• symptoms
  • Evidence is mounting that a diet mimicking the effects of fasting has health benefits beyond weight loss, with a new study indicating that it may reduce symptoms of multiple sclerosis. (fightaging.org)
  • Obtain preliminary data on the effectiveness of HT on psychological distress and treatment-related symptoms focusing on fatigue and sleep disturbances in these patients. (clinicaltrials.gov)
  • Background and Purpose -The purpose of this study was to investigate the possibility of obtaining prognostic indications in patients with internal carotid occlusion on the basis of intracranial hemodynamic status, presence of previous symptoms of cerebrovascular failure, and baseline characteristics. (ahajournals.org)
  • CBT based on this model attempts to reverse patients' symptoms by altering their interpretation of their symptoms and/or the behaviours they engage in as a result. (wikipedia.org)
  • Under intense stress patients with BPD may exhibit transient dissociative or paranoid symptoms. (wikipedia.org)
  • researcher
  • However, it is also important that none of those involved in a clinical trial, whether the researcher, the subject patient or any other involved parties, should allow their own prior expectations to affect reporting of results. (wikipedia.org)
  • It is recommended in several treatment guidelines for PTSD, however it has been controversial and its efficacy is still debated due to concerns over the quality of evidence, contradictory findings, significant rates of researcher bias, and dropout rates in studies. (wikipedia.org)
  • However, due to "very low" quality of evidence, significant rates of researcher bias, and some participant drop outs, the meta-analysts cautioned against interpreting the results of the studies which were analyzed. (wikipedia.org)
  • discomfort
  • For instance, cancer patients will generally tolerate an immense amount of pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache, will not. (wikipedia.org)
  • versus
  • In early 2008, a noninferiority study versus vancomycin or metronidazole for Clostridium difficile associated diarrhea (CDAD) found that about half of the patients in the tolevamer group did not complete the treatment, versus 25% in the vancomycin and 29% in the metronidazole groups. (wikipedia.org)
  • Borderline Personal
  • The objective of this study is to quantitatively examine the efficacy of Seroquel (active ingredient quetiapine fumarate) in subjects with Borderline Personality Disorder (BPD). (clinicaltrials.gov)
  • A secondary objective is to characterize the safety and tolerability of utilizing quetiapine in patients with Borderline Personality Disorder. (clinicaltrials.gov)
  • TFP has been validated as an efficacious treatment for borderline personality disorder (BPD), though too few studies have been conducted to allow firm conclusions about its value. (wikipedia.org)
  • When compared to psychotropic medications, review studies have found CBT-alone to be as effective for treating less severe forms of depression and anxiety, post-traumatic stress disorder (PTSD), tics, substance abuse (with the exception of opioid use disorder), eating disorders, and borderline personality disorder. (wikipedia.org)
  • Enrollment
  • Reports should be available at the study, country, site and user level and should the assignment/completion of tasks, audit trails on all activity, recruitment/enrollment progress, and other milestone/timeline driven activities. (wikipedia.org)
  • Clinical Trial Portals can include patient recruitment management applications that track actual vs projected enrollment, site recruitment plans, IRB/EC submission/approval dates, recruitment material management, outreach tactics and ROI. (wikipedia.org)
  • fail
  • Under conditions of high stress, borderline patients may fail to appreciate the "whole" of the situation and interpret events in catastrophic and intensely personal ways. (wikipedia.org)
  • Schema therapy was developed by Jeffrey E. Young for use in treatment of personality disorders and chronic DSM Axis I disorders, such as when patients fail to respond or relapse after having been through other therapies (for example, traditional cognitive behavioral therapy). (wikipedia.org)
  • participants
  • This study is currently recruiting participants. (clinicaltrials.gov)
  • Based on the lowest estimated prevalence of pre-eclampsia of 3% and a test sensitivity of 93% and a test specificity of 97%, then to be 90% certain that the true specificity of the patient population is no less than 95%, a sample size of 4,800 participants is required. (clinicaltrials.gov)
  • Determine the feasibility of conducting a randomized controlled trial, in terms of recruiting and retaining participants, to a study of healing touch (HT) as supportive care in patients receiving chemotherapy for acute myeloid leukemia or acute lymphoblastic leukemia. (clinicaltrials.gov)
  • The participants in the study were recruited from consecutive patients with occlusion of the extracranial segment of the internal carotid artery admitted to our stroke unit from April 1993 to May 1997 for a transient ischemic attack (TIA) involving the vascular territory of middle cerebral artery (MCA) or for a functionally independent or minor stroke (Rankin Scale score of 1 to 2) in the same district. (ahajournals.org)
  • The study began enrolling participants in August 2016, and a total of 1400 participants (700 per treatment group) are expected to be enrolled by March 2018. (bmj.com)
  • efficacy
  • In this phase Ib/II study, we aimed to assess the safety and efficacy of afatinib plus nimotuzumab (N) in advanced non-small cell lung cancer (NSCLC) patients with acquired resistance to gefitinib or erlotinib. (aacrjournals.org)
  • Evidence is lacking for both efficacy and safety of cannabis and cannabinoids in treating patients with HIV/AIDS or for anorexia associated with AIDS. (wikipedia.org)
  • Since patients often drop out because they find a treatment doesn't seem to be working for them or because it causes harmful side effects, missing data is often correlated with the treatment's efficacy or safety. (wikipedia.org)
  • baseline
  • Patients also complete self-report questionnaires at baseline, during week 5 of induction or reinduction chemotherapy or prior to discharge from the hospital, and during the first week of consolidation chemotherapy (approximately week 9-13). (clinicaltrials.gov)
  • The possible role of baseline clinical and epidemiological characteristics in influencing the prognosis of such patients was also considered. (ahajournals.org)
  • Simultaneous
  • In this thesis, we propose an exact method and an approximate method for GLMMs with informative dropouts and missing covariates, and provide a unified approach for simultaneous inference. (ubc.ca)
  • Kunling W u 19/12/2003 Name of Author (please print) Date (dd/mm/yyyy) Title of Thesis: Simultaneous Inference for Generalized Linear Mixed Models with Informative Dropout and Missing Covariates Degree: Master of Science Department of Statistics The University of British Columbia Vancouver, B C Canada Year: 2003 Abstract Generalized linear mixed effects models (GLMMs) are popular in many longitudinal studies. (ubc.ca)
  • data
  • We conducted a retrospective cohort study analysing data on patients who presented to McCord Hospital, Durban, and started ART between 1 January 1999 and 29 February 2004. (scielo.org.za)
  • Study record managers: refer to the Data Element Definitions if submitting registration or results information. (clinicaltrials.gov)
  • Dropout rates and the future economic value of a CL patient were calculated from the survey data. (reviewofoptometry.com)
  • Conclusions -These data suggest that impaired cerebrovascular reactivity is predictive for cerebral ischemic events in patients with carotid occlusion. (ahajournals.org)
  • In these studies, however, missing data problems arise frequently, which makes statistical analyses more complicated. (ubc.ca)
  • If a patient drops out of the study after the third week, then this value is "carried forward" and assumed to be his or her score for the 5 missing data points. (wikipedia.org)
  • When looking at patient dropout rates, these inconsistencies can make the data difficult to understand, as patients in one study would be considered completers, but the same patients might be considered non-completers in another study. (wikipedia.org)
  • Data on adverse effects were not systematically presented by any included study. (wikipedia.org)
  • In addition, portals can incorporate data from other clinical trial systems to provide meaningful dashboard and detail level reports that help manage the overall study progress. (wikipedia.org)
  • Basic demographics data like address and phone number are also recorded into the system along with the schedule of the patient for coming into Operation ASHA's centers to take their medication. (wikipedia.org)
  • high
  • The factors that have predicted mortality in studies evaluating patients prior to initiation of ART include a low CD4 cell count, high HIV RNA, mild to severe anaemia, low body mass index, elevated aspartate aminotransferase (AST), a history of opportunistic infections, and depression. (scielo.org.za)
  • However at other points of the study, high antibody users had more positive urine results. (wikipedia.org)
  • Due to their high reactivity to environmental stimuli, patients with BPD often experience dramatic and short-lived shifts in their mood, alternating between experiences of euphoria, depression, anxiety, and nervousness. (wikipedia.org)
  • Methods
  • Methods -Cerebral hemodynamics were studied with transcranial Doppler ultrasonography. (ahajournals.org)
  • A simulation study is conducted to evaluate the performance of the proposed methods under various situations. (ubc.ca)
  • The purpose of this manuscript is to describe patient-centred approaches used both in developing and testing the Health-E You app and to present the research methods used to evaluate its effectiveness in improving intentions to use an effective method of contraception as well as actual contraceptive use. (bmj.com)
  • Methods and analysis This study is designed to assess the effectiveness of a patient-centred computer-based clinic intervention, Health-E You/Salud iTu, on its ability to reduce health disparities in unintended pregnancies among Latina adolescent girls. (bmj.com)
  • predictive
  • This will involve a multicentre, phase IIa clinical predictive study to assess and refine novel and innovative prototype tests based on emerging metabolomic and proteomic technologies developed by SMEs (small to medium size enterprise) within the consortium. (clinicaltrials.gov)
  • The IMPROvED study is expected to refine proteomic and metabolomic panels, combined with clinical parameters, and evaluate clinical applicability as an early pregnancy predictive test for pre-eclampsia. (biomedcentral.com)
  • phase
  • In phase Ib stage, patients received afatinib (40 mg or 30 mg once daily) plus nimotuzumab (100 mg or 200 mg once weekly) for 28-day cycles to determine the recommended phase II dose (RPIID). (aacrjournals.org)
  • In total, 50 patients were enrolled (13 to phase Ib and 37 to phase II). (aacrjournals.org)
  • initiation
  • Interventions enabling patients to be identified before they develop these clinical markers and earlier initiation of ART will help to ensure maximum benefits of therapy. (scielo.org.za)
  • denial
  • This denial of care can quickly lead to patient dropout. (wikipedia.org)
  • In June 2008, the American Medical Association (AMA) House of Delegates stated that the denial to patients with gender dysphoria or otherwise covered benefits represents discrimination, and that the AMA supports "public and private health insurance coverage for treatment for gender dysphoria as recommended by the patient's physician. (wikipedia.org)
  • often
  • It is often beneficial to both the client and the patient to have a balance in which the clinician asks questions and the patient also volunteers certain information. (wikipedia.org)
  • Early studies used the sodium salt, but it was soon replaced with the potassium sodium salt to prevent hypokalaemia, which is often associated with diarrhea. (wikipedia.org)
  • Patients with BPD are often characterized by intense affects, stormy relationships, and impulsive behaviors. (wikipedia.org)
  • Patients with BPD often experience intolerable feelings of emptiness that they attempt to fill with impulsive and self-damaging behaviors, such as substance abuse, risky sexual behavior, uncontrolled spending, or binge eating. (wikipedia.org)
  • violations
  • Protocol violations" may occur, such as when the patients do not receive the full intervention or the correct intervention or a few ineligible patients are randomly allocated in error. (wikipedia.org)
  • group
  • Of the 1405 consecutive TMD patients examined in a recent 10-year period, 367 (26.1%) drop-out pati ents or patients identified with a control group were sampled. (quintpub.com)
  • For the first part of the study, researchers put a group of mice with autoimmune disease on a fasting-mimicking diet for three days, every seven days for three cycles, with a control group on a standard diet for comparison. (fightaging.org)
  • Variations in the immune status of patients in each group throughout follow-up. (clinicaltrials.gov)
  • This study uses a cluster randomised control trial design in which 18 school-based health centers from the Los Angeles Unified School District were randomly assigned, at equal chance, to either the intervention ( Health-E You app) or control group. (bmj.com)
  • At follow up (mean 32.6 months), patients in the eccentric group were still satisfied and sports active, but all patients in the concentric group had been treated surgically or by sclerosing injections. (bmj.com)
  • The study aimed to include 20 patients in each group, but was stopped at the half time control because of poor results achieved in the concentric group. (bmj.com)
  • After a defined time period, the patients in the test group are assessed for health improvements in comparison with the control group. (wikipedia.org)
  • Blinding should be appropriate to the study, and is ideally double blind, wherein neither the patient nor doctor is aware of whether they are in the control or test group, eliminating any such psychological effects from the study. (wikipedia.org)
  • RESULTS
  • Here, results are presented for a study of its effects on multiple sclerosis in animal models of the disease and human patients. (fightaging.org)
  • Results -During the follow-up period, 11 symptomatic patients and 1 asymptomatic patient had another ischemic event ipsilateral to carotid occlusion. (ahajournals.org)
  • For the purpose of this study, all patients referred have received western treatment for one month without positive results. (orientalhealthsolutions.com)
  • A recent study reported promising clinical results using eccentric quadriceps training on a decline board to treat jumper's knee (patellar tendinosis). (bmj.com)
  • effects
  • Generalized linear mixed effects models (GLMMs) are popular in many longitudinal studies. (ubc.ca)
  • Percentage of patients that drop out of the study due to intolerance or adverse effects. (clinicaltrials.gov)
  • Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient. (wikipedia.org)
  • Comparative studies have found cannabinoids to be more effective than some conventional antiemetics such as prochlorperazine, promethazine, and metoclopramide in controlling CINV, but these are used less frequently because of side effects including dizziness, dysphoria, and hallucinations. (wikipedia.org)
  • Cyclically, long waiting lists have shown some increased dropout effects, further exacerbating the problem. (wikipedia.org)
  • mean
  • Listing a study does not mean it has been evaluated by the U.S. Federal Government. (clinicaltrials.gov)
  • In this prospective study, athletes (mean age 25 years) with jumper's knee were randomised to treatment with either painful eccentric or painful concentric quadriceps training on a decline board. (bmj.com)
  • factors
  • As more patients begin treatment, it is important to identify factors that predict a higher risk of mortality so that they can be more closely monitored. (scielo.org.za)
  • Among respondents in the Asia/Pacific region, inconvenience (10%) and fear of or history of ocular infections (17.5%) were also important factors contributing to patient dropouts. (reviewofoptometry.com)
  • We have had one patient drop out of the study who had severe multi-systemic complicating factors, for whom we were of no help. (orientalhealthsolutions.com)
  • However, there are different factors associated with patient dropout that are worth identifying. (wikipedia.org)
  • Environmental factors relate both to the environment of the patient and to the physical environment of the clinician's office. (wikipedia.org)
  • conduct
  • Despite the fact that the most clinical trials are carefully planned, many problems can occur during the conduct of the study. (wikipedia.org)
  • Links to other clinical trial technologies being used for a study can be incorporated into the portal to provide users with a common technology platform for the studies they conduct. (wikipedia.org)
  • research
  • Within 1 week of admission to the hospital, patients are interviewed by a research assistant about previous use of complementary or alternative medicine therapies, knowledge of healing touch (HT), previous experience with HT, willingness to participate in a study of HT for acute leukemia patients, and willingness to be randomized in a HT study. (clinicaltrials.gov)
  • For non-commercial purposes only, such as research, private study and education. (ubc.ca)
  • To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. (clinicaltrials.gov)
  • Clinical portals can be developed for a particular study, however study-specific portals may be part of larger, clinical sponsor or Contract Research Organization (CRO) portals that cover multiple trials. (wikipedia.org)
  • antiretroviral
  • To identify predictors of mortality in patients initiating antiretroviral therapy (ART) in Durban, South Africa. (scielo.org.za)
  • To evaluate whether the combined therapy of two nucleosides plus one nucleotide (Trizivir + TDF) manages to keep CD4 lymphocytes stable in patients with HIV infection on antiretroviral treatment that present virological failure and multiple resistance to antiretrovirals. (clinicaltrials.gov)
  • This study has been designed to determine whether the use of a regimen based exclusively on NTRI, containing tenofovir, zidovudine and lamivudine, is able to preserve immunological status in patients with detectable viral load for whom an efficacious salvage regimen cannot be designed, slowing the progression of the viral load and reducing antiretroviral treatment-associated toxicity. (clinicaltrials.gov)
  • meta-analysis
  • There are several meta-analysis studies that addressed these issues. (wikipedia.org)
  • A 2007 meta-analysis found that the effectiveness of CBT depends on the diagnostic criteria used, with studies using the Oxford criteria having a trend towards significantly higher effect sizes that those using the CDC criteria. (wikipedia.org)
  • psychological
  • For example, it may be used help the patient cope with their disability by better management of rest and activity within the boundaries of the energy constraints of the disorder, and does not actively attempt to improve the patient's physical or psychological capacity. (wikipedia.org)
  • effectiveness
  • This can lead to lower self-esteem, confidence, and thus their effectiveness which will negatively impact their delivery of treatments to other patients. (wikipedia.org)
  • Perceptions of mental health may also alter patient beliefs about the effectiveness of mental health treatment. (wikipedia.org)
  • describe
  • To receive the corresponding point, an article should describe the number of withdrawals and dropouts, in each of the study groups, and the underlying reasons. (wikipedia.org)
  • estimation
  • patient estimation of pain during exercise) and Victorian Institute of Sport Assessment (VISA) scores, before and after treatment, and patient satisfaction, were used for evaluation. (bmj.com)
  • significant
  • If 'at risk' patients can be identified, this will allow stratified care with personalised fetal and maternal surveillance, early diagnosis, timely intervention, and significant health economic savings. (biomedcentral.com)
  • 1999
  • McCord Hospital's Sinikithemba ('We Give Hope') Clinic has offered ART to patients at cost since 1999. (scielo.org.za)
  • We conducted a retrospective cohort study of all patients who started ART at the Sinikithemba Clinic from 1 January 1999 to 29 February 2004. (scielo.org.za)
  • findings
  • These latest findings follow studies that showed cycles of a similar but shorter fasting-mimicking diet, when paired with drug treatments for cancer, protect normal cells while weakening cancerous ones. (fightaging.org)
  • closely
  • Closely monitor patients with history of allergic reactions to sulfasalazine or sulfite sensitivity (if using enema). (thefreedictionary.com)
  • Goldberger on the other hand suspected that diet was the true cause, which he came to believe through his observations of pellagra and the fact that hospital staff who worked closely with pellagra patients did not fall sick themselves. (wikipedia.org)
  • median
  • The median future value over the lifetime of a single contact lens dropout was calculated to be $19,497 to $24,556. (reviewofoptometry.com)
  • Sixty-five patients with internal carotid artery occlusion were followed-up prospectively (median, 24 months), 23 patients were asymptomatic and 42 symptomatic (20 with transient ischemic attack and 22 with stroke). (ahajournals.org)