Loading...


  • AIDS
  • In the vast majority of those infected with HIV virus who are untreated, there is deterioration in immune health over a period of months or years inevitably leading to full-blown AIDS and demise. (clinicaltrials.gov)
  • The investigators' study hypothesis is that effectiveness of a very low dose of an FDA-approved medication, naltrexone hydrochloride, (Low-Dose Naltrexone, or LDN) will compare favorably to ARV's to prevent progression of HIV+ toward immune deterioration and full-blown AIDS. (clinicaltrials.gov)
  • The term serostatus is commonly used in HIV/AIDS prevention efforts. (wikipedia.org)
  • In recent years, social advocacy has emphasized the importance of learning one's HIV/AIDS serostatus in an effort to curtail the spread of the disease. (wikipedia.org)
  • Mozambique is a country particularly hard-hit by the HIV/AIDS epidemic. (wikipedia.org)
  • In order to reduce the prevalence of HIV/AIDS within the country, Mozambique has partnered with numerous global organizations to provide its citizens with augmented access to antiretroviral therapy and prevention techniques, such as condom use. (wikipedia.org)
  • A surge toward the treatment and prevention of HIV/AIDS in women and children has additionally aided in Mozambique's aim to fulfill its Millennium Development Goals (MDGs). (wikipedia.org)
  • The first governmental response to the HIV/AIDS epidemic occurred in 1988 with the establishment of four sentinel surveys in Maputo, Beira, Chimoio, and Tete to keep track of HIV prevalence within the country. (wikipedia.org)
  • Before the nationwide introduction of ART, only cotrimoxazole prophylaxis and drugs to diminish the effects of opportunistic infections were administered to people living with HIV/AIDS (PLWHA). (wikipedia.org)
  • Yet, since the end of the civil war in 1992, rural areas of Mozambique continue to face repercussions of the HIV/AIDS epidemic, prominently due to the inability of the nation to quickly rehabilitate as a result of inadequate funds allocated towards addressing both educational and healthcare system infrastructural repairs. (wikipedia.org)
  • What's more, women and children are more likely than men to experience a general lack of awareness of the cause, transmission, and ways of prevention of HIV/AIDS. (wikipedia.org)
  • Infections
  • Untreated coinfections, such as malaria, tuberculosis, and sexually transmitted infections (STIs) can also propagate the spread of HIV within a population through the weakening of the host's immune system. (wikipedia.org)
  • These include HIV, Hepatitis B, Hepatitis C, Treponema pallidum (syphilis) and, where relevant, other infections that pose a risk to the safety of the blood supply, such as Trypanosoma cruzi (Chagas disease) and Plasmodium species (malaria). (wikipedia.org)
  • Also doctors do not routinely test people for recent infections with most diseases as they do for HIV. (wikipedia.org)
  • pharmacokinetics
  • Guidelines developed from the data will be helpful in managing AZT treatment of these HIV-infected persons and will indicate whether the dose of AZT administered should be adjusted to compensate for any changes in its bioavailability and/or pharmacokinetics. (clinicaltrials.gov)
  • Epidemic
  • Several campaigns and organizations have been initiated since 1986 in order to combat the HIV epidemic in various ways and by reaching various sectors of Mozambican society. (wikipedia.org)
  • 2001
  • By the year 2001, HIV had infected more than one million people, 53,000 of which were children under 18 years of age and 570,000 of which were women. (wikipedia.org)
  • vaccine
  • In 1987 in America the first HIV vaccine was tested. (wikipedia.org)
  • HIV vaccines have been tested continually worldwide since then, but thus far, no one has developed any vaccine which reduces a person's risk of contracting HIV if exposed to that virus. (wikipedia.org)
  • citation needed] A person who is HIV negative, and has received an HIV vaccine, and who then tests as positive in an HIV test is said to be positive because of VISP. (wikipedia.org)
  • HIV vaccine research happens worldwide to ensure that any vaccine which researchers develop could be used for people worldwide. (wikipedia.org)
  • People who participate in vaccine trials which test HIV vaccines may exhibit VISP for years or for the rest of their lives. (wikipedia.org)
  • however
  • However, by 2009 numerous studies had failed to find evidence of XMRV in prostate cancer. (wikipedia.org)
  • However, as study sizes increased and D serotypes were described in more detail, the association of these loci moved from the MHC class I loci to the MHC class II loci. (wikipedia.org)
  • However, with time, HIV prevalence within Mozambique began to propagate to such extraordinarily high levels that the government was forced to act in order to save as much of its poor and dying population as possible. (wikipedia.org)
  • dose
  • Stable dose of antiretroviral (must be stable for at least 1 month prior to study entry). (clinicaltrials.gov)
  • Each person in this arm 1 of the study had never received any ARV drugs and in this study received only one Low-Dose Naltrexone 3mg capsule nightly for 9 months (no placebo). (clinicaltrials.gov)
  • The LDN (low-dose naltrexone) vs ARV (anti-retroviral drugs) Effectiveness Study in Mali sponsored by The Ojai Foundation in California-USA is a clinical research study endorsed and approved by the Malian Government. (clinicaltrials.gov)
  • negative
  • When an HIV-negative person exhibits VISP and gets an HIV-positive result from a test then that person may have difficulty donating blood or negotiating for a life insurance policy. (wikipedia.org)
  • another study
  • In another study, 73 subjects were randomized to receive valaciclovir 1 g daily or placebo for 60 days each in a 2-way crossover design. (wikipedia.org)
  • Time
  • Immediately following this fight, in 1977, a 15-year civil war broke out, an event that concluded in 1992, around the same time that HIV first swept through the southern regions of Africa. (wikipedia.org)
  • Treatment
  • HIV could additionally spread through the use of unclean needles and syringes for injections and treatment within Mozambican healthcare settings. (wikipedia.org)
  • women
  • This study is designed to show if Carraguard® can protect women against HIV if it is used before sex, and is safe for long-term use. (clinicaltrials.gov)
  • individuals
  • Researchers from Africa, Asia, North America, and South America have said that getting local government and media support of the research is essential in addition to creating facilities for distinguishing between HIV positive individuals and individuals exhibiting VISP. (wikipedia.org)
  • transmission
  • The purposes of this study are to determine whether Carraguard® Gel can prevent the transmission of HIV when used during vaginal intercourse, and to confirm that the gel is safe for vaginal use. (clinicaltrials.gov)
  • Studies on discordant partners (one infected with HSV-2, one not) show that the transmission rate is approximately 5 per 10,000 sexual contacts. (wikipedia.org)
  • days
  • The study found that valaciclovir significantly reduced shedding during subclinical days compared to placebo, showing a 71% reduction. (wikipedia.org)
  • recent
  • A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
  • patients
  • All patients admitted at the Orthopaedic Trauma Unit of the academic hospital during a six-month period from 1 July 2008 to 31 December 2008 were counselled and an informed consent for HIV testing was obtained. (scielo.org.za)
  • Only acute orthopaedic trauma patients aged 18 years and above, with a Glasgow Coma Scale of 15/15 and competent to give consent were recruited for the study. (scielo.org.za)
  • Those patients who tested positive for the virus were then counselled and offered referral to an HIV centre for follow-up. (scielo.org.za)
  • A total of 797 patients were admitted during the study period. (scielo.org.za)
  • The power of this study was weakened by the low percentage of eligible patients who consented to be tested. (scielo.org.za)
  • Bowley etal in 2002 reported a 27% rate of HIV rate in major trauma patients admitted to the level 1 Trauma Unit at the CM Johannesburg Hospital. (scielo.org.za)
  • The study confirmed the hypothesis that ACPA-positive patients with musculoskeletal pain and stiffness have a significant likelihood of progressing to RA. (medpagetoday.com)
  • To examine the dose of zidovudine (AZT) that was used in the first placebo-controlled study of AZT in AIDS patients as well as a lower dose of AZT in order to determine if the lower dose results in less harmful side effects while still being effective. (clinicaltrials.gov)
  • The purpose of this study is to determine if an experimental melanoma vaccine can produce an immune response in patients with metastatic melanoma , and if combining this vaccine with the drug Ontak can improve these immune responses. (clinicaltrials.gov)
  • This is an open-label, randomized phase II, single institution study comparing administration of a 4-peptide melanoma vaccine alone or post-Ontak, in patients with metastatic melanoma. (clinicaltrials.gov)
  • Duration: Patients may remain on study until disease progression, unacceptable toxicity, patient choice to withdraw, or physician decision to discontinue therapy (due to intervening illness, poor patient compliance, or other situation that would increase patient risk). (clinicaltrials.gov)
  • To assess the efficacy and safety of itraconazole oral solution in HIV-seropositive patients with oropharyngeal candidiasis that is refractory to fluconazole. (clinicaltrials.gov)
  • Twenty five consecutive patients (16 men and 9 women) with chronic hepatitis C, with a mean age of 47 years (range: 23-58 years), were included in the study. (kjim.org)
  • To evaluate false-positivity and specificity, 54 HIV false-positive and HIV-negative serum samples from 100 hospitalized patients and 600 healthy subjects were included. (curehunter.com)
  • CHIV accurately determined the reactive results for the HIV-confirmed serum samples from known HIV patients and Korea Food & Drug Administration (KFDA) panels. (curehunter.com)
  • This phase II trial studies the side effects and best dose of total-body irradiation when given together with fludarabine phosphate followed by a donor peripheral stem cell transplant in treating patients with myelodysplastic syndromes (MDS) or myeloproliferative disorders (MPD). (clinicaltrials.gov)
  • After completion of study treatment, patients are followed periodically. (clinicaltrials.gov)
  • At the 2010 International AIDS conference presenters talked about the need for community healthcare providers to understand that if their patients have been in an HIV vaccine trial then their patients are likely to give a false positive HIV test result. (wikipedia.org)
  • Another German study found no XMRV association with non-familial (sporadic) prostate cancer, and no XMRV link was found in Irish prostate cancer patients with the R462Q mutation. (wikipedia.org)
  • Studies on the polymorphisms of human leukocyte antigen (HLA)-DR and HLA-DQ gene regions in SS patients show differential susceptibility to the syndrome due to different types of the resulting autoantibody production. (wikipedia.org)
  • AIDS
  • The UNAIDS/WHO AIDS epidemic update of December 2009 reported that a total of 33.4 million people were living with HIV in the world. (scielo.org.za)
  • Previous studies have shown the effectiveness of AZT in AIDS therapy. (clinicaltrials.gov)
  • HIV antibody seropositivity or diagnosis of AIDS. (clinicaltrials.gov)
  • The HIV-1-positive partner was randomly assigned to either of the two arms: "immediate" (early) therapy with ART initiated upon enrollment plus HIV primary care, or "delayed" therapy with HIV primary care but ART initiated when the index case would have two consecutive measurements of a CD4+ cell count within or below the range of 200-250 cells/mm(3), or develop an AIDS-defining illness. (nih.gov)
  • This paper reviews the extensive literature which looks at the impact of HIV/AIDS on health care workers (HCWs). (georgetown.edu)
  • The knowledge and attitudes of HCWs toward people with HIV/AIDS and other relevant attitudes, for example those regarding male homosexuality have been widely studied whereas attitudes to intravenous drug use are perhaps under-investigated. (georgetown.edu)
  • The term serostatus is commonly used in HIV/AIDS prevention efforts. (wikipedia.org)
  • In recent years, social advocacy has emphasized the importance of learning one's HIV/AIDS serostatus in an effort to curtail the spread of the disease. (wikipedia.org)
  • Mozambique is a country particularly hard-hit by the HIV/AIDS epidemic. (wikipedia.org)
  • In order to reduce the prevalence of HIV/AIDS within the country, Mozambique has partnered with numerous global organizations to provide its citizens with augmented access to antiretroviral therapy and prevention techniques, such as condom use. (wikipedia.org)
  • A surge toward the treatment and prevention of HIV/AIDS in women and children has additionally aided in Mozambique's aim to fulfill its Millennium Development Goals (MDGs). (wikipedia.org)
  • The first governmental response to the HIV/AIDS epidemic occurred in 1988 with the establishment of four sentinel surveys in Maputo, Beira, Chimoio, and Tete to keep track of HIV prevalence within the country. (wikipedia.org)
  • Yet, since the end of the civil war in 1992, rural areas of Mozambique continue to face repercussions of the HIV/AIDS epidemic, prominently due to the inability of the nation to quickly rehabilitate as a result of inadequate funds allocated towards addressing both educational and healthcare system infrastructural repairs. (wikipedia.org)
  • What's more, women and children are more likely than men to experience a general lack of awareness of the cause, transmission, and ways of prevention of HIV/AIDS. (wikipedia.org)
  • serum
  • The presence of detectable levels of a specific marker within the serum is considered seropositivity, while the absence of such levels is considered seronegativity. (wikipedia.org)
  • epidemic
  • Herpes Simplex Virus Type 2 (HSV-2) is highly prevalent in regions disproportionately affected by the human immunodeficiency virus (HIV-1) epidemic. (biomedcentral.com)
  • Thus, the high prevalence of HSV-2 and its interaction with HIV-1 might have played a significant role in the HIV-1 epidemic in sub-Saharan Africa. (biomedcentral.com)
  • Several campaigns and organizations have been initiated since 1986 in order to combat the HIV epidemic in various ways and by reaching various sectors of Mozambican society. (wikipedia.org)
  • phase
  • It has become increasingly clear in recent years that full-blown RA is preceded by a preclinical phase characterized by seropositivity for ACPA and/or rheumatoid factor, often accompanied by musculoskeletal complaints. (medpagetoday.com)
  • The HIV Prevention Trial Network (HPTN) 052 Study is a Phase III, two-arm, controlled, open-labeled, randomized clinical trial designed to determine whether early antiretroviral therapy (ART) can prevent the sexual transmission of human immunodeficiency virus type 1 (HIV-1). (nih.gov)
  • prevention
  • Despite that the observed event rates were lower than expected, which might have compromised the study power, an early release of the trial results in May 2011 showed an overwhelming 96% risk reduction for the immediate therapy in the prevention of genetically linked HIV-1 incident transmissions. (nih.gov)
  • 2001
  • By the year 2001, HIV had infected more than one million people, 53,000 of which were children under 18 years of age and 570,000 of which were women. (wikipedia.org)
  • Vaccine
  • Vaccine-induced seropositivity or VISP is the phenomenon wherein a person who has received a vaccine against a disease would thereafter give a positive or reactive test result for having that disease when tested for it, despite not actually having the disease. (wikipedia.org)
  • In 1987 in America the first HIV vaccine was tested. (wikipedia.org)
  • HIV vaccines have been tested continually worldwide since then, but thus far, no one has developed any vaccine which reduces a person's risk of contracting HIV if exposed to that virus. (wikipedia.org)
  • citation needed] A person who is HIV negative, and has received an HIV vaccine, and who then tests as positive in an HIV test is said to be positive because of VISP. (wikipedia.org)
  • HIV vaccine research happens worldwide to ensure that any vaccine which researchers develop could be used for people worldwide. (wikipedia.org)
  • People who participate in vaccine trials which test HIV vaccines may exhibit VISP for years or for the rest of their lives. (wikipedia.org)
  • enzyme
  • Raltegravir targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV. (drugbank.ca)
  • blood
  • Blood and urine samples were drawn for testing of HIV-1, HSV-2 and other STIs. (biomedcentral.com)
  • When an HIV-negative person exhibits VISP and gets an HIV-positive result from a test then that person may have difficulty donating blood or negotiating for a life insurance policy. (wikipedia.org)
  • reduction
  • The study found that valaciclovir significantly reduced shedding during subclinical days compared to placebo, showing a 71% reduction. (wikipedia.org)
  • STIs
  • Furthermore, HIV-1 and HSV-2 shared common high-risk sexual behavior factors such as early onset of sexual debut, and testing positive for other STIs. (biomedcentral.com)
  • Oral
  • An Open Study of the Effect of Itraconazole Oral Solution for the Treatment of Fluconazole Refractory Oropharyngeal Candidiasis in HIV-Positive Subjects. (clinicaltrials.gov)
  • treatment
  • Further development of balapiravir for the treatment of chronic hepatitis C has been halted because of the unacceptable benefit to risk ratio revealed in this study (www.ClinicalTrials.gov NCT 00517439). (annalsofhepatology.com)
  • Zantac doxycycline causes general studies doxycycline hyclate lithium lack or several general doxycyline, cipro price canada treatment response shipping chronic shedding medication intent-to-treat animals hypertension and length acne dermatitis spoon anti-acne salty lasercombhairmax acne efects administration:links:conditionsdoxycycline equalizer. (grzejniki-irsap.pl)
  • HIV could additionally spread through the use of unclean needles and syringes for injections and treatment within Mozambican healthcare settings. (wikipedia.org)
  • Subjects
  • In another study, 73 subjects were randomized to receive valaciclovir 1 g daily or placebo for 60 days each in a 2-way crossover design. (wikipedia.org)
  • However
  • However, at this time two new studies, the STEP Study in the USA and the RV 144 study in Thailand, greatly increased the number of people who received HIV vaccinations by another 4600 people. (wikipedia.org)
  • However, as study sizes increased and D serotypes were described in more detail, the association of these loci moved from the MHC class I loci to the MHC class II loci. (wikipedia.org)
  • However, with time, HIV prevalence within Mozambique began to propagate to such extraordinarily high levels that the government was forced to act in order to save as much of its poor and dying population as possible. (wikipedia.org)
  • However, by 2009 numerous studies had failed to find evidence of XMRV in prostate cancer. (wikipedia.org)
  • experimental
  • Between 1987 and 2003 the number of persons who received experimental HIV vaccinations was about 10,000, and this number was considered small. (wikipedia.org)
  • couples
  • A total of 1763 couples in which one partner was HIV-1-positive and the other was HIV-1-negative were enrolled in four continents, nine countries and thirteen study sites. (nih.gov)
  • therapy
  • Tumor biopsy: patient must agree to undergo biopsy of accessible tumor before and after therapy, when feasible, to study tumor cell properties and characteristics of immune cells. (clinicaltrials.gov)
  • The purpose of this study was to investigate the factors predictive of response to interferon-alfa therapy in chronic hepatitis C. (kjim.org)
  • The purpose of this study was to evaluate clinical, biochemical and virological factors that would predict response to IFN-alfa therapy by univariate or multivariate analysis. (kjim.org)
  • Unfortunately, the effect of HSV-2 suppressive therapy - with acyclovir - on HIV-1 transmission in these studies has been mixed. (biomedcentral.com)
  • Type
  • The correlate of herpes simplex type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1) epidemics is intriguing and has been the subject of several studies. (biomedcentral.com)
  • populations
  • Yet, because our current understanding of T cell repertoire composition derives predominantly from studies of rather restricted epitope-specific responses, it remains unclear whether the individual clonotypes (T cell populations defined by their expressed TCRs) that make up such highly diverse naive T cell pools are equally represented to produce a featureless "repertoire landscape" or whether the distribution of clonotype sizes is quantitatively varied. (jimmunol.org)
  • pregnant women
  • The study population consisted of pregnant women from the Jomoro, Nzema East Municipal, Ahanta West, and Ellembelle district (Western Region of Ghana) attending the hospital for delivery during time of investigation. (biomedcentral.com)
  • people
  • South Africa is home to the world's largest population of people living with HIV (5.7 million). (scielo.org.za)
  • Neglected areas include attitudes to women, people of colour and consideration of the organizational and societal factors mediating the impact of HIV upon health care workers. (georgetown.edu)
  • drug
  • It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval. (drugbank.ca)
  • design
  • In this paper, we describe several key statistical considerations for the design of this landmark study. (nih.gov)
  • population
  • With 1,600,000 Mozambicans (11.5 percent of the population) living with HIV, 990,000 of which are women and children, Mozambique's government realizes that there is much work to be done on the path towards the eradication of this infectious disease. (wikipedia.org)
  • risk
  • Underlying clinical condition that precludes study completion or places the patient at significant risk. (clinicaltrials.gov)
  • Our findings suggest that HSV-2 may be both a biological and risk-associated cofactor for HIV-1 acquisition. (biomedcentral.com)
  • A recent study of DR3-DQ2/DR4-DQ8 phenotype found that A1-cw7-B8 was actually lower than expected relative to other A-B types, indicating that risk associated genes are located between B8 and DR3. (wikipedia.org)
  • Presence of Cytomegalovirus (CMV) may also be tested because of the risk to certain immunocompromised recipients if given, such as those with organ transplant or HIV. (wikipedia.org)
  • research
  • The study was supported by the National Institute for Health Research (NIHR), Arthritis Research UK, and AbbVie. (medpagetoday.com)
  • To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. (clinicaltrials.gov)
  • Researchers from Africa, Asia, North America, and South America have said that getting local government and media support of the research is essential in addition to creating facilities for distinguishing between HIV positive individuals and individuals exhibiting VISP. (wikipedia.org)