• neurons
  • Previous studies have demonstrated that polyribosomes are selectively positioned beneath postsynaptic sites on CNS neurons. (jneurosci.org)
  • In spine-bearing neurons, these polyribosomes are selectively localized at the base of the spines, and occasionally within spine heads. (jneurosci.org)
  • Although the numerical density of neurons in the granule cell layer did not differ significantly between transgenic and control mice at any age studied, the total number of neurons was significantly greater in transgenic mice by 29-61% beginning on day 14. (jneurosci.org)
  • Studies of Fragile X syndrome have significantly aided in the understanding of the functionality of FMRP through the observed effects of FMRP loss on neurons. (wikipedia.org)
  • polysome
  • Polysome profiling is a cornerstone method in these studies. (jove.com)
  • The goal of polysome profiling is to capture mRNA translation by immobilizing actively translating ribosomes on different transcripts and separate the resulting polyribosomes by ultracentrifugation on a sucrose gradient, thus allowing for a distinction between highly translated transcripts and poorly translated ones. (jove.com)
  • A polyribosome (or polysome) is a complex of an mRNA molecule and two or more ribosomes that act to translate mRNA instructions into polypeptides. (wikipedia.org)
  • protein
  • Post-Transcriptional Gene Regulation, Second Edition is organized in six sections describing bioinformatics approaches for studying post-transcriptional regulation, various expression profiling approaches, protein-RNA interaction and non-coding RNA investigation techniques, methods for profiling RNA modifications, and other techniques such as alternative translation initiation or polyadenylation sites determination. (springer.com)
  • The results show that unfertilized eggs synthesize protein upon RNase-sensitive polyribosomes. (caltech.edu)
  • In 1959 he became a research biochemist at the NIH and began to study the steps that relate DNA, RNA and protein. (wikipedia.org)
  • proteins
  • At ISREC he pursued the study of pre-rRNA and pre-mRNA, and extended his research to RNA-proteins (RNP) of the type pre-mRNP and functional mRNP. (wikipedia.org)
  • Azacitidine's incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of proteins. (wikipedia.org)
  • molecules
  • Between the molecules studied by chemists and the tiny structures visible under the optical microscope, such as the cellular nucleus or the chromosomes, there was an obscure zone, "the world of the ignored dimensions," as it was called by the chemical-physicist Wolfgang Ostwald. (wikipedia.org)
  • In eukaryotic organisms most messenger RNA (mRNA) molecules are polyadenylated at the 3' end, but recent studies have shown that short stretches of uridine (oligouridylation) are also common. (wikipedia.org)
  • researchers
  • Featuring current resources used to discover new legume family genes and to understand genes and their interactions, Legume Genomics: Methods and Protocols provides techniques from expert researchers to study these plants that are so vitally important for food, feed, human nutrition, bioenergy, and industrial purposes. (stanford.edu)
  • mechanisms
  • Its physiological substrate has yet to be identified and the molecular mechanisms in which mutated laforin causes Lafora disease is unknown, though there has been progress made in the study by Ortolano et al. (wikipedia.org)
  • Furthermore, recent studies have further revealed some mechanisms of contact inhibition of proliferation and its potential implications in cancer therapy. (wikipedia.org)
  • cells
  • At the IBPC, he studied the structure of giant RNA of the messenger type in cells differentiation (avian erythroblasts) and formulated the hypothesis of the existence of pre-messengers pre-mRNA by analogy to pre-rRNA. (wikipedia.org)
  • complex
  • Up to now, the structure-function relationship between heparin and the ?II-tryptase monomer has not been studied with atomic resolution due to the lack of a complex structure of tryptase and heparin. (jove.com)
  • molecular
  • Leading scientists provide revisions and updates in their respective areas of study offering readers current research and relevant information on the rapidly changing subjects in molecular biology. (stanford.edu)
  • Our study identified molecular subgroups of cholangiocarcinomas that can be explored for specific drug targeting in clinical trials. (jove.com)
  • found
  • We found that in both the dentate gyrus and hippocampus, about 50% of the polyribosomes that were present beneath the base of spines were associated with membranous cisterns. (jneurosci.org)
  • known
  • The first known written record of a study of the anatomy of the human brain is the ancient Egyptian document the Edwin Smith Papyrus. (wikipedia.org)
  • structures
  • The images were then reconstructed to depict structures in three-dimensions, thereby facilitating the study into how polysomes are organized. (wikipedia.org)
  • activity
  • Our study revealed that how heparin affected the activity of the human ?II-tryptase monomer (hBTM) through salt bridge interactions. (jove.com)
  • level
  • He also studied prosome as regulating modules associated to pre-mRNA et to mRNA at the level of chromatine and of the cytoskeleton and developed a clinic diagnosis based on that system. (wikipedia.org)
  • further
  • The knowledge of heparin binding characteristics and the key residue contributions in this study may enlighten further the inhibitor design of this enzyme and may also improve our understanding of inflammatory and allergy related diseases. (jove.com)