• bacterial or viral similarity with self-antigens (molecular mimicry) leading to production of cross-reactive antibodies. (pocketdentistry.com)
  • ABSTRACT We have raised a panel of 15 monoclonal antibodies (MAbs) recognizing cell surface antigens of the rat osteoblast-like cell line ROS 17/2.8. (docksci.com)
  • Monoclonal antibodies (MAbs) have been used successfully to characterize the cell surface of T other cell types, such as o s t e o ~ l a s t s (and ~ ~ ~lymphoid ) and myeloid cells, and to study the lineage of cells of the hematopoietic system. (docksci.com)
  • In this way it was hoped to select antibodies to antigens associated specifically with the OB phenotype and eliminate those of housekeeping or transformation antigens. (docksci.com)
  • Individuals expressing certain[specify] human leukocyte antigen (i.e. (wikipedia.org)
  • Individuals possessing human leukocyte antigen (HLA)-B12 are 3 times more likely to develop this disorder. (medscape.com)
  • Transcriptome analysis of mouse spleen cells cultured with miso and its raw material revealed that the expression of genes, including interleukin (IL)-10, IL-22 and CD86, was upregulated. (bvsalud.org)
  • This study has also identified cell surface antigens of ROS 17/2.8 cells that are not expressed by osteoblasts in vivo. (docksci.com)
  • We have generated a panel of 15 MAbs to ROS 17/2.8 cells, 5 of which recognize antigens restricted to normal rat OBs and chondrocytes in vivo. (docksci.com)
  • HLA-B*51 was protective from neurological and vascular involvement. (medscape.com)
  • Prospective studies examining whether assessments of vascular function are predictive of long-term CV outcomes in RA are required. (biomedcentral.com)
  • HLA) serotypes (i.e. genetic alleles), genetical-based T cell receptors, or variations in their efficiency to absorb, distribute to tissues, metabolize, or excrete (this combination is termed ADME) a drug are predisposed to develop SJS. (wikipedia.org)
  • The antigens appear to be localized to the cell surface of the osteoblast, with no apparent staining of bone matrix in either undecalcified or decalcified sections. (docksci.com)
  • In vitro, these MAbs recognize cell surface antigens present on two additional cell lines, ROS 24/1 and Rat 2 cells, and on the adherent cell population cultured from rat long bone marrow. (docksci.com)
  • Studies of the interactions of this panel of MAbs with osteogenic tissues and cell lines may have an important impact on the understanding of osteoblast physiology. (docksci.com)
  • 4.5)The object of our study was to raise MAbs to antigens restricted to the plasma membrane of the normal rat OB and to use these MAbs to further characterize the cell surface phenotype of the OB. (docksci.com)
  • This technique has produced a MAb specific to the cell surface of the chick osteOcyte,'6) to the murine PTH receptor,") and to OB-restricted antigens. (docksci.com)
  • In this study we have raised MAbs directed against the rat clonal OB-like cell line ROS 17/28. (docksci.com)
  • In this chapter, autoimmune mechanisms found in periodontitis are outlined and existing studies investigating the possible association between periodontitis and autoimmune diseases and vice versa are discussed. (pocketdentistry.com)
  • The present study was a prospective study. (bvsalud.org)
  • therefore, the association between MICA6 and Behçet disease may be a secondary phenomenon related to HLA-B51. (medscape.com)
  • Although HLA-B51 transgenic mice do not develop any manifestations of Behçet disease, their neutrophils show excessive function. (medscape.com)
  • NKG2D expression on iDNT cells enhanced the regulatory function of these cells. (bvsalud.org)
  • The study of OB function and differentiation has been hampered by the inability to purify pure OB populations. (docksci.com)
  • In a study of 57 Egyptian patients with Behçet disease, it was found that Behçet disease was associated with HLA-A*24 and HLA-B*42 and highly associated with HLA-A*68 and B*15 and B*51, while HLA-A*03 and B*52 were protective against Behçet disease. (medscape.com)
  • They were found to be risk factors in Behçet disease patients, while HLA-A03 and B49 were found to be protective for Behçet disease. (medscape.com)
  • Epistatic interaction was found between HLA-B 51 and ERAP1 , which is believed to play a pathogenic role through HLA-B 51. (medscape.com)
  • A number of studies have reported the presence of microvascular and macrovascular ED in RA patients relative to age- and sex-matched healthy controls, which can be improved after treatment with antiinflammatory medications (such as anti-tumor necrosis factor-alpha (anti-TNF-α) [ 9 ]. (biomedcentral.com)
  • ERAP1 is a gene that encodes an endoplasmic reticulum amino peptidase, which acts on amino acid terminals in peptides that are then involved in HLA class I molecules, affecting their length for optimum major histocompatibility complex (MHC)-I binding. (medscape.com)
  • Likewise, low expression of inhibitory human leukocyte antigen (HLA) class I molecules is an important prerequisite for successful natural killer cell triggering. (biomedcentral.com)
  • ERAP1 isoforms may affect some HLA molecules' properties. (medscape.com)
  • Cancer immunotherapy harnesses a patient's CD4+ and CD8+ T cell responses toward peptide neoantigens, which are displayed on the surface of tumor cells by major histocompatibility complex molecules [MHC, termed human leukocyte antigen (HLA) in humans] ( 1 ). (frontiersin.org)
  • HLA) serotypes (i.e. genetic alleles), genetical-based T cell receptors, or variations in their efficiency to absorb, distribute to tissues, metabolize, or excrete (this combination is termed ADME) a drug are predisposed to develop SJS. (wikipedia.org)
  • Their study showed that TNF-alpha -1031*C, -863*A, -857*C, and -308*G alleles were significantly associated with Behçet disease. (medscape.com)
  • Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Therapy, to analyze sequencing data from neuroblastoma patients and identify a recurrent anaplastic lymphoma kinase mutation ( ALK R1275Q) that leads to two high affinity neoepitopes when expressed in complex with common HLA alleles. (frontiersin.org)
  • To evaluate the range of HLA alleles that could display the ALK neoepitopes, we used structure-based Rosetta comparative modeling calculations, which accurately predict several additional high affinity interactions and compare our results with commonly used prediction tools. (frontiersin.org)
  • Analysis of the X-ray structures of the two peptides bound to HLA-B*15:01 reveals drastically different conformations with measurable changes in the stability of the protein complexes, while the self-epitope is excluded from binding due to steric hindrance in the MHC groove. (frontiersin.org)
  • Individuals expressing certain[specify] human leukocyte antigen (i.e. (wikipedia.org)
  • The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. (frontiersin.org)
  • Individuals possessing human leukocyte antigen (HLA)-B12 are 3 times more likely to develop this disorder. (medscape.com)
  • BACKGROUND AND OBJECTIVES: Human neutrophil antigens (HNAs) are categorized into five systems: HNA-1 to HNA-5. (bvsalud.org)
  • Using ATM/ATR inhibitor caffeine, the contribution of the DNA damage response pathway to histone deacetylase inhibitor-induced ligand expression was assessed. (biomedcentral.com)
  • For example, pre-conditioning of various cancer cell types by agents that activate the DNA damage response pathway may sensitize for natural killer cell cytotoxicity via induction of activating natural killer cell receptor ligands and/or death receptor expression. (biomedcentral.com)
  • Subsequent determination of the X-ray structure of an HLA-A*01:01 bound neoepitope validates atomic features seen in our Rosetta models with respect to key residues relevant for MHC stability and T cell receptor recognition. (frontiersin.org)
  • This work provides a rational approach toward high-throughput identification and further optimization of putative neoantigen/HLA targets with desired recognition features for cancer immunotherapy. (frontiersin.org)
  • BACKGROUND: In order to support the comprehensive classification of Leukocyte Adhesion Deficiency-I (LAD-I) severity by simultaneous screening of CD11a/CD18, this study assessed clinical, laboratory, and genetic findings along with outcomes of 69 LAD-I patients during the last 15 years. (bvsalud.org)
  • METHODS: Sixty-nine patients (40 females and 29 males) with a clinical phenotype suspected of LAD-I were referred to Immunology, Asthma, and Allergy research institute, Tehran, Iran between 2007 and 2022 for further advanced immunological screening and genetic evaluations as well as treatment, were enrolled in this study. (bvsalud.org)
  • CONCLUSION: Physicians' awareness of LAD-I considering delayed separation of umbilical cord marked neutrophilic leukocytosis, and variability in CD11 and CD18 expression levels, and genetic analysis leads to early diagnosis and defining disease severity. (bvsalud.org)
  • The aim of this study was to evaluate the hardness and wear resistance of self-adhesive flowable composite (SAF) in comparison with conventional flowable composites. (bvsalud.org)
  • However, we did not find it helpful for the evaluation of patients with large vessel involvement who clearly depended on imaging studies (CT angiography or positron emission tomography) for obtaining reasonably precise information on disease activity and progression. (medscape.com)
  • 4] HLA-B*51 and HLA-A*68 were associated with blinding eye disease and could be a poor prognostic factor for eye involvement. (medscape.com)
  • HLA-B*51 was protective from neurological and vascular involvement. (medscape.com)
  • Finally, MHC tetramer staining of peripheral blood mononuclear cells from HLA-matched donors shows that the two neoepitopes are recognized by CD8+ T cells. (frontiersin.org)
  • Through this process, a large and heterogeneous pool of p/MHC antigens is continuously generated in healthy, pathogen infected, or tumor cells as a means of displaying a cell's peptide repertoire to the immune system ( 4 ). (frontiersin.org)
  • In contrast to T-lymphocytes, these cells lack antigen-specific receptors. (biomedcentral.com)
  • Sensitivity of tumours to natural killer cells critically depends on expression of ligands for activating receptors. (biomedcentral.com)
  • An important attempt to identify those clinical features that can be summoned to form an overall index of disease activity, which would be appropriate for research studies internationally, has been made by Lawton et al. . (medscape.com)
  • Although HLA-B51 transgenic mice do not develop any manifestations of Behçet disease, their neutrophils show excessive function. (medscape.com)
  • This has studies of potential etiologic determinants, focusing been due, in part, to a failure to account for host on host and environmental risk factors and their inter- susceptibility in most studies. (nih.gov)
  • They were found to be risk factors in Behçet disease patients, while HLA-A03 and B49 were found to be protective for Behçet disease. (medscape.com)
  • Functional studies consisted of gene expression analysis in cultured PBMCs exposed to 21OH and evaluation of serum interleukin by ELISA assays. (nih.gov)
  • Low-resolution DNA typing for HLA-B and high resolution HLA-B(∗)15 typing was performed. (nih.gov)
  • In a study that included 305 Korean patients with Behçet disease, polymorphism in gene CD11a/DC18 was found to be significantly low, whereas CD11c/CD18 was found high, suggesting its role in the pathogenesis of Behçet disease. (medscape.com)
  • Good interobserver reliability for general disease activity was reported in one study by Bhakta et al. . (medscape.com)
  • Few, if any, studies investigating markers of disease activity have used the BDCAF in a statistically relevant mode. (medscape.com)
  • HLA-B51 or its B101 allele is significantly associated with Behçet disease in Japan, Korea, Turkey, and France and with ocular manifestations in Britain. (medscape.com)