Structures peptide fragments. Medical search. Frequent questions

These directions allow scientists to map and determine the detailed structure of proteins, which is then recorded and uploaded to the PDB. (wikipedia.org)
There, the peptides are attached to MHC class I proteins. (medlineplus.gov)
Because there are no peptides for MHC class I proteins to bind, they are broken down, which results in a shortage of MHC class I proteins on the surface of cells. (medlineplus.gov)
Mutations in another gene involved in the attachment of peptides to MHC class I proteins very rarely cause BLS I. (medlineplus.gov)
Copper ions bind to biomolecules (e.g., peptides and proteins) playing an essential role in many biological and physiological pathways in the human body. (mdpi.com)
The binding mode of this fragment is similar in both proteins. (uni-marburg.de)
The molecular process underlying the reaction is known to involve the fibrous muscle proteins, the peptide chains of which undergo a change in conformation during contraction. (britannica.com)
Over 250 crystal structures of monoclonal Fab fragments and complexes with a variety of antigens, such as peptides, steroids, cocaine, and proteins, including HIV-1, gp120 and gp41, have led to significant insights into antibody-antigen recognition, virus neutralization, and vaccine design for HIV-1. (scripps.edu)
We have also determined structures of almost all of the rare, broadly neutralizing antibodies against the HIV-1 envelope proteins, gp120 and gp41, in order to elucidate the sites of vulnerability that can be used for HIV-1 vaccine design. (scripps.edu)
We designed new peptides of GRA6, GRA7, and SAG1 proteins, with more SNPs among the three clonal strains than those previously designed. (frontiersin.org)
developed a typing method based on antibody binding to polymorphic peptides, designed from proteins related to virulence. (frontiersin.org)
MHC II proteins present peptide antigens that originate extracellularly from foreign bodies such as bacteria. (embl-heidelberg.de)
Proteins from the pathogen are degraded into peptide fragments within the APC, which sequesters these fragments into the endosome so they can bind to MHC class II proteins, before being transported to the cell surface. (embl-heidelberg.de)
However, both present peptide fragments rather than entire proteins to T cells, and are required to mount an immune response. (embl-heidelberg.de)
Bacteria also secrete proteases to hydrolyze (digest) the peptide bonds in proteins and therefore break the proteins down into their constituent monomers (amino acids). (stratech.co.uk)
A peptide scaffold made partly of nonnatural β-amino acids could serve as a versatile source of potential drugs that bind large proteins such as the anticancer target VEGF, researchers report. (acs.org)
The nonnatural peptides offer a possibly advantageous alternative to antibody-based agents that target large proteins because the peptides are easier to make and may last longer in the body. (acs.org)
The use of amino acids, proteins and peptides is not expected to have any environmental impact. (janusinfo.se)
According to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00) vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids proteins, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. (janusinfo.se)

We present the structure of an Aβ(1-42) fibril composed of two intertwined protofilaments determined by cryo-electron microscopy (cryo-EM) to 4.0-angstrom resolution, complemented by solid-state nuclear magnetic resonance experiments. (nih.gov)
We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. (duke.edu)

Recently, it has been shown that the three-dimensional structure of a majority of disease-related amyloid fibrils contains a β-strand-loop-β-strand motif called β-arch. (nih.gov)
Previous studies in the literature have resulted in conflicting reports on the potential neurotoxicity of the beta-cleaved Alzheimer's disease C-terminal fragment (beta-CTF) of beta-amyloid precursor protein in vivo. (amsterdamumc.org)

Taking this fragment from HGH, including the peptide bonds from 176-191, they found they had developed a peptide that regulated fat loss 12.5 times better than regular HGH. (giantlab.net)

Based on the the conserved sequences of antimicrobial peptides of insects (mainly Diptera) from different antimicrobial peptide databases, thirty-seven pairs of degenerate primers were designed, and the antimicrobial peptide genes from Hermetia illucens L were screened using these primers. (ukessays.com)
Seven gene fragments for three types of antimicrobial peptides cecropin, sarcotoxin and stomoxyn were acquired. (ukessays.com)
Currently, the need for safe and effective antimicrobial peptides agents increases in parallel with the emergence of many antibiotic-resistant strains as a consequence of excessive use and widespread of the antibiotics [1]. (ukessays.com)
Many desirable features, such as low cost of production, rapidity, heat-tolerant, relatively broad antimicrobial spectrum and low toxicity to eukaryotic cells made of antimicrobial peptides to be a new alternative to the conventional antibiotic [2]. (ukessays.com)
The insects immune systems possess several features in common, does not have specific immune system as found in the higher animals , lacking of B and T lymphocytes and no immunoglobulins and complement production [3], this make insect developed effective and complex innate immune and antimicrobial peptides are a key factor of the insect's immune system [ 4 , 5 ]. (ukessays.com)
Antimicrobial peptides (AMPs) have a variety of interesting biological functions including antibacterial, antifungal, antiparasitic, antitumoral, and antiviral activities [6-8]. (ukessays.com)
Nowadays, molecular biology researchs are featured a wide range of antimicrobial peptides (AMP)-related topics such as AMP genome library construction, development of antimicrobial peptides and their mimetics as therapeutic agents, structure/function analysis, cloning and expression, regulation, mechanisms of action, microbial escaping strategies and human disease associations. (ukessays.com)
In this regard, antimicrobial peptides or the bacteriocins from food grade lactic acid bacteria (LAB) have engrossed because of their safety and broad range of antibacterial spectrum. (researchsquare.com)

The protein structure file is downloaded from the PDB and opened in a molecular docking software. (wikipedia.org)
The amino acid sequence of the protein that is being constructed is then used in combination with the protein structure found in the PDB with the highest percent similarity (template protein) in order to create the target protein used in docking. (wikipedia.org)
DNA sequence alignment analysis and the forecast-analysis of protein structure indicated that these seven antimicrobial peptide genes were not homologous to any other antimicrobial peptide genes in GenBank. (ukessays.com)
Fragment libraries play a key role in fragment-assembly based protein structure prediction, where protein fragments are assembled to form a complete three-dimensional structure. (biomedcentral.com)
To better leverage the valuable structural information for protein structure prediction, we extracted seven types of structural information from fragment libraries. (biomedcentral.com)
Our work implies that the rich structural information extracted from fragment libraries can complement sequence-derived features to help protein structure prediction. (biomedcentral.com)
Although fragment libraries are extensively utilized in fragment assembly, the rich structural information has not yet been systematically analyzed and leveraged by other protein structure prediction approaches. (biomedcentral.com)
Although direct identification of abnormal protein structure still was not possible, such defects could be inferred, indirectly, by demonstrating alterations in the kinetic properties of patients' enzymes (ie, rates of reaction as concentrations of cofactor or substrate were varied) or in the rate at which heating the enzyme altered its catalytic properties. (medscape.com)

We now report that human fibrinogen, which is known not to bind APRP, binds the synthetic peptide AHRPam. (rcsb.org)
Moreover, a crystal structure of AHRPam complexed with fragment D from human fibrinogen shows that AHRPam binds exclusively to the beta-chain hole and, unlike GHRPam, not at all to the homologous gamma-chain hole. (rcsb.org)

By Edman degradation of the deacetylated peptide and by sequencing of the PCR-amplified DNA that encodes the peptide, the complete amino acid sequence was determined to be AEVAPAPAAAAPAKAPKKKAAAKPKKAGPS. (nofima.no)

Knowledge of the structures of variable surface antigens such as PorA is an essential prerequisite to a molecular understanding of antigenic variation and its implications for vaccine design. (rcsb.org)
The T-cell receptor in complex with pMHC has revealed how peptide antigens can be recognized in the context of the MHC molecule. (scripps.edu)

In order to produce a protein molecule that can be used for docking, scientists can use the amino acid sequence of a protein and a program named UniProt to find protein structures in the PDB that have similar amino acid sequences. (wikipedia.org)
Here, we identify an evolutionarily conserved hexapeptide sequence as the major aggregation-prone region (APR) of gastrointestinal peptides of the glucagon family: xFxxWL. (nature.com)
Finally, these new peptides reveal a carbohydrate moiety, indicating a glycosylation in the sequence. (springer.com)
Peptides were characterized by a combined use of MALDI- TOF/TOF and nanoESI-IT-ETD experiments to determine not only the peptide sequence but also the composition and the position of the carbohydrate moiety. (springer.com)
A synthetic peptide whose sequence was identical to that of the isolated fragment was initially inactive but could be activated by binding it to a cation-exchange column. (nofima.no)
The protein sequence and the three-dimensional folding structure for cytochrome c 550 from Micrococcus denitrificans are reported. (caltech.edu)
Standard protein chemistry techniques were applied to sequence all the fragment peptides from a tryptic digest of c 550 . (caltech.edu)
This information was combined with a 2.45 Å electron density map of the protein where identifying the tryptic fragments in the map led to the correct ordering of the peptides and the final complete sequence. (caltech.edu)
Proteases can either break specific peptide bonds, depending on the amino acid sequence of a protein, or break down a complete peptide to amino acids. (stratech.co.uk)

Bax is activated when small protein fragments called BH3-peptides bind to it. (edu.au)
There were 24 fragments detected to bind in the ATP-binding pocket. (uni-marburg.de)

The structure of a peptide antigen corresponding to the subtype P1.7 variant of the porin PorA from the human pathogen Neisseria meningitidis was determined by solution of the X-ray crystal structure of the ternary complex of the peptide (ANGGASGQVK) in complex with a Fab fragment and a domain from streptococcal protein G to 1.95 A resolution. (rcsb.org)
Major Histocompatibility Complex (MHC) glycoproteins are heterodimeric cell surface receptors that function to present antigen peptide fragments to T cells responsible for cell-mediated immune responses. (embl-heidelberg.de)

Second, the new peptides do not contain disulfide bonds, a post-translational modification commonly encountered in animal toxins. (springer.com)
Compstatin (SEQ ID NO:2), a 13-residue peptide, circularized by disulfide bond (Cys-2-Cys-12), displays an inhibitory activity of IC 50 =12 μM. (justia.com)

Interestingly, these peptides differ in several points from other already known mamba toxins. (springer.com)
Anyway, such small glycosylated and proline-rich toxins are totally different from any other known snake peptide and form, as a consequence, a new family of peptides. (springer.com)
Animal venoms represent a very large group of bioactive peptide toxins. (springer.com)
Different aspects of the interaction between peptides from the toxins' N-termini (StI1-31 and StI12-31 SELAGTIIDGASLTFEVLDKVLGELGKVSRK, and StII1-30 and StII11-30 ALAGTIIAGASLTFQVLDKVLEELGKVSRK) and model membranes - micelles and bilayers - have been studied to contribute to the elucidation of the toxins mechanism of action at the molecular level. (bvsalud.org)
For over two decades, Artur Schmidtchen and his research group have studied endogenous peptides, smaller protein fragments in the body with the ability to both kill bacteria and neutralize the bacterial toxins released during an infection. (lu.se)
Additionally, the designed structure also blocks various toxins released by bacteria, thereby regulating inflammation. (lu.se)

describes the use of a phage-displayed combinatorial random peptide library to identify a 27-residue peptide that binds to C3 and inhibits complement activation. (justia.com)
A designed α/β-peptide binds to a VEGF dimer (gray). (acs.org)

The additivity of substrate fragments in enzyme-ligand binding. (expasy.org)

Due to the efficient pre-screening selection and the difficult crystallisation of Pim1 complexes, only three of the 361 fragments were commonly studied by protein crystallography with both kinases. (uni-marburg.de)
In the second subproject of this thesis, complexes of PKA and fragments were analyzed by direct exposure of soaked crystal to X-ray analysis. (uni-marburg.de)
Complexes of Vps34, the sole class III PI3K member, produce PI 3-phosphate (PI(3)P) in the endolysosomal system and during autophagy to regulate vesicle-mediated sorting en route to lysosomes 1 . (nature.com)

The peptide adopted a beta-hairpin structure with a type I beta-turn between residues Gly4P and Gly7P, the conformation of the peptide being further stabilised by a pair of hydrogen bonds from the side-chain of Asn2P to main-chain atoms in Val9P. (rcsb.org)
Recognition was supplemented by hydrogen bonds from heavy chain residues Thr50H, Asp95H, Leu97H and Tyr100H to main-chain and side-chain atoms in the peptide. (rcsb.org)
The backbone of all 42 residues and nearly all side chains are well resolved in the EM density map, including the entire N terminus, which is part of the cross-β structure resulting in an overall "LS"-shaped topology of individual subunits. (nih.gov)
A cooperative and competitive interaction between multiple enzymes, cell lines, and cell culture conditions causes processing of the oligosaccharide structure during which some of the already attached moieties like mannose are trimmed to yield a fiveâ residue core (Man3GlcNAc2), to which N-acetylglucosamine (GlcNAc), fucose, galactose, and N-acetylneuraminic acid (sialic acid or Neu5Ac) residues get added in a probabilistic fashion. (chromatographyonline.com)
Proteases are involved in digesting long protein chains into short fragments, splitting the peptide bonds that link amino acid residues. (stratech.co.uk)

We used DeepFragLib, the state-of-the-art fragment library construction approach when benchmarked on recent CASPs [ 21 ], to generate fragment libraries for subsequent studies. (biomedcentral.com)
I'm having the same question that how to generate fragment library for peptide(9 length).Could you provide me a detailed tutorial on FlexPepDock ab-initio( [email protected] )? (rosettacommons.org)

Attachment of a protease to a certain group depends on the structure of catalytic site and the amino acid (as one of the constituents) essential for its activity. (stratech.co.uk)
A change in structure was in those days thought to be due to a change in an amino acid somewhere in the peptide chain of the protein. (medscape.com)

The avian H5N1 and swine H1N1 influenza virus HA structures have been determined as well as mutations that enhance binding to human receptors that may allow the virus to cross the species barrier into humans and be transmissible. (scripps.edu)
In conclusion, serotyping using the improved GRA6 peptide triad is useful to serotype T. gondii in humans and could be implemented for clinical management and epidemiological studies, to provide information on the parasite type in specific areas. (frontiersin.org)

We determine nine polymorphic crystal structures of the APR segments of glucagon-like peptides 1 and 2, and exendin and its derivatives. (nature.com)

The tertiary structure resulted from an x-ray crystallographic determination. (caltech.edu)
The addition of a precursor 13-residue oligosaccharide moiety GlcNAc2Man8Gluc3 to the nascent polypeptide chain occurs in the endoplasmic reticulum, following which the assembly folds and acquires its secondary, tertiary, and quaternary structure. (chromatographyonline.com)

Scholars@Duke publication: Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. (duke.edu)
Certolizumab pegol is a recombinant, humanized antibody Fab' fragment against tumour necrosis factor alpha (TNFα), conjugated to polyethylene glycol (PEG) and in accordance with the CHMP guideline on the environmental risk assessment (EMEA/CHMP/SWP/4447/00) is exempted from testing because of its chemical structure. (janusinfo.se)

This University of California, San Diego advance will finally enable scientists to rapidly characterize ring-shaped nonribosomal peptides (NRPs) - a class of natural compounds of intense interest due to their potential to yield or inspire new pharmaceuticals. (scienceblog.com)
The focus of present study was to characterize antimicrobial peptide produced by probiotic cultures, Enterococcus durans DB-1aa (MCC4243), Lactobacillus plantarum Cu2-PM7 (MCC4246) and Lactobacillus fermentum Cu3-PM8 (MCC4233) against Staphylococus aureu s and E. coli . (researchsquare.com)

Nonribosomal peptides (NRPs) often serve as chemical defenses for the bacteria that manufacture them. (scienceblog.com)
The peptide was active against both gram-negative and -positive bacteria. (nofima.no)

By mimicking the natural structure of peptides from the protein thrombin, researchers have designed a peptide-based treatment, sHVF18. (lu.se)

Bioinformatic analysis was done to predict the secondary structure and three-dimensional structure of these seven gene fragments that may exist. (ukessays.com)
Fragment libraries contain rich structural information, including 1D structural properties such as secondary structure and torsion angles, and 2D structural properties such as distances and orientations between pairs of heavy atoms. (biomedcentral.com)
The Robetta Server requires a minimum AA length of 26 as the various tools used during fragment generation like secondary structure prediction are not optimized for very small peptides. (rosettacommons.org)
After making the required changes for the number of CPUs for Fragment_Picker and BLAST_NUM_CPUS, I tried to inactivate the "EXTRA OPTIONAL FEATURES", but the same is also required for secondary stucture prediction. (rosettacommons.org)

Each hormone peptide has its own class B type G-protein coupled receptor 19 , 21 functioning along identical receptor activating schemes (Fig. 1c ). (nature.com)

I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)

A protease is an enzyme that conducts proteolysis, i.e., the protein catabolism by hydrolysis of the peptide bonds that link amino acids together in the polypeptide chain which form the protein. (stratech.co.uk)
Some of them can detach the terminal amino acids from the protein chain (exopeptidases, such as aminopeptidases, carboxypeptidase A), while others attack internal peptide bonds of a protein (endopeptidases, such as trypsin, chymotrypsin, pepsin, papain and elastase). (stratech.co.uk)

This bacterial c 550 possesses a structure similar to the known cytochromes from eukaryotic sources and from a photosynthetic bacterium. (caltech.edu)
Bacterial exotoxic proteases destroy extracellular structures. (stratech.co.uk)
In the mid-1990s, Per-Åke Nygren of the Royal Institute of Technology, in Stockholm, and coworkers showed that the Z-domain, a three-helix fragment of a bacterial protein, fulfills that role. (acs.org)
Now, drawing inspiration from the body's own defence mechanisms based on peptides, we have developed a new approach to treating severe bacterial infections", says Artur Schmidtchen, professor in dermatology and venereology and senior consultant at Skåne University Hospital, who led the study. (lu.se)

interpretation of the classical "iceberg" metaphor.11 To a first approximation, the hydrogen-bonded water structure seems to As a result of the small size and multiple hydrogen-bonding be the same in the hydrophobic hydration shell as in the bulk capacity of the water molecule, the cohesive energy density of solvent. (lu.se)

Based on NMR and mass spectroscopy data, the structures of these natural compounds were identified as containing phenylalaninol or methioninol fragments. (thieme.de)

The structure of C3c in complex with the complement inhibitor, compstatin, and use of this information for rational design or identification of complement-inhibiting drugs are disclosed. (justia.com)
Because compstatin blocks this critical step of complement activation and because it is a small non-immunogenic peptide, compstatin has the potential to be developed into a therapeutic agent. (justia.com)
However, those features only leverage sequential information, and incorporating new features from known protein structures could serve as a complement and thus benefit protein property predictions. (biomedcentral.com)

This study describes the structural characterization of a totally new family of peptides from the venom of the snake green mamba ( Dendroaspis angusticeps) . (springer.com)
The last two features have made the structural characterization of the new peptides by mass spectrometry a real analytical challenge. (springer.com)
In particular, this invention provides the structure of the C3 inhibitor, compstatin, in complex with C3c, and uses of that structural information for rational drug design. (justia.com)
I also directed the Joint Center for Structural Genomics (2000-2016) that pioneers new high throughput methodologies and technologies for protein production, structure determination and functional analysis in order to investigate the Expanding Protein Universe and the human gut microbiome and other high-value targets in the regulation of stem cells and T cells. (scripps.edu)
Rich and accurate structural information embedded in fragment libraries has not been systematically extracted and used beyond fragment assembly. (biomedcentral.com)
We broadened the usage of such structural information by transforming fragment libraries into protein-specific potentials for gradient-descent based protein folding and encoding fragment libraries as structural features for protein property prediction. (biomedcentral.com)
In this study, to leverage the structural information provided by fragment libraries, we first directly extracted multiple structural properties from fragment libraries and proposed novel fragment-level metrics for evaluation. (biomedcentral.com)

More than 90 percent of its peptide chains are present in the α-helix form. (britannica.com)

These algorithms make sense of the flood of tiny peptide fragments that are generated by machines called mass spectrometers that blast nonribosomal peptides apart and determine their sizes. (scienceblog.com)
Two complementary processes are used to glean insights from data generated from the mass spectrometers that break the cyclic peptides into smaller and smaller linear pieces. (scienceblog.com)
Second, the researchers created "dereplication" tools for moving the other direction: taking the chemical structures of known NRPs and other related information and determining what the data signature would look like if a mass spectrometer had blown the compound part. (scienceblog.com)

The primary aim of this thesis was the crystallographic analysis of PKA and Pim1 crystals in complex with small fragment-like molecules to identify potential fragment binders in the protein kinase binding pockets. (uni-marburg.de)
Remote binding fragments were analyzed in terms of the buried surface area with respect to the proximate PKA molecules to obtain some figures-of-merits, whether binding only occurs in the crystallographic packing and would turn out as 'artefacts' during an analysis by a method focussing on conditions in the solute phase. (uni-marburg.de)
class II molecules present exogenously derived antigenic peptides (~15 amino acids) to helper T cells. (embl-heidelberg.de)
MHC class I and II molecules are assembled and loaded with their peptide ligands via different mechanisms. (embl-heidelberg.de)

Figure 2A), and 3) those based on fragments containing binding to the receptor, angiotensin-converting enzyme 2 neutralizing epitopes (Figure 2B). (cdc.gov)

Treatment of the synthetic peptide when it was bound to the exchange column with peptidylproline cis-trans-isomerase increased the amount of active peptide, indicating that isomerization of the proline peptide bond(s)was necessary for activation of the synthetic peptide. (nofima.no)
Comparison of the active and inactive forms by circular dichroism and chromatographic analyses suggests that the active form, both the natural and the synthetic forms, is more structured, condensed, and rigid than the inactive form, which has a more nonstructured conformation. (nofima.no)
The structures of the synthetic acidiphilamides A, B and C were characterized by NMR, MS and Specific Optical Rotation data, and were shown to match those of the natural products, whereas the structures of epi -acidiphilamides A, B and C were confirmed by 2D NMR studies. (thieme.de)

First, the authors present new algorithms that computers use to piece these peptide fragments back together in order to determine the chemical structure of a cyclic NRP. (scienceblog.com)

More researches stated that, HGH Fragment 176-191 can make one's metabolism run faster. (giantlab.net)

Trypsin splits myosin into large fragments called meromyosin. (britannica.com)

The subsequent crystallographic analysis of these candidates revealed that 15 fragments had bound to PKA and 13 to Pim1. (uni-marburg.de)
The "bottom-up" approach bypasses the limitations of enumerated libraries through identification of the essential binding units, the fragments, and the subsequent selection of compounds containing those substructures from large chemical spaces. (biosolveit.de)

With over 600 registrations from across the globe, the scientific community and fragment enthusiasts came together virtually to discuss the most recent advances in the field of fragment-based drug discovery (FBDD), small compound binders, and modifications of functional groups. (biosolveit.de)
The sensitivity of the SAXS-TT method to small differences in periodicity of the myelin structure also enables it to distinguish between the central and peripheral nervous system (CNS/PNS) myelin. (stanford.edu)

Fragment libraires improved the accuracy of protein folding and outperformed state-of-the-art algorithms with respect to predicted properties, such as torsion angles and inter-residue distances. (biomedcentral.com)

Here, we report high-resolution crystal structures as well as a 4.4-Å cryogenic-electron microscopic (cryo-EM) structure of PI3KC2α in active and inactive conformations. (nature.com)

When X-rays are projected to a crystal structure, the crystal diffracts the X-rays in specific directions. (wikipedia.org)

Additionally, HGH Fragment 176-191 can also help in managing one's blood sugar levels. (giantlab.net)

Current proposed mechanisms for the action of c-type cytochromes are rejected as being incompatible with the c 550 structure. (caltech.edu)

Pharmacological assessment of the compounds confirmed several highly potent (K D 1-100 nM) and chemically diverse BRD4 binders with a hit rate of 7, 8, and 28% for fragments derived from drug candidates, experimental fragment hits, and computationally predicted fragment hits, respectively. (biosolveit.de)

Fragment F222 was the only one, which bound to PKA and Pim1. (uni-marburg.de)
Since several fragments bound multiple times in one structure, 15 fragments were detected in a remote position leading overall to 39 different binding poses. (uni-marburg.de)

The fragments used for this study were extracted as a part of an in-house library comprising 361 entries. (uni-marburg.de)

Mutations in the TAP1 or TAP2 gene prevent formation of the TAP complex, which impairs the transport of peptides into the endoplasmic reticulum. (medlineplus.gov)
The obtained hits were split into 15 PKI-containing and 15 PKI-free complex structures. (uni-marburg.de)

This peptide was truncated to a 13-residue cyclic segment that maintained complete activity, which is referred to in the art as compstatin (SEQ ID NO: 2J. (justia.com)

The three are contrasted to conclude that for the cytochrome family, there exists a core structure of polypeptide folding. (caltech.edu)
Due to the nature of certolizumab pegol (polypeptide) and according to the current Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use (EMEA/CHMP/SWP/4447/00 corr 2), products containing peptides are unlikely to result in significant risk to the environment. (janusinfo.se)

Anatomy13

Organisms11

Diseases1

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes59

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science7

Health Care1

Proteins19

Nuclear Magnetic2

Amyloid2

Including the peptide bonds1

Antimicrobial peptides8

Protein Structure8

Fibrinogen2

Complete amino acid seq1

Antigens2

Sequence9

Bind2

Antigen2

Disulfide2

Toxins6

Binds2

Ligand1

Complexes3

Residues5

Generate fragment2

Amino acid2

Humans2

Polymorphic1

Tertiary2

Antibody2

Characterize2

Bacteria2

Thrombin1

Secondary4

Coupled receptor1

Chemistry1

Bonds2

Bacterial4

Hydrophobic1

Natural compounds1

Complement3

Structural7

Chains1

Mass3

Molecules4

Epitopes1

Synthetic3

Chemical structure1

Metabolism1

Trypsin1

Subsequent2

Small2

Algorithms1

Conformations1

Crystal1

Additionally1

Mechanisms1

Candidates1

Bound2

Library1

Complex2

Cyclic1

Polypeptide2