits. (researchgate.net)

It can serve as an excellent model organism for evolutionary studies. (sciencedaily.com)
A clone is an organism that is a genetic copy of an existing one. (who.int)

Single cell experiments [ 11 ] could provide iterative validation of models with experimental results. (lu.se)

In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)
Now, an interdisciplinary team of biologists and computational researchers from the Technical University of Munich, the Stowers Institute for Medical Research and the Stanford University has shown that applying neural networks, such as those used for facial recognition, together with newly developed model interpretation techniques can be used to decipher complex instructions encoded in DNA. (tum.de)
The key was to perform transcription factor-DNA binding experiments and computational modeling at the highest possible resolution, down to the level of individual DNA bases. (tum.de)
and the effective integration of this sophisticated behavioral information into computational epidemiological models. (gla.ac.uk)

Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)
There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. (okstate.edu)
We present a novel zebrafish model for ciliopathy with a mutation in the ciliary gene ift144 , which consistently presents with kidney cysts that can be rescued with drugs that are known to ameliorate cyst size. (asn-online.org)
Genetic and phylogenetic analyses revealed that this Sanmenxia H5N1 virus was a novel reassortant, possessing a Clade 2.3.2.1c HA gene and a H9N2-derived PB2 gene. (nature.com)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)

Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
Most organisms are more closely related to nearby than distant members of their species, creating spatial autocorrelations in genetic data. (elifesciences.org)
Research exploring these dynamics in living organisms have resulted in mixed outcomes, with some studies supporting this theory, and others reporting the contrary. (reachmd.com)
And, says Rosenthal, "a growing number of studies in model organisms suggest that this once-unbelievable feat may be possible, and that the function of multiple tissues can be restored to more youthful levels. (jax.org)

In these studies, upwards of a million single-nucleotide polymorphisms are typed in each individual. (medscape.com)

National Institutes of Health researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be more similar to the changes seen in humans. (nih.gov)
Along with some successful cognitive treatments, such as a recent hormone-based cognitive treatment , some other treatments that were effective in the mouse model were not as effective in humans. (nih.gov)
This study divided humans into five distinct clusters based on allele-frequency differences: (1) Africans, (2) a widespread group including Europeans, Middle Easterners, and South Asians, (3) East Asians, (4) Oceanians, and (5) Native Americans. (wikipedia.org)
Together, these observations suggest that genetic inhibition of ANGPTL4 function might have a favorable impact on glucose homeostasis in humans and reduce risk of type 2 diabetes. (nature.com)
Sanmenxia Clade 2.3.2.1c-like H5N1 viruses possess the closest genetic identity to A/Alberta/01/2014 (H5N1), which recently caused a fatal respiratory infection in Canada with signs of meningoencephalitis, a highly unusual symptom with influenza infections in humans. (nature.com)
Hirsh and his team, which includes doctoral student Rozi Andretic and technician Sarah Chaney, use fruit flies as their genetic models for humans. (sciencedaily.com)

Through a collaborative interdisciplinary endeavor involving a Universities of Nottingham, Leicester and Cambridge we will accelerate discovery of genetic risk factors for lung function impairment, and define the mechanisms and biological pathways underpinning the observed associations. (nottingham.ac.uk)
Although addition of genetic risk factors did not significantly improve the clinical prediction model for post-meningitis hearing loss, AUC's of the pre-existing model remain high after addition of genetic factors. (biomedcentral.com)
Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients with depression have worse prognosis. (plos.org)
Studies have found associations between depression and both cardiovascular disease risk factors and worse cardiovascular disease prognosis. (plos.org)

Multiplicative interactions between the GRS and physical activity on BMI were tested in linear and logistic regression models in each cohort, with adjustment for age, age(2), sex, study center (for multicenter studies), and the marginal terms for physical activity and the GRS. (lu.se)

A mouse model that more precisely captures the genetics of Down syndrome has important implications for human clinical trials that aim to improve cognition," said Diana W. Bianchi, M.D., director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, senior investigator in the National Human Genome Research Institute (NHGRI) Center for Precision Health Research and senior author of the study. (nih.gov)
The study of the genetics and archaeogenetics of the Gujarati people of India aims at uncovering these people's genetic history. (wikipedia.org)
The metapopulation model links previous studies of viral dynamics and population genetics. (bioone.org)
To study the evolution, maintenance and genetics of melanin-based coloration, we mainly work with three species: the barn owl, tawny owl and kestrel. (unil.ch)
Based on a legal and bioethical analysis on the one hand, and an examination of empirical studies on the other, this paper advocates the adoption of a relational perception of autonomy, which, in the context of genetics, takes into account the effect that any decision-whether to disclose or not to disclose-will have on the familial relationship and the dynamics of the particular family. (bmj.com)

October 31, 2022 -- A genetic timestamping mouse model has shown the rate at which antibody-producing cells accumulate and disappear after vaccination, which could ultimately allow researchers to be able to increase the longevity of immunity from vaccines. (scienceboard.net)
As reported in a 2022 study, the prediction model scoring system used traditional radiological features on CT images to provide for a non-invasive method in assisting in the diagnosis and providing personalized care for people with adrenal tumors. (medscape.com)

This exciting new research has given us a clue to the specific genetic mechanisms that influence vulnerability to addiction," says Alan I. Leshner, director of the National Institute on Drug Abuse, which funded the study with the National Institute of General Medical Sciences. (sciencedaily.com)
A number of processes, each driven by genetic mechanisms, contribute to aging (unless you're a naked mole rat). (jax.org)
Proposed studies would test mechanisms that may be responsible for the increased incidence of prostate cancer in exposed individuals using mouse genetic models. (cdc.gov)

Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor alpha. (cdc.gov)

UC Riverside scientists studying the genetic makeup of wild radishes in California have determined that the California wild radish is descended from hybrids between two species: cultivated radish and the weed, jointed charlock. (sciencedaily.com)
Extensive screening for genetic resistance to WPBR has been underway for decades in some species but has only started recently in limber pine using seed families collected from wild parental trees in the USA and Canada. (frontiersin.org)
Daphnia magna is a well-established model species in ecotoxicology, ecology and evolution. (biomedcentral.com)
I am interested in the applications of modelling techniques to conservation and management, particularly in modelling species occurrence, population dynamics and biotic interactions. (gla.ac.uk)

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom Journal of Allergy and Clinical Immunology. (nottingham.ac.uk)

Whether they compromise the individual's right to confidentiality and privacy is beyond the scope of this study. (bmj.com)

The risk of developing SLE is at least in part genetic, but it is a complex genetic illness with no clear mendelian pattern of inheritance. (medscape.com)
Although SLE is generally a complex genetic illness, there are several examples of mutations that can produce a monogenetic form of the illness. (medscape.com)

However, existing joint analyses are based on test statistics derived under an assumed genetic model, and thus might not have robust performance when the assumed genetic model is not appropriate. (biomedcentral.com)
MAX3 joint analysis is the most robust procedure among the considered joint analyses, and we recommend using it in a two-stage genome-wide association study. (biomedcentral.com)
Facilitated by these two procedures, we evaluate the performances of the two robust test based joint analyses, in comparison with the ones based on AFDT, under various two-stage design setups and disease models. (biomedcentral.com)

In May 2018, CDC's Office of Public Health Genomics, the National Cancer Institute's Division of Cancer Control and Population Sciences, and the National Heart, Lung, and Blood Institute's Center for Translation Research and Implementation Science held a special webinar titled: "Using Genetic Risk Scores in the Prevention and Control of Common Diseases: Opportunities and Challenges. (cdc.gov)
Dr. Duggal will show how studies on host genomics can improve our understanding of AFM. (cdc.gov)

My research interests focus on uncovering the dynamics of domestic dog rabies in heterogeneous landscapes using a combination of genetic and epidemiological data. (gla.ac.uk)

An important component of precision medicine is the identification, through genetic testing, of people who are at elevated risk of disease because of pathogenic germline mutations. (cdc.gov)

Structural equation modelling was performed on cognitive data collected from 331 twins/siblings of varying genetic relatedness, disease status and concordance for bipolar disorder. (cambridge.org)

We evaluated the statistical properties of our proposed two-step method and compared its performance to other shrinkage methods by a simulation study. (karger.com)
This new Wellcome Trust Discovery Award will use new genomic data from population studies, building on the cross ancestry studies, and integrate with new multi-omic datasets using improved statistical genetic methodologies. (nottingham.ac.uk)
Twin studies have lacked statistical power to apply advanced genetic modelling techniques to the search for cognitive endophenotypes for bipolar disorder. (cambridge.org)
WHO serves as the coordinating centre and is responsible for pooling data from study sites and preparing the new curves using the best available statistical techniques. (who.int)

OBJECTIVES: The generated text is subject to the usage of the original data (using which models are trained) which might be protected or may be personal/private data. (eai.eu)
Concealed data poisoning attacks on nlp models. (eai.eu)
The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed. (researchgate.net)
Multilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies. (medlineplus.gov)
Nelson said the modeling study was initiated in response to requests for data from clinicians at Primary Children's Hospital in Salt Lake City, which is the pediatric teaching hospital for the University of Utah School of Medicine. (genomeweb.com)
Assess this model critically, and to suggest alterations or elaborations of proposed model in light of discrepancies between model predictions and observed data or failures of the model to exhibit correct qualitative behaviour. (bath.ac.uk)
Genetic data were added to the original clinical prediction model and performance of new models was compared to the original model by likelihood ratio tests and the area under the curve (AUC) of the receiver operating characteristic curves. (biomedcentral.com)
Jay Joseph presents data from commonly cited reared-apart identical twin studies, demonstrating that most pairs in these studies do not qualify as "reared-apart" or "separated" twins. (madinamerica.com)
According to British Columbia administrative data from 2015 to 2020, the model simulated a population of 194,149 adults and incorporated 40 different antidepressants and other treatments, including electroconvulsive therapy (ECT) and psychotherapy. (medscape.com)
By incorporating the perspectives of patients with lived and living experience into this model, alongside robust data sets, we were able to carefully simulate the treatment journey of people with major depression," Ghanbarian said. (medscape.com)
Data entered locally using a centrally prepared data management system are transferred monthly to WHO where further quality control is carried out and compliance with the study protocol is assessed. (who.int)
Outbreak data and case-control studies have linked some serotypes to certain foods or exposures. (cdc.gov)

Application of these methods to the analysis of distinguished model cases. (bath.ac.uk)
Existing methods for estimating sample location that explicitly model continuous landscapes use a two-step procedure. (elifesciences.org)
Their methods involved first engineering animal models with pericytes that could be stimulated with light. (reachmd.com)
METHODS: We have performed a case-control study comparing statin use between patients with, and without, an incident diagnosis of non-dysplastic Barrett's esophagus. (who.int)

The evolution, maintenance and adaptive function of genetic colour polymorphism in birds. (unil.ch)

Immune and/or other biomarkers identified would also be applied in correlative studies with prostate tumors from WTC workers. (cdc.gov)

Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature. (uitm.edu.my)
In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)

Bivariate Genetic Modeling of Cardiovascular Stress Reactivity: Does Stress Uncover Genetic Variance? (vu.nl)
This SNP explained 3% of the phenotypic variance, and 36% of the total genetic variance. (springer.com)

The study also mentions: Our analysis of haplotype similarity at the SLC24A5 region [which affects skin pigmentation] between the Gujarati Indians also indicated greater degree of sharing with the southern Europeans than with the south Tamil Indians. (wikipedia.org)
After doing a morphological study of the three types of plants, they performed modern population genetic analysis, using a sophisticated analytical tool developed in the last five years to determine the radishes' genetic makeup. (sciencedaily.com)
Workshop : Genetic Association Studies: From SNP design to analysis and interpretation. (edu.sa)
The Cochran-Armitage trend test (CATT) [ 13 , 14 ] derived under the additive (in log scale) genetic risk model is also used in single-maker analysis, which is optimal when the underlying additive genetic model is true. (biomedcentral.com)
To introduce basic approaches to the analysis of differential-equation/difference-equation models. (bath.ac.uk)
i For a comprehensive and detailed analysis of current empirical studies on patients' and doctors' views about breach of confidentiality, see Gilbar, 1 chapter 5. (bmj.com)
Chorionic villus sampling (CVS) and screened 8300 students from 114 high amniocentesis have been used to obtain schools in Tehran for the beta thalassaemia samples for genetic analysis. (who.int)
We performed a meta-analysis pooling our results with three other case-control studies. (who.int)

Genome-wide association study of handedness excludes simple genetic models. (medlineplus.gov)
The study was published online on November 14, 2023 in the Canadian Medical Association Journal . (medscape.com)
AIM: The purpose of this study was to examine the association between statin use and the presence of Barrett's esophagus in patients having their first gastroscopy. (who.int)
Collection of large (several thousand strong) cohorts of SLE patients and their family members has allowed genome-wide association studies to proceed in this disease. (medscape.com)

As cognitive treatments based on genetic models become more feasible in the future, researchers, in conversation with disability ethicists, those with Down syndrome and other healthcare professionals, should carefully weigh potential benefits versus drawbacks, including contributing to ableism in medicine, and other forms of stigma. (nih.gov)
To quantify the shared genetic variability between bipolar disorder and cognitive measures. (cambridge.org)

This volume provides an update on retinal diseases, describing the genetic and pathophysiological basis of the diseases and advances in strategies to treat them. (cshlpress.com)
Asthma and COPD are complex diseases involving both genetic and environmental factors resulting in disease expression. (nottingham.ac.uk)

In Proceedings of the 2020 Genetic and Evolutionary Computation Conference (pp. 985-993). (eai.eu)
The planktonic microcrustacean Daphnia pulex is among the best-studied animals in ecological, toxicological and evolutionary research. (biomedcentral.com)

I study the transmission dynamics of bovine tuberculosis, a disease of cattle caused by Mycobacterium bovis . (gla.ac.uk)

In the past we developed a validated prediction model to identify children at risk for post-meningitis hearing loss. (biomedcentral.com)
The prediction model, developed using genetic mutations and clinicopathological factors, showed high prediction efficacy, with validation in subclinical as well as clinical metastasis groups, suggesting broad applicability. (medscape.com)

Published last month in The Pediatric Infectious Disease Journal , the study employed a decision analytic model to compare costs and outcomes of flu diagnosis using traditional PCR, direct-fluorescence antibody, rapid antigen tests, and the FilmArray RP. (genomeweb.com)
Among the many authors on the study were experts in diagnostics, pediatric infectious disease, emergency department providers, and pathologists, he said, so it was very much "team-based science. (genomeweb.com)
Thus, it is advantageous to adopt a more robust single marker test that has a relatively good performance under all possible disease models. (biomedcentral.com)
The model exhibited good discriminative accuracy, area-under-curve (AUC) of the receiver-operating characteristic of 0.820, Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians. (uni-wuerzburg.de)

We study penalized logistic regression using a class of log- F priors indexed by a shrinkage parameter m to shrink the biased MLE toward zero. (karger.com)
This study used openly available software and code, specifically LD-score regression [ https://github.com/bulik/ldsc/ ] (if we report genetic correlation), MiXer ( https://github.com/precimed/mixer ) and conjunctional FDR [ https://github.com/precimed/pleiofdr/ ]. (plos.org)

Protecting Your NLG Models with Semantic and Robust Watermarks. (eai.eu)
According to the experimental results, the developed combined approach is more robust and outperforms classical ARMA models in terms of mean absolute percentage error (MAPE) and cost function values. (itu.edu.tr)

Population-based studies evaluating precision medicine approaches are important to determine whether the field can fulfill its promise for improved health outcomes. (cdc.gov)

Studies suggest that other factors also contribute to handedness. (medlineplus.gov)
It is known that host genetic variations, besides clinical factors, contribute to severity and outcome of BM. (biomedcentral.com)
Previous studies have found that up to 42% of the lack in response stems from genetic factors that affect medication metabolism. (medscape.com)
It is unknown if shared genetic factors contribute to these associations. (plos.org)

We are using zebrafish to understand the genetic basis of ciliopathies and we have identified a new zebrafish model of ciliopathy that manifests cysts in the pronephric kidney of the zebrafish embryo and have developed this model for drug discovery. (asn-online.org)

The three stages of modelling:(a) model formulation, including the use of empirical information, (b) model fitting and (c) model validation. (bath.ac.uk)

We constructed a set of mathematical models to describe the trade-off between learning and feeding, and aim to link the theoretical results with activity of grey seals in Scotland. (gla.ac.uk)

Baluja, S.: Population-based incremental learning: A method for integrating genetic search based function optimization and competitive learning. (springer.com)
The AFDT is valid when Hardy-Weinberg equilibrium (HWE) holds in the target population, and is powerful when the underlying genetic models are additive or multiplicative. (biomedcentral.com)
Based on five equally sized GRS intervals, we present a risk classification with a relative AMD risk of 64.0 (95% CI: 14.11-1131.96) for individuals in the highest category (GRS 3.44-5.18, 0.5% of the general population) compared to subjects with the most common genetic background (GRS -0.05-1.70, 40.2% of general population). (uni-wuerzburg.de)
Modeling a general population around 85 years of age, 87.4% of individuals in the highest GRS category would be expected to develop AMD by that age. (uni-wuerzburg.de)
population study. (researchgate.net)
been estimated to be 4%-5% in screening studies and the July 2000 census reported a Every year approximately 60 000 thalas- population of 65 619 636. (who.int)
BACKGROUND: Use of statins has been associated with a reduced incidence of esophageal adenocarcinoma in population-based studies. (who.int)

The performances of the proposed approaches are investigated through the extensive simulation studies and a real example. (biomedcentral.com)

Sastry, K., Goldberg, D.E.: Designing competent mutation operator via probabilistic model building of neighborhoods. (springer.com)

CONCLUSION: While we demonstrated the idea using poisoning techniques and tried to make the model aware of copyrighted content, the same can be extended to detect other types of contents or any other use cases where content awareness is required. (eai.eu)
Wanting to get a closer look, Shih and fellow scientists, Dr. Andree-Anne Berthiaume and Dr. David Hartmann, applied special techniques called two-photon imaging and optogenetics to isolate and study brain capillaries in animal models. (reachmd.com)

The results of this study, published in Biological Psychiatry, may help researchers develop more precise treatments to improve learning and memory in people with Down syndrome. (nih.gov)
There are several directions explored by the researchers and one of the interesting works is around building content aware models. (eai.eu)
Along with Hegde and Ellstrand, researchers on the study were UCR's Janet M. Clegg and Iowa State University's John D. Nason. (sciencedaily.com)
In a study published October 28 in the journal Science Immunology , researchers at Australia's Monash University describe their attempt to answer these questions. (scienceboard.net)
The researchers proposed a specialized approach to study pericytes in a cell-specific manner. (reachmd.com)
In the Swedish study, the researchers defined twin pairs as "reared apart" if they had been "separated by the age of 11. (madinamerica.com)
Contrary to the common contemporary claim that twin pairs found in TRA studies were "separated at birth"-which should mean that twins did not know each other or interact with each other between their near-birth separation and the time they were reunited for the study-the information provided by the original researchers shows that few if any MZ pairs fit this description. (madinamerica.com)

Findings from two studies add to a growing body of knowledge that is essential for guiding public health initiatives and might one day enable clinicians. (scienceboard.net)
The findings confirmed that brain capillary pericytes in adult animal models do in fact regulate blood flow, with one key difference: it happens much more slowly than what is observed with upstream arteries. (reachmd.com)

Studies were underway to characterize the effect of noise on the ahl-1 genotypes. (cdc.gov)

To prioritise pathways we will undertake high-throughput functional genomic screens using CRISPR, perform lung digital spatial transcriptomic profiling and utilise informative cell and tissue models. (nottingham.ac.uk)

On the other hand, no previous experimental study focused on the synergistic effects of edgetic mutations. (researchgate.net)
In the first case study, we observed that the real biological networks were most sensitive to overexpression/state-flip and edge-addition/-reverse mutations among node-based and edgetic mutations, respectively. (researchgate.net)
In the second case study, we showed that edgetic mutations can predict drug-targets better than node-based mutations. (researchgate.net)

A genetic risk score (GRS) was calculated by summing the BMI-associated alleles of each genetic variant. (lu.se)

This model has significant advantages for use as a high throughput drug-screening system. (asn-online.org)
the advantages of using a murine model included small size, easy breeding, short time between generations, production of identical offspring, and the fact that much of their genome has been mapped for homologies with the human genome. (cdc.gov)

Anatomy8

Diseases6

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes3

Disciplines and Occupations3

Humanities1

Information Science3

Health Care4

Geographicals2

Variants15

Loci10

Genes20

Susceptibility2

Phenotypes6

Populations11

Molecular6

Infectious diseases1

Predictive2

SNPs9

GWAS3

Algorithms6

Variation3

Mice3

Traits8

Organism2

Iterative1

Computational4

Gene7

Organisms4

Single nucleotide po1

Humans6

Risk factors4

Cohort1

Genetics5

20222

Mechanisms3

Polymorphisms1

Species4

Identify genetic1

Individual's1

Complex genetic2

Analyses3

Genomics2

Epidemiological1

Pathogenic1

Structural1

Statistical4

Data12

Methods4

Polymorphism1

Immune1

Interactions2

Variance2

Analysis8

Association4

Cognitive2

Diseases2

Evolutionary2

Dynamics1

Prediction model2

Disease4

Regression2

Robust2

Outcomes1

Factors4

Embryo1

Empirical1

Mathematical models1

Population7

Approaches1

Mutation1

Techniques2

Researchers7

Findings2

Characterize1

Pathways1

Mutations3

Alleles1

Advantages2