• discomfort
  • However, patients often complained of pain during dressing change and discomfort during knee range-of-motion exercise after surgery by the use of gauze dressings [ 6 ]. (hindawi.com)
  • For instance, cancer patients will generally tolerate an immense amount of pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache, will not. (wikipedia.org)
  • In hyperalgesic patients, a 25-gauge, 3.8-cm (1.5-in) needle may cause less discomfort, but will not provide the clear "feel" of the structures being penetrated by the needle and is more likely to be deflected by the dense contraction knots that are the target. (wikipedia.org)
  • versus
  • In early 2008, a noninferiority study versus vancomycin or metronidazole for Clostridium difficile associated diarrhea (CDAD) found that about half of the patients in the tolevamer group did not complete the treatment, versus 25% in the vancomycin and 29% in the metronidazole groups. (wikipedia.org)
  • symptoms
  • Evidence is mounting that a diet mimicking the effects of fasting has health benefits beyond weight loss, with a new study indicating that it may reduce symptoms of multiple sclerosis. (fightaging.org)
  • Obtain preliminary data on the effectiveness of HT on psychological distress and treatment-related symptoms focusing on fatigue and sleep disturbances in these patients. (clinicaltrials.gov)
  • Background and Purpose -The purpose of this study was to investigate the possibility of obtaining prognostic indications in patients with internal carotid occlusion on the basis of intracranial hemodynamic status, presence of previous symptoms of cerebrovascular failure, and baseline characteristics. (ahajournals.org)
  • CBT based on this model attempts to reverse patients' symptoms by altering their interpretation of their symptoms and/or the behaviours they engage in as a result. (wikipedia.org)
  • Under intense stress patients with BPD may exhibit transient dissociative or paranoid symptoms. (wikipedia.org)
  • Borderline Personal
  • The objective of this study is to quantitatively examine the efficacy of Seroquel (active ingredient quetiapine fumarate) in subjects with Borderline Personality Disorder (BPD). (clinicaltrials.gov)
  • A secondary objective is to characterize the safety and tolerability of utilizing quetiapine in patients with Borderline Personality Disorder. (clinicaltrials.gov)
  • TFP has been validated as an efficacious treatment for borderline personality disorder (BPD), though too few studies have been conducted to allow firm conclusions about its value. (wikipedia.org)
  • efficacy
  • AQUACEL Ag Surgical dressing is an ideal dressing to provide wound care efficacy, patient satisfaction, reduction of SSI, and cost-effectiveness following MIS-TKA. (hindawi.com)
  • In this phase Ib/II study, we aimed to assess the safety and efficacy of afatinib plus nimotuzumab (N) in advanced non-small cell lung cancer (NSCLC) patients with acquired resistance to gefitinib or erlotinib. (aacrjournals.org)
  • Since patients often drop out because they find a treatment doesn't seem to be working for them or because it causes harmful side effects, missing data is often correlated with the treatment's efficacy or safety. (wikipedia.org)
  • fail
  • Under conditions of high stress, borderline patients may fail to appreciate the "whole" of the situation and interpret events in catastrophic and intensely personal ways. (wikipedia.org)
  • Schema therapy was developed by Jeffrey E. Young for use in treatment of personality disorders and chronic DSM Axis I disorders, such as when patients fail to respond or relapse after having been through other therapies (for example, traditional cognitive behavioral therapy). (wikipedia.org)
  • participants
  • This study is currently recruiting participants. (clinicaltrials.gov)
  • Based on the lowest estimated prevalence of pre-eclampsia of 3% and a test sensitivity of 93% and a test specificity of 97%, then to be 90% certain that the true specificity of the patient population is no less than 95%, a sample size of 4,800 participants is required. (clinicaltrials.gov)
  • Determine the feasibility of conducting a randomized controlled trial, in terms of recruiting and retaining participants, to a study of healing touch (HT) as supportive care in patients receiving chemotherapy for acute myeloid leukemia or acute lymphoblastic leukemia. (clinicaltrials.gov)
  • The participants in the study were recruited from consecutive patients with occlusion of the extracranial segment of the internal carotid artery admitted to our stroke unit from April 1993 to May 1997 for a transient ischemic attack (TIA) involving the vascular territory of middle cerebral artery (MCA) or for a functionally independent or minor stroke (Rankin Scale score of 1 to 2) in the same district. (ahajournals.org)
  • The study began enrolling participants in August 2016, and a total of 1400 participants (700 per treatment group) are expected to be enrolled by March 2018. (bmj.com)
  • Questionnaires
  • Questionnaires of subfertile patients have indicated that a majority make use of the internet to find information relating to their condition, 1 , 2 with a recent survey in Poland suggesting that 93% of respondents used online resources for this purpose. (bmj.com)
  • Patients also complete self-report questionnaires at baseline, during week 5 of induction or reinduction chemotherapy or prior to discharge from the hospital, and during the first week of consolidation chemotherapy (approximately week 9-13). (clinicaltrials.gov)
  • Percentage of patients that present improvement in the quality of life (MOS-HIV) and satisfaction questionnaires. (clinicaltrials.gov)
  • assess
  • This will involve a multicentre, phase IIa clinical predictive study to assess and refine novel and innovative prototype tests based on emerging metabolomic and proteomic technologies developed by SMEs (small to medium size enterprise) within the consortium. (clinicaltrials.gov)
  • Methods and analysis This study is designed to assess the effectiveness of a patient-centred computer-based clinic intervention, Health-E You/Salud iTu, on its ability to reduce health disparities in unintended pregnancies among Latina adolescent girls. (bmj.com)
  • data
  • We conducted a retrospective cohort study analysing data on patients who presented to McCord Hospital, Durban, and started ART between 1 January 1999 and 29 February 2004. (scielo.org.za)
  • Study record managers: refer to the Data Element Definitions if submitting registration or results information. (clinicaltrials.gov)
  • Conclusions -These data suggest that impaired cerebrovascular reactivity is predictive for cerebral ischemic events in patients with carotid occlusion. (ahajournals.org)
  • The performance of these methods in the presence of missing data completely at random (MCAR), at random (MAR) and non-ignorable (NIM) were compared in simulation studies. (lshtm.ac.uk)
  • In these studies, however, missing data problems arise frequently, which makes statistical analyses more complicated. (ubc.ca)
  • If a patient drops out of the study after the third week, then this value is "carried forward" and assumed to be his or her score for the 5 missing data points. (wikipedia.org)
  • Data on adverse effects were not systematically presented by any included study. (wikipedia.org)
  • A clinical portal is typically developed by a sponsor or CRO to facilitate centralized access to relevant information, documentation and online applications by investigational sites participating (or considering participation) in a trial, as well as for the monitors, study managers, data managers, medical, safety and regulatory staff that help plan, conduct, manage and review the trial. (wikipedia.org)
  • In addition, portals can incorporate data from other clinical trial systems to provide meaningful dashboard and detail level reports that help manage the overall study progress. (wikipedia.org)
  • Basic demographics data like address and phone number are also recorded into the system along with the schedule of the patient for coming into Operation ASHA's centers to take their medication. (wikipedia.org)
  • Enrollment
  • Reports should be available at the study, country, site and user level and should the assignment/completion of tasks, audit trails on all activity, recruitment/enrollment progress, and other milestone/timeline driven activities. (wikipedia.org)
  • Clinical Trial Portals can include patient recruitment management applications that track actual vs projected enrollment, site recruitment plans, IRB/EC submission/approval dates, recruitment material management, outreach tactics and ROI. (wikipedia.org)
  • Simultaneous
  • In this thesis, we propose an exact method and an approximate method for GLMMs with informative dropouts and missing covariates, and provide a unified approach for simultaneous inference. (ubc.ca)
  • often
  • It is often beneficial to both the client and the patient to have a balance in which the clinician asks questions and the patient also volunteers certain information. (wikipedia.org)
  • Early studies used the sodium salt, but it was soon replaced with the potassium sodium salt to prevent hypokalaemia, which is often associated with diarrhea. (wikipedia.org)
  • Patients with BPD are often characterized by intense affects, stormy relationships, and impulsive behaviors. (wikipedia.org)
  • Due to their high reactivity to environmental stimuli, patients with BPD often experience dramatic and short-lived shifts in their mood, alternating between experiences of euphoria, depression, anxiety, and nervousness. (wikipedia.org)
  • Patients with BPD often experience intolerable feelings of emptiness that they attempt to fill with impulsive and self-damaging behaviors, such as substance abuse, risky sexual behavior, uncontrolled spending, or binge eating. (wikipedia.org)
  • high
  • The factors that have predicted mortality in studies evaluating patients prior to initiation of ART include a low CD4 cell count, high HIV RNA, mild to severe anaemia, low body mass index, elevated aspartate aminotransferase (AST), a history of opportunistic infections, and depression. (scielo.org.za)
  • However at other points of the study, high antibody users had more positive urine results. (wikipedia.org)
  • Cohort
  • We conducted a retrospective cohort study of all patients who started ART at the Sinikithemba Clinic from 1 January 1999 to 29 February 2004. (scielo.org.za)
  • In the first dose-finding cohort (afatinib 40 mg plus nimotuzumab 100 mg), one patient experienced dose-limiting toxicity (DLT) of grade 3 diarrhea and in the subsequent cohort (afatinib 40 mg plus nimotuzumab 200 mg), two DLTs (grade 3 diarrhea and grade 3 neutropenia) occurred in 2 of 6 patients. (aacrjournals.org)
  • characteristics
  • It was usual for clinics to present results without relevant contextual information such as sample size, reporting period, the characteristics of patients and particular details of treatments. (bmj.com)
  • The possible role of baseline clinical and epidemiological characteristics in influencing the prognosis of such patients was also considered. (ahajournals.org)
  • Patient characteristics are anything innate about the patients themselves. (wikipedia.org)
  • The impact of perceived therapist characteristics on patients decision to return or not return for more sessions. (wikipedia.org)
  • phase
  • In phase Ib stage, patients received afatinib (40 mg or 30 mg once daily) plus nimotuzumab (100 mg or 200 mg once weekly) for 28-day cycles to determine the recommended phase II dose (RPIID). (aacrjournals.org)
  • In total, 50 patients were enrolled (13 to phase Ib and 37 to phase II). (aacrjournals.org)
  • initiation
  • Interventions enabling patients to be identified before they develop these clinical markers and earlier initiation of ART will help to ensure maximum benefits of therapy. (scielo.org.za)
  • denial
  • This denial of care can quickly lead to patient dropout. (wikipedia.org)
  • In June 2008, the American Medical Association (AMA) House of Delegates stated that the denial to patients with gender dysphoria or otherwise covered benefits represents discrimination, and that the AMA supports "public and private health insurance coverage for treatment for gender dysphoria as recommended by the patient's physician. (wikipedia.org)
  • violations
  • Protocol violations" may occur, such as when the patients do not receive the full intervention or the correct intervention or a few ineligible patients are randomly allocated in error. (wikipedia.org)
  • Methods
  • Methods -Cerebral hemodynamics were studied with transcranial Doppler ultrasonography. (ahajournals.org)
  • The purpose of this manuscript is to describe patient-centred approaches used both in developing and testing the Health-E You app and to present the research methods used to evaluate its effectiveness in improving intentions to use an effective method of contraception as well as actual contraceptive use. (bmj.com)
  • discontinuation
  • Social stigma of mental health treatment may also result in increased patient discontinuation. (wikipedia.org)
  • HIV-infected patients taking cenicriviroc had significant reductions in viral load, with the effect persisting up to two weeks after discontinuation of treatment. (wikipedia.org)
  • group
  • For the first part of the study, researchers put a group of mice with autoimmune disease on a fasting-mimicking diet for three days, every seven days for three cycles, with a control group on a standard diet for comparison. (fightaging.org)
  • In a prospective, randomized, controlled study, 240 patients were randomized to receive either AQUACEL Ag Surgical dressing (study group) or a standard dressing (control group) after MIS-TKA. (hindawi.com)
  • Variations in the immune status of patients in each group throughout follow-up. (clinicaltrials.gov)
  • This study uses a cluster randomised control trial design in which 18 school-based health centers from the Los Angeles Unified School District were randomly assigned, at equal chance, to either the intervention ( Health-E You app) or control group. (bmj.com)
  • After a defined time period, the patients in the test group are assessed for health improvements in comparison with the control group. (wikipedia.org)
  • Blinding should be appropriate to the study, and is ideally double blind, wherein neither the patient nor doctor is aware of whether they are in the control or test group, eliminating any such psychological effects from the study. (wikipedia.org)
  • conduct
  • Links to other clinical trial technologies being used for a study can be incorporated into the portal to provide users with a common technology platform for the studies they conduct. (wikipedia.org)
  • research
  • Within 1 week of admission to the hospital, patients are interviewed by a research assistant about previous use of complementary or alternative medicine therapies, knowledge of healing touch (HT), previous experience with HT, willingness to participate in a study of HT for acute leukemia patients, and willingness to be randomized in a HT study. (clinicaltrials.gov)
  • For non-commercial purposes only, such as research, private study and education. (ubc.ca)
  • To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. (clinicaltrials.gov)
  • Clinical portals can be developed for a particular study, however study-specific portals may be part of larger, clinical sponsor or Contract Research Organization (CRO) portals that cover multiple trials. (wikipedia.org)
  • viral load
  • This study has been designed to determine whether the use of a regimen based exclusively on NTRI, containing tenofovir, zidovudine and lamivudine, is able to preserve immunological status in patients with detectable viral load for whom an efficacious salvage regimen cannot be designed, slowing the progression of the viral load and reducing antiretroviral treatment-associated toxicity. (clinicaltrials.gov)
  • antiretroviral
  • To identify predictors of mortality in patients initiating antiretroviral therapy (ART) in Durban, South Africa. (scielo.org.za)
  • To evaluate whether the combined therapy of two nucleosides plus one nucleotide (Trizivir + TDF) manages to keep CD4 lymphocytes stable in patients with HIV infection on antiretroviral treatment that present virological failure and multiple resistance to antiretrovirals. (clinicaltrials.gov)
  • important
  • As more patients begin treatment, it is important to identify factors that predict a higher risk of mortality so that they can be more closely monitored. (scielo.org.za)
  • Among respondents in the Asia/Pacific region, inconvenience (10%) and fear of or history of ocular infections (17.5%) were also important factors contributing to patient dropouts. (reviewofoptometry.com)
  • Choosing to participate in a study is an important personal decision. (clinicaltrials.gov)
  • One of the most important problems in analyzing a clinical trial is the occurrence of the dropout. (wikipedia.org)
  • The most important one is that the quality of included studies was not optimal. (wikipedia.org)
  • Training of study teams and site staff is becoming more important as the industry shifts to a more technology-driven environment. (wikipedia.org)
  • It was found that eCompliance helps to draw patients to the center by incentivizing health workers to convince patients to come and by persuading patients that in-person visits are important. (wikipedia.org)
  • effects
  • Here, results are presented for a study of its effects on multiple sclerosis in animal models of the disease and human patients. (fightaging.org)
  • Cyclically, long waiting lists have shown some increased dropout effects, further exacerbating the problem. (wikipedia.org)
  • meta-analysis
  • There are several meta-analysis studies that addressed these issues. (wikipedia.org)
  • A 2007 meta-analysis found that the effectiveness of CBT depends on the diagnostic criteria used, with studies using the Oxford criteria having a trend towards significantly higher effect sizes that those using the CDC criteria. (wikipedia.org)
  • psychological
  • For example, it may be used help the patient cope with their disability by better management of rest and activity within the boundaries of the energy constraints of the disorder, and does not actively attempt to improve the patient's physical or psychological capacity. (wikipedia.org)
  • effectiveness
  • This can lead to lower self-esteem, confidence, and thus their effectiveness which will negatively impact their delivery of treatments to other patients. (wikipedia.org)
  • Perceptions of mental health may also alter patient beliefs about the effectiveness of mental health treatment. (wikipedia.org)
  • describe
  • To receive the corresponding point, an article should describe the number of withdrawals and dropouts, in each of the study groups, and the underlying reasons. (wikipedia.org)
  • findings
  • These latest findings follow studies that showed cycles of a similar but shorter fasting-mimicking diet, when paired with drug treatments for cancer, protect normal cells while weakening cancerous ones. (fightaging.org)
  • However
  • However, by restricting the analysis to a selected patient population, it does not show the practical value of the new drug. (wikipedia.org)
  • However, the authors of this analysis addressed several limitations with this study by stating, "This study has several limitations. (wikipedia.org)
  • however, only TFP has been shown to change how patients think about themselves in relationships. (wikipedia.org)
  • closely
  • Closely monitor patients with history of allergic reactions to sulfasalazine or sulfite sensitivity (if using enema). (thefreedictionary.com)
  • Goldberger on the other hand suspected that diet was the true cause, which he came to believe through his observations of pellagra and the fact that hospital staff who worked closely with pellagra patients did not fall sick themselves. (wikipedia.org)
  • treatments
  • Also, the per-protocol restricts the comparison of the treatments to the ideal patients, that is, those who adhered perfectly to the clinical trial instructions as stipulated in the protocol. (wikipedia.org)
  • median
  • The median future value over the lifetime of a single contact lens dropout was calculated to be $19,497 to $24,556. (reviewofoptometry.com)
  • Sixty-five patients with internal carotid artery occlusion were followed-up prospectively (median, 24 months), 23 patients were asymptomatic and 42 symptomatic (20 with transient ischemic attack and 22 with stroke). (ahajournals.org)