Central adiposityIndicator of adiposityGluteo-femoral adiposityIndices of adiposityVisceralCircumferenceAbdominalObesityRegional adiposityPositively associatedComorbiditiesMarkersMetabolic syndromeExcessAdulthoodGlucoseIncreased riskPredictiveDiabetesMortalityCorrelatesCONCLUSIONSRatioPredictAdjustmentSignificantlyAdultsMarkerFactorsAssociationsHigherInsulin resistanceHyperglycemiaResultsParticipantsIncidentMeasureVigorousFindingsRisk factorAssociationHigh
Central adiposity13
- The primary risk factors of NASH include obesity (body mass index [BMI] >30), insulin resistance, Type II diabetes, "central adiposity" ( Paskos & Paletas, 2009 , para. (nursingcenter.com)
- Metabolic risk factors such as percent body fat, central adiposity, and fasting blood glucose were also measured. (nutrition.org)
- Frequent consumers of snacks had 2 times higher likelihood for having obesity, central adiposity, higher percent body fat, and higher fasting glucose than consumers who consumed snacks rarely. (nutrition.org)
- Our findings suggest that in relatively lean Chinese adults, general adiposity is more strongly assciated with blood pressure than central adiposity. (ox.ac.uk)
- Blood pressure in relation to general and central adiposity among 500 000 adult Chinese men and women. (ox.ac.uk)
- Multiple linear regression was used to estimate the effects on systolic blood pressure (SBP) of general adiposity [e.g. body mass index (BMI), body fat percentage, height-adjusted weight] vs central adiposity [e.g. waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR)], before and after adjustment for each other. (ox.ac.uk)
- CONCLUSION: In adult Chinese, blood pressure is more strongly associated with general adiposity than with central adiposity, and the associations with BMI were about 50% stronger than those observed in Western populations. (ox.ac.uk)
- WHtR has been proposed as a more robust indicator of central adiposity than WC, since it results in an estimate that is not biased by height. (scielosp.org)
- Waist circumference (WC) is a measure of central adiposity is associated with many diseases as well as a shorter lifespan. (positivechoices.com)
- Prospective studies have confirmed that lower endogenous androgens predict central adiposity in men (Rosmond et al, 2003) and that these low testosterone levels are significantly inversely associated with levels of blood pressure, fasting plasma glucose, triglycerides, and body mass index and positively correlated with HDL-cholesterol (Zmuda et al, 1997). (bhma.org)
- Peters noted that previous studies have indeed shown that central adiposity might be a stronger risk factor than overall obesity, but there have been studies that have shown the opposite - that it actually does not matter where adiposity is measured. (medscape.com)
- The critical new thing in our work is that we've looked at sex differences between both central and overall adiposity and the risk of heart disease and what we found is that central adiposity is actually an even stronger risk factor for heart disease in women than in men," she said. (medscape.com)
- In both sexes, there was an approximate log-linear relationship between measures of general and central adiposity and the risk for incident MI. (medscape.com)
Indicator of adiposity2
- Note that the accuracy of BMI as an indicator of adiposity varies depending on the degree of adiposity. (cdc.gov)
- in addition, loss of muscle tissue affects its validity as an indicator of adiposity in elderly people, regardless of changes in weight. (scielosp.org)
Gluteo-femoral adiposity2
- Associations for general and abdominal adiposity are fairly independent of each other but, given general and abdominal adiposity, higher gluteo-femoral adiposity is associated with a strongly favourable cardiometabolic lipid profile. (ox.ac.uk)
- Cox regression, adjusted for confounders, yielded mortality rate ratios (RRs) associated with three markers of abdominal adiposity (waist circumference, waist-hip ratio, and waist-height ratio) and one marker of gluteo-femoral adiposity (hip circumference) for cause-specific mortality before age 75 years. (ox.ac.uk)
Indices of adiposity6
- Established indices of adiposity include BMI, waist circumference (WC), and waist-hip ratio (WHR). (pace-cme.org)
- In the last years, novel indices of adiposity have been introduced that are also easy to measure and calculate, but better reflect the body fat distribution and total fat mass than the traditional indices. (pace-cme.org)
- This study investigated the association between multiple indices of adiposity (BMI, WC, WHR. (pace-cme.org)
- These measures were used to calculate the different indices of adiposity. (pace-cme.org)
- This study assessed the association between multiple novel and established indices of adiposity and the risk of incident HF in community-dwelling individuals. (pace-cme.org)
- Uncertainty remains, however, about which indices of adiposity most strongly predict blood pressure, particularly among those who were relatively lean, such as those from rural China. (ox.ac.uk)
Visceral2
- We found that neonatal androgenization induced adult animals displaying higher visceral adiposity mass, body weight and leptinemia than CT rats. (nel.edu)
- WC represents accumulated abdominal fat and is strongly correlated with visceral adipose tissue. (scielosp.org)
Circumference5
- The researchers found that BMI at baseline, BMI at 50 years of age, weight, fat mass, waist circumference, waist-hip ratio, and waist-height ratio were all strongly related to the risk of diabetes. (healthnewstrack.com)
- In girls, waist circumference was the best performing marker overall, and was also strongly correlated with %BF in boys. (bmj.com)
- This is because RFM not only correlates strongly with HF risk, but can also be calculated using a relatively simple formula*, requiring only height and waist circumference-both of which could be determined using a measuring tape. (pace-cme.org)
- For a given amount of general and abdominal adiposity, however, higher hip circumference was associated with lower vascular-metabolic mortality. (ox.ac.uk)
- A 1-standard deviation higher waist circumference was more strongly linked with MI risk in women than in men, although the difference just reached statistical significance ( P for interaction = .048). (medscape.com)
Abdominal6
- In addition, the body adiposity index (BAI), abdominal volume index (AVI), body shape index (ABSI), or conicity index (CI) could have a predictive ability for evaluating HTN [ 16 - 19 ], while the ponderal index (PI) could do the same for preHTN [ 20 ]. (hindawi.com)
- RESULTS: Markers of general (ie, BMI), abdominal (ie, WC and WHR) and gluteo-femoral (ie, HC) adiposity all display similar and strong associations across the NMR-platform of biomarkers, particularly for biomarkers that increase cardiometabolic risk. (ox.ac.uk)
- Abdominal and gluteo-femoral markers of adiposity and risk of vascular-metabolic mortality in a prospective study of 150 000 Mexican adults. (ox.ac.uk)
- AIMS: Results of previous studies of abdominal adiposity and risk of vascular-metabolic mortality in Hispanic populations have been conflicting. (ox.ac.uk)
- We report results from a large prospective study of Mexican adults with high levels of abdominal adiposity. (ox.ac.uk)
- CONCLUSIONS: In this study of Mexican adults, abdominal adiposity (and in particular the waist-height ratio) was strongly and positively associated with vascular-metabolic mortality. (ox.ac.uk)
Obesity10
- Assessment of obesity before old age may be a more accurate representation of adiposity as the ratio of lean to fat mass changes with ageing, 5 resulting in a decreased body mass index. (bmj.com)
- 8 Obtaining weight measurements many years before the onset of dementia, as well as other measures of adiposity, would provide stronger evidence of causality between obesity and increased risk of dementia. (bmj.com)
- Sugars in a liquid form may induce less satiety than in a solid form [ 9 ] and may promote the over-consumption of energy, contributing to the development of obesity and excess adiposity, and associated comorbidities (e.g. metabolic syndrome and diabetes). (biomedcentral.com)
- Glucocorticoid-dependency of increased adiposity in a model of hypothalamic obesity. (nel.edu)
- It is known that rats treated, at neonatal age, with monosodium L-glutamate (MSG) develop neuroendocrine and metabolic abnormalities, resulting in a phenotype of hypothalamic obesity, characterized by increased adiposity, corticosteronemia and leptinemia. (nel.edu)
- Perelló M, Moreno G, Gaillard R, Spinedi E. Glucocorticoid-dependency of increased adiposity in a model of hypothalamic obesity. (nel.edu)
- Introduction We aimed to test whether the serum adipokines leptin and adiponectin are more strongly associated with body fat percentage (BF%) than body mass index (BMI) in adolescents with type 1 diabetes (T1D) and overweight/obesity. (bmj.com)
- Furthermore, mutations of melanocortin receptors are strongly correlated with human obesity( ref ) and alterations in cholesterol transport are a common occurrence in obesity and the metabolic syndrome( ref ). (anti-agingfirewalls.com)
- Sarcopenic obesity, defined as reduced skeletal muscle mass and power with increased adiposity, was reported to be associated with cardiovascular disease risks in previous cross-sectional studies. (biomedcentral.com)
- Adiposity, regardless of the marker used to define obesity, was associated with an increased risk of 10 cancer sites. (easo.org)
Regional adiposity2
- Total (postprandial) and parasympathetic-dependent IS correlated negatively with whole-body fat (R-2 0.81 and 0.87) and regional adiposity (R-2 0.85 and 0.79). (ibict.br)
- However, while quick and easy to calculate, it is important to highlight that BMI tells clinicians nothing about regional adiposity (pear vs apple shape) or muscle mass. (medscape.com)
Positively associated4
- Among 113 163 participants without prior disease and aged 35-74 years at recruitment, all adiposity markers were positively associated with vascular-metabolic mortality. (ox.ac.uk)
- BACKGROUND: Adult adiposity is positively associated with pancreatic cancer in Western populations. (ox.ac.uk)
- Young adulthood BMI was strongly positively associated with pancreatic cancer in CKB (adjusted HR=1.36, 95% CI 1.16 to 1.61, per 5 kg/m2 higher BMI) and in meta-analysis of CKB and four other studies (1.18, 1.12 to 1.24). (ox.ac.uk)
- CONCLUSIONS: In both East Asian and Western populations, adiposity was positively associated with risk of pancreatic cancer, with a somewhat stronger association for young than late-life adiposity. (ox.ac.uk)
Comorbidities1
Markers7
- Emerging evidence indicates a correlation between increased adiposity and markers of oxidative DNA damage. (westminster.ac.uk)
- Correlations of these markers is explored against three different measures of adiposity - waist to hip ratio, body fat percentage and body mass index. (westminster.ac.uk)
- Whether serum adipokines could be used as convenient, surrogate markers of adiposity in obese/overweight adolescents with T1D is not known. (bmj.com)
- CONCLUSIONS: Our results provide insight to the lipidic and metabolomic signatures of different adiposity markers in a previously understudied population where adiposity is common but lipid-lowering therapy is not. (ox.ac.uk)
- Associations were mostly linear among all adiposity markers. (easo.org)
- Although we investigated the association of 6 adiposity markers with cancer risk, our findings suggest that all markers predict cancer risk at a similar extent, so therefore using a cheap and simple method, such as body mass index, could predict cancer as well as some expensive methods such as DXA or bioimpedance. (easo.org)
- The RRs corresponding to each standard deviation (SD) higher usual levels of these adiposity markers were 1.34 (95% CI 1.27-1.41), 1.31 (1.23-1.39), 1.38 (1.31-1.45), and 1.18 (1.13-1.24), respectively. (ox.ac.uk)
Metabolic syndrome2
- Unexplained aminotransferase elevation was strongly associated with adiposity and other features of the metabolic syndrome, and thus may represent nonalcoholic fatty liver disease. (nih.gov)
- CONCLUSIONS: Low serum vitamin D in US adolescents is strongly associated with hypertension, hyperglycemia, and metabolic syndrome, independent of adiposity. (johnshopkins.edu)
Excess2
- Naveed Sattar, MD, PhD, said in an interview that these latest findings are "highly consistent with other studies that point to excess adiposity as a potential modifiable risk factor for more severe COVID-19. (the-hospitalist.org)
- Individuals have all the health effects of excess adiposity, coupled with the adverse risks of sarcopenia. (medscape.com)
Adulthood4
- Neonatal hypothalamic androgenization in the female rat induces changes in peripheral insulin sensitivity and adiposity function at adulthood. (nel.edu)
- Perelló M, Castrogiovanni D, Moreno G, Gaillard R, Spinedi E. Neonatal hypothalamic androgenization in the female rat induces changes in peripheral insulin sensitivity and adiposity function at adulthood. (nel.edu)
- Young adulthood and adulthood adiposity in relation to incidence of pancreatic cancer: a prospective study of 0.5 million Chinese adults and a meta-analysis. (ox.ac.uk)
- Little is known, however, about the association in China where many have lower body mass index (BMI) or about the relevance of young adulthood adiposity for pancreatic cancer in both Western and East Asian populations. (ox.ac.uk)
Glucose4
- While BMI has been shown to be strongly associated with high blood pressure and impaired glucose, we found a weak correlation among agricultur al workers. (cdc.gov)
- Given the common and high use of pesticides and elevated rates of hypertension, impaired glucose, and adiposity in agricultur al workers, the public health impact of this relationship may require and lead to occupational reform that protects the health of agricultur al workers. (cdc.gov)
- In turn, the melanocortin system is an essential and potent regulator of body adiposity, glucose metabolism and blood pressure( ref ). (anti-agingfirewalls.com)
- Reported hazard ratios (HR) represent HR per standard deviation (SD) change in adiposity index and are adjusted for age, sex, smoking, cholesterol, SBP, glucose, and history of MI, stroke and AF. (pace-cme.org)
Increased risk1
- Participants in the highest category of adiposity had an approximately 2- to 6-fold increased risk of developing diabetes compared with those in the lowest category. (healthnewstrack.com)
Predictive1
- We determined the predictive value of mid-life adiposity, including body mass index and tricep and subscapular skinfold thickness, on the risk of developing dementia in a large multiethnic cohort of men and women followed for an average of 27 years. (bmj.com)
Diabetes2
- Adiposity [body fat] is a well-recognized risk factor for type 2 diabetes among young and middle-aged adults, however, the relationships between different measures of body composition and diabetes in older adults [65 years of age or older] are not well described," the authors write. (healthnewstrack.com)
- For each measure, there was a graded increase in the risk of diabetes with increasing quintiles of adiposity. (healthnewstrack.com)
Mortality2
- BACKGROUND: Adiposity is a major cause of morbidity and mortality in part due to effects on blood lipids. (ox.ac.uk)
- Data from a large longitudinal nutrition study of 105,000 adults over age 50 has found all-cause mortality strongly associated with WC. (positivechoices.com)
Correlates1
- HFD-associated postprandial insulin resistance is largely mediated by impairment of parasympathetic-dependent insulin action, which correlates with adiposity. (ibict.br)
CONCLUSIONS2
Ratio2
- Different anthropometric measurements are used in clinical practice and in epidemiological studies to assess body adiposity, owing to their practicality and low cost, such as WC, BMI and waist-to-height ratio (WHtR). (scielosp.org)
- waist hip ratio, WHR) and overall and site-specific (colon, proximal colon, distal colon, and rectal) CRC risk, (II) adiposity measures and plasma proteins, and (III) adiposity-associated plasma proteins and CRC risk. (who.int)
Predict1
- Substantial uncertainty remains, however, about which measures of adiposity most strongly predict blood pressure and whether these associations differ materially between populations. (ox.ac.uk)
Adjustment1
Significantly1
Adults2
- Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults. (ox.ac.uk)
- Adiposity and blood pressure among 55 000 relatively lean rural adults in southwest of China. (ox.ac.uk)
Marker1
- Due to the close relation between age, gender, adiposity, preHTN, and HTN [ 2 , 10 , 11 ], the search of anthropometric marker predictors of cardiovascular risk (CVR) such as HTN has revolutionized the field. (hindawi.com)
Factors5
- Higher BMIs are more strongly associated with higher adiposity and cardiovascular risk factors. (cdc.gov)
- For example, daily physical activity of at least moderate intensity is associated with reduced clustering of cardiovascular risk factors in youths, including high blood pressure, insulin level, lipids, and adiposity (7). (cdc.gov)
- Multivariable regression models were used to determine the relationship between dietary and physical factors and adiposity. (shbc.com.sg)
- For these factors, there were similar HRs for pulmonary embolism and deep vein thrombosis in UK Biobank (except adiposity was more strongly associated with pulmonary embolism) and similar HRs for unprovoked vs provoked VTE. (ox.ac.uk)
- Apart from adiposity, these risk factors were less strongly associated with VTE than CHD. (ox.ac.uk)
Associations3
- Most associations were independent of BF% suggesting that the differences in serum metabolites between children are driven by cardiorespiratory fitness and not adiposity. (frontiersin.org)
- Associations of adiposity indices with incident HF were analyzed. (pace-cme.org)
- 6,591 adiposity-protein (2,628 unique proteins) and 33 protein-CRC (8 unique proteins) associations were identified using UVMR and colocalization. (who.int)
Higher2
- There was a strongly positive, and apparently linear, relationship of BMI and WC with blood pressure, with 1 s.d. higher BMI associated with 4.3/2.3 mm Hg higher SBP/DBP and 1 s.d. (ox.ac.uk)
- BACKGROUND: Greater adiposity is associated with higher blood pressure. (ox.ac.uk)
Insulin resistance1
- Our study strongly supports the hypothesis that development of insulin resistance seems to be dependent on early hyperandrogenicity. (nel.edu)
Hyperglycemia1
- As an important part of that model, the gut hormone ghrelin is believed to inform the brain about energy availability and has been shown to increase adiposity, raise blood pressure and promote hyperglycemia( ref ). (anti-agingfirewalls.com)
Results3
- Results showed that RFM was most strongly associated with incident HF risk. (pace-cme.org)
- Additionally, these results strongly suggest the need to improve the food environment by promoting policies for ensuring healthier food options to unhealthy snacking, and thereby reduce associated metabolic risk. (nutrition.org)
- These results highlight the impact of adiposity on the plasma proteome and of adiposity-associated circulating proteins on the risk of CRC. (who.int)
Participants1
- Measures of adiposity were determined when participants entered the study, and repeated 3 years later. (healthnewstrack.com)
Incident3
- Amongst investigated adiposity indices, RFM showed the strongest association with incident HF (HR 1.67 per 1 SD increase, 95% CI 1.37-2.04). (pace-cme.org)
- All adiposity indices were similarly associated with incident HF in men and women. (pace-cme.org)
- All adiposity indices were similarly associated with incident HFpEF in both sexes. (pace-cme.org)
Measure2
- BMI is not a direct measure of adiposity (body fatness). (cdc.gov)
- It is a crude tool that theoretically serves as a proxy measure of total adiposity. (medscape.com)
Vigorous2
- Fitness and physical activity are strongly associated, and frequent vigorous physical activities are likely to improve fitness (6). (cdc.gov)
- Low saturated fat intake, high fibre intake and engagement in high levels of vigorous physical activities are independently associated with lower adiposity. (shbc.com.sg)
Findings1
- Optional but strongly recommended) Share main findings with LEAD Center investigators. (cuanschutz.edu)
Risk factor1
- Adiposity is an established risk factor for colorectal cancer (CRC). (who.int)
Association2
- We used multivariable MR (MVMR) to investigate the potential mediating role of adiposity- and CRC-related proteins in the adiposity-CRC association. (who.int)
- In MVMR, adjusting the BMI-CRC association for GREM1, effect estimates were attenuated - suggestive of a potential mediating role - most strongly for the BMI-overall CRC association in women. (who.int)
High2
- Our study strongly supports that high glucocorticoid production is the main factor responsible for the development of enhanced adiposity in MSG rats and, importantly, that this abnormality could be reversed by an appropriate therapy. (nel.edu)
- Not really, currently we know that meat and processed meat are strongly associated with a high risk of several cancers. (easo.org)