Increased risk in patients with renal impairment, including preterm neonates. (drugs.com)
This study evaluated rivaroxaban (RVX) protective effects in testicular impairment by cisplatin (CP). (bvsalud.org)
Severe Renal or Hepatic Impairment in Adults: Use a lower starting dose of 0.5 mg twice daily. (nih.gov)
HIV infection and HAART is associated with low grade hepatotoxicity but no impairment of renal functions in the population studied. (ijbls.org)
In patients with moderate or severe renal impairment, co-administration of bilastine with P-glycoprotein inhibitors, such as ketoconazole, erythromycin, cyclosporine, ritonavir or diltiazem, may increase plasmatic levels of bilastine and, therefore, increase the risk of adverse effects of bilastine. (medscape.co.uk)
Dosage in patients with renal impairment (≤40 mL/min of CRCL) and dialysis patients should be reduced, based on the degree of actual renal function impairment. (sdrugs.com)
In patients with renal impairment (creatinine clearance ≤ 40 mL/min) and dialysis patients (hemodialysis and CAPD), the intravenous dose of Alpit should be reduced to the degree of actual renal function impairment. (sdrugs.com)
Glutamyl11
Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. (wikipedia.org)
Human kidney gamma-glutamyl transpeptidase. (wikipedia.org)
Objective: To compare clinicopathologic features of idiopathic IgA nephropathy in terms of serum gamma-glutamyl transferase (GGT) levels. (afsu.edu.tr)
Can Gamma Glutamyl Transferase Serve as a Marker to Predict the Risk of Metabolic Syndrome in Patients with Type 2 Diabetes Mellitus? (ijmb.in)
Liver disease or liver injury as indicated by abnormal liver function tests such as AST, ALT, gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), or serum bilirubin in the presence of normal serum creatine kinase (CK). (ucbraid.org)
Gamma glutamyl transferase (GGT) is an enzyme found in cell membranes of many tissues mainly in the liver, kidney, and pancreas. (medscape.com)
The enzyme catalyzes the transfer of the gamma-glutamyl group from gamma-glutamyl peptides, such as glutathione to an acceptor such as peptides and L-amino acids. (medscape.com)
This panel may be modified as appropriate for other species, eg, glutamate dehydrogenase (GDH) and/or gamma-glutamyl transferase (GGT) are more appropriate "liver enzymes" for horses and farm animals, or it may be more appropriate to concentrate primarily on muscle enzymes (CK and AST) in athletic animals. (merckvetmanual.com)
In addition, patient N03 had a grade 3 elevation of gamma-glutamyl transferase, and not grade 2 (see corrected Table 2 overleaf). (uni-frankfurt.de)
Results: Overall AUROC values for Age Platelet Index (API), Aspartate to Alanine Ratio (AAR), AST-to-Platelet Ratio Index (APRI), Fibrosis Index based on 4 Factors (FIB-4) and Gamma glutamyl transferase to Platelet Ratio Index (GPR) were 0.52, 0.49, 0.55, 0.55 and 0.54 respectively. (bvsalud.org)
The gamma-glutamyl transferase -to platelet ratio (GPR) was developed and investigated as available test that is useful in predicting liver fibrosis stages in chronic HBV patients. (bvsalud.org)
Hepatic5
patients presented several alterations in hematological, renal, hepatic, and inflammatory marker parameters, which offer a general overview of the state of health with which the patient with COVID-19 is admitted to the hospital. (bvsalud.org)
The efficacy of methotrexate (MTX), a widely used cytotoxic chemotherapeutic agent, is often limited by severe hepatic and renal toxicity. (arccjournals.com)
Here, the aim of this work was to investigate the effect of g-radiation processing on the total phenolic and total flavonoids content of dried basil as well as to study the protective role of g-irradiated dried basil leaves against MTX-induced hepatic and renal toxicity in rats. (arccjournals.com)
It was concluded that basil can protect against MTX-induced hepatic and renal injury and may be of therapeutic potential in alleviating the systemic side effects of this chemotherapeutic agent. (arccjournals.com)
Computed tomography (CT) scanning and MRI studies of the brain may be important in ruling out intracranial lesions when the diagnosis of hepatic encephalopathy is in question. (medscape.com)
Patients29
For patients on renal dialysis, an additional dose of [HA570 trade name] is recommended after each dialysis. (who.int)
Most common adverse drug reactions (≥5%) from clinical trials in pediatric patients were anemia, vomiting, increased gamma-glutamyltransferase, and cholestasis. (drugs.com)
median: 14 days) have been studied in 100 adult patients with candidemia and other Candida infections. (wikidoc.org)
A retrospective study using the medical charts of 103 patients admitted to the hospital due to a diagnosis of COVID-19 was carried out. (bvsalud.org)
Significant advances in the diagnosis and management of patients with liver disease were presented at The Liver Meeting® 2014, which is the annual meeting of the American Association for the Study of Liver Diseases (AASLD). (medscape.com)
The present study is a real‑life prospective cohort study involving 143 elderly non‑hospitalized patients with SARS‑CoV‑2 (≥65 years of age) who attended the emergency department of the authors' hospital seeking care for COVID‑19 symptoms appearing within the prior 7 days. (spandidos-publications.com)
All patients enrolled completed the 3‑day course, with a total of 6 out of 143 patients (4.2%) having a COVID‑19‑related hospitalization by day 28, and 5 patients (3.5%) succumbing to the disease within the study period. (spandidos-publications.com)
Remdesivir, provided to adult patients hospitalized for COVID-19-associated pneumonia as a 10-day ( 6 ) or 5-day ( 7 ) course, shortens the recovery time and allows for early clinical improvement, according to phase 3 studies. (spandidos-publications.com)
In another study, remdesivir was shown to decrease the likelihood of patients requiring high-flow supplementary oxygen and invasive mechanical ventilation, as well as the risk of 14-day mortality, when compared to the placebo ( 8 ). (spandidos-publications.com)
A multicenter study in Argentina reported 515 episodes of FN in 346 patients, of which 77 % were secondary to chemotherapy. (ijpsonline.com)
The study group included 56.5 % of patients with hematological malignancies and 20.2 % with solid neoplasms [ 7 ]. (ijpsonline.com)
CheckMate -67T is a Phase 3 randomized, open-label trial evaluating subcutaneous administration of Opdivo co-formulated with Halozyme's proprietary recombinant human hyaluronidase, rHuPH20, or subcutaneous nivolumab (nivolumab and hyaluronidase) compared to intravenous (IV) Opdivo , in patients with advanced or metastatic clear cell renal cell carcinoma (ccRCC) who have received prior systemic therapy. (businesswire.com)
Purpose In our study, diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) by biopsy, clinical and laboratory findings in our country were investigated. (afsu.edu.tr)
Objective: We aimed at investigating the effect of non-albumin proteinuria on renal outcomes in patients with biopsy-proven diabetic nephropathy. (afsu.edu.tr)
The aim of this study was therefore to evaluate the plasma levels of FABP3 at different stages of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM). (medsci.org)
It affects approximately 20-40% of patients with diabetes mellitus and is recognized as the most common cause of end-stage renal disease (ESRD) [ 1 ]. (medsci.org)
The half-life does not differ in patients with renal failure at doses not exceeding 600 mg daily, and, consequently, no dosage adjustment is required. (nih.gov)
The half-life of rifampin at a dose of 720 mg daily has not been established in patients with renal failure. (nih.gov)
Following a single 900 mg oral dose of rifampin in patients with varying degrees of renal insufficiency, the mean half-life increased from 3.6 hours in healthy adults to 5.0, 7.3, and 11.0 hours in patients with glomerular filtration rates of 30 to 50 mL/min, less than 30 mL/min, and in anuric patients, respectively. (nih.gov)
In one study, pediatric patients 6 to 58 months old were given rifampin suspended in simple syrup or as dry powder mixed with applesauce at a dose of 10 mg/kg body weight. (nih.gov)
In a completed study of nosocomial lower respiratory tract infections, 222 patients were treated with ZOSYN in a dosing regimen of 4.5 g every 6 hours in combination with an aminoglycoside and 215 patients were treated with imipenem/cilastatin (500 mg/500 mg q6h) in combination with an aminoglycoside. (druglib.com)
MORRISTOWN, N.J., Nov. 07, 2022 (GLOBE NEWSWIRE) -- Intercept Pharmaceuticals, Inc. (Nasdaq:ICPT), a biopharmaceutical company focused on the development and commercialization of novel therapeutics to treat progressive non-viral liver diseases, today announced additional supportive data from its pivotal Phase 3 REGENERATE study of obeticholic acid (OCA) in patients with liver fibrosis due to nonalcoholic steatohepatitis (NASH). (biospace.com)
In this study, BAVENCIO plus best supportive care (BSC) as first-line maintenance therapy significantly extended the survival of patients with previously untreated locally advanced or metastatic UC whose disease did not progress on induction chemotherapy, compared with BSC only. (emdserono.com)
Results: No hematologic, renal, and/or cardiovascular toxicities were noted in any of the patients treated. (uni-frankfurt.de)
Safety data obtained in 1823 patients with advanced solid tumors who received LENVIMA as single agent across multiple clinical studies was used to further characterize the risks of serious adverse reactions. (drugcentral.org)
This study aimed to study the clinical, and laboratory characteristics of cirrhotic patients in a tertiary hospital in Ghana. (bvsalud.org)
Design: This was a retrospective study of sociodemographic characteristics, symptoms and signs, biochemical and fibrotic indices, treatments, and complications data of 247 patients with cirrhosis who died on admission. (bvsalud.org)
Setting: This study was carried out at the Gastroenterology Unit of the Korle-Bu Teaching Hospital, Ghana, Results: Two-thirds (68.0%) of the patients were within 30 to 60 years, with more than half (73.7%) being males. (bvsalud.org)
Pathogenesis2
Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)
In this review, we discuss the induction protocols for kidney organoids and tubuloids, as well as their potential applications in understanding kidney development, renal pathogenesis, and drug screening. (j-organoid.org)
Alanine aminotransferase1
Venkat and colleagues [ 1 ] described the clinical response to protocolized immunosuppression withdrawal in an ongoing multicenter study of 74 children who were more than 4 years post-transplantation, had normal alanine aminotransferase (ALT) and gamma-glutamyltransferase levels, and were receiving calcineurin inhibitor monotherapy. (medscape.com)
Chronic4
Can Mean Platelet Volume Predicts Renal Outcome in Acute on Chronic Kidney Disease? (afsu.edu.tr)
Introduction: This study aimed to investigate the role of mean platelet volume (MPV) in predicting renal outcome in acute kidney injury (AKI) developing on pre-existing chronic kidney disease (CKD). (afsu.edu.tr)
Candidate thesis on "Study of the effect of chronic alcohol intoxication on the metabolism of zinc, copper and lithium in the body" was defended, speciality 14.00.45 - Narcology. (rudn.ru)
Iron (non-heme) measurements are used in the diagnosis and treatment of diseases, such as iron deficiency anemia, chronic renal disease, and hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin). (cdc.gov)
Complications3
Can we reduce renal and infectious complications through immunosuppressive withdrawal? (medscape.com)
Alterations in liver and renal functions are among the complications of HIV infection, and highly active antiretroviral therapy (HAART) has been implicated. (ijbls.org)
Prospective studies in T2DM have shown an association between the degree of hyperglycemia and the risk of micro- and macrovascular complications, including fatal CVD events. (ddw-online.com)
Tubular1
Dentre os mecanismos fisiopatológicos desta enfermidade destacam-se a vasoconstrição intrarrenal prolongada, consequente redução da perfusão renal, hipóxia e isquemia medulares, associada ao dano tubular renal devido à citotoxicidade do contraste. (usp.br)
Rifampicin reduces nephrotoxicity of cyclosporine A in rats: studies of renal enzyme excretion. (ox.ac.uk)
Dose3
A 70-mg loading dose has not been studied for this indication. (wikidoc.org)
Male subjects and their female spouses/partners who are of childbearing potential must agree to use highly effective contraception consisting of 2 forms of birth control (at least 1 of which must be a barrier method) starting from the first dose of the study drug and continuing throughout the study period and for 90 days after the last dose of the study drug. (ucbraid.org)
Methods: We have performed a phase I dose-finding study, with the objective to assess the maximum tolerated dose and the dose-limiting toxicity of intravenously injected scFv(FRP5)-ETA. (uni-frankfurt.de)
Toxicity1
At the time of writing animal studies have not indicated any direct or indirect harmful effects with respect to reproductive toxicity, parturition or postnatal development. (medscape.co.uk)
Metabolic3
This study aims to identify metabolic, clinical, and microbiota differences between small and larger dogs. (hindawi.com)
We conducted a diet- and environment-controlled study in canines to understand metabolic, clinical, and microbiota differences between small and larger dogs. (hindawi.com)
BUN measurements are used in the diagnosis of certain renal and metabolic diseases. (cdc.gov)
Glutathione1
1(4) Furthermore, such studies also indicated decreased/exhausted concentrations of glutathione and antioxidant activity. (mcisaachealthsystems.com)
20221
These data will be presented on Monday, November 7, 2022, at The Liver Meeting®, the annual meeting of the American Association for the Study of Liver Diseases (AASLD) in Washington, D.C. (biospace.com)
REACTIONS1
Known history of allergic reactions to curcumin analogs or excipients in the study drug formulation. (ucbraid.org)
Tertiary1
The combined nephrotoxic and hepatotoxic effects of HAART were determined by assessing the renal and liver functions of HIV sero-positive subjects on HAART in a tertiary hospital. (ijbls.org)
Subjects3
A total of 334 subjects with T2DM who enrolled in a disease management program were included in this study and stratified according to eGFR. (medsci.org)
This is a phase 1/2a randomized, double-blind study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of study drug AJ201 in subjects with Spinal and Bulbar Muscular Atrophy (SBMA). (ucbraid.org)
Male subjects should also not donate sperm during the study and for 90 days after the final administration of the study drug. (ucbraid.org)
Diagnosis2
The test is frequently requested in conjunction with the serum creatinine test for the differential diagnosis of prerenal, renal, and post renal uremia. (cdc.gov)
Creatinine measurements are useful in the diagnosis and treatment of renal diseases. (cdc.gov)
Adults2
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, accounting for more than 431,000 new cases and 179,000 deaths worldwide each year. (businesswire.com)
Methods: We conducted a cross sectional study among 520 HIV infected and HIV uninfected adults attending care clinics in Kampala Uganda. (bvsalud.org)
Disease3
The objective of this study was to diagnose the disease in the municipalities of Cachoeira do Arari, Salvaterra, Santa Cruz do Arari and Soure, on Marajó Island, state of Pará, Brazil. (scielo.br)
EIA is considered endemic in the municipalities studied, due to the ecology of the region with a high numbered population of bloodsucking insect vectors and the absence of official measures for the control of the disease. (scielo.br)
Given the importance that this disease has for Equidae associated with the role that horses play in the development of livestock on the island, the aim of this study was to determine the prevalence of EIA on Marajó Island, at the mouth of the Amazon river, since there are no reports in the literature of this infection for this region. (scielo.br)
Secondary1
Study follow-up is ongoing to assess additional secondary efficacy and safety endpoints. (businesswire.com)
Her liver function was found to be within normal limits as was her renal function. (biomedcentral.com)
Abnormal1
An abnormal ECG at screening visit which is judged to be clinically relevant and represents an unacceptable risk for study participation by the Investigator. (ucbraid.org)
Treatment1
700 million individuals, resulting in more than six million deaths worldwide ( https://covid19.who.int/ ). At the beginning of the pandemic, several drugs were used experimentally to manage this infection due to the emergency situation, and since then, numerous studies regarding treatment strategies have been conducted ( 1 ). (spandidos-publications.com)
Survival1
Prior to studies of and broad institution of antifungal prophylaxis in high-risk preterm infants, the incidence of fungal infections had been rising in infants born at less than 1000 g, with the ensuing resuscitation and survival of more and more infants. (medscape.com)
Effect1
Investigators have studied the effect of steroids and antibiotics in mice orally inoculated with C albicans to mimic conditions in the preterm infant. (medscape.com)