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  • Efficacy
  • This information will be used to design similar future studies for the initial assessment of the efficacy of novel antimalarial drugs in development. (clinicaltrials.gov)
  • A Double-blind, Double-dummy, Placebo-controlled, Randomized, Three Parallel Groups Study Comparing the Efficacy, Safety and Tolerability of Pramipexole Extended Release (ER) Versus Placebo and Versus Pramipexole Immediate Release (IR) Administered Orally Over a 26-week Maintenance Phase in L-Dopa+ Treated Patients With Advanced Parkinsons Disease (PD). (clinicaltrials.gov)
  • Finally, the efficacy of 10-μm microparticles was investigated using a model of antigen-induced arthritis (AIA) in mice. (biomedcentral.com)
  • The modelling of schizophrenia in animals can range from attempts to imitate the full extent of symptoms found in schizophrenia, to more specific modelling which investigate the efficacy of antipsychotic drugs. (wikipedia.org)
  • One clinical study in agitated elderly patients compared the effects of tiapride, haloperidol and placebo and found that while the two drugs had comparable efficacy superior to the placebo effect, tiapride had fewer and less severe side effects than haloperidol. (wikipedia.org)
  • hematologic
  • Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is caused by exposure to certain medications that may result in a rash, fever, inflammation of internal organs, lymphadenopathy, and characteristic hematologic abnormalities such as eosinophilia, thrombocytopenia, and atypical lymphocytosis. (wikipedia.org)
  • DRESS syndrome is one of several terms that have been used to describe a severe idiosyncratic reaction to a drug that is characterized by a long latency of onset after exposure to the offending medication, a rash, involvement of internal organs, hematologic abnormalities, and systemic illness. (wikipedia.org)
  • carbamazepine
  • While tiapride does not affect positive symptoms of psychosis such as hallucinosis or delirium sometimes manifested in alcohol withdrawal syndrome, if combined with a drug such as carbamazepine that addresses those symptoms, it is ideal for treating alcohol dependency because its metabolism does not depend on liver function and it has low potential for abuse. (wikipedia.org)
  • cognitive
  • The non-selective melanocortin receptor agonist afamelanotide (NDP-α-MSH) has been found to induce brain-derived neurotrophic factor (BDNF) expression in the rodent brain via activation of the MC4 receptor and mediate "intense" neurogenesis and cognitive recovery in an animal model of Alzheimer's disease. (wikipedia.org)
  • Persistent treatment of rodents with amphetamine models some symptoms of schizophrenia including hyperactivity, enduring prepulse inhibition abnormalities, and cognitive abnormalities associated with the prefrontal cortex including attention deficits. (wikipedia.org)
  • liver
  • Many drugs can cause abnormal liver function tests and can be diagnosed clinically by excluding other etiologies. (neurologyadvisor.com)
  • Many drugs can cause abnormal liver function tests, including immunosuppressive drugs cyclosporine and tacrolimus (mainly elevated direct bilirubin due to inhibition of bilirubin transport), total parenteral nutrition (TPN), antimicrobiological agents including trimethoprim/sulfamethoxazole (mainly cholestasis), or antifungal azoles (itraconazole, voriconazole, posaconazole) which cause transaminitis. (neurologyadvisor.com)
  • 3.2% (194/5995) of Asian patients and 1.8% (100/5641) of Caucasian patients experienced liver function test abnormalities. (drugs.com)
  • exposure
  • 2) Three case-control studies have examined pseudoephedrine exposure among mothers of children born with gastroschisis. (biomedsearch.com)
  • In two studies, pseudoephedrine exposure was associated with a significant odds ratio. (biomedsearch.com)
  • Contemporarily we studied the pregnancy outcomes, the clinical, the psychological and the socio-economic factors of 142 women who contacted our Teratology Information Service (TIS) in the 1(st)trimester of pregnancy because suspected of teratogen exposure: 72 decided to terminate their pregnancy, whereas 70 were used as a control group. (biomedsearch.com)
  • THC exposure in rats during the prenatal developmental phase may cause epigenetic changes in gene expression, but there is limited knowledge about the risk for psychiatric disorders because of ethical barriers to studying the developing human brain. (wikipedia.org)
  • While animal studies cannot take into account factors that could influence the effects of cannabis on human maternal exposure, such as environmental and social factors, a 2011 review of rodent studies by Campolongo et al. (wikipedia.org)
  • The symptoms of DRESS syndrome usually begin several weeks after exposure to the offending drug. (wikipedia.org)
  • Environmental causes involving exposure to PCBs (ex.dioxin), radiation, anticancer chemotherapeutic agents, allergy and toxic epidermal necrolysis after drug. (wikipedia.org)
  • These conditions are listed below: Perinatal (during birth) cerebral injury Kernicterus Cerebrovascular diseases Drug induced Central nervous system tumor Peripheral or central trauma Infectious or post infectious encephalopathies Toxins Metabolic Paraneoplastic syndromes Central pontine myelinolysis Secondary spasmodic torticollis is diagnosed when any of the following are present: history of exogenous insult or exposure, neurological abnormalities other than dystonia, abnormalities on brain imaging, particularly in the basal ganglia. (wikipedia.org)
  • tumor
  • Over the last two decades, dozens of novel chemotherapeutic agents have been developed, including targeted inhibitors of tumor growth pathways, immunostimulatory, and immunomodulatory drugs. (endocrinologyadvisor.com)
  • clinically
  • To overcome these limitations, we investigated magnetically retainable drug delivery systems, an approach as yet clinically unexploited despite the intense need for the development of novel i-a. delivery modalities. (biomedcentral.com)
  • Because PGE2 activates multiple prostanoid receptors and has a short half-life in vivo due to its rapidly metabolism in cells by omega oxidation and beta oxidation, metabolically resistant EP2-selective activators are useful for the study of this receptor's function and could be clinically useful for the treatment of certain diseases. (wikipedia.org)
  • symptoms
  • 2007). "Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? (wikipedia.org)
  • In another study in which alcoholic patients were given titrated doses up to 800 mg/day, subjects showed significant improvements in ratings of withdrawal, craving, psychiatric symptoms and quality of life. (wikipedia.org)
  • Antipsychotic drugs are the most common treatment for these symptoms, but often come with a host of side-effects including orthostatic hypotension and deficits in vigilance and attention. (wikipedia.org)
  • One clinical study of patients with tardive dyskinesia associated with Parkinson's disease found that tiapride significantly improved motor abilities without affecting other parkinsonian symptoms. (wikipedia.org)
  • pregnancy
  • Treatment of breast cancer during pregnancy: an observational study. (biomedsearch.com)
  • The objective of our study is to evaluate the importance of the perception of the risk level in making the decision to end the pregnancy and the relevance that a teratology consultation can have in preventing unmotivated terminations of pregnancy METHODS: We carried out a survey on 350 women in Rome who voluntarily interrupted their pregnancy to evaluate the prevalence due to presumed teratogen. (biomedsearch.com)
  • Most studies through 2013 linking development of the fetus and cannabis show effects of consumption during the gestational period, but abnormalities in the endocannabinoid system during the phase of placental development are also linked with problems in pregnancy. (wikipedia.org)
  • A report prepared for the Australian National Council on Drugs concluded cannabis and other cannabinoids are contraindicated in pregnancy as they may interact with the endocannabinoid system. (wikipedia.org)
  • commonly
  • The side-effect reported most commonly to the U.S. Food and Drug Administration (FDA) is rhabdomyolysis, a condition characterized by muscle tissue breakdown. (wikipedia.org)
  • antipsychotic
  • Each extreme has its limitations, with whole-syndrome modelling often failing due to the complexity and heterogeneous nature of schizophrenia, and antipsychotic-specific modelling being often not useful for discovering drugs with unique mechanisms of action. (wikipedia.org)
  • lesion
  • The posterior cingulate cortex has been linked by lesion studies to spatial memory, configural learning, and maintenance of discriminative avoidance learning. (wikipedia.org)
  • patients
  • A total of 75 patients will be recruited: 25 for each arm of the study. (clinicaltrials.gov)
  • Although these therapies have only been in widespread use for a short period of time, a growing body of evidence from case reports and cohort studies has suggested that HIV-infected patients on HAART may experience premature coronary artery disease. (clinicaltrials.gov)
  • Under-nutrition is the stark reality of 90% of pulmonary TB cases in India, or more than 1 million patients," said Bhargava, based on his 2013 study of 1,700 patients from rural India. (hindustantimes.com)
  • That 52% of the patients had stunting-low height-for-age-showed that their undernutrition status was chronic, said Bhargava, co-author of the study. (hindustantimes.com)
  • In a retrospective Taiwanese cohort study of 60 patients, these incidences were observed. (wikipedia.org)
  • Studies have shown[weasel words] that nitrate tolerance is associated with vascular abnormalities which have the potential to worsen patients' prognosis. (wikipedia.org)
  • Abnormalities in PPI are seen in patients with schizophrenia. (wikipedia.org)
  • Dopamine release Neuroimaging studies on patients with schizophrenia have found increased dopamine release after treatment with amphetamine relative to normal controls. (wikipedia.org)
  • Studies have shown that over 75% of patients report neck pain, and 33% to 40% experience tremor of the head. (wikipedia.org)
  • chemotherapy
  • The first chemotherapy drugs, nitrogen mustards, were developed after the observation in World War I that soldiers who survived inhalation of poison gases often developed cytopenias days later. (endocrinologyadvisor.com)
  • This observation led to the first class of chemotherapy agents and exemplifies both the desired cytotoxic effects of these drugs as well as the potential for fatal toxicities. (endocrinologyadvisor.com)
  • tolerance
  • Tolerance is defined as the loss of symptomatic and hemodynamic effects of GTN and/or the need for higher doses of the drug to achieve the same effects,[citation needed] and was first described soon after the introduction of GTN in cardiovascular therapy. (wikipedia.org)
  • abnormal
  • The study is indicated to investigate the cause, location of origin, and best treatment for various abnormal heart rhythms. (wikipedia.org)
  • If the arrhythmia is reproduced by the drugs, the electrophysiologist will search out the source of the abnormal electrical activity. (wikipedia.org)
  • If at any step during the EP study the electrophysiologist finds the source of the abnormal electrical activity, he/she may try to ablate the cells that are misfiring. (wikipedia.org)
  • therapy
  • These drug interactions with fenofibrate are considered major and may need therapy modifications: Bile acid sequestrants (e.g. cholestyramine, colestipol, etc. (wikipedia.org)
  • include
  • Other synonymous names and acronyms include drug-induced hypersensitivity syndrome (DIHS), anticonvulsant hypersensitivity syndrome, drug-induced hypersensitivity syndrome, drug-induced delayed multiorgan hypersensitivity syndrome, and drug-induced pseudolymphoma. (wikipedia.org)
  • Genetic associations for selective tooth agenesis ("STHAG") include: In the 1960s and 1970s, several studies were conducted sponsored by the U.S. Atomic Energy Commission, with the aim of finding a link between genetics and hypodontia. (wikipedia.org)
  • patient's
  • deciding whether a patient can continue a potential culprit drug may have significant impact on the patient's future cancer treatment. (endocrinologyadvisor.com)
  • Then the electrophysiologist tries to provoke arrhythmias and reproduce any conditions that have resulted in the patient's placement in the study. (wikipedia.org)
  • investigate
  • The purpose of this study was to investigate an innovative alternative consisting of corticosteroid encapsulation into magnetically retainable microparticles. (biomedcentral.com)
  • Treatment
  • The study will follow the sequence of the challenge inoculation, reference treatment and follow-up. (clinicaltrials.gov)
  • On day 5 evening, participants will be admitted to the study unit and confined for safety monitoring and antimalarial treatment. (clinicaltrials.gov)
  • Prior to the development of anti-TB drugs in the middle of the twentieth century, good food, open air, a dry climate and rest constituted the main treatment for TB, and those who could afford it would retreat to sanatoriums. (hindustantimes.com)
  • animal models
  • PF-04418948 (Ki=16 nM), TG4-155 (Ki=9.9 nM), TG8-4, and TG6-129 are selective competitive antagonists for EP2 that have been used for studies in animal models of human diseases. (wikipedia.org)
  • Research into the psychotic disorder of schizophrenia, involves multiple animal models as a tool, including in the pre-clinical development of drugs. (wikipedia.org)
  • Animal models were first produced for schizophrenia by altering the dopaminergic system using drugs. (wikipedia.org)
  • injury
  • Drug-induced hepatic injury, including fatalities, have been reported. (drugs.com)
  • A significant number of drugs found within this class, including moxifloxacin, are not licensed by the FDA for use in children due to the risk of permanent injury to the musculoskeletal system. (wikipedia.org)
  • development
  • This is an enabling study using registered antimalarial drugs as reference treatments (one slow acting and one fast acting), aimed to inform trial design, endpoints and testing regimens for assessing new candidate antimalarial drugs in development. (clinicaltrials.gov)
  • Among the more concerning are the development of atherogenic lipoprotein abnormalities and a state of relative insulin resistance. (clinicaltrials.gov)
  • interval
  • Ten other individuals who displayed no changes in QT interval after administration of the same drugs, were selected. (ahajournals.org)
  • In the most recent study, the risk of gastroschisis was increased 4.2-fold among women taking the pseudoephedrine-paracetamol combination (95% confidence interval 1.9-9.2). (biomedsearch.com)
  • agents
  • This is a single-center, controlled, randomized, study using a BSP inoculum challenge as a model to assess the activity of antimalarial agents. (clinicaltrials.gov)
  • After the success of the nitrogen mustards in the 1950s, several new classes of chemotherapeutic agents were developed including alkylating agents, anti-metabolites, nitrosureas, and antibiotic-derived drugs. (endocrinologyadvisor.com)
  • Finally, chemotherapeutic agents are often given in combinations, complicating the assessment of which drug is responsible. (endocrinologyadvisor.com)
  • Last, the electrophysiologist may administer various drugs (proarrhythmic agents) to induce arrhythmia. (wikipedia.org)
  • found
  • Only two listed contraindications are found within the 2008 package insert: "Nonsteroidal anti-inflammatory drugs (NSAIDs): Although not observed with moxifloxacin in preclinical and clinical trials, the concomitant administration of a nonsteroidal anti-inflammatory drug with a fluoroquinolone may increase the risks of CNS stimulation and convulsions. (wikipedia.org)
  • Furthermore, a study searching for 18 major species of gut flora, including L. acidophilus, in a variety of animals found L. reuteri was the only bacterium to constitute a "major component" of the Lactobacillus species present in the gut of each of the tested host animals. (wikipedia.org)
  • typically
  • An EP study is typically performed in an EP lab or cath lab. (wikipedia.org)
  • Moreover, its selectivity for the dopaminergic system is thought to account for its avoidance of the side effects typically associated with other neuroleptic drugs, such as chlorpromazine, which act on a number of neurotransmitter systems. (wikipedia.org)