• Efficacy
  • This information will be used to design similar future studies for the initial assessment of the efficacy of novel antimalarial drugs in development. (clinicaltrials.gov)
  • A Double-blind, Double-dummy, Placebo-controlled, Randomized, Three Parallel Groups Study Comparing the Efficacy, Safety and Tolerability of Pramipexole Extended Release (ER) Versus Placebo and Versus Pramipexole Immediate Release (IR) Administered Orally Over a 26-week Maintenance Phase in L-Dopa+ Treated Patients With Advanced Parkinsons Disease (PD). (clinicaltrials.gov)
  • Finally, the efficacy of 10-μm microparticles was investigated using a model of antigen-induced arthritis (AIA) in mice. (biomedcentral.com)
  • One clinical study in agitated elderly patients compared the effects of tiapride, haloperidol and placebo and found that while the two drugs had comparable efficacy superior to the placebo effect, tiapride had fewer and less severe side effects than haloperidol. (wikipedia.org)
  • The modelling of schizophrenia in animals can range from attempts to imitate the full extent of symptoms found in schizophrenia, to more specific modelling which investigate the efficacy of antipsychotic drugs. (wikipedia.org)
  • carbamazepine
  • While tiapride does not affect positive symptoms of psychosis such as hallucinosis or delirium sometimes manifested in alcohol withdrawal syndrome, if combined with a drug such as carbamazepine that addresses those symptoms, it is ideal for treating alcohol dependency because its metabolism does not depend on liver function and it has low potential for abuse. (wikipedia.org)
  • severe
  • This is a multicenter Phase 2 randomized parallel-group study to determine the effect of Telintra treatment on severe chronic neutropenia. (clinicaltrials.gov)
  • Pulmonary toxicity due to bleomycin is one of the most common, severe and extensively studied chemotherapy complications. (endocrinologyadvisor.com)
  • First, the toxicity grading scale used in the study to define severe hepatotoxicity is limited because the magnitude of the increase of serum transaminase levels has no prognostic value. (natap.org)
  • Another GWAS performed in 2012 identified twenty SNPs located ~190 Kb downstream of MC4R in association with severe antipsychotic-induced weight gain. (wikipedia.org)
  • GTN also can cause severe hypotension, circulatory collapse, and death if used together with vasodilator drugs that are used for erectile dysfunction, such as sildenafil, tadalafil, and vardenafil. (wikipedia.org)
  • cognitive
  • The non-selective melanocortin receptor agonist afamelanotide (NDP-α-MSH) has been found to induce brain-derived neurotrophic factor (BDNF) expression in the rodent brain via activation of the MC4 receptor and mediate "intense" neurogenesis and cognitive recovery in an animal model of Alzheimer's disease. (wikipedia.org)
  • Persistent treatment of rodents with amphetamine models some symptoms of schizophrenia including hyperactivity, enduring prepulse inhibition abnormalities, and cognitive abnormalities associated with the prefrontal cortex including attention deficits. (wikipedia.org)
  • rheumatoid arthritis
  • The mean follow-up periods were 32 ± 16 months in Group A and 51 ± 23 months in Group B. Patients who underwent revision arthroplasty and those who were susceptible to infection due to factors such as diabetes mellitus, rheumatoid arthritis, or steroid therapy, were excluded from this study. (hindawi.com)
  • exposure
  • 2) Three case-control studies have examined pseudoephedrine exposure among mothers of children born with gastroschisis. (biomedsearch.com)
  • In two studies, pseudoephedrine exposure was associated with a significant odds ratio. (biomedsearch.com)
  • THC exposure in rats during the prenatal developmental phase may cause epigenetic changes in gene expression, but there is limited knowledge about the risk for psychiatric disorders because of ethical barriers to studying the developing human brain. (wikipedia.org)
  • While animal studies cannot take into account factors that could influence the effects of cannabis on human maternal exposure, such as environmental and social factors, a 2011 review of rodent studies by Campolongo et al. (wikipedia.org)
  • The symptoms of DRESS syndrome usually begin several weeks after exposure to the offending drug. (wikipedia.org)
  • Environmental causes involving exposure to PCBs (ex.dioxin), radiation, anticancer chemotherapeutic agents, allergy and toxic epidermal necrolysis after drug. (wikipedia.org)
  • These conditions are listed below: Perinatal (during birth) cerebral injury Kernicterus Cerebrovascular diseases Drug induced Central nervous system tumor Peripheral or central trauma Infectious or post infectious encephalopathies Toxins Metabolic Paraneoplastic syndromes Central pontine myelinolysis Secondary spasmodic torticollis is diagnosed when any of the following are present: history of exogenous insult or exposure, neurological abnormalities other than dystonia, abnormalities on brain imaging, particularly in the basal ganglia. (wikipedia.org)
  • tumor
  • Over the last two decades, dozens of novel chemotherapeutic agents have been developed, including targeted inhibitors of tumor growth pathways, immunostimulatory, and immunomodulatory drugs. (endocrinologyadvisor.com)
  • clinically
  • To overcome these limitations, we investigated magnetically retainable drug delivery systems, an approach as yet clinically unexploited despite the intense need for the development of novel i-a. delivery modalities. (biomedcentral.com)
  • Because PGE2 activates multiple prostanoid receptors and has a short half-life in vivo due to its rapidly metabolism in cells by omega oxidation and beta oxidation, metabolically resistant EP2-selective activators are useful for the study of this receptor's function and could be clinically useful for the treatment of certain diseases. (wikipedia.org)
  • Phase
  • Most studies through 2013 linking development of the fetus and cannabis show effects of consumption during the gestational period, but abnormalities in the endocannabinoid system during the phase of placental development are also linked with problems in pregnancy. (wikipedia.org)
  • medications
  • Obviously, consensus criteria for the assessment of causality in cases of drug-induced liver damage cannot be used in this population because of a high prevalence of coinfection with hepatotropic viruses and concomitant therapy with several potentially hepatotoxic medications. (natap.org)
  • also known as drug-induced hepatotoxicity ) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. (uspharmacist.com)
  • 11-14 Another drug reference list, DILIrank, contains information on 1,036 FDA-approved medications ranked according to their potential to cause DILI. (uspharmacist.com)
  • Intervention
  • A 2002 study concluded that the most frequent causes of death and disability in the United States today are not heart disease or cancer, but iatrogenic and pharmacogenic effects.3 The researchers found a mortality of more than 780,000 deaths per year from conventional medical intervention. (homeopathicassociates.com)
  • pregnancy
  • Treatment of breast cancer during pregnancy: an observational study. (biomedsearch.com)
  • The objective of our study is to evaluate the importance of the perception of the risk level in making the decision to end the pregnancy and the relevance that a teratology consultation can have in preventing unmotivated terminations of pregnancy METHODS: We carried out a survey on 350 women in Rome who voluntarily interrupted their pregnancy to evaluate the prevalence due to presumed teratogen. (biomedsearch.com)
  • A report prepared for the Australian National Council on Drugs concluded cannabis and other cannabinoids are contraindicated in pregnancy as they may interact with the endocannabinoid system. (wikipedia.org)
  • commonly
  • The side-effect reported most commonly to the U.S. Food and Drug Administration (FDA) is rhabdomyolysis, a condition characterized by muscle tissue breakdown. (wikipedia.org)
  • patients
  • A total of 75 patients will be recruited: 25 for each arm of the study. (clinicaltrials.gov)
  • Although these therapies have only been in widespread use for a short period of time, a growing body of evidence from case reports and cohort studies has suggested that HIV-infected patients on HAART may experience premature coronary artery disease. (clinicaltrials.gov)
  • As you know a number of studies by HIV researchers have found HCV/HIV coinfected patients on HAART can experience elevated liver enzymes (AST/ALT) exascerbated by HCV or HBV infection. (natap.org)
  • Because HAART-associated immune restoration may have a positive impact on the course of liver disease in coinfected patients, the assessment of the risk-benefit ratio of NNRTIs, especially in this population, requires further study. (natap.org)
  • In a retrospective Taiwanese cohort study of 60 patients, these incidences were observed. (wikipedia.org)
  • Studies have shown[weasel words] that nitrate tolerance is associated with vascular abnormalities which have the potential to worsen patients' prognosis. (wikipedia.org)
  • Research in animal models and clinical studies in alcoholic patients have found that tiapride has anxiolytic effects. (wikipedia.org)
  • In another study in which alcoholic patients were given titrated doses up to 800 mg/day, subjects showed significant improvements in ratings of withdrawal, craving, psychiatric symptoms and quality of life. (wikipedia.org)
  • One clinical study of patients with tardive dyskinesia associated with Parkinson's disease found that tiapride significantly improved motor abilities without affecting other parkinsonian symptoms. (wikipedia.org)
  • Studies have shown that over 75% of patients report neck pain, and 33% to 40% experience tremor of the head. (wikipedia.org)
  • Abnormalities in PPI are seen in patients with schizophrenia. (wikipedia.org)
  • Dopamine release Neuroimaging studies on patients with schizophrenia have found increased dopamine release after treatment with amphetamine relative to normal controls. (wikipedia.org)
  • liver
  • They do not feel such increases translate into liver damage but say we cannot conclude such elevations equal liver damage and we better need studies to explore this. (natap.org)
  • Antipsychotic
  • Antipsychotic drugs are the most common treatment for these symptoms, but often come with a host of side-effects including orthostatic hypotension and deficits in vigilance and attention. (wikipedia.org)
  • Each extreme has its limitations, with whole-syndrome modelling often failing due to the complexity and heterogeneous nature of schizophrenia, and antipsychotic-specific modelling being often not useful for discovering drugs with unique mechanisms of action. (wikipedia.org)
  • lesion
  • The posterior cingulate cortex has been linked by lesion studies to spatial memory, configural learning, and maintenance of discriminative avoidance learning. (wikipedia.org)
  • Treatment
  • This is a pilot study of a protocol for inducing a falciparum malaria infection in healthy volunteers in order to test the activity of novel agents being developed as drugs for the treatment of uncomplicated malaria. (clinicaltrials.gov)
  • The study will follow the sequence of the challenge inoculation, reference treatment and follow-up. (clinicaltrials.gov)
  • On day 5 evening, participants will be admitted to the study unit and confined for safety monitoring and antimalarial treatment. (clinicaltrials.gov)
  • deciding whether a patient can continue a potential culprit drug may have significant impact on the patient's future cancer treatment. (endocrinologyadvisor.com)
  • The first objective of this study was to choose the most suitable drug delivery system for the local treatment of joint inflammation. (biomedcentral.com)
  • Conventional medicine does not have an effective evidence-based treatment for arsenic-induced toxicity, although some chelators, like DMSA and DTPA, have been tried without success. (homeopathicassociates.com)
  • The study is indicated to investigate the cause, location of origin, and best treatment for various abnormal heart rhythms. (wikipedia.org)
  • tolerance
  • Tolerance is defined as the loss of symptomatic and hemodynamic effects of GTN and/or the need for higher doses of the drug to achieve the same effects,[citation needed] and was first described soon after the introduction of GTN in cardiovascular therapy. (wikipedia.org)
  • therapy
  • These drug interactions with fenofibrate are considered major and may need therapy modifications: Bile acid sequestrants (e.g. cholestyramine, colestipol, etc. (wikipedia.org)
  • include
  • Genetic associations for selective tooth agenesis ("STHAG") include: In the 1960s and 1970s, several studies were conducted sponsored by the U.S. Atomic Energy Commission, with the aim of finding a link between genetics and hypodontia. (wikipedia.org)
  • full citation needed] Recent evidence suggests[weasel words] that deleterious GTN-induced production of oxygen free radicals might induce a number of abnormalities, include those described above, so that the oxidative stress hypothesis might represent a unifying principle. (wikipedia.org)
  • patient's
  • Then the electrophysiologist tries to provoke arrhythmias and reproduce any conditions that have resulted in the patient's placement in the study. (wikipedia.org)
  • investigate
  • The purpose of this study was to investigate an innovative alternative consisting of corticosteroid encapsulation into magnetically retainable microparticles. (biomedcentral.com)
  • found
  • Only two listed contraindications are found within the 2008 package insert: "Nonsteroidal anti-inflammatory drugs (NSAIDs): Although not observed with moxifloxacin in preclinical and clinical trials, the concomitant administration of a nonsteroidal anti-inflammatory drug with a fluoroquinolone may increase the risks of CNS stimulation and convulsions. (wikipedia.org)
  • Furthermore, a study searching for 18 major species of gut flora, including L. acidophilus, in a variety of animals found L. reuteri was the only bacterium to constitute a "major component" of the Lactobacillus species present in the gut of each of the tested host animals. (wikipedia.org)
  • animal models
  • PF-04418948 (Ki=16 nM), TG4-155 (Ki=9.9 nM), TG8-4, and TG6-129 are selective competitive antagonists for EP2 that have been used for studies in animal models of human diseases. (wikipedia.org)
  • Research into the psychotic disorder of schizophrenia, involves multiple animal models as a tool, including in the pre-clinical development of drugs. (wikipedia.org)
  • Animal models were first produced for schizophrenia by altering the dopaminergic system using drugs. (wikipedia.org)
  • effects
  • This observation led to the first class of chemotherapy agents and exemplifies both the desired cytotoxic effects of these drugs as well as the potential for fatal toxicities. (endocrinologyadvisor.com)
  • Moreover, its selectivity for the dopaminergic system is thought to account for its avoidance of the side effects typically associated with other neuroleptic drugs, such as chlorpromazine, which act on a number of neurotransmitter systems. (wikipedia.org)
  • interval
  • Ten other individuals who displayed no changes in QT interval after administration of the same drugs, were selected. (ahajournals.org)
  • In the most recent study, the risk of gastroschisis was increased 4.2-fold among women taking the pseudoephedrine-paracetamol combination (95% confidence interval 1.9-9.2). (biomedsearch.com)
  • agents
  • This is a single-center, controlled, randomized, study using a BSP inoculum challenge as a model to assess the activity of antimalarial agents. (clinicaltrials.gov)
  • After the success of the nitrogen mustards in the 1950s, several new classes of chemotherapeutic agents were developed including alkylating agents, anti-metabolites, nitrosureas, and antibiotic-derived drugs. (endocrinologyadvisor.com)
  • Last, the electrophysiologist may administer various drugs (proarrhythmic agents) to induce arrhythmia. (wikipedia.org)
  • development
  • This is an enabling study using registered antimalarial drugs as reference treatments (one slow acting and one fast acting), aimed to inform trial design, endpoints and testing regimens for assessing new candidate antimalarial drugs in development. (clinicaltrials.gov)
  • Among the more concerning are the development of atherogenic lipoprotein abnormalities and a state of relative insulin resistance. (clinicaltrials.gov)