CorneaInfiltrateHerpes simplHerpetic stromal keratitisEdemaUlcerationRecurrentDiffuseInfectiousInterstitial keratitisBacterialInflammationRecurrenceDiagnosisEndothelialPenetrating keratoplastySuperficialAcanthamoebaCause of blindnessOcularUveitisUlcersInfectionBlepharitisTissueReactivationPatientsHazeInvolvementDisciformFungalPrognosisSecondaryDefectsAtypicalThicknessContact lens
Cornea14
- Chronic superficial keratitis (CSK), also known as pannus or Uberreiter's disease, is an inflammatory condition of the cornea in dogs, particularly seen in the German Shepherd. (wikipedia.org)
- Interstitial keratitis is inflammation of the tissue of the cornea, the clear window on the front of the eye. (medlineplus.gov)
- Interstitial keratitis is a serious condition in which blood vessels grow into the cornea. (medlineplus.gov)
- Diagnosing and treating interstitial keratitis and its cause early can preserve the clear cornea and good vision. (medlineplus.gov)
- Acanthamoeba keratitis (AK) is a severe and vision-threatening infection of the cornea. (researchsquare.com)
- Interstitial Keratitis Interstitial keratitis is chronic, nonulcerative inflammation of the mid-stroma (the middle layers of the cornea) that is sometimes associated with uveitis. (msdmanuals.com)
- Herpes simplex keratitis usually affects the corneal surface but sometimes involves the corneal stroma (the deeper layers of the cornea) or the inner corneal surface (endothelium), anterior chamber, and iris. (msdmanuals.com)
- Bacterial keratitis denotes a bacterial infection of the eye that causes inflammation and, potentially, ulceration of the cornea, whereas corneal ulcer describes a loss of corneal tissue due to many possible causes. (medscape.com)
- Less frequently, the autoinflammatory process also can directly attack the cornea, causing peripheral ulcerative keratitis (PUK), a condition that demands aggressive treatment. (medscape.com)
- Peripheral ulcerative keratitis (PUK) is a rare manifestation of RA characterized by a progressive thinning of the peripheral cornea. (medscape.com)
- Cornea showed a paracentral solitary, large, well circumscribed, full thickness, and yellowish white stromal infiltrate measuring 4.5 mm × 5.5 mm with a central 2-mm perforation. (biomedcentral.com)
- In most cases, the infection is just in the top layer of the cornea and is called epithelial keratitis. (eyes4kids.com)
- If the deeper layers of the cornea are involved, this is more serious and is called stromal keratits. (eyes4kids.com)
- Stromal keratitis is more likely to lead to scarring of the cornea. (eyes4kids.com)
Infiltrate7
- No visual loss was reported, and a slit-lamp examination showed a millimetric epithelial defect associated with a round stromal infiltrate ( Figure ). (cdc.gov)
- Necrotizing stromal keratitis is characterized by dense stromal infiltrate, ulceration, and necrosis. (medscape.com)
- Clinical signs of endotheliitis include keratic precipitates (KP), overlying stromal and epithelial edema, and absence of stromal infiltrate or neovascularization. (medscape.com)
- Severe stromal keratitis is present with malacia and stromal cellular infiltrate as well as diffuse edema in the left eye of a horse with presumed infectious keratitis. (msdvetmanual.com)
- Examination revealed a paracentral large stromal infiltrate with a central 2-mm perforation. (biomedcentral.com)
- We report here an unusual case of perforated corneal ulcer with a large infiltrate, caused by HSV-1 in a contact lens wearer, initially diagnosed as bacterial keratitis. (biomedcentral.com)
- A . Slit lamp biomicroscopy under optical section of the right eye showing a solitary paracentral, well circumscribed, large, full thickness stromal infiltrate, collapsed anterior chamber and a central area of perforation. (biomedcentral.com)
Herpes simpl5
- Stromal keratitis may be caused by both the herpes simplex virus (HSV) and varicella-zoster virus (VZV). (ekjo.org)
- Read a case study from the Division of Ophthalmology about pink eye, the detection of herpes simplex virus-1 (HSV-1) and the recurrence of HSV keratitis in children. (chop.edu)
- Herpes simplex virus (HSV) keratitis is the most frequent cause of blindness due to corneal disease in the United States and the most common source of infectious blindness in the Western world. (medscape.com)
- Herpes simplex keratitis is corneal infection with herpes simplex virus. (msdmanuals.com)
- Herpes simplex virus bullous keratitis misdiagnosed as a. (web.app)
Herpetic stromal keratitis4
- In this article, we present a unique case of relapsed herpetic stromal keratitis after vaccination with the mRNA COVID-19 vaccine. (ekjo.org)
- A 30-year-old female patient with no history of systemic disease, who was treated for herpetic stromal keratitis in her right eye about a year prior, and is undergoing follow-up, was revisited with decreased visual acuity in her right eye. (ekjo.org)
- Herpetic stromal keratitis is a primary endotheliitis that results in both stromal and epithelial edema in a disciform infiltration with anterior chamber reaction. (ekjo.org)
- 13. Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. (kseh.kr)
Edema3
- The migrated cells reduce the corneal stromal edema and vision improves. (merckmanuals.com)
- Recurrent episodes of "keratoendothelitis" associated with mild iritis and stromal edema. (mhmedical.com)
- Disciform keratitis is a deeper, disc-shaped, localized area of secondary corneal stromal edema and haze accompanied by anterior uveitis. (msdmanuals.com)
Ulceration3
- in cases of superficial keratitis the epithelium is likely to faintly stain, although true ulceration is absent. (vin.com)
- These erosions may progress to a persistent epithelial defect and eventual stromal ulceration. (medscape.com)
- This vasculopathy can cause resorption of stromal tissue with ulceration and necrosis. (medscape.com)
Recurrent4
- Our case report indicates that canakinumab is effective not only for the treatment of systemic inflammation but also for treating ophthalmic involvement, such as recurrent stromal keratitis and anterior uveitis. (springeropen.com)
- 6 Stromal HSK only represents two percent of the initial HSV ocular presentations but causes 20-61% of recurrent disease. (dovepress.com)
- Compared to HSV-1 infected non-treated mice, the infected and TTHX1114 treated mice exhibited significant reduction of primary and recurrent stromal keratitis and blepharitis, without affecting virus corneal replication. (escholarship.org)
- Inherited condition characterized by recurrent stromal keratitis and vascularization. (mhmedical.com)
Diffuse2
- Diffuse lamellar keratitis. (crstodayeurope.com)
- Diffuse lamellar keratitis (DLK) associated with femtosecond lasers is relatively uncommon. (crstodayeurope.com)
Infectious3
- Herpes simplex keratitis (HSK) is the most common infectious cause of blindness. (dovepress.com)
- Gentle epithelial débridement may be performed to remove infectious virus and viral antigens that may induce stromal keratitis. (medscape.com)
- However, Giemsa stained smear showed the presence of multinucleated giant cells, with characteristic molding of nuclei (Fig. 1B ), suggesting infectious keratitis, probably of a viral etiology. (biomedcentral.com)
Interstitial keratitis7
- However, interstitial keratitis accounts for 10% of avoidable blindness in the least developed countries worldwide. (medlineplus.gov)
- Interstitial keratitis can be easily diagnosed by slit-lamp examination of the eyes. (medlineplus.gov)
- A corneal transplant is not as successful for interstitial keratitis as it is for most other corneal diseases. (medlineplus.gov)
- People with interstitial keratitis need to be followed closely by an ophthalmologist and a medical specialist with knowledge of the underlying disease. (medlineplus.gov)
- Prevention consists of avoiding the infection that causes interstitial keratitis. (medlineplus.gov)
- Stromal interstitial keratitis in a patient with COVID-19. (medlineplus.gov)
- Gauthier A-S, Noureddine S, Delbosc B. Interstitial keratitis diagnosis and treatment. (medlineplus.gov)
Bacterial3
- No intraocular reaction was observed, and bacterial keratitis was diagnosed. (cdc.gov)
- The term "corneal ulcer" often is used interchangeably with "bacterial keratitis," although, in practice, these are 2 different entities. (medscape.com)
- To report a case of atypical herpes simplex keratitis initially diagnosed as bacterial keratitis, in a contact lens wearer. (biomedcentral.com)
Inflammation2
- The patient was clinically diagnosed with recurrence of viral stromal keratitis that previously had appeared as round stromal infiltration and anterior chamber inflammation +1. (ekjo.org)
- Stromal inflammation did not differ between groups at any time point, although the intensity of α-SMA over the number of nuclei was significantly greater at day 21 between groups receiving simultaneous CXL and PTK and those receiving CXL before PTK. (bvsalud.org)
Recurrence3
- In this case, VZV-related keratitis is strongly suspected because high VZV-IgG antibody titers were obtained despite secondary recurrence. (ekjo.org)
- Recurrence of HSV keratitis is more likely to occur in children, with a rate above 50% and a mean time to recurrence of 13 months. (chop.edu)
- Prophylaxis against recurrence of ocular HSV disease † in immunocompetent adults and children ≥12 years of age who had ocular HSV disease (blepharitis, conjunctivitis, epithelial keratitis, stromal keratitis, iritis) in one or both eyes within the preceding 12 months. (drugs.com)
Diagnosis5
- V corneae infection was identified as a cause of unilateral stromal keratitis in a case report by Font et al, and topical steroid use had preceded the diagnosis. (medscape.com)
- Whereas most cases of HSV keratitis are diagnosed based on clinical exam, atypical presentations benefit from laboratory confirmation to more rapidly and definitively confirm a diagnosis. (chop.edu)
- If these measures are not successful, the diagnosis of herpetic keratitis (Fig 15-4) should be considered even if this was not the underlying reason for the graft. (aao.org)
- HSV keratitis remains primarily a clinical diagnosis based on characteristic features of the corneal lesion. (medscape.com)
- Diagnosis is based on clinical findings and exclusion of other causes of stromal keratitis (eg, syphilis, Lyme disease, Epstein-Barr virus infection) by appropriate serologic tests. (msdmanuals.com)
Endothelial2
- 4 , 5 HSK can be further divided anatomically into epithelial, stromal, or endothelial involvement. (dovepress.com)
- Epithelial involvement typically causes pain and redness, while stromal and endothelial HSK can cause vision loss. (dovepress.com)
Penetrating keratoplasty1
Superficial3
- Chronic superficial keratitis is most commonly seen in German Shepherds, but it is also found in Belgian Tervurens, Greyhounds, Siberian Huskies, Australian Shepherds, and Border Collies. (wikipedia.org)
- Her condition improved after a 7-day topical fluoroquinolone treatment, and follow-up at 13 months showed only a slight superficial stromal scar. (cdc.gov)
- If close to the limbus, primary inflammatory lesions should be considered (especially in dogs, e.g., fibrous histiocytoma, chronic superficial keratitis, pannus). (vin.com)
Acanthamoeba5
- However, 1 of the 2 new ameba-resistant bacteria isolated from the contact lens storage case liquid had a 16S rDNA sequence similar to that of the endosymbiont of an Acanthamoeba species isolated from the corneal sampling of a patient with keratitis in South Korea ( 5 ). (cdc.gov)
- To study the predisposing factors, clinical manifestations, and treatment outcome of patients with Acanthamoeba keratitis (AK) at Tanta University's Ophthalmology Hospital in Tanta, Egypt. (dovepress.com)
- A retrospective study of 42 patients (44 eyes) with Acanthamoeba keratitis who had medical records available for review over 4 years. (dovepress.com)
- Acanthamoeba keratitis (AK) is one of the most challenging cases in Ophthalmology. (dovepress.com)
- Backgroud To report the clinical and microbiological features of Acanthamoeba keratitis (AK) related to contact lens in a tertiary hospital in China. (researchsquare.com)
Cause of blindness1
- Herpes simplex keratitis is a major cause of blindness worldwide. (msdmanuals.com)
Ocular2
- The incidence of herpes simplex keratitis (HSK) in patients following corneal refractive surgery is higher than in the general population, and several case reports of ocular morbidity in HSK infection following corneal refractive surgery have been published. (dovepress.com)
- Ulcerative keratitis is a major ocular disease entity, its common occurrence and the inherent difficulties met in its treatment assuring its significance in both the canine and feline species. (vin.com)
Uveitis1
- Here, we describe a case of an adult female with CINCA/NOMID syndrome-related stromal keratitis and uveitis, which was successfully treated with canakinumab. (springeropen.com)
Ulcers1
- Dendritic ulcers are the most common presentation of HSV keratitis. (medscape.com)
Infection1
- Amebic keratitis is an aggressive infection usually associated with soft contact lenses, and its poor outcome can lead to a corneal graft ( 1 ). (cdc.gov)
Blepharitis1
- The severity of primary stromal keratitis and blepharitis were monitored up to 28 days PI. (escholarship.org)
Tissue1
- Patients with CTK typically develop dense central corneal opacification, stromal tissue loss, striae, and significant hyperopic refractive shift [7] [8] . (aao.org)
Reactivation1
Patients5
- most recently reported final vision of 20/40 or worse in 10 of 39 eyes (26%) of their pediatric patients with HSV keratitis. (chop.edu)
- In addition, patients are at risk for refractive amblyopia caused by keratitis-induced astigmatism. (chop.edu)
- Treatment of HSV keratitis † [off-label] in HIV-infected patients. (drugs.com)
- Most patients with disciform keratitis, which involves the corneal endothelium primarily, have a history of epithelial keratitis. (msdmanuals.com)
- Purpose to compare amniotic membrane transplantation amt and anterior stromal puncture asp in the management of pain in patients with symptomatic bullous. (web.app)
Haze3
- Results: Stromal haze formation following simultaneous PTK and CXL was significantly greater than in corneas that received PTK only and persisted for more than 90 days. (bvsalud.org)
- No significant difference in stromal haze was noted between groups receiving simultaneous CXL and PTK and those receiving CXL before PTK. (bvsalud.org)
- Conclusions: We showed that stromal haze formation and stromal stiffness is significantly increased following CXL, regardless of whether it is performed at or before the time of PTK. (bvsalud.org)
Involvement1
- Stromal involvement is probably an immunologic response to the virus. (msdmanuals.com)
Disciform1
Fungal1
- Misdiagnosis is not unusual, and in many instances, it presents in ways similar to keratitis of herpetic and fungal origins. (dovepress.com)
Prognosis1
- The prognosis in HSV keratitis, however, is generally favorable with aggressive treatment. (medscape.com)
Secondary1
Defects1
- fluorescein will pool in epithelialized stromal defects. (vin.com)
Atypical1
- Atypical HSV keratitis can occur in contact lens wearers. (biomedcentral.com)
Thickness1
- 50% stromal thickness. (who.int)