• POTENT
  • It was revealed that TCS PIM-1 1 was the most potent inhibitor of Pim-1 by outlining the crystal structure and it was also shown that TCS PIM-1 1 had better inhibitory activity to Pim-1 compared with Pim-2 . (apexbt.com)
  • organic
  • have proposed a structure for this organic cofactor (minus the iron atom and CO molecules) as shown: Although the mechanism by which Hmd acts is unknown, the iron-containing cofactor is in part responsible for the catalytic activity. (wikipedia.org)
  • formation
  • Non-polar solvents favour the formation of 2-hydroxypyridine whereas polar solvents such as alcohols and water favour the formation of 2-pyridone. (wikipedia.org)
  • Cleavage of the acetyl group and ester hydrolysis with HCl in methanol resulted in formation of pyridone ester 12 with additional isomerization of the exocyclic double bond to an endocyclic double bond (destroying one asymmetric center). (wikipedia.org)
  • forms
  • Originally this research on alternative forms of DNA was driven by the question of how life evolved on earth and why RNA and DNA were selected by (chemical) evolution over other possible nucleic acid structures. (wikipedia.org)
  • known
  • Two unusual pyridones, trichodin A ( 1 ) and trichodin B ( 2 ), together with the known compound, pyridoxatin ( 3 ), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. (mdpi.com)
  • relationship
  • Antiviral and quantitative structure activity relationship study for dihydropyridones derived from curcumin. (biomedsearch.com)
  • Very little was published about the antitumor activities of dihydropyridones and the aim of this study is to investigate the relationship between structure and antitumor activity of a series of dihydropyridones derived from curcumin. (biomedsearch.com)
  • family
  • However, when accessible, this method can be used to build 8-membered ring with complex stereocenters and structures in one step, as is seen in proposed syntheses for Taxol and molecules of the fusicoccin family. (wikipedia.org)
  • reported the crystal structure
  • In 2007, the team of Gabriel Waksman at University College London and Birkbeck College, London, in collaboration with Scott Hultgren at Washington University, St Louis, US, reported the crystal structure of PapA in an environment believed to reflect conditions in a real pilus (see Fig 1 ). (rsc.org)
  • Methods
  • The research plan described in this proposal will enable new methods to prepare [2.2. diazabicyclic, 2-pyridone, and ETP structures from a common intermediate, a 2,5-diketopiperazine azadiene (pyrazinone) precursor. (grantome.com)
  • available
  • It works interfaced to a number of electronic structure programs available for computational chemistry, including Gaussian, Turbomole, Gamess, and Columbus. (wikipedia.org)
  • configuration
  • This method can be generally used for any electronic-structure method, provided that a configuration interaction representation of the electronic wavefunction can be worked out. (wikipedia.org)