Study lymphatic metastasis. Medical search. Frequent questions

Routine histologic examination of axillary lymph nodes, including sentinel lymph nodes, in cases of breast carcinoma significantly underestimates lymph node metastases. (nih.gov)
However, lymph node metastases of this tumor have been described in few reports. (nih.gov)
Disease prognosis could be improved if there was a way to safely and effectively treat lymph node metastases. (reachmd.com)
Kodama and his colleagues in Japan had previously tested their treatment on mice with a type of breast tumour that produces lymph node metastases with low invasive growth and well-defined borders. (reachmd.com)
Although CT and MRI also provide fairly accurate and equivalent assessments of lymph node metastases, ultrasound and PET/CT have been shown to have a slightly superior accuracy for this function. (ahns.info)

We studied tumour lymphangiogenesis and lymphatic invasion using D2-40 endothelial marker in 35 breast cancer patients treated by primary surgery and correlated it with various clinico-pathological prognostic parameters. (scirp.org)
M. A. Ansari, V. Pandey, V. Srivastava, M. Kumar, R. Mishra and A. Kumar, "Lymphangiogenesis as a Prognostic Marker in Breast Cancer Using D2-40 as Lymphatic Endothelial Marker-A Preliminary Study," Journal of Cancer Therapy , Vol. 3 No. 5A, 2012, pp. 814-821. (scirp.org)
Suppression of Tumour Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling," Journal of the National Cancer Institute, Vol. 94, No. 11, 2002, pp. 819-825. (scirp.org)
Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium," American Journal of Pathology, Vol. 154, 1999, pp. 385-394. (scirp.org)
We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)
In addition, lymphatic endothelial cells of different organs have been recently shown to have alternative developmental origins, which may contribute to the development of the diverse lymphatic vessel and endothelial functions seen in the adult. (nih.gov)
LYVE1, also known as lymphatic vessel endothelial receptor 1 or lymphatic vessel endothelial hyaluronic acid receptor 1, is a member of the link protein family, which has the capability to bind with hyaluronic acid. (prospecbio.com)
A CD44 homolog, which is located primarily in lymphatic endothelial cells, LYVE 1 has a number of known functions, but research is ongoing and more could be established in the future. (prospecbio.com)
LYVE1 is mainly found in the endothelial cells that line lymphatic vessels. (prospecbio.com)
LYVE1 has also been found to play a role in HA localisation to the surface of the endothelial cells that line the lymphatic tissue. (prospecbio.com)
When acting as a transporter for HA, LYVE1 can take on various roles, including moderating the uptake for catabolism within the lymphatic endothelial cells or delivering HA into the lumen of lymphatic vessels for reuptake in the lymph nodes. (prospecbio.com)
These structures express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both fluid and immune cells from the CSF, and are connected to the deep cervical lymph nodes. (scienceopen.com)

20 years ago [ 1 ], sentinel lymph node biopsy (SLNB) was introduced for melanoma patients and later for numerous other tumors with lymphatic metastatic propensity. (hindawi.com)
Biodistribution studies revealed accretion of 89 Zr-DFO-mAb-B43.13 in the OVCAR3 tumors, ultimately reaching 22.3 ± 6.3 percentage injected dose per gram (%ID/g) at 72 h after injection. (snmjournals.org)
Sertoli cell tumors and seminomas rarely exhibit regional or distant metastasis, though local invasion is common. (acvr.org)
In 1995, we demonstrated the prognostic importance of lymphatic invasion in rectal cancer and advocated the subdivision of stage III (Dukes' C) tumors according to lymphatic invasion ( 12 ). (iiarjournals.org)
They travel around a person's body in the blood and lymphatic system to other locations, where they may grow and form new tumors in the surrounding tissues. (medicalnewstoday.com)
This is the most sensitive test available to detect metastasis or second primary tumors. (medscape.com)
Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)

In fact, over two-thirds of lung cancer patients have regional lymph-node involvement or distant metastases at the time of presentation [ 3 ]. (hindawi.com)
Ultimately, physicians can exercise their own preferences for imaging of patients with HRcSCC in order to evaluate 1) the extent of local invasion, 2) the possibility of regional metastases to the parotid and/or neck, and 3) the presence of distant metastases. (ahns.info)
7 Positron emission tomography (PET)/CT provides additional information about the presence or absence of distant metastases. (ahns.info)
0.001 for both), stage (p=0.002), and presence of distant metastases (p=0.03). (omicsonline.org)

Cervical metastasis has a tremendous impact on the prognosis in patients with carcinomas of the head and neck. (medscape.com)
In view of poor prognosis at the time of future relapse, persons with primary lesions with more than 20% likelihood of metastasis should undergo either surgery or radiation therapy at the time of primary treatment. (medscape.com)
The prognosis is dependent on the stage of the disease and extent of metastases. (hindawi.com)
The aim of the present study was to perform the accurate prognosis of different molecular types breast cancer (BC) by using the partitioning calculation method of the Ki‑67 index. (spandidos-publications.com)
On the whole, the present study demonstrates that the partitioning calculation of the Ki‑67 index can be used to judge the prognosis of patients with BC accurately. (spandidos-publications.com)
Lymph nodes are the most common location for metastasis, with a strong correlation between metastasis in the lymphatic system and prognosis. (medscape.com)
The aim of this study was to investigate the importance of ENE in predicting prognosis and presence of pelvic lymph node metastasis (PLNM) in penile cancer patients. (omeka.net)

165 U/L were 3.29 times more likely to have lymph node involvement than patients with ALP levels 165 U/L. There was no statistically significant correlation between ALP level and sex, age, tumour histological type, site and size of tumour, depth of penetration, distant metastasis, degree of differentiation, presence of lymphatic invasion and presence of simultaneous multiple cancers. (who.int)
Tumour Angiogenesis and Metastasis-Correlation in Invasive Breast Carcinoma," The New England Journal of Medicine, Vol. 324, No. 1, 1991, pp. 1-8. (scirp.org)
We believe that our technique has the potential to be developed into a new treatment for lymph nodes invaded by metastatic tumour cells," says Tetsuya Kodama, the Tohoku University biomedical engineer who led the study. (reachmd.com)
In its advanced stages, cancer cells can break away from the original tumour and travel through the lymphatic system to establish metastases in lymph nodes that can then travel to other parts of the body. (reachmd.com)
As well as being involved in HA degradation and transportation, studies indicate that HA localisation towards lymphatic surfaces, which is linked to LYVE1, can affect the body's immune responses and tumour metastases. (prospecbio.com)

The goals of the studies proposed in this Project are to extend past analyses of platelet thrombus formation and structure from the microvasculature to the macrovasculature, from mice to humans, and from hemostasis to thrombosis. (hhs.gov)

Lymphatic invasion was observed in 3 cases, two of them had pelvic lymph node metastasis. (nih.gov)

Twelve PCa patients with biochemical recurrence (BCR) after primary therapy who prospectively underwent a baseline 68 Ga-PSMA-PET/CT initially showed MLN metastases. (frontiersin.org)
PET imaging of CA125 expression by ovarian cancer cells may enhance the evaluation of the extent of disease and provide a roadmap to surgery as well as detect recurrence and metastases. (snmjournals.org)
High-risk" features of cSCC are defined as those that are associated with increased risk of recurrence, increase risk of regional and/or distant metastasis, and/or increased risk disease-specific death. (ahns.info)
BACKGROUND: Although only a small proportion of thin melanomas result in lymph node metastasis, the abundance of these lesions results in a relatively large absolute number of patients with a diagnosis of nodal metastases, determined by either sentinel lymph node (SLN) biopsy or clinical nodal recurrence (CNR). (providence.org)

It is widely accepted that tumor metastasis is a formidable barrier to effective treatment of lung cancer. (hindawi.com)
In addition to forming hemostatic plugs at sites of vascular injury, platelets make important contributions to processes such as inflammation, tissue regeneration, host defense, angiogenesis, lymphatic development, and tumor metastasis. (hhs.gov)

Retrospective serial sectioning of axillary lymph nodes has revealed undetected metastases in 9-30% of these patients. (nih.gov)
Tumor metastases were found in 6 patients (12%) when the sentinel lymph nodes were sectioned at 2 mm intervals and stained with H & E, compared with 30 patients (58%) when the same lymph nodes were serially sectioned at 0.25 mm intervals and stained with cytokeratin. (nih.gov)
Of 24 patients whose metastases were detected by SS and cytokeratin staining, 12 had isolated tumor cells and 12 had colonies of several thousand malignant cells. (nih.gov)
This multicenter trial included esophageal cancer patients with clinical T4 disease and/or unresectable regional lymph node metastasis. (nih.gov)
In 1880, Kocher and Uber reported the detrimental effect of neck metastasis in patients with head and neck cancer. (medscape.com)
Fifteen studies that analyzed the expression of 15 lncRNAs in 1434 CRC patients were included. (jcancer.org)
Previous studies have indicated that the colorectal cancer patients in the early stage would gain longer survival time with standard treatment [ 3 - 5 ]. (jcancer.org)
The primary objective of the overall study is to determine the maximum tolerated dose (MTD) of ipilimumab that can be administered through the DoseConnect™ device, followed 30 minutes later by nivolumab IV on Day 1 of a 21-day cycle in patients with metastatic melanoma. (mayo.edu)
Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. (hindawi.com)
Bone metastasis is a major determinant of treatment outcome, quality of life, and survival for lung cancer patients [ 12 - 14 ]. (hindawi.com)
Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)
Besides the known oncological benefits of ADT and sRT, in case of sole MLN metastases individualized therapy like salvage lymphadenectomy or RT with a defined radiation field could be options for these patients. (frontiersin.org)
Further studies have confirmed the advantage of 68 Ga-PSMA PET/CT compared to conventional imaging as well as functional 18 F-choline-based PET/CT for patients with BCR ( 5 , 8 - 11 ). (frontiersin.org)
however showed PCa metastases in mesorectal lymph nodes (MLN) in 12 of 76 patients with BCR, which were detected by 68 Ga-PSMA PET/CT ( 11 ). (frontiersin.org)
Previous reports either described MLN metastases of PCa occurring in sentinel lymph node scintigraphy or as a random result during anterior rectal resection in patients with rectal cancer ( 16 - 19 ). (frontiersin.org)
However, many studies have reported that lymphadenectomy is associated with increased morbidity and no survival benefit in low-risk EC patients [ 6 - 8 ]. (medsci.org)
However, because of its low morbidity when compared to empiric elective lymph node dissection or radiation therapy of lymphatic basins, SLNB has allowed sparing a lot of morbidity and could therefore be used in nonmelanoma skin cancer patients, even though a significant impact on survival has not been demonstrated. (hindawi.com)
The aim of our present study was to analyze the rate of positive SNs and reliability regarding false negative rate during followup in nonmelanoma skin cancer patients in our series and compare our data with a review of the current literature. (hindawi.com)
In this study, we extended the prognostic analysis to CRC patients with metastasis who underwent surgery in order to select the predictive factors from these available and inexpensive laboratory data. (scirp.org)
Patients with clinically confirmed stage IV CRC diagnosed at Juntendo University Hospital between January 2006 and December 2012 were eligible to be in this study. (scirp.org)
Patients who had non-elective surgery, pre-operative radiotherapy and chemotherapy and showed clinical evidence of infection or other inflammatory conditions were excluded from the study. (scirp.org)
A previous study demonstrated elevated sVAP-1 levels in CRC patients. (biomedcentral.com)
Patients with FTC are more likely to develop lung and bone metastases than are patients with papillary thyroid cancer. (medscape.com)
Older patients have an increased risk of developing bone and lung metastases. (medscape.com)
It could improve quality of life in patients with bone metastases. (medscape.com)
In HRcSCC patients, imaging has been shown, at least by one study 6 , to change management in one-third of patients and may even improve outcomes. (ahns.info)
For lymph node metastasis assessment, the majority of studies that evaluate the utility and accuracy of head and neck imaging are in patients with mucosal SCC, not cutaneous SCC. (ahns.info)
8 A review of 17 studies that each compared imaging assessments of neck lymph nodes to histopathologic findings in patients with head and neck aerodigestive SCC found that CT, MRI, and US all had fairly similar sensitivities, ranging from 80-87%, with US having the highest sensitivity. (ahns.info)
In the present study, we retrospectively reviewed the treatments given to patients with LGESS to evaluate the efficacy of different treatment modalities on survival. (heraldopenaccess.us)
The study included the LGESS patients from January 2006 to December 2018 who had been pathologically diagnosed according to 2014 WHO classification and staged based on International Federation of Gynecology and Obstetrics (FIGO) 2009 staging classification. (heraldopenaccess.us)
For patients with multiple metastases, cytoreductive surgeries were performed. (heraldopenaccess.us)
Apart from these, the results from clinical studies have shown that Astragalus polysaccharides counteract against the side-effects of chemotherapeutic drugs, including a significant attenuation of myelosuppression in cancer patients ( 7 ). (spandidos-publications.com)
Dr. Elliott and his team are working to understand the mechanisms of cancer metastasis to the lymph nodes, a key indicator of a poor outcome in cancer patients. (queensu.ca)
Materials and methods A total of 218 eligible patients with advanced stage (stage III/IV) OSCC and neck metastasis were enrolled. (ntu.edu.tw)
RESULTS: A total of ten studies with 1,142 patients were included in this meta-analysis. (omeka.net)
At both centers, SLN metastasis patients were included. (providence.org)
CONCLUSION: Patients with nodal metastases from thin melanomas have a substantial risk of melanoma death. (providence.org)
The present study examined correlations between lymphatic invasion and lymph node metastasis or disease stage, and clarified the prognostic impact of lymphatic invasion, based on a large series and long-term follow-up of patients with colorectal cancer curatively treated. (iiarjournals.org)
This study was approved by our hospital Ethics Committee (#06043) and informed consent was obtained from patients prior to enrollment. (iiarjournals.org)
Age and sex of patients, site, gross type, size (maximum tumor diameter), preoperative serum level of carcinoembryonic antigen (CEA), depth of wall invasion, status of lymph node metastasis, histopathological differentiation, degree of lymphatic and venous invasion, and presence or absence of postoperative adjuvant chemotherapy were extracted from operation records and pathology reports. (iiarjournals.org)
This study was conducted on 33 biopsies obtained from patients with OSCC and 10 normal oral mucosa as controls. (bvsalud.org)
Future studies with a larger number of patients are highly recommended to address the possible association between TIMp-2 and OSCC positive HPV-16. (bvsalud.org)
Thus, the goal of this study was to determine if K17 expression is a negative prognostic biomarker associated with decreased survival of patients with endocervical adenocarcinoma. (medscape.com)
The role of staging laparoscopy in primary gall bladder cancer--an analysis of 409 patients: a prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer. (cancercentrum.se)
AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group. (cancercentrum.se)
bed into the left ventricle, from where or intramyocardial, However, when a Most patients with calcification of it could reach any part of the body cyst is located in subendocardial en- the cyst wall remain asymptomatic for through systemic circulation [1-3]. (who.int)

In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)

Presence of lymphatic invasion and deep stromal involvement appeared to be the risk factors for lymph node metastasis of well-differentiated villoglandular adenocarcinoma. (nih.gov)
Predictive factors of cervical metastasis are primary site, primary tumor size, degree of differentiation of tumor, perineural invasion, perivascular invasion, inflammatory response, and tumor DNA content (ploidy). (medscape.com)
Prognostic Value of Lymphatic and Blood Vessel Invasion in Neuroendocrine Tumours of the Lung," The American Journal of Surgical Pathology, Vol. 29, 2005, pp. 324-328. (scirp.org)
Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. (hindawi.com)
Brigham and Womens' stage T2b (defined as 2-3 of the following risk factors: tumor diameter ≥ 2 cm, poorly differentiated histology, depth of tumor invasion beyond fat, and/or perineural invasion ≥ 0.1 mm) has been shown to have a 21-30% risk of regional micrometastases, thereby indicating a significant risk for occult metastasis. (ahns.info)
Histopathology of the testicle showed both a Sertoli cell tumor and seminoma with invasion of neoplastic Sertoli cells into blood vessels and lymphatics. (acvr.org)
Surgical excision is generally curative, however given the evidence of vascular and lymphatic invasion in this case, post-operative chemotherapy was recommended. (acvr.org)
Aim: To determine correlations between lymphatic invasion and lymph node metastasis or disease stage, and clarify the prognostic impact of lymphatic invasion. (iiarjournals.org)
Lymphatic invasion was calculated as an average and the degree was also determined (Ly0-3). (iiarjournals.org)
Clinicopathological factors including lymphatic invasion were assessed by uni- and multivariate analyses to determine factors affecting survival. (iiarjournals.org)
Survival was compared between different degrees of lymphatic invasion and lymph node metastasis. (iiarjournals.org)
Conclusion: Lymphatic invasion in colorectal cancer correlates well with the status of lymph node metastasis and disease stage, representing an independent prognostic factor after curative resection. (iiarjournals.org)
Lymphatic invasion can be used for evaluating tumor aggressiveness and estimating patient survival, irrespective of the actual number of positive lymph nodes found. (iiarjournals.org)
It is well-known that not only the presence or absence of lymph node metastasis, but also the degree of presence, is an important prognostic factor, along with depth of tumor invasion, and is useful in determining the adjuvant chemotherapy and surveillance program ( 3 , 4 ). (iiarjournals.org)

Therefore, this complex regulatory network requires precise control of gene expression patterns at both transcriptional and post-transcriptional levels in order to ensure proper maturation, differentiation, and formation of blood and lymphatic vessels. (nature.com)

The presence of neck metastasis is known to reduce survival by 50%, and the frequency of such spread is greater than 20% for most squamous cell carcinomas (SCCAs). (medscape.com)

With regard to sentinel node (SN) biopsy, few studies have validated the SN hypothesis for oral and oropharyngeal cancer. (medscape.com)
Previous large observational cohort studies showed higher blood pressure (BP) positively associated with cancer. (biomedcentral.com)
Leptin Receptor (LEPR) has been suggested to have several roles in cancer metastasis. (biomedcentral.com)
High LYVE-1-Positive Lymphatic Vessel Numbers Are Associated with Poor Outcome in Breast Cancer," Clinical Cancer Research, Vol. 10, No. 21, 2004, pp. 7144-7149. (scirp.org)
Absence of Functional Lymphatics within a Murine Sarcoma: A Molecular and Functional Evaluation," Cancer Research, Vol. 60, No. 16, 2000, pp. 4324-4327. (scirp.org)
We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
Involvement of bone in lung cancer metastases is a major source of morbidity and mortality arising from skeletal related events (SREs) [ 10 ]. (hindawi.com)
This underscores the need to assess molecular targets that can be exploited in prevention or clinical management of lung cancer metastases to bone. (hindawi.com)
Thus, in this report, we will assess the data on lung cancer bone metastases with the intention of evaluating key molecular targets that could be applied in optimizing lung cancer treatment strategies. (hindawi.com)
We conducted a pan-cancer association (26 cancers) study in the Surveillance, Epidemiology, and End Results (SEER) database (non-Hispanic whites). (elifesciences.org)
A certain type of primary cancer may cause another second primary cancer, and the profound mechanisms need to be studied in the future. (elifesciences.org)
This study presents a valuable finding on the causal relationship between second primary cancers and the initial diagnosis of a primary cancer via rigorous analysis of large-scale data. (elifesciences.org)
The strength of the study lies within the combination of pan-cancer analysis and the incorporation of Mendelian randomization. (elifesciences.org)
They are not caused by the spread of the original tumor like a cancer metastasis. (elifesciences.org)
Several studies have demonstrated an advantage of 68 Ga-PSMA-PET/CT as staging modality for detection of prostate cancer (PCa) metastases. (frontiersin.org)
However, studies with the major focus on immune mechanisms, role of lymphatics in cancer metastasis and study of lymphatic vessels in organs other than those from the digestive system will not be considered responsive. (nih.gov)
The vesicles travel through the lymphatic system to reach lymph nodes in the armpit affected by breast cancer metastases. (reachmd.com)
For this study, they tried the treatment on the more invasive metastases generated by breast cancer. (reachmd.com)
The team demonstrated that the treatment was effective in killing the cancerous tissue using a bioluminescence technique that monitors cancer growth, and by studying excised lymph nodes under a microscope. (reachmd.com)
In cancer, the lymph nodes that drain solid tumours are a primary site of metastasis, and recent studies have suggested intrinsic links between lymphatic function, lipid deposition, obesity and atherosclerosis. (monash.edu)
The Review Board of Fudan University Shanghai Cancer Center approved the study. (heraldopenaccess.us)
Sometimes cancer cells break away from a tumor and spread to other parts of the body through the lymphatic system or bloodstream. (survivorshipatoz.org)
Deciphering the mechanisms underlying increased risk of brain metastases in young women with triple negative breast cancer. (cuanschutz.edu)
Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
MMPs have been implicated in these processes and a previous study has suggested that the plasma level of MMP-2 and MMP-9 may be viewed as a non-invasive indicator of invasiveness and metastasis in colon cancer ( 3 ). (spandidos-publications.com)
Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
Working in the Queen's Cancer Research Institute, researchers study cancer cells under a microscope. (queensu.ca)
Dr. Greer is studying Arpin, a recently discovered protein that plays a role in the spread of cancer. (queensu.ca)
This information will move us a step closer to testing therapies that can prevent early cancer spread to the lymphatic system. (queensu.ca)
BACKGROUND: The role of extranodal extension (ENE) in penile cancer is controversial and has not been well studied. (omeka.net)
Background: The degree of lymph node metastasis represents an important prognostic factor for cancer. (iiarjournals.org)
Although the prognostic import of lymph node metastasis is widely accepted in colorectal cancer, 12 nodes or more must be examined to adequately assess the degree of lymph node metastasis ( 5 , 6 ). (iiarjournals.org)
Healthcare professionals call the process of cancer spreading metastasis. (medicalnewstoday.com)
In metastasis, cancer cells grow and then break away from where they first formed. (medicalnewstoday.com)
The prevalence of oral cancer during 2003-2006 in Iraqi governorates in relation to sex, age and site has been estimated, and the study found that the highest prevalence (55.81%) was observed in tongue, while the lowest (3.87%) was found in the floor of the mouth (Al-Kawaz, 2010) 8 . (bvsalud.org)
Trends in cancer incidence, mortality, and patient survival in the United States, as well as many other studies, are derived from this data bank. (cdc.gov)
Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
This study is a systematic review of scientific articles on IBC with reference to the diagnosis, treatment, determinants and prognostics of this type of cancer. (bvsalud.org)
Winter PD, Gardner MJ, Fletcher AC, Jones RD. A mortality follow-up study of pottery workers: preliminary findings on lung cancer. (who.int)
Lung, kidney, and brain cancer showed elevation in some studies but were not consistent. (who.int)
2006) it would be good if that future epidemiological studies of relationships between lead exposures and cancer should include evaluation of genetic susceptibility factors, such as the ALAD gene. (who.int)
Finally, further experimental research studies are needed to evaluate the complex mechanisms by which lead may cause cancer with particular emphasis on the roles of oxidative stress / apoptosis and the roles of cellular defense mechanisms, signaling pathways and intracellular lead binding patterns in mediating these processes. (who.int)

The true clinical significance of these occult metastases will be determined by long term follow-up. (nih.gov)
This study was registered at the UMIN Clinical Trials Registry as UMIN000000861. (nih.gov)
Describes the nature of a clinical study. (mayo.edu)
They also quantify the relative incidence and extension of these anatomical variations and provide several preoperative, postoperative, and microneurosurgical clinical case study examples. (thejns.org)
Thus, animal models and clinical studies, although still in their infancy, strongly suggest that AD inflammation significantly contributes to AD pathogenesis. (scienceopen.com)
Clinical evaluation, imaging studies, indications for cytologic study and preprocedural requirements for duct brushing studies and pancreatic fine-needle aspiration: The Papanicolaou Society of Cytopathology Guidelines. (cancercentrum.se)

However, the role of LEPR and its underlying mechanisms in lymphatic metastasis of hepatocarcinoma have not yet been studied. (biomedcentral.com)
Studies to understand the factors that control local lymphatic vessel functional anatomy and physiology and development during health or disease in this system and its organs, and the mechanisms by which alterations of lymphatic vessel function affect organ function, are of interest. (nih.gov)
Here, we briefly summarize the lymphatic system in health and disease and the varying mechanisms of lymphatic entry and transport, as well as discussing examples of lymphatic delivery that have enhanced therapeutic utility. (monash.edu)

In the cases of lung metastasis, metachronous resection was performed. (scirp.org)
In our in vivo experiments, apelin significantly increased the number and size of lung metastases of murine melanoma cells. (hal.science)
Molecular Features in Lymphatic Metastases Reflect the Metastasis Mechanism of Lymph Nodes With Non-Small-Cell Lung Cancers. (cdc.gov)

Lymphatic vessels perform critical roles in organ functions, yet their roles in health and disease are poorly understood and understudied. (nih.gov)
In the digestive system, lymphatic vessel function is interwoven with organ function, both anatomically and physiologically and these vessels lie at the nexus of critical hormonal, digestive and immune functions. (nih.gov)
Lymphatic vessels within different organs and in different physiological and pathological processes show a remarkable plasticity and heterogeneity, reflecting their functional specialization. (nih.gov)
Many of these functions include key roles of lymphatic vessels, yet the roles of lymphatics, the character of the vessels in the intestinal environment and key regulators of lymphatic function in intestinal health and disease remain understudied. (nih.gov)
Immunohistochemical studies have demonstrated weak expression of VAP-1 in Peyer's patches and lamina proprial vessels of the gut with increased staining in inflammatory bowel disease. (biomedcentral.com)
In searching for T cell gateways into and out of the meninges, we discovered functional lymphatic vessels lining the dural sinuses. (scienceopen.com)
The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature in the CNS. (scienceopen.com)

This patient series included those who underwent primary tumor resection, a bypass or a proctostomy and those who underwent the simultaneous resection of metastases with curative intent. (scirp.org)

[ 15 ] Other studies have shown K17 to be a negative prognostic indicator in gastric adenocarcinoma, bladder carcinoma, epithelial ovarian carcinoma, and triple-negative breast carcinoma. (medscape.com)

Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis. (bvsalud.org)
Recent studies outline the altered microenvironment of LNs shaped by melanoma mediators. (bvsalud.org)
METHODS: Independent cohorts with thin melanoma and either SLN metastasis or CNR were identified at two melanoma referral centers. (providence.org)
Melanoma cell proliferation rates and lymph and blood microvessel densities were significantly higher in the apelin-overexpressing pulmonary metastases. (hal.science)
Our results show that apelin promotes blood and lymphatic vascularization and the growth of pulmonary metastases of skin melanoma. (hal.science)

1906: Crile developed the en bloc cervical lymphadenectomy known as the RND. (medscape.com)

Four of thirteen cases without nodal metastasis were lost to follow-up 36 to 59 months after surgery. (nih.gov)

The blood and lymphatic vascular systems are essential for the efficient transport of oxygen, nutrients, signaling molecules, and leukocytes to and from peripheral tissues, the removal of waste products, and the preservation of fluid homeostasis. (nature.com)

We use a broad repertoire of biochemistry, cell biology, live cell imaging and animal models to study the impact of mitochondria shape, number and subcellular distribution in metastatic dissemination. (cuanschutz.edu)

[ 6 , 7 ] When adenocarcinomas are present, they tend to be larger in size and have a propensity for early lymphatic and hematogenous metastasis. (medscape.com)

Drugs can be safely delivered to cancerous lymph nodes via the lymphatic system and then released inside the nodes using sound waves. (reachmd.com)
Lymphoscintigraphy is an important procedure because if the sentinel node is free of metastasis, subsequent nodes are also likely to be free of disease. (medscape.com)
Histopathological examination of dissected nodes was performed to confirm metastasis. (jefferson.edu)
Lymph nodes are located in many places on the lymphatic system throughout the body. (survivorshipatoz.org)
Lymph nodes filter lymphatic fluid. (survivorshipatoz.org)

These occult metastases have been shown to have an adverse effect on survival. (nih.gov)

The objective of this study was to propose a new classification system for these parasagittal bridging veins, which are herein described as being arranged in 3 configurations with 4 drainage routes. (thejns.org)
[ 6 ] Sentinel node scanning was initially studied in cutaneous melanomas to detect lymphatic drainage patterns before surgery. (medscape.com)
One of the characteristics of the CNS is the lack of a classical lymphatic drainage system. (scienceopen.com)

We believe that these molecular targets could guide in determining timing of therapeutic interventions that offer the best opportunity to prevent and/or halt extent of bone metastases. (hindawi.com)
Our lab is interested in studying metabolic properties of myelodysplastic syndrome cells in order to develop novel therapeutic strategies. (cuanschutz.edu)
Further studies are warranted to validate apelin signaling as a new potential therapeutic target in this malignancy. (hal.science)
If metastases are present in the chest, the therapeutic decision tree changes entirely. (medscape.com)

Squamous cell carcinoma arising from giant porokeratosis: a case with extensive metastasis and hypercalcemia. (qxmd.com)

We evaluated whether RT plus LDPF chemotherapy had an advantage in terms of survival and/or toxicity over RT plus standard-dose cisplatin and 5-fluorouracil (SDPF) chemotherapy in this study. (nih.gov)
Certainly, the presence of bone metastasis usually leads to worse outcome and shorter median survival [ 11 , 15 , 16 ]. (hindawi.com)

Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. (nature.com)
The aim of this study was to confirm this finding and study the differences in tissue VAP-1 expression between CRC and healthy tissues. (biomedcentral.com)
Also known as a lymph gland): A small rounded or bean-shaped mass of lymphatic tissue. (survivorshipatoz.org)
A number of studies have also flagged LYVE1 as a marker for lymphoid tissue and lymphangiogenesis. (prospecbio.com)
Most often, doctors study a sample of tissue from a person's tumor. (medicalnewstoday.com)

Although screening programs have been very effective in decreasing the incidence of SCC by as much as 80%, [ 8 ] studies have shown a contrasting increase in the incidence of cervical adenocarcinoma, particularly in younger women. (medscape.com)

The lymphatic system plays an important role in uptake of dietary fat and clearance of cholesterol from peripheral tissues and has been implicated in several disease states such as obesity, metabolic syndrome and inflammatory bowel disease (IBD). (nih.gov)
This is a systematic review of studies in the PubMed database to April 2013, which fit the eligibility criterion of "Inflammatory Breast Neoplasms" (MeSH Terms), filtered by Languages (English OR Portuguese OR Spanish). (bvsalud.org)

In the cases with lymph node metastasis, adjuvant radiation therapy was also given. (nih.gov)

The team first used an ultrasound imaging technique to follow the movement of drug-free 'acoustic liposomes', vesicles containing gas bubbles, through the lymphatic system in mice. (reachmd.com)
Trans-lymphatic Contrast-Enhanced Ultrasound in Combination with Blue " by Xiangmei Chen, MD, Jieyu Zhong, MD et al. (jefferson.edu)
This study aimed to evaluate a novel method by combining trans-lymphatic contrast-enhanced ultrasound (TLCEUS) with blue dye injection as a guidance of SLNB. (jefferson.edu)

Intraoperative use of phenylephrine versus ephedrine and postoperative delirium: A multicenter retrospective cohort study. (qxmd.com)
A retrospective observational study in Taiwan, 1998- as described ( 10 ). (cdc.gov)
GGS strains identifi ed to the species level ( 2-4 ), we con- to that of the initial episode, including 1 in a patient with ducted a retrospective observational study. (cdc.gov)

Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)

Where longitudinal studies are carried out they should be analysed to look at the way in which changes in exposure are related to changes in outcome. (who.int)

Lymphangiogenesis was quantified using lymphatic micro vessel density (LMVD) by counting the immunostained lymphatic microvessels at 200X. (scirp.org)
The purpose of this FOA is to invite applications that investigate aspects of lymphatic vessel physiology, development and pathophysiology related to health and diseases of the digestive system. (nih.gov)

Some carcinomas can be life threatening or associated with distant metastasis. (touchophthalmology.com)

If the sentinel lymph node is negative for metastasis, it is likely that the neoplasm is still within the location of the primary tumor. (medscape.com)

Improving resectability of hepatic colorectal metastases: expert consensus statement. (cancercentrum.se)
Hepatic resection in 485 R0 pT2 and pT3 cases of advanced carcinoma of the gallbladder: results of a Japanese Society of Biliary Surgery survey--a multicenter study. (cancercentrum.se)

The surgical anatomy of the temporal branches of the FN was studied bilaterally in 5 embalmed heads (n = 10 extracranial FNs). (thejns.org)

Observational study - observes people and measures outcomes without affecting results. (mayo.edu)
Due to the limited number of studies included in this meta-analysis, a large-scale, well-designed study will be required to verify our results. (omeka.net)
These studies may be indicated, as may tests of serum calcium levels, because the results are occasionally anomalous after surgery. (medscape.com)
Results of a Japanese Society of Biliary Surgery Survey: a multicenter study. (cancercentrum.se)
In addition, given positive results from some studies (Keteleslegers et al. (who.int)

In contrast, lymphatic vasculogenesis starts after the establishment of the blood circulatory system. (nature.com)
The lymphatic system is a crucial component of nutrient and hormone absorption, fluid homeostasis and immunity. (nih.gov)
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control. (monash.edu)
The discovery of the CNS lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and shed new light on the etiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction. (scienceopen.com)

Anatomy15

Organisms9

Diseases59

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes12

Disciplines and Occupations1

Information Science2

Health Care12

Geographicals1

Lymph node metastases5

Endothelial13

Tumors7

Distant metastases4

Prognosis7

Tumour5

Humans1

Pelvic lymph node1

Recurrence4

Tumor metastasis2

Patients46

Angiogenesis3

Invasion14

Differentiation1

Neck metastasis1

Cancer42

Clinical6

Mechanisms3

Lung3

Vessels7

Curative1

Breast carcinoma1

Melanoma5

Lymphadenectomy1

Nodal1

Vascular1

Metastatic1

Propensity1

Nodes5

Occult1

Drainage3

Therapeutic4

Squamous Cell Carc1

Survival2

Tissue5

Cervical1

Inflammatory2

Radiation1

Ultrasound3

Retrospective3

Cell proliferation1

Outcome1

Vessel2

Carcinomas1

Primary tumor1

Hepatic2

Surgical1

Results5

System4