• Mutations
  • Mutations within the desmosome are the main cause of Arrhythmogenic right ventricular cardiomyopathy (ARVC),a life-threatening disease caused by mutations usually in Desmoglein 2, but sometimes in Desmocollin 2. (wikipedia.org)
  • These findings further support the notion that desmosomes crosstalk with sodium channels in the heart, and suggest that the risk of arrhythmias in patients with PKP2 mutations may be unveiled with pharmacological challenge. (wikipedia.org)
  • keratinocytes
  • Compared with keratinocytes, SCC cells showed increased levels of S(1356) phosphorylation in the absence of EGF, correlating with reduced HD-like structures. (biomedsearch.com)
  • Merkel cells are located in the deepest layer (stratum basale) of the epidermis of hairless skin, where they are attached to keratinocytes by desmosomes. (gaia.com)
  • epidermis
  • We used cryoelectron tomography of vitreous sections from human epidermis to record 3D images of desmosomes in vivo and in situ at molecular resolution. (nih.gov)
  • Ultrastructure of the desmosome from human epidermis. (nih.gov)
  • These skin structures are the Epidermis and Dermis. (gaia.com)
  • This junction holds the epidermis and dermis together and this is achieved by various fibers including collagen and desmosomes. (gaia.com)
  • Other significant work by Bizzozero included research of haematopoiesis in the bone marrow, studies involving phagocytosis in the eye, and the identification of desmosomes (nodes of Bizzozero), structures that he first discovered in the stratum spinosum of epidermis. (wikipedia.org)
  • plasmodesmata
  • Plasmodesmata evolved independently in several lineages, and species that have these structures include members of the Charophyceae, Charales, Coleochaetales and Phaeophyceae (which are all algae), as well as all embryophytes, better known as land plants. (wikipedia.org)
  • fibers
  • Butterfield and Nicholas (1996) argued that they were closely related to sponges on the grounds that the detailed structure of chancellorid sclerites is similar to that of fibers of spongin, a collagen protein, in modern keratose (horny) demosponges such as Darwinella. (wikipedia.org)
  • electron
  • Around the desmotubule and the plasma membrane areas of an electron dense material have been seen, often joined together by spoke-like structures that seem to split the plasmodesma into smaller channels. (wikipedia.org)
  • cellular
  • They are important in forming a type of cellular junction called a desmosome. (news-medical.net)
  • Here we report through ultrastructural analysis that IBC exhibits a high degree of cellular organization with polar elements such as apical/lateral positioning of E-cadherin, apical surface microvilli, and tortuous lumen-like (canalis) structures. (beds.ac.uk)
  • This study has determined that the highly metastatic IBC with an exaggerated malignant phenotype challenges conventional wisdom in that instead of displaying a loss of cellular organization, IBC acquires a highly structured architecture. (beds.ac.uk)
  • The morphology and configuration of a cell depends completely on the precise surface tension and viscosity of the cytoplasm organelle situated within, Countless cellular organelles when separated in a liquid medium have a tendency to develop into a spherical structure, as a result of the principles of surface tension. (edu.au)
  • cell's
  • Nevertheless, if observed in more detail, it will appear that a cell's morphology frequently relates directly to its role and function in the organism or structure as well as it behavioral adaptations in it specific environment. (edu.au)
  • cells
  • The function of desmosomes is to adhere cells together. (biologydictionary.net)
  • This diagram depicts how cells adhere at desmosomes. (biologydictionary.net)
  • In essence, both desmosome-like junctions and basal ESs are known to coexist between Sertoli cells at the level of the blood-testis barrier where they cofunction with the well-studied tight junction in maintaining the immunological barrier. (royalsocietypublishing.org)
  • However, the type of anchoring device that is present between Sertoli and germ cells depends on the developmental stage of the germ cell, i.e. desmosome-like junctions are present between Sertoli and germ cells up to, but not including, step 8 spermatids after which this junction type is replaced by the apical ES. (royalsocietypublishing.org)
  • Bologna M, Allen R, Dulbecco R. Organization of cytokeratin bundles by desmosomes in rat mammary cells. (pubmedcentralcanada.ca)
  • Desmosomes are structures in the heart that ensure that the heart muscle cells remain connected to each other. (healthcanal.com)
  • Moreover, these inhibitors stabilized HD-like structures in SCC cells and reduced their migratory ability. (biomedsearch.com)
  • Mutation of S(1356)S(1360)S(1364) in SCC cells to non-phosphorylatable alanines stabilized HD-like structures and substantially reduced migration, while mutation into phosphorylation mimicking aspartate reduced HD-like structures but had no effect on migration, suggesting that serine phosphorylation function is releasing anchorage rather than promoting migration. (biomedsearch.com)
  • Cells of diverse categories differ broadly in size and structure. (edu.au)
  • Neuron cells are even more significant and specialized, resulting in their complex structure and appearance. (edu.au)
  • Similar structures, called gap junctions and membrane nanotubes, interconnect animal cells and stromules form between plastids in plant cells. (wikipedia.org)
  • coiled-coil
  • The major force that keeps the coiled-coil structure is hydrophobic interactions between apolar residues along the keratins helical segments. (wikipedia.org)
  • furthermore
  • Furthermore, DP-NTP assembled into ultrastructurally identifiable junctional structures lacking associated IF bundles. (pubmedcentralcanada.ca)
  • These results indicate that DP is required for anchoring IF networks to desmosomes and furthermore suggest that the DP-IF complex is important for governing the normal spatial segregation of adhesive junction components during their assembly into distinct structures. (pubmedcentralcanada.ca)
  • arrhythmias
  • Studies employing another transgenic mutant DSG2 mouse model harboring a Asn271Ser showed that this mutation caused widening of desmosomes and adherens junctions concomitant with electrophysiologic abnormalities and enhanced susceptibility to cardiac arrhythmias. (wikipedia.org)
  • squamous cell carc
  • Ninety percent of cases of head and neck cancer (cancer of the mouth, nasal cavity, nasopharynx, throat and associated structures) are due to squamous cell carcinoma. (wikipedia.org)
  • Once the lesion has grown and progressed to the point where it has breached, penetrated, and infiltrated adjacent structures, it is referred to as "invasive" squamous cell carcinoma. (wikipedia.org)
  • function
  • But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
  • cell
  • To test this proposal directly, we generated A431 cell lines stably expressing DP NH2-terminal polypeptides, which were expected to compete with endogenous DP during desmosome assembly. (pubmedcentralcanada.ca)
  • These connections help define how a cell will be integrated into a structure, like a layer of skin or an organ. (news-medical.net)
  • A desmosome is a structure inside the membrane of a cell. (news-medical.net)
  • For instance a single E. coli bacterium calculates to only be approximately two microns in diameter, yet smaller than a individual mitochondrion cell, a eukaryotic structure. (edu.au)
  • The plasma membrane portion of the plasmodesma is a continuous extension of the cell membrane or plasmalemma and has a similar phospholipid bilayer structure. (wikipedia.org)
  • repeats
  • A crystal structure of part of the plakin domain has been resolved, while the entire plakin domain has been elucidated using small angle X-ray scattering which revealed a non-linear structure, an unexpected result considering spectrin repeats are observed in linear orientations. (wikipedia.org)
  • both have 12 armadillo repeats as well as N-terminal and C-terminal globular domains of unknown structure. (wikipedia.org)
  • body
  • Combined with -some, which comes from soma, body, it thus makes a desmosome a "binding body. (wikipedia.org)
  • In fact he thought they were more similar to the chitinous bristles (setae) that project from the bodies of modern annelids and in some genera form leaf-like scales that cover the back like roof tiles - in composition, in detailed structure, in how they were attached to the body via follicle-like pockets in the skin, and in overall appearance. (wikipedia.org)
  • skin
  • The human skin consists of two major structures. (gaia.com)
  • He performed histological and histopathological studies of the skin and was the first scientist to discover desmosomes and the tonofilament system, but was unable to identify the role these structures played from a physiological basis. (wikipedia.org)
  • major
  • Although 3D structures of the major plaque components are known, the overall architecture remains unknown. (nih.gov)
  • regions
  • C ) Graph of relative density as projected orthogonally to the normal of the plasma membrane (in three different colors corresponding to the different regions of the desmosome). (nih.gov)