• Suppressor mutations are useful for identifying new genetic sites which affect a biological process of interest. (wikipedia.org)
  • Intragenic suppression results from suppressor mutations that occur in the same gene as the original mutation. (wikipedia.org)
  • This is to our knowledge the first direct genetic evidence demonstrating that mutations in the fly version of a known human epilepsy gene produce seizures through altered vesicle transport," says John Manak, senior author and associate professor of biology in the College of Liberal Arts and Sciences and pediatrics in the Carver College of Medicine . (uiowa.edu)
  • The loss of such protective functions as a result of LRRK2 genetic mutations could explain the link between LRRK2 and Parkinson's disease, the researchers say. (medicalxpress.com)
  • Computational analysis predicted pK perturbations for the substrate lysine, and Ubc9 mutations weakened pK suppression through improper side chain coordination. (rcsb.org)
  • Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
  • Specifically, we focused on understanding the disease mechanisms and studied two of the most common chromosomal translocations, or genetic mutations, that lead to pediatric leukemia. (lu.se)
  • Since these mutations occur in utero and are very hard to study in humans, we used mouse models that express the same genetic mutations to investigate their impact on the blood or hematopoietic system. (lu.se)
  • Dichotomously, the primary inducer of IDO1, the inflammatory cytokine IFNγ (interferon-γ), is a key mediator of immune-based tumor suppression. (jefferson.edu)
  • Consequently, these changes in gene expression can inhibit genetic regions related to tumor suppression, cell growth, DNA repair, intracellular binding, and inhibition of metastasis, among other processes. (bvsalud.org)
  • Once the decision to initiate antiretroviral therapy has been made, treatment should be aggressive with the goal of maximal viral suppression. (cdc.gov)
  • Dolutegravir plus lamivudine continues to demonstrate long-term non-inferior efficacy compared to dolutegravir plus TDF/FTC with benefits beyond viral suppression. (natap.org)
  • The momentum behind 2DRs is growing: Dovato has now shown sustained efficacy and tolerability through three years of treatment, with people able to maintain viral suppression with fewer medicines than a 3-drug regimen. (natap.org)
  • These studies evaluate a 2-drug regimen of dolutegravir plus lamivudine compared with a 3-drug regimen of dolutegravir plus TDF/FTC in HIV-1 infected, antiretroviral treatment-naïve adult participants with baseline HIV-1 viral loads between 1,000 and 500,000 c/mL. (natap.org)
  • Resistance depends on the efficient sensing of the infection and mounting of antiviral responses that involve programmed death of infected cells, suppression of viral replication, inflammation and the establishment of adaptive immunity. (frontiersin.org)
  • Contraception must be used from 10 days prior to study entry and participants must agree to use contraception for 36 weeks after receiving study treatment, and until ART is reinitiated and viral suppression is achieved. (who.int)
  • The importance of chromosomal rearrangements for speciation can be inferred from studies of genetic exchange between hybridising chromosomal races within species. (conicet.gov.ar)
  • We studied genetic exchange between two hybridising groups of chromosomal races of house mouse in Upper Valtellina (Lombardy, Italy), using microsatellites. (conicet.gov.ar)
  • Importantly, we found that centromeric regions of some non-rearranged chromosomes also showed genetic differentiation between the hybridising groups, indicating a complex interplay between chromosomal rearrangements and other parts of the genome in maintaining or promoting differentiation and potentially driving speciation between chromosomal races. (conicet.gov.ar)
  • The team discovered that 73 of the B. cinerea sRNAs could target host genes in both of the plants studied "under stringent target prediction criteria," the scientists noted. (genomeweb.com)
  • Meanwhile, two plant defense marker genes, which do not contain target sites for the fungal sRNAs, were highly upregulated, leading the researchers to conclude that suppression of some but not all genes is a result of sequence-specific sRNA interaction and not cell death within infected lesions. (genomeweb.com)
  • From this study it was shown that genes are expressed as non-overlapping triplets (codons). (wikipedia.org)
  • Other resistance mechanisms include DNA repair, suppression of oncogene activation, tumor-suppressor genes, epigenetic stabilization of chromatin structure, and apoptosis. (the-scientist.com)
  • This presentation will discuss the modulation of immune related genes following PFOA exposure, helping to explain the reciprocal relationship between the mechanisms governing immune suppression and augmentation of IgE-mediated hypersensitivity and demonstrating the kinetics of absorption and penetration of PFOA through human and mouse skin. (cdc.gov)
  • in particular, genetic markers of risk, and integrating these genes with core brain and body measures including magnetic resonance imaging (MRI), electroencephalography (EEG), and electrocardiography (ECG). (edu.au)
  • Here, we performed a comparative genomics study of RNA sensor genes in three species of pangolins. (frontiersin.org)
  • We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
  • The approach points to a framework for lineage commitment studies in general and could aid the search for lineage-determining genes. (lu.se)
  • These mechanisms are well-studied, and each provides a potential road map for prevention and treatment. (the-scientist.com)
  • Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. (duke.edu)
  • These data suggest causal links between genetic, molecular, and circuit mechanisms underlying the pathophysiology of ASDs. (duke.edu)
  • Since models are limited to study the mechanism of the neurotoxicity of tranylcypromine, here we utilized an in vitro brain organoid culture system which mimics neurogenesis experimentally to investigate the mechanisms by studying the effect of brain development of tranylcypromine and monitoring the brain damage of different concentrations. (frontiersin.org)
  • My research has focused on pediatric leukemia and its mechanisms of initiation and suppression. (lu.se)
  • Manak and his fellow researchers show that seizure-prone prickle mutant flies have behavioral defects (such as uncoordinated gait) and electrophysiological defects (problems in the electrical properties of biological cells) similar to other fly mutants used to study seizures. (uiowa.edu)
  • Naturally, the suffering of cancer patients and their families has inspired researchers to study the cellular changes unique to cancer and the genetics of cancer susceptibility. (the-scientist.com)
  • In a new study, Yale researchers reveal new insights into this question, finding that the LRRK2 gene can suppress activity in lysosomes, microscopic organelles that play a key role in breaking down and disposing of cellular waste. (medicalxpress.com)
  • Researchers use new approach to identify genetic components of bipolar disorder. (neurosciencenews.com)
  • Researchers report EvC, a rare genetic disorder could protect against bipolar affective disorder. (neurosciencenews.com)
  • Biochemical studies with p53, RanGAP1 and the Nup358/RanBP2 E3 were used to determine rate constants and pK values, confirming both structural and computational predictions. (rcsb.org)
  • Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)
  • The research in Jiang’s lab is directed at understanding genetic and epigenetic basis of human diseases with a focus on genomic imprinting disorders of Angelman and Prader-Willi syndrome as well as autism spectrum disorders. (duke.edu)
  • Reduced fertility or recombination suppression in karyotypic hybrids has the potential to maintain or promote genetic differentiation in genomic regions near rearrangement breakpoints. (conicet.gov.ar)
  • In recent years, studies on the differences between genomic and epigenomic characteristics of MZs have led to the development of new approaches for elucidating the etiology of psychiatric disorders (Liang et al. (springer.com)
  • Genetic suppression therefore restores the phenotype seen prior to the original background mutation. (wikipedia.org)
  • These results suggest that sufficient DNA methyltransferase expression is a prerequisite for polyp formation and that hypomorphic alleles of Dnmt1 are not merely genetic modifiers but the first identified true genetic suppressors of the Min phenotype. (nih.gov)
  • Intergenic (also known as extragenic) suppression relieves the effects of a mutation in one gene by a mutation somewhere else within the genome. (wikipedia.org)
  • The genetic alteration causative of SCAN-1 is a mutation altering the function of a gene called tdp1 (tyrosyl- DNA phosphodiesterase 1). (ataxia.org)
  • Most childhood leukemias are thought to originate in the womb and occur due to a genetic error or a mutation. (lu.se)
  • Further genome-wide association studies in obese and diabetic Arab populations could add to our understanding of the pathophysiology, prevention and reversal of this disease. (who.int)
  • The tiny fruit fly, Drosophila, is an organism extremely useful for studies on human biology, health and a wide range of pathologies including neurodegenerative diseases. (ataxia.org)
  • Genetic elimination of the fibrinogen-binding motif to CD11b in Alzheimer's disease mice reduced microglial lipid metabolism and neurodegenerative signatures that were shared with autoimmune-driven neuroinflammation in multiple sclerosis mice. (nature.com)
  • Moreover, our study provides a resource for the investigation of the immunology of blood proteins in inflammatory, autoimmune and neurodegenerative diseases. (nature.com)
  • A major epidemiological study on environmental tobacco smoke has been completed and revealed a significant dose-response relationship between passive smoking (at home or at the workplace) and lung cancer. (who.int)
  • Twin studies of psychiatric disorders such as schizophrenia and autism spectrum disorder have employed epidemiological approaches that determine heritability by comparing the concordance rate between monozygotic twins (MZs) and dizygotic twins. (springer.com)
  • In epidemiological twin studies, comparisons of the concordance rate between monozygotic twins (MZs) and dizygotic twins (DZs) are very important. (springer.com)
  • 2017 ). The current paper focuses on epidemiological and molecular genetic research studies in MZs with the purpose of unravelling useful insights on factors that can lead to SCZ and ASD. (springer.com)
  • This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
  • Recent statistics indicate that number of epidemiological studies standing of the role of excessive fat dep- nearly 50% of the total Arab population from each country, we did not set any osition in promoting insulin resistance, are less than 25 years of age. (who.int)
  • We used a nematode (small round worm) that is used as an environmentally friendly pesticide to demonstrate that detrimental genetic changes can be prevented by creating inbred lines (groups that are the same genetically). (usda.gov)
  • Continuous subculturing of organisms used for biological pest suppression can lead to detrimental genetic changes and loss of utility. (usda.gov)
  • There are, however, several studies designed to examine whether or not detrimental effects on the health and/or development of breast-fed children may be associated with persistent chemicals detected in breast milk. (cdc.gov)
  • Recently, biological studies based on molecular methods are now being increasingly applied to examine the differences between MZs discordance for psychiatric disorders to unravel their possible causes. (springer.com)
  • By altering intracellular Ca 2+ and InsP 3 levels through genetic means, we now show that signaling through the InsP 3 R is required at multiple steps for generating the neural circuit required in air puff-stimulated Drosophila flight. (jneurosci.org)
  • Here, we have addressed these questions by altering intracellular Ca 2+ signals in flight-deficient itpr mutants through genetic means. (jneurosci.org)
  • Neural stem cells, neurons and brain organoids derived from the engineered hiPSCs continue to express the amber suppression machinery and produce ncAA-bearing reporter. (nih.gov)
  • However, despite recent technical achievements 1 , 2 , the type of chemical modification that can be accomplished by genetic means (e.g. amber codon suppression) is limited to incorporation of non-canonical amino acids (ncAAs) due to the tolerance of the cell's translational machinery. (biorxiv.org)
  • A new brain tissue study has shown gene expression in bipolar patients treated with antipsychotic medications is similar to the expression in subjects with no history of bipolar disorder. (neurosciencenews.com)
  • In this study, we show that low levels of CpG island methylation occur in the normal intestinal mucosa of Apc(Min/+) mice and are increased in Multiple Intestinal Metaplasia (Min) polyps. (nih.gov)
  • Genetic diversity in these immune responses was also demonstrated between Th1 and Th2 strains of mice. (cdc.gov)
  • Here, we used mice with a genetic deletion of miR-22 to extend these insights. (researchsquare.com)
  • RNA sequencing analysis of the hippocampus during the period of epileptogenesis revealed a specific suppression of inflammatory signalling in the hippocampus of miR-22-deficient mice. (researchsquare.com)
  • The immune tolerogenic effects of IDO1 (indoleamine 2,3-dioxygenase 1) have been well documented and genetic studies in mice have clearly established the significance of IDO1 in tumor promotion. (jefferson.edu)
  • The GL-induced conformational change of Bax and apoptosis were significantly suppressed by genetic suppression of JNK activation. (aspetjournals.org)
  • In conclusion, the present study indicates that ROS-dependent apoptosis by GL is regulated by JNK signaling axis. (aspetjournals.org)
  • Since the epigenetic status differs in each tissue type, in addition to the DNA from the peripheral blood, studies using DNA from nerve cells induced from postmortem brains or induced pluripotent stem cells are being carried out. (springer.com)
  • We show that a combination of Dnmt1 hypomorphic alleles results in the complete suppression of polyp formation and an accompanying reduction in the frequency of CpG island methylation in both the normal intestinal mucosa and intestinal adenomas. (nih.gov)
  • Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T. (nih.gov)
  • vSSCs are physiologic mediators of vertebral bone formation, as genetic blockade of the ability of vSSCs to generate osteoblasts results in defects in the vertebral neural arch and body. (bvsalud.org)
  • As an optically transparent model organism with an endothelial blood-brain barrier (BBB), zebrafish offer a powerful tool to study the vertebrate BBB. (elifesciences.org)
  • Electron microscopy studies further reveal high levels of transcytosis in brain endothelium early in development that are suppressed later. (elifesciences.org)
  • MRI is particularly suitable for brain imaging, and diffusion tensor imaging is an important tool for studying brain microstructure, and the connectivity amongst gray matter regions. (duke.edu)
  • She took up a postdoctoral research position at the Brain Dynamics Centre based within the Westmead Millennium Institute, with a focus on the genetic and brain markers of risk for mental health. (edu.au)
  • MicroRNA-22 (miR-22) has been reported to protect against the development of epileptogenic brain networks through suppression of neuroinflammatory signalling. (researchsquare.com)
  • Furthermore, outside the brain, the suppression of lysosomes by LRRK2 in macrophages may help explain links between LRRK2 and other diseases including leprosy and Crohn's disease. (medicalxpress.com)
  • Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology. (frontiersin.org)
  • However, animal models lack human genetic features and some brain region identities, such as outer subventricular zone, making it hard to figure out how these drugs affect central nervous system ( 7 , 8 ). (frontiersin.org)
  • The cerebral organoids, which can mimic the endogenous development of human brain, have been applied to different studies as in vitro models for a wide range of brain diseases ( 16 , 21 , 22 ). (frontiersin.org)
  • Moreover, 3D human brain organoids show great potential to investigating psychiatric disease origin and pathology, as well as drug screening and genetic modifications ( 19 ). (frontiersin.org)
  • The main goal of our project is the development of a powerful genetic model to investigate pathogenesis of spinocerebellar ataxia with axonal neuropathy-1 (SCAN-1) disease. (ataxia.org)
  • The objectives of this population-based study were to investigate the potential association between bone mineral density (BMD) and serum lipid profiles and to compare the effects of serum lipids on BMD at various skeletal sites in pre- and post-menopausal women. (who.int)
  • Replication studies identify several genetic variants in Arabs with obesity-linked diabetes. (who.int)
  • This study provides insights into the mechanism of Tao-1 regulation and a potential growth control function for SCHIP1 in mammals. (sdbonline.org)
  • These intermediate strains are subjected to bottlenecking and thus making it difficult for the alleles to be reverted prior to Intergenic suppressions. (wikipedia.org)
  • Indeed, patients with inherited forms of Alzheimer's disease also present with epilepsy, and this has been documented in a number of published studies. (uiowa.edu)
  • We plan to obtain a Drosophila model of SCAN- 1 disease by applying a well-known genetic approach. (ataxia.org)
  • Genetic and pharmacological interventions have successfully extended healthspan and lifespan in animals, but their genetic interventions are not appropriate options for human applications and pharmacological intervention needs more solid clinical evidence. (mdpi.com)
  • Intervention delivery modes included genetic counselling with additional telephone or in-person follow-up, letters, videos, and decision aids. (cdc.gov)
  • 12 ] Recent small clinical studies have also demonstrated potential therapeutic effects of supplementing the fibrinolytic system, where exogenous administration of tissue plasminogen activator (tPA) resulted in improvement of respiratory function and reduced mortality in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS). (thieme-connect.com)
  • The mRNA COVID vaccines contain genetic code to produce the so-called "spike protein," a component of the SARS-CoV-2 virus that allows the virus to penetrate and infect human cells. (shtfplan.com)
  • Similarly, human cells with COVID vaccine genetic code reverse-transcribed into them may also endlessly produce the spike protein for the affected individuals' lives," Chudov says. (shtfplan.com)
  • Chemical or genetic engineering of proteins provides great potential to study protein function and pharmacology or to generate proteins with novel properties. (biorxiv.org)
  • The isoform beta 1 has been studied as a possible target for anti-cancer drugs and as an inducer, via diacylglycerol generation, of the translocation of specific protein kinase C (PKC) isozyme to the nucleus. (curehunter.com)
  • This study shows that Schip1 , a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. (sdbonline.org)
  • When live organisms are grown repeatedly in the laboratory or in industrial, beneficial characteristics can be lost due to potentially harmful genetic changes. (usda.gov)
  • understand definitions and principles of the molecular genetics of bacteria · describe molecular genetic processes in prokaryotic organisms · understand relevant molecular genetic methods and their applicability and limitations. (lu.se)
  • The study group, from southern Italy, was 40 subjects, 20 were vaccinated with the full cycle of mRNA vaccine as of April 2022, being part of the health sector, and 20 were unvaccinated with negativity for COVID-19 to nasopharyngeal test and with no titer of any antibodies. (shtfplan.com)
  • Studies show that obesity-linked genetic variations increase belly fat. (orderhalalhavenrestaurant.com)
  • A new study finds that adipocyte SLC7A10 impairments may impact lipid accumulation during insulin resistance in patients with obesity. (medscape.com)
  • A major limitations on the study design in our particularly in central obesity, which is health issue in the Arab world is the ris- exclusion criteria. (who.int)
  • To gain insight this study quantitatively investigated synaptic growth and connectivity in the Drosophila nociceptive network during larval development. (sdbonline.org)
  • We utilized this model system to achieve overexpression and suppression of miR-137, both transiently and stably through transgenesis. (nature.com)
  • Here, we use PiggyBac-mediated transgenesis to engineer hiPSCs with an expanded genetic code. (nih.gov)
  • CONCLUSIONS: Our study provides the first insights into how primary tumor removal enriches PCa cell dissemination in the bones, defines a unique osteoblast-induced PCa dormancy signature, and identifies FAK as a PCa cell dormancy gatekeeper. (bvsalud.org)
  • 7 While its etiology is poorly defined there is now substantial support for a complex polygenic inheritance model involving interplay between genetic and environmental factors. (nature.com)
  • Dolutegravir plus lamivudine continued to demonstrate a high genetic barrier to treatment-emergent resistance. (natap.org)
  • While overall adverse event rates were similar across the study arms, we saw fewer drug-related adverse events with dolutegravir plus lamivudine. (natap.org)
  • However, the minimization of vibration response cannot warrant a minimum sound power and fewer studies have considered optimal CLD configurations for acoustic problems. (hindawi.com)
  • The scientists then confirmed that the target suppression observed was triggered by the sRNAs using coexpression assays in Nicotiana benthamiana . (genomeweb.com)
  • Here, we examine growth suppression efficiency of human glioblastomas by dual-peptide targeting. (aacrjournals.org)
  • The studies were designed to demonstrate the non-inferior efficacy at Week 48, as well as the safety and tolerability of once-daily dolutegravir plus lamivudine compared to once-daily dolutegravir plus the fixed-dose combination of TDF/FDC in HIV-1-infected, antiretroviral treatment-naïve adult participants. (natap.org)
  • Human induced pluripotent stem cell (hiPSC) technology has revolutionized studies on human biology. (nih.gov)
  • A wide range of cell types and tissue models can be derived from hiPSCs to study complex human diseases. (nih.gov)
  • LRRK2 acts like a brake on a garbage truck and if the brake is too strong it limits the ability of these scavenger cells to eliminate damaging material," said Shawn Ferguson, associate professor of cell biology and of neuroscience at Yale School of Medicine and senior author of the study. (medicalxpress.com)
  • To discover the molecular programs controlling microglial and macrophage polarization by blood proteins, we developed an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline consisting of deep sequencing of blood-induced transcriptomes, functional single-cell and oxidative stress transcriptomics, global phosphoproteomics and integration with innate immune signatures from AD and MS models (Extended Data Fig. 1 ). (nature.com)
  • Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. (lu.se)
  • From forced expression studies in both cell lines and primary turned ON/OFF. (lu.se)
  • From these results it was concluded that an inserted or deleted triplet does not disturb the reading frame and the genetic code is in fact a triplet. (wikipedia.org)
  • Results from studies examining concentrations of CDDs, p,p' -DDE, hexachlorobenzene, mercury, and PCBs in breast milk indicate that mean or median concentrations show a 10- to 100-fold range among studies for each of these chemicals (Table 2). (cdc.gov)
  • Results from these studies are suggestive that the observed delays may have been associated with gestational exposure rather than lactational exposure. (cdc.gov)
  • London, 5 October 2020 - ViiV Healthcare, the global specialist HIV company majority owned by GSK, with Pfizer Inc. and Shionogi Limited as shareholders, today presented three-year results from the phase III GEMINI 1 & 2 studies at the HIV Glasgow 2020 congress. (natap.org)
  • Recent studies have demonstrated that as compared to oral dosing, dermal exposure results in qualitatively similar immunosuppressive effects and additionally, that while not allergenic itself, dermal exposure to PFOA simultaneously with exposure to a respiratory allergen augments the IgE response to that allergen. (cdc.gov)
  • practically apply molecular genetic technologies · interpret, compile and present experimental results in a scientific way for a given target group. (lu.se)
  • Multicentre case-control studies clearly demonstrated a cervical cancer risk associated with infection with a variety of human papillomaviruses (HPV) other than types 16 and 18. (who.int)
  • Additionally, insertion of multiple chemical modifications by genetic code expansion remains a challenge, particularly in eukaryotic cells. (biorxiv.org)
  • Once this occurs, a person's body endlessly produces copies of HIV, hence why there is no cure for HIV, only suppression with drugs. (shtfplan.com)
  • The safety, efficacy, and side effects of different drugs have been extensively studied using current research models ( 6 ). (frontiersin.org)
  • My lab studies neural circuit basis of sensory perception. (duke.edu)
  • Develop your entrepreneurial skills while you study molecular biology to enhance your employability. (manchester.ac.uk)
  • According to new findings, lithium's therapeutic effects stems from its suppression of myo-inositol. (neurosciencenews.com)
  • The similarity of the genetic information in MZs provides a useful means for determining the disorder-causing role of environmental factors. (springer.com)
  • An interesting fallout from this architecture is that suppression of the cofactor through external means can lead to a loss of cooperativity, and hence to a primed state for PU.1 and GATA-1. (lu.se)
  • Adoption of our technique could lead to improved natural pest control because nematodes kept as inbred lines would be resistant to harmful genetic changes. (usda.gov)
  • Treatment resistant bipolar disorder patients experienced a reversal of a key symptom 40 minutes after a single infusion of ketamine, a new study reports. (neurosciencenews.com)
  • T2DM has become a source total of 122 studies were considered phied, becoming more resistant to the of suffering to both patients and their for the article and were reviewed in antilipolytic effects of insulin, resulting caregivers. (who.int)
  • As a result, twin studies of psychiatric disorders are greatly contributing to the elucidation of genetic and environmental factors in the etiology of psychiatric conditions. (springer.com)
  • Concerns that biopersistent and lipophilic chemicals accumulating in breast milk may present health problems offsetting benefits of breast feeding have led to studies examining possible relationships between adverse effects in breast-fed children and chemicals detected in breast milk, and to studies examining several health endpoints in animals following exposure to mixtures of biopersistent chemicals during gestation and/or lactation. (cdc.gov)
  • IARC scientists coordinated several studies on the adverse health effect of exposure to styrene, man-made vitreous fibres, organic mercury compounds and substances affecting workers in the paper, wood, leather and asphalt industry and in biological research laboratories. (who.int)
  • Among the various regulatory/suppressive cells hitherto described, CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. (epa.gov)
  • RNA-Seq revealed the suppression of mitochondrial-related biological processes in osteoblast-induced dormant PCa cells. (bvsalud.org)
  • Of those who were informed, 24.4-60.0% contacted a genetics clinic and 22.8-76.2% had genetic testing after they were counselled at a genetics clinic. (cdc.gov)
  • No studies were located that examined health effects in humans or animals exposed to mixtures exclusively containing CDDs, hexachlorobenzene, p,p' -DDE, methylmercury, and PCBs. (cdc.gov)
  • Expanding our understanding of the zebrafish BBB can thus reveal the mechanistic similarities between the zebrafish and mammalian BBB to further evaluate the position of zebrafish as a model organism for studying the BBB. (elifesciences.org)
  • At the end of the nineteenth century, Francis Golton was the first to consider twins as a useful scientific model, questioning whether human traits originated from genetic or environmental causes. (springer.com)