• Clinicians treating these problems are well aware that extracapsular (muscular) problems have a significantly better prognosis for resolution than intracapsular (structural) problems. (scirp.org)
  • Electromyography measures the character and intensity of electrical activity associated with muscular contraction. (scirp.org)
  • Due to its potent effect of promoting calcium entry into cells, calcitriol tends to upgrade muscular contraction. (ironmanmagazine.com)
  • Muscular fatigue causes a slowing of muscle contraction velocity, reversing as the muscle recovers from fatigue [ 21 - 24 ]. (plos.org)
  • The chip, a soft polymer well that is mounted on a glass substrate, contains a planar array of microscale, engineered human airway muscles, designed to mimic the laminar structure of the muscular layers of the human airway. (harvard.edu)
  • Bones often act as levers, which, in conjunction with muscular contraction, initiate and sustain movement. (medscape.com)
  • Measured time courses of force decay during isometric contractions of rabbit M. gastrocnemius and M. plantaris were employed for model verification, with the finding that our suggested model enhancement proved eminently promising. (frontiersin.org)
  • Inverse relationship between amplitude and latency of physiological mirror activity during repetitive isometric contractions. (mpg.de)
  • Structural neural correlates of physiological mirror activity during isometric contractions of non-dominant hand muscles. (mpg.de)
  • Anodal tDCS of the ipsilateral primary motor cortex prolongs the latency of physiological mirror activity during unilateral isometric contractions of intrinsic hand muscles. (mpg.de)
  • Written in terms of differential-algebraic equations, the new sub-model allows to enhance existing Hill-type excitation-contraction models in a straightforward way. (frontiersin.org)
  • As such, a twitch provides information on muscle contractile properties and the functioning of the excitation-contraction coupling process. (plos.org)
  • The bladder detrusor smooth muscle cells (SMCs) and fibroblasts were observed under transmission electron microscopy (TEM). (hindawi.com)
  • The level of myosin light chain (MLC) phosphorylation is an important determinant of smooth muscle contraction. (hindawi.com)
  • The phosphorylation of MLC primarily regulates the force production and maintenance in the smooth muscle [ 6 ]. (hindawi.com)
  • The function of striated or smooth muscle is regulated by the balance of myosin light chain kinase (MLCK) and MLCP activity. (hindawi.com)
  • It is suggested that the phosphorylation of MLC catalyzed by Ca 2+ -calmodulin- (CAM-) dependent MLCK and dephosphorylation catalyzed by MLCP help regulate the contraction and relaxation of smooth muscle [ 8 , 9 ]. (hindawi.com)
  • The phosphorylation of smooth muscle regulatory light chain by MLCK is the basic requirement for smooth muscle contraction and hollow organ physiological activities [ 10 ]. (hindawi.com)
  • A few years later, von Euler of Sweden independently discovered similar effects of human seminal fluid on smooth muscle tissue. (medscape.com)
  • When that happens in the smooth muscle that lines blood arteries, higher blood pressure can result. (ironmanmagazine.com)
  • Because airway smooth muscle (ASM) is the principal cell determining airway contractile responsiveness, while also possessing immunomodulatory functions [ 8 ], human ASM cells in culture were stimulated with OxPAPC, a family of OxPCs containing several whose expression was shown to be increased in the (+AHR) and (allergen-challenged) samples. (ersjournals.com)
  • In 1994, it was found that mechanical properties of airway smooth muscle (ASM) preparations from healthy and asthmatic patients differed significantly. (nextgenrnd.com)
  • The ability of ASM cells (ASMs), i.e. , bronchial smooth muscle cells (BSMCs), to secrete battery of cytokines prompts that the local and also systemic (in both autocrine and paracrine fashion) airway inflammation can be achieved without inflammatory cells. (nextgenrnd.com)
  • Harvard bioengineers have developed a human airway muscle-on-a-chip that could be used to test new drugs because it accurately mimics the way smooth muscle contracts in the human airway. (harvard.edu)
  • Hope for healthier airways may be on the horizon thanks to a Harvard University team that has developed a human airway muscle-on-a-chip that could be used to test new drugs because it accurately mimics the way smooth muscle contracts in the human airway, under normal circumstances and when exposed to asthma triggers. (harvard.edu)
  • IL-13 is a natural protein often found in the airway of asthmatic patients that mediates the response of smooth muscle to an allergen. (harvard.edu)
  • Then they introduced acetylcholine, a neurotransmitter that causes smooth muscle to contract. (harvard.edu)
  • The team then investigated what happened on a cellular level in response to the IL-13 and confirmed, for example, that the smooth muscle cells grew larger in the presence of IL-13 over time-a structural hallmark of the airways in asthma patients as well. (harvard.edu)
  • They also documented an increased alignment of actin fibers within smooth muscle cells, which is consistent with the muscle in the airway of asthma patients. (harvard.edu)
  • these changes can contribute directly to airway narrowing and/or exaggerate the effect of airway smooth muscle contraction. (ersjournals.com)
  • Airway inflammation, smooth muscle contraction, epithelial sloughing, mucous hypersecretion, bronchial hyperresponsiveness, and mucosal edema are some of the common pathophysiological mechanisms seen in asthma. (medscape.com)
  • Achalasia is an esophageal motor disorder characterized by increased lower esophageal sphincter (LES) pressure, diminished-to-absent peristalsis in the distal portion of the esophagus composed of smooth muscle, and lack of a coordinated LES relaxation in response to swallowing. (medscape.com)
  • Initiated by neural impulses and subsequent calcium release, skeletal muscle fibers contract (actively generate force) as a result of repetitive power strokes of acto-myosin cross-bridges. (frontiersin.org)
  • A myosin-based mechanism for stretch activation and its possible role revealed by varying phosphate concentration in fast and slow mouse skeletal muscle fibers. (umass.edu)
  • Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. (thermofisher.com)
  • Muscle contraction consists of a cyclical interaction between myosin and actin. (embl.de)
  • Titin activates myosin filaments in skeletal muscle by switching from an extensible spring to a mechanical rectifier. (unifi.it)
  • Matching Mechanics and Energetics of Muscle Contraction Suggests Unconventional Chemomechanical Coupling during the Actin-Myosin Interaction. (unifi.it)
  • Anisotropic Elasticity of the Myosin Motor in Muscle. (unifi.it)
  • The force of the myosin motor sets cooperativity in thin filament activation of skeletal muscles. (unifi.it)
  • Myosin motors that cannot bind actin leave their folded OFF state on activation of skeletal muscle. (unifi.it)
  • OxPAPC also induced expression of cyclo-oxygenase-2 (COX2), as well as 32 different oxylipins, including those generated in the cyclo-oxygenase/lipoxygenase pathways and capable of regulating either ASM contraction or airway inflammation. (ersjournals.com)
  • As implied by this term, it has been proposed that the associated pain and stiffness stem from micro-lesions, inflammation, or metabolite accumulation within the skeletal muscle. (mdpi.com)
  • The chronic persistent inflammation may result in airway remodeling and structural changes of the airway wall. (medscape.com)
  • Functional analysis showed that the muscle contraction, immune system/inflammation, and extracellular matrix pathways were the most affected pathways. (cdc.gov)
  • The TTN gene provides instructions for making a protein called titin, which is found in the sarcomeres of many types of muscle cells, including cardiomyocytes. (medlineplus.gov)
  • This gene encodes the skeletal muscle specific member of the calsequestrin protein family. (nih.gov)
  • This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. (nih.gov)
  • Published as the cover story in the January 14, 2005 issue of the journal Cell, the study identifies a protein called ASF/SF2 as a regulator of a calcium enzyme responsible for heart contraction and tissue growth. (news-medical.net)
  • Dulhunty and her colleagues were studying how the ryanodine receptor, a type of protein receptor, functions in muscle cells. (the-scientist.com)
  • Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation [ 1-3 ]. (nih.gov)
  • In addition, structural as well as functional aspects of the different classes of membrane proteins are discussed along with an outline of experimental approaches used to achieve an understanding of membrane protein structure and function at a molecular level. (yale.edu)
  • Magnesium is a cofactor in more than 300 enzyme systems that are needed to maintain life and health, from protein synthesis, to muscle and nerve function, blood glucose control, and blood pressure regulation. (anhinternational.org)
  • Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). (thermofisher.com)
  • The researchers mimicked an asthmatic airway on their airway muscle-on-a-chip by first introducing Interleukin-13 (IL-13), a natural protein often found in the airway of asthmatic patients. (harvard.edu)
  • It is a progressive and wasting disease, characterized by a degeneration of skeletal and cardiac muscles caused by the lack of dystrophin protein. (bvsalud.org)
  • The absence of this crucial structural protein leads to sarcolemmal fragility, resulting in muscle fiber damage during contraction. (bvsalud.org)
  • These genes code for proteins involved in essential processes such as muscle contraction, nerve signaling, and structural integrity. (alliedacademies.org)
  • Researchers have discovered how specific gene mutations lead to muscle degeneration, impaired nerve signaling, and compromised muscle function. (alliedacademies.org)
  • Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm [ 3 ]. (nih.gov)
  • Magnesium is involved in nerve impulse conduction, muscle contraction, and crucially, maintaining normal heart rhythm . (anhinternational.org)
  • It is currently believed that the slow, deep strokes of Rolfing SI stimulate intra-fascial mechanoreceptors (sensory neurons of the muscle nerve), which in turn trigger the nervous system to reduce the tension of the related muscles and fascia. (rolf.org)
  • The facial muscles are innervated peripherally (infranuclear innervation) by the ipsilateral 7th cranial nerve and centrally (supranuclear innervation) by the contralateral cerebral cortex. (msdmanuals.com)
  • Having pioneered the study of muscle physiology in mammals, she uncovered how ion channels enable muscle movement. (the-scientist.com)
  • Dulhunty was attracted to learning how muscle works as an undergraduate student studying physiology and biochemistry at the University of Sydney. (the-scientist.com)
  • Throughout her career, Dulhunty has been driven by her curiosity to know how the underlying physiology of the body works, and, as a result, has made important discoveries about how skeletal and heart muscle contractions are generated and regulated. (the-scientist.com)
  • Deduce the structural and functional and structural roles of nebulin in muscle contraction and their role in nemaline myopathy, collaboration with University of Arizona/NIH. (iit.edu)
  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (ucsc.edu)
  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (antikoerper-online.de)
  • Genomics describes the determination of the nucleotide sequence and many further analyses to discover functional and structural information on all the genes of an organism. (yale.edu)
  • Topics include the methods and results of functional and structural gene analysis on a genome-wide scale as well as a discussion of the implications of this research. (yale.edu)
  • We reveal the formation of amorphous complexes via an en masse pathway and their relaxation into virions via a synchronous pathway. (cea.fr)
  • It was further suggested that due to the above pathology, the ASM contraction might occur faster rather than stronger and its relaxation might be impaired 5 . (nextgenrnd.com)
  • These important inhibitory neurons induce LES relaxation and coordinate proximal-to-distal peristaltic contraction of the esophagus. (medscape.com)
  • Within a few months, Dulhunty and her colleagues published their first paper on the role of the omega class glutathione S-transferase, GSTO1-1, in inhibiting the ryanodine receptor in cardiac muscle and in increasing the activity of the skeletal muscle ryanodine receptor. (the-scientist.com)
  • In addition, EA repaired the damaged bladder detrusor muscle of diabetic rats by reducing mitochondrial damage of the SMCs and fibroblasts. (hindawi.com)
  • The heart patch contains cardiomyocytes, which control muscle contraction, fibroblasts, which provide a structural framework to tissue, and endothelial cells that line blood vessels. (labroots.com)
  • Reproducibility of knee extensor and flexor contraction velocity in healthy men and women assessed using tensiomyography: A registered report. (plos.org)
  • Langen G, Lohr C, Ueberschär O, Behringer M (2022) Reproducibility of knee extensor and flexor contraction velocity in healthy men and women assessed using tensiomyography: A study protocol. (plos.org)
  • Finger flexor contractile properties and hemodynamics following a sustained submaximal contraction: a study using electrical stimulation and near-infrared spectroscopy. (cdc.gov)
  • A muscle twitch is the contractile response to a single electrochemical signal of the nervous system or artificial electrical stimulation of the muscle. (plos.org)
  • Put another way, Rolfing SI allows the brain and nervous system to "re-boot" areas of the body that are receiving too much electrical stimulation (chronically tight or sore muscles). (rolf.org)
  • Kushol Gupta is a Research Assistant Professor in the department, a member of the BMB graduate group, and directs the Johnson Foundation Biophysics and Structural Biology Core (JFBSB), a departmental resource that serves Penn and the greater region. (upenn.edu)
  • The structural biology of Phenylalanine Hydroxylase, the enzyme that underlies the condition phenylketonuria (PKU) ( recent publication ). (upenn.edu)
  • The Perelman School of Medicine (PSOM) has announced the establishment of the Penn Institute for Structural Biology (ISB) , which will be led by Dr. Vera Moiseenkova-Bell , Professor in the Department of Systems Pharmacology and Translational Therapeutics and Secondary faculty in the Department of Biochemistry and Biophysics. (upenn.edu)
  • The ISB will catalyze novel advances in the areas of structural biology, provide access to expertise and technology to support cryo-EM, Xray crystallography, NMR, molecular dynamics simulations and more, and promote collaborative studies across the biomedical community. (upenn.edu)
  • Rather than having to wait sometimes days to get the results of a biochemistry experiment, with electrophysiology "you see what is happening in an individual cell in the moment," says the muscle biology researcher and now emeritus professor at Australian National University in Canberra. (the-scientist.com)
  • An in-depth analysis of macromolecular structure and its elucidation using modern methods of structural biology and biochemistry. (yale.edu)
  • My research goal is to understand how structural and functional alterations at the molecular and single fiber levels affect whole skeletal muscle contraction and whole body function, primarily to find potential countermeasures to the loss of skeletal muscle performance under a variety of conditions, including aging, obesity, fatigue and illness (influenza). (umass.edu)
  • By identifying the specific molecular mechanisms that lead to alterations in whole muscle function, my findings will impact clinical care by providing novel information about the treatment of conditions that reduce skeletal muscle performance. (umass.edu)
  • Effects of glutathione depletion and age on skeletal muscle performance and morphology following chronic stretch-shortening contraction exposure. (cdc.gov)
  • Is "Delayed Onset Muscle Soreness" a False Friend? (mdpi.com)
  • Strenuous and unaccustomed exercise frequently lead to what has been coined "delayed onset muscle soreness" (DOMS). (mdpi.com)
  • On the basis of bio-chemical kinetics, we present a model of muscle fiber exhaustion based on hydrolytic ATP-ADP-P i dynamics, which are assumed to be length- and calcium activity-dependent. (frontiersin.org)
  • Straight CR, Ringham OR, Bartley JM, Keilich SR, Kuchel GA, Haynes L, Miller MS. Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice. (umass.edu)
  • Straight CR, Ades PA, Toth MJ, Miller MS. Age-related reduction in single muscle fiber calcium sensitivity is associated with decreased muscle power in men and women. (umass.edu)
  • Dulhunty had set up electrophysiology experiments on a receptor from mammalian cardiac muscle fiber to measure its activity, and her initial measurements on the receptor's activity were going nicely. (the-scientist.com)
  • These connective tissues surround ever muscle fiber, encase all joints and even have a role in the nervous system. (rolf.org)
  • Accordingly, the volume of SR tubules localized around the myofibrils is strongly reduced in skeletal muscle fibers of 4- and 10-month-old sAnk1 knockout (KO) mice, while additional structural alterations only develop with aging. (mdpi.com)
  • To verify whether the lack of sAnk1 also alters intracellular Ca 2+ handling, cytosolic Ca 2+ levels were analyzed in stimulated skeletal muscle fibers from 4- and 10-month-old sAnk1 KO mice. (mdpi.com)
  • Actin fibers are super-thin cellular components involved in muscle contraction. (harvard.edu)
  • This medical-grade, closed-cell material not only offers antibacterial and moisture-resistant properties, but also adds to the density and structural integrity of the mat, preventing the arch from flattening out over time, so you get a consistent abdominal workout day to day, year to year. (roguefitness.com)
  • The point of added muscle is to give your skeleton greater structural integrity under load. (forgefitnesswichita.com)
  • BrS is associated with an increased risk of syncope, palpitations, chest pain, convulsions, difficulty in breathing (nocturnal agonal breathing) and/or Sudden Cardiac Death (SCD) secondary to PVT/VF, unexplained cardiac arrest or documented PVT/VF or Paroxysmal atrial fibrillation (AF) in the absence of apparent macroscopic or structural heart disease, electrolyte disturbance, use of certain medications or coronary heart disease and fever. (bvsalud.org)
  • Central innervation tends to be bilateral for the upper face (eg, forehead muscles) and unilateral for the lower face. (msdmanuals.com)
  • On a whim, she decided to add the enzyme glutathione transferase to the muscle cells' medium, just because the chemical was sitting on the lab bench next to her. (the-scientist.com)
  • These genes provide instructions for making proteins that are found in cardiac muscle cells called cardiomyocytes. (medlineplus.gov)
  • Many other proteins associated with familial dilated cardiomyopathy make up the structural framework (the cytoskeleton) of cardiomyocytes. (medlineplus.gov)
  • Examining the contractile apparatus in the mutant heart, the investigators found striking structural defects, including shortened contractile tissue called sarcomeres and altered ridges in heart tissue. (news-medical.net)
  • In 1930, American gynecologists Kurzok and Lieb first described the stimulatory effects of seminal fluid on human uterine muscle tissue. (medscape.com)
  • Crunches have a short range of motion and recruit relatively little muscle tissue, meaning the calories you burn are going to be nominal. (forgefitnesswichita.com)
  • Significantly, they were able to measure the contractile stress of the muscle tissue as it responded to varying doses of the drugs, said lead author Alexander Peyton Nesmith, a Ph.D./M.D. student at Harvard SEAS and the University of Alabama at Birmingham. (harvard.edu)
  • Alterations to ECM structural and mechanical properties due to mechanical loading and tissue healing may affect this multiscale strain transfer and stress transmission through the ECM. (nsf.gov)
  • The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. (thermofisher.com)
  • For women with pelvic-floor symptoms, menopause is associated with a weaker pelvic floor support and impaired responsiveness of involuntary PFM contractions to sudden increases in the intra-abdominal pressure, but is not associated with the capability of voluntary PFM contractions," Dr. Wen-Chen Huang and Dr. Jenn-Ming Yang of Taipei Medical University write in their article, published online October 19 in Neurourology and Urodynamics. (medscape.com)
  • It is generally believed that sustained contraction mainly occurs through Ca 2+ sensitization. (hindawi.com)
  • We conclude that the sarcolemma membrane anchoring that occurs during the contraction/elongation process of muscles could be ensured by this coiled-coil opening. (cea.fr)
  • they are made of proteins that generate the mechanical force needed for muscles to contract. (medlineplus.gov)
  • This was the start of Dulhunty's work to discover the significance of these proteins in muscle. (the-scientist.com)
  • Scaffolding proteins play important roles in supporting the plasma membrane (sarcolemma) of muscle cells. (cea.fr)
  • Finally, our strategy opens up new possibilities for structure determination of peripheral and integral membrane proteins not compatible with different high-resolution structural methods. (cea.fr)
  • Deduce the structural and functional l roles of My-BP-C in muscle contraction, collaboration with University of Massachusetts Medical School. (iit.edu)
  • SRT also incorporates the principles of Muscle Energy Technique (MET) and fascia release. (heavenlyhandspllc.com)
  • Broke my fascia muscle apparently as I was wearing crappy shoes for too long and I have a high arch and instep. (heavenlyhandspllc.com)
  • Mammalian PI3Ks are grouped into three classes based on their structural organization. (nature.com)
  • Small Ankyrins (sAnk1) are muscle-specific isoforms generated by the Ank1 gene that participate in the organization of the sarcoplasmic reticulum (SR) of striated muscles. (mdpi.com)
  • Spectral properties of physiological mirror activity: An investigation of frequency features and common input between homologous muscles. (mpg.de)
  • To compensate, the heart attempts to increase the amount of blood being pumped through the heart, leading to further thinning and weakening of the cardiac muscle. (medlineplus.gov)
  • It is likely that the changes impair cardiomyocyte function and reduce the ability of these cells to contract, weakening and thinning cardiac muscle. (medlineplus.gov)
  • I could see immediately that the glutathione transferase began to inhibit the cardiac muscle receptor's activity," she recalls. (the-scientist.com)
  • Effects of repeated lengthening contractions on skeletal muscle adaptations in female rats. (cdc.gov)
  • Muscles performing mechanical work become exhausted, that is, they fail to maintain high force levels for a longer time period. (frontiersin.org)
  • Results show that macroscale mechanical and structural properties are inferior following high magnitude dynamic loading (fatigue) in uninjured living tendon and that these effects propagate to the microscale. (nsf.gov)
  • Understanding cellular function requires structural and biochemical studies at an ever-increasing level of complexity. (yale.edu)
  • Well, BfR is at it again - this time with magnesium, one of the most essential minerals for life, needed for bone health and muscle contraction, as well as over 300 biochemical reactions in the body. (anhinternational.org)
  • Several formulas currently exist to calculate the rate of displacement during the contraction phase of the maximal twitch response. (plos.org)
  • Older, postmenopausal women with pelvic-floor dysfunction symptoms, such as incontinence and prolapse, likely have structural changes in their pelvic-floor support structures that are certainly related to aging and possibly to changes in estrogen levels. (medscape.com)
  • Mice developed without ASF/SF2 appeared normal at birth, but developed a notable decrease in heart contraction as they neared adulthood. (news-medical.net)
  • Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. (embl.de)
  • Complexes of Vps34, the sole class III PI3K member, produce PI 3-phosphate (PI(3)P) in the endolysosomal system and during autophagy to regulate vesicle-mediated sorting en route to lysosomes 1 . (nature.com)
  • Therefore, understanding these structural changes may help in the design of rationalized shortened dystrophins for gene therapy. (cea.fr)
  • In particular, it was demonstrated that maximum contractility for healthy ASM was ~11%, whereas asthmatic ASM allowed up to ~31% contraction. (nextgenrnd.com)
  • Due to hyperplasia and hypertrophy, a significant increase in ASM mass is observed in asthmatic airway wall, whereas the muscle is thought not to be stronger 2-4 . (nextgenrnd.com)
  • In this Solution, NextGenRnD reports novel platform technology that should enable direct measurement of pressure generated by ASM spheroid during contraction in high throughput format (healthy vs. asthmatic ASM spheroids). (nextgenrnd.com)
  • Overall, our findings underscore the potential of bioengineered 3D skeletal muscle technology to advance DMD research and facilitate the development of novel therapies for DMD and related neuromuscular disorders. (bvsalud.org)
  • Noninvasive methods are required to further investigate the pathogenesis of airway wall remodelling, to assess changes over time, and to allow the assessment of new therapeutic interventions designed to attenuate or reverse these structural changes. (ersjournals.com)
  • An adult body contains stores of around 25 g magnesium, with about half of this in the bones and almost all the rest in soft tissues including muscles. (anhinternational.org)
  • Moderate-intensity resistance exercise alters skeletal muscle molecular and cellular structure and function in inactive, older adults with knee osteoarthritis. (umass.edu)
  • Convergent evolutionary pathways toward energy saving in muscle? (unifi.it)
  • Rolfing [a massage technique], or what owner Brain Stern calls 'structural integration,' is the best way to correct range of motion or body alignment issues," Petrusky says. (phillymag.com)
  • We discuss implications of our model approach for enhancing muscle models in general, as well as a few aspects regarding the significance of phosphate kinetics as one contributor to muscle fatigue. (frontiersin.org)
  • One of the first books addressing (muscle as well as whole body) fatigue was published at the beginning of the 20th century ( Mosso, 1904 ) and a multitude of research has followed since, see Gandevia (2001) for a thorough review. (frontiersin.org)
  • Commonly, muscle fatigue, i.e., the decline of the generable force level over time, is differentiated between central fatigue , i.e., the inability of the neural network to provide sufficient stimulation, and peripheral fatigue , i.e., the inability of the muscle cells to provide energy through metabolic activities (cf. (frontiersin.org)
  • The above hypotheses and models, however, have never been directly and decisively tested due to absence of appropriate ASM spheroid contraction sensor platform. (nextgenrnd.com)
  • The main advantage offered by interference microscopy measurements is the possibility of measuring the projected dry mass of living cells, which was first effectively exploited by Andrew Huxley in studies of striated muscle cell structure and function, leading to the sliding filament model of muscle contraction. (wikipedia.org)
  • The hallmark of Rolfing Structural Integration is a standardized 'recipe' known as the Ten-Series, the goal of which is to systematically balance and optimize both the structure (shape) and function (movement) of the entire body over the course of ten Rolfing sessions. (rolf.org)
  • However, age should not be a factor in recommending pelvic-floor therapy because women's voluntary pelvic-muscle function appears to be less affected than the passive pelvic support," Dr. Waetjen said in an email. (medscape.com)