• renin
  • Renin is the rate-limiting factor of the renin-angiotensin-aldosterone-system, which is of fundamental importance to the regulation of blood pressure. (ahajournals.org)
  • 2 The renin enhancer contains an ≈50-bp-long region, which attracts much attention because it is involved in the regulation of renin transcription by virtually all cues tested until now. (ahajournals.org)
  • An accumulating body of evidence has shown that the renin-angiotensin system is involved in the fertility problems observed in some populations. (mdpi.com)
  • Evidence of enhanced renin-angiotensin system (RAS) activity in PCOS suggests an important correlation between the RAS and PCOS [ 10 , 11 ]. (mdpi.com)
  • VTP-27999 is a new renin inhibitor with an aliskiren-like IC 50 and t 1/2 , and a much higher bioavailability. (ahajournals.org)
  • This study addressed (pro)renin changes during treatment of volunteers with VTP-27999 or aliskiren. (ahajournals.org)
  • The VTP-27999-induced rises in renin immunoreactivity could be competitively prevented by aliskiren, and antibody displacement studies revealed a higher affinity of the active site-directed antibodies in the presence of VTP-27999. (ahajournals.org)
  • Children with a history of hypertension, renal disease, cardiac disease, or diabetes mellitus as well as those taking medication that could affect BP or the renin-angiotensin system were excluded from the study. (ahajournals.org)
  • activity
  • Our experiments also address the hypothesis that angiotensinogenic depressor responses could be mediated by non-AT 1 /AT 2 receptors, because of the experiments by Haberl 6 described above and the observation that angiotensin IV and angiotensin-(1-7) have dilator or depressor activity. (ahajournals.org)
  • We studied the I/D polymorphism of ACE in relation to serum ACE activity in 141 white and 62 black healthy, unrelated children and adolescents (mean age, 14.7 years). (ahajournals.org)
  • 24 25 26 In the present study we addressed whether the association of the ACE polymorphism with serum ACE activity observed in whites also occurs in blacks. (ahajournals.org)
  • less
  • Large intravenous boluses of angiotensin III (15 nmol/kg) produced a predictable pressor peak (82±4 mm Hg) followed by a depressor phase (20±3 mm Hg), whereas equipressor doses of angiotensin II were less effective at producing depressor responses. (ahajournals.org)
  • different
  • Vasodilatation by angiotensins in the cerebral circulation might occur by different mechanisms, in view of the fact that it appears to be blocked by both AT 1 and AT 2 antagonists and seems to be similar to arginine-induced vasodilatation. (ahajournals.org)
  • effect
  • The AT 1 antagonist losartan (1 mg/kg) blocked both the pressor and depressor components of the angiotensin III response, whereas the AT 2 antagonist PD 123319 (35 mg/kg) had no effect on either element of the response. (ahajournals.org)