• nightshade
  • A spooky cloud of mist wafted through borders planted with strychnine, cannabis, devil's eye, stinking nightshade and mandrake which, legend has it, emits an ear-piercing scream when uprooted, and begins to sweat blood. (bgci.org)
  • toxic
  • The poisons spanned such a range that the professor felt compelled, as one reviewer noted, to include a 76-page alphabetical listing of all the toxic compounds - from strychnine to arsenic to thallium to taxine - and all the related chemistry in the Christie ouevre. (plos.org)
  • In high doses, strychnine is very toxic to humans and many other animals (LD50 = 16 mg/kg in humans, 1-2 mg/kg orally in rats and mice), and poisoning by inhalation, swallowing, or absorption through eyes or mouth can be fatal. (wikipedia.org)
  • glycine
  • In our study, evidence is provided that strychnine, a competitive antagonist at glycine-gated Cl − channels, is also a potent competitive antagonist at native α-7-containing, α-bungarotoxin-sensitive nicotinic acetylcholine receptor (nAChRs). (aspetjournals.org)
  • fatal
  • Strychnine poisoning can be fatal to humans and other animals and can occur by inhalation, swallowing or absorption through eyes or mouth. (wikipedia.org)
  • Strychnine is easily quantitated in body fluids and tissues using instrumental methods in order to confirm a diagnosis of poisoning in hospitalized victims or to assist in the forensic investigation of a case of fatal overdosage. (wikipedia.org)
  • dependent
  • Type IA and type II nicotinic currents evoked by acetylcholine (ACh) were inhibited by strychnine in a concentration-dependent manner with IC 50 s of 1.2 and 38 μM, respectively. (aspetjournals.org)
  • In contrast, the inhibition by strychnine of type II current was strongly voltage dependent, and the decay phase of this current was markedly accelerated by the toxin, suggesting an open-channel blockade by strychnine of the α4β2 nAChRs subserving type II currents. (aspetjournals.org)
  • Case
  • CASE REPORT: A 34 year-old male presented to the emergency department 20 minus after ingesting half of a 250-mL container of 2% strychnine sulfate (2.25 g). (biomedsearch.com)
  • There is altogether too much strychnine about this case - The Mysterious Affair at Styles, Agatha Christie, 1920. (plos.org)
  • We feel that the results obtained in the human case and in our animal experiments justify the supposition that magnesium sulphate may be of use in controlling cases of poisoning by strychnine. (rupress.org)
  • plot
  • The plot twists and turns (and thickens) but Cyril wins Amelia in the end, thanks to a wandering copy of the new Inspector Mould mystery, Strychnine in the Soup. (wikipedia.org)
  • effects
  • Strychnine was popularly used as an athletic performance enhancer and recreational stimulant in the late 19th century and early 20th century, due to its convulsant effects. (wikipedia.org)
  • The treatment for strychnine poisoning in the late 19th and early 20th centuries was to administer tannic acid which precipitates the strychnine as an insoluble tannate salt, and then to anaesthetise the patient with chloroform until the effects of the strychnine had worn off. (wikipedia.org)
  • To address the effects of strychnine on two types of nicotinic responses, the whole-cell mode of the patch-clamp technique was applied to rat hippocampal neurons in culture. (aspetjournals.org)
  • However, it is unlikely that strychnine poisoning could be accounted for by these effects, because they are observed at concentrations that are considerably greater than those at which the alkaloid exerts its excitatory and depressant effects in the CNS ( Franz, 1975 ). (aspetjournals.org)
  • usually
  • citation needed] Strychnine poisoning in animals usually occurs from ingestion of baits designed for use against gophers, moles, and coyotes. (wikipedia.org)
  • Strychnine poisoning in animals occurs usually from ingestion of baits designed for use against rodents (especially gophers and moles) and coyotes. (wikipedia.org)
  • Group
  • The veratryl group not only blocks the 2-position for further electrophilic substitution but will also become part of the strychnine skeleton. (wikipedia.org)
  • French
  • Strychnine was first discovered by French chemists Joseph Bienaimé Caventou and Pierre-Joseph Pelletier in 1818 in the Saint-Ignatius' bean. (wikipedia.org)
  • combination
  • An scare e-mail claiming that gang members are placing a deadly LSD/strychnine combination on public telephones shows no signs of being true. (nuketown.com)
  • shown
  • In contrast to the previously noted low potency of strychnine at nonneuronal nAChRs, the toxin has been shown to have potent actions on certain subtypes of neuronal nAChRs. (aspetjournals.org)
  • The synthesis is one of the simplest methods for creating poly-substituted indoles, this procedure has been utilized in numerous natural product syntheses, including aspidophytine, vinblastine, and strychnine Shown below is the fourth step in the synthsis of (+)-Vinblastine, the application of the Fukuyama Indole synthesis to create a disubstituted indole. (wikipedia.org)
  • page
  • A version of this archives appears in print on March 7, 1913, on Page 4 of the New York edition with the headline: WON RACES BY STRYCHNINE. (nytimes.com)
  • salt
  • In order to hasten the excretion of strychnine, 200 to 300 cc. of salt solution should be given intravenously. (rupress.org)
  • Open
  • Preexposure of the neurons to strychnine enhanced its ability to decrease the peak amplitude of type II currents, indicating that the toxin may also act on α4β2 nAChR channels that are not open. (aspetjournals.org)
  • animals
  • Bill : an act to legalize the use of strychnine in Upper Canada for the destruction of wolves and other noxious animals, and to repeal part of the 5th section of an act of the 14th and 15th years of Her Majesty's reign, intituled, "An act to prevent the hunting of deer at improper seasons of the year and further to amend the laws for the preservation of game. (worldcat.org)
  • possible
  • It seems that a new form of gang initiation is to go find as many pay phones as possible and put a mixture of LSD and Strychnine onto the buttons. (nuketown.com)