Stromal mast cells. Medical search. Frequent questions

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. (wikipedia.org)
Small tumors are generally not aggressive, especially when cell division rate is slow. (wikipedia.org)
Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. (nih.gov)
Whole-genome and Epigenomic Landscapes of Malignant Gastrointestinal Stromal Tumors Harboring KIT Exon 11 557-558 Deletion Mutations. (nih.gov)
Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. (ca.gov)
A constitutively activating mutation, cKit(V558Δ), causes gain-of-function phenotypes in mast cells and intestines, and gastrointestinal stromal tumors (GISTs) when heterozygous. (ca.gov)
The test also plays a role in helping differentiate between intra-abdominal mesenchymal tumors and gastrointestinal stromal tumors. (flebo.in)
In addition, the research will expand therapeutic potential of HT-KIT for the treatment of other cancers where aberrant cKIT signaling contributes to the cancer progression, such as gastrointestinal stromal tumors (GIST) and acute myeloid leukemia (AML). (reachmd.com)
Mutations in the KIT pathway have been associated with several human cancers, such as gastrointestinal stromal tumors and mast cell-derived cancers (mast cell leukemia and mast cell sarcoma). (reachmd.com)
Gastrointestinal (GI) stromal tumors (GISTs) account for less than 1% of all GI tumors, yet are still the most common mesenchymal tumors of the GI tract. (arupconsult.com)
How are gastrointestinal stromal tumors diagnosed? (arupconsult.com)
Suspected gastrointestinal (GI) stromal tumors (GISTs) usually present initially with GI bleeding (the most common manifestation), abdominal pain, and obstructive symptoms. (arupconsult.com)
What is the role of mutational analysis in determining therapy for gastrointestinal stromal tumors? (arupconsult.com)
KIT / PDGFRA mutational assessment is important for decision-making and treatment purposes, given that gastrointestinal (GI) stromal tumors (GISTs) have a variety of subtypes with different predictive and prognostic relevance. (arupconsult.com)
Gastrointestinal stromal tumors (GISTs) have been recognized as a biologically distinctive type of tumor, different from smooth muscle and neural tumors of the gastrointestinal tract. (biomedcentral.com)
Research into the oncogenic mechanisms of GISTs has found that these tumors frequently contain activating gene mutations in either platelet-derived growth factor receptor A ( PDGFRA ) or a receptor tyrosine protein associated with a mast cell growth factor receptor encoded by the KIT gene. (biomedcentral.com)
Molecular subsets of gastrointestinal stromal tumors (GISTs). (biomedcentral.com)
Functioning paraganglioma and gastrointestinal stromal tumor (GIST) are uncommon tumors that occur mostly in a sporadic and isolated form, occasionally as components of multiple neoplasia syndromes, either separately or together. (elsevierpure.com)
Single-cell transcriptomics identified an increased number of cells with a stromal signature in tumors, and subsequent histology revealed an increased abundance of mast cells in the tumor stromal regions. (uea.ac.uk)
We show that administration of a mast cell stabilizer, cromolyn, rescues increased tumor growth in antibiotic treated animals but has no influence on tumors from control cohorts. (uea.ac.uk)
A recently published study found the long sought after bridge between mast cells and asthma by demonstrating the positive effects of imatinib (Gleevec, Novartis), a kinase inhibitor currently approved for treatment of chronic myeloid leukemias and stromal tumors. (reviewofophthalmology.com)
Exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. (lifecarenews.in)

MC903-treatment on the ear lobe increased clinical scores and ear-thickening, along with increased MC and granulocyte infiltration and activity, as well as increased levels of interleukin 33 (IL-33) locally and thymic stromal lymphopoietin (TSLP) both locally and systemically. (slu.se)
Mast cell thymic stromal lymphopoietin (TSLP) production was assessed by quantitative real-time PCR. (johnshopkins.edu)
Liu YJ: Thymic stromal lymphopoietin: Master switch for allergic inflammation. (spandidos-publications.com)

In the gut, however, a mass staining positive for CD117 is likely to be a GIST, arising from ICC cells. (wikipedia.org)
This medication is used to treat a certain type of stomach , bowel, or esophagus cancer (gastrointestinal stromal tumor-GIST). (webmd.com)
Staining for DOG1, also known as anoctamin-1/ANO1, a voltage-gated calcium-activated anion channel highly expressed in the interstitial cells of Cajal, may be useful for cases that cannot be categorized as GIST based on CD117 immunostaining. (arupconsult.com)
This is especially true in the case of mutant tumor DNA derived "driver" and "drug-resistant" alleles that are present in the circulating cell-free tumor DNA (cfDNA) in the peripheral blood circulation of GIST patients. (biomedcentral.com)
The neoplastic GIST cell appears to arise from a common precursor cell, which gives rise to the interstitial cells of Cajal in the normal myenteric plexus [ 3 ]. (biomedcentral.com)
Separately, they occur in several inherited syndromes including multiple endocrine neoplasia 2, and the GIST, lentigines, and mast cell tumor syndrome. (elsevierpure.com)
The paraganglioma-jejunal GIST combination may be the harbinger of a rare genetic syndrome, a variant of the Carney triad or the paraganglioma-gastric stromal sarcoma syndrome, or be coincidental. (elsevierpure.com)

GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. (wikipedia.org)
GISTs are thought to arise from interstitial cells of Cajal (ICC), that are normally part of the autonomic nervous system of the intestine. (wikipedia.org)
GISTs are characterized by mutations in a receptor tyrosine protein (encoded by the KIT gene) associated with a mast cell growth factor receptor or in the gene encoding platelet-derived growth factor receptor A ( PDGFRA ). (biomedcentral.com)

Further, activated Socs7 -/- bone marrow derived mast cells have increased IL-7Rα transcript, which is part of the heterodimeric receptor for TSLP. (johnshopkins.edu)
Finally, lack of SOCS7 was accompanied by an increase in TSLP mRNA and protein production by mast cells following FcεRI aggregation. (johnshopkins.edu)
These data implicate SOCS7 in the modulation of allergic inflammation and demonstrate that SOCS7 is involved in the regulation of TSLP signaling in mast cells. (johnshopkins.edu)

The research will be led by Dr. Glenn Cruse , Assistant Professor, and will focus on characterizing the HT-KIT dose and dosing frequency for treatment of aggressive mastocytosis and mast cell neoplasms using humanized tumor mouse models. (reachmd.com)
Gastrointestinal stromal tumor tissue. (arigobio.com)
We demonstrate M2 macrophages and mast cells as key cellular sources of tumor necrosis factor (TNF) that promotes myofibroblast development. (ox.ac.uk)

She is now a recognized expert in Mastocytosis and Mast Cell Activation disorders. (allergynk.com)
KIT D816V is responsible for driving systemic mastocytosis, a serious disease caused by unchecked proliferation of mast cells. (lifecarenews.in)

It works by slowing or stopping the growth of cancer cells and certain immune system cells (mast cells). (webmd.com)
He is looking at gene signatures, different immune cell types and how they change. (stanford.edu)
Mast cells are inflammatory immune cells that play an essential role in mediating allergic reactions in humans. (figshare.com)
The regulation of immune system occurs with vitamin D receptor (VDR) binding on elements responsive to vitamin D (VDRE) on many target genes of immune cells, determining their transcription or silencing [ 19 ]. (biomedcentral.com)
During the inflammatory response, immune cells egress from the circulation and follow a chemotactic and haptotactic gradient within the tissue, interacting with matrix components in the stroma and with parenchymal cells, which guide them towards the sites of inflammation. (hindawi.com)
Leukocyte recruitment into the inflamed parenchyma requires successive interactions with cellular and stromal barriers that establish mechanical, chemotactic and haptotactic gradients to guide immune cells towards the inflammatory focus. (hindawi.com)
Compared to the endothelium, the molecular mechanisms involved in the interaction of infiltrated or tissue-resident immune cells with parenchymal barriers have not been so extensively studied. (hindawi.com)
So far, most of the in vivo and in vitro approaches to study leukocyte migration across the tissue parenchyma have addressed the role of each single tissue barrier that immune cells encounter in their journey to the inflammatory focus. (hindawi.com)
We believe that successfully combining our current knowledge about leukocyte extravasation, three-dimensional migration through the stroma and the sequential interactions with parenchymal cell barriers, which include adopting unified experimental models, will help shed light on the entire migratory route of each immune cell type and on the specificity of the innate inflammatory responses in each type of tissue. (hindawi.com)
Here, we provide a detailed single-cell analysis of the immune landscape in Dupuytren's disease, a localized fibrotic condition of the hand, and identify a pathogenic signaling circuit between stromal and immune cells. (ox.ac.uk)
In turn, stromal cell IL-33 acts as a potent stimulus for TNF production from immune cells. (ox.ac.uk)
Autotransplanted mouse model of endometriosis showed lenvatinib treatment abrogated the increased lymphatic vessels development in the endometriotic lesion, enlarged retroperitoneal lymph nodes, and immune cells infiltration, indicating that blocking VEGF-C signaling can reduce local chronic inflammation and concomitantly endometriosis development. (endometriosistreatmentreport.com)
In immune reactions such as allergic conjunctivitis, there is a series of cellular events, including sensitization to the allergen, presentation by dendritic cells and priming of naïve T cells that collectively lead to production of IgE-producing B cells. (reviewofophthalmology.com)
In the continued presence of antigen, this immediate hypersensitivity can lead to a late-phase response (typically hours later) in which other immune cells, particularly neutrophils and basophils, are recruited to infiltrate into the conjunctiva. (reviewofophthalmology.com)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
B cells The immune system consists of cellular components and molecular components that work together to destroy antigens. (msdmanuals.com)
these responses may include proinflammatory cytokines, inflammasome activation, barrier integrity, skin microbiota, and the presence of immune cells. (cdc.gov)
Taken together, these results demonstrate that exposure to an immunomodulatory chemical, triclosan, differentially impacts immune cell populations in the skin of haired and hairless mice. (cdc.gov)

Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye, which acts as a protective barrier and is critical for clear and stable vision. (wjgnet.com)
Compared with follicular epithelial cells, there are a few morphological studies on the stroma of human thyroid gland. (nih.gov)
To evaluate the expression of E-cadherin (E-cad) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). (ijpmonline.org)
Immunohistochemistry was used to detect E-cad expression in 20 cases each of normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. (ijpmonline.org)
The adaptation of cells to hypoxia appears to be mediated via hypoxia inducible factor-1α (HIF-1α) which is also said to be associated with malignant transformation of epithelial cells in various other carcinomas like prostate and cervical carcinoma. (ijpmonline.org)
Polarized epithelial cells compartmentalize tissue cavities and are often exposed to inflammatory challenges such as toxics or infections in non-lymphoid tissues. (hindawi.com)
We also discuss recent findings showing that the loss of apicobasal polarity increases leukocyte adhesion to epithelial cells and the consequences that this could have for the inflammatory response towards damaged, infected or transformed epithelial cells. (hindawi.com)
These areas are often made up of polarized parenchymal epithelial cells that form barriers to compartmentalize functions in cavities of the liver, intestine or lungs (Figure 1 ). (hindawi.com)
and T-LYMPHOCYTES, and is produced by various cell types, including epithelial and dendritic cells. (bvsalud.org)
Flow Cytometry Underestimates and Planimetry Overestimates Alveolar Epithelial Type 2 Cell Expansion after Lung Injury. (ucdavis.edu)
Over the past decades, luminal epithelial cell lineage has gained considerable attraction as the functionally milk-secreting units and as the most fruitful acreage for breast cancer launching. (biomedcentral.com)
The ductal system is coated by a chain of luminal epithelial cells (LECs) situated on a layer of myoepithelial cells (MECs) and encompassed by a distinguished basement membrane. (biomedcentral.com)
Two major cell types cooperate to build up the ductal units: inner polarized luminal epithelial cells (LECs) embraced by a layer of myoepithelial cells (MECs), both cell types are rimmed by a cohesive basement membrane (BM) [ 2 ]. (biomedcentral.com)
Therefore, damaging the MECs layer resulted in the release of various factors (such as SDF1/CXCL12, CXCL14, MMP, and tenascin) [ 11 , 12 ] with a potential to modify the tumour microenvironment and facilitate the paracrine communication between the tumour epithelial cells and the enclosed stroma enhancing the tumour aggressiveness [ 11 , 13 ]. (biomedcentral.com)
http://dx.doi.org/10.1016/j.jaci.2014.02.015 epithelial cells and airway smooth muscle cells. (cdc.gov)
[ 2 ] The arachnoid cells have several proposed functions, including acting as a structural barrier with cellular wrapping/ensheathing, acting as a conduit for cerebrospinal fluid (CSF) drainage/absorption into dural sinuses/veins (arachnoid villi), epithelial-like/secretory functions, monocytelike functions, trophic support and byproduct detoxification for glial and neuronal cells, and participation in reactive/reparative processes. (medscape.com)
Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)
All layers of the cornea are believed to be affected by keratoconus, although characteristic structural changes include epithelial basement membrane fragmentation and scarring and breaks in the anterior limiting lamina (ie, Bowman membrane), with axial stromal thinning and scarring. (medscape.com)

Deposition of collagen and proliferation of smooth muscle cells are the response to chronic inflammation and injury of the submucosa leading to fibrosis and thickening of the submucosa and the smooth muscle layers of the bowel wall. (bmj.com)
This disease is characterized by a chronic inflammation of lower airways that include complex pathophysiological mechanisms involving several pro-inflammatory cells and molecules, including different cytokine profiles that can change according to environmental and genetic factors [ 3 , 4 ]. (biomedcentral.com)
Maximal bladder capacity was negatively correlated with inflammation, mast cell count, haemorrhages and the overall cystoscopic aspect. (uantwerpen.be)
This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)

KIT has also gone by several other names including c-kit , v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, stem cell factor receptor, mast cell growth factor receptor, and CD117 . (creation.com)

SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
Although mesenchymal stem cells (MSCs) have been shown as a novel approach in tissue regeneration, the therapeutic potential of MSCs mediated by the interaction between MSC-derived paracrine mediators and Mφs remains elusive. (frontiersin.org)
In the 1980's, Arnold Caplan and his colleagues published an isolation method of fibroblast-like stromal cells from bone marrow and first identified them as mesenchymal stem cells (MSCs) because of their multilineage differentiation potential ( Caplan, 1991 ). (frontiersin.org)

a partial map of receptors on human mast cells cultured in vitro. (bdbiosciences.com)
2 Upon subsequent exposure, the complex of antigen, IgE and immunoglobulin receptors will cross-link on conjunctival mast cells, causing degranulation and release of histamine and other pro-inflammatory factors. (reviewofophthalmology.com)

On the one hand, similar to endothelial cells, parenchymal epithelia must guide leukocytes to traverse them in order to reach a localized inflammatory focus, for example, in the lung or intestinal mucosa. (hindawi.com)
More importantly, we show that functional VEGF-C is transported by extracellular vesicles (EVs) to enhance the lymphangiogenic ability of lymphatic endothelial cells. (endometriosistreatmentreport.com)

Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. (nih.gov)
The HT-KIT drug is designed to more specifically target the receptor tyrosine kinase KIT in mast cells, which is required for the proliferation, survival and differentiation of bone marrow-derived hematopoietic stem cells. (reachmd.com)
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. (arigobio.com)

Mutations make c-KITfunction independent of activation by scf, leading to a high cell division rate and possibly genomic instability. (wikipedia.org)
In Section II, Dr. James Griffin reviews the mechanisms that lead to activation of tyrosine kinases by mutations in AML, the consequences of that activation for the cell, and the opportunities for targeted therapy and discusses some examples of developing novel drugs (tyrosine kinase inhibitors) and their effectiveness in AML (FLT3). (ashpublications.org)

Comparative immunophenotypic analysis of human mast cells, blood basophils and monocytes. (bdbiosciences.com)

5 Richter et al 6 reported elevated mast cell numbers in association with increased transforming growth factor-β immunoreactivity in radiation induced enteropathy in rats, which is characterised by intestinal wall fibrosis, serosal thickening, and chronic ulceration. (bmj.com)

Cytokine production by bone marrow derived mast cells was determined by ELISA. (johnshopkins.edu)

To investigate the role of mast cells (MCs) and MC-specific proteases on the immunopathogenesis of AD, a vitamin D3-analog (MC903) was used to induce clinical AD-like symptoms in c-kit-dependent MC-deficient Wsh−/− and the MC protease-deficient mMCP-4−/−, mMCP-6−/−, and CPA3−/− mouse strains. (slu.se)
The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)

Allergic (or atopic) asthma is characterized by the presence of ILC2 and T helper 2 (Th2) response that covers the production of cytokines such as, interleukin (IL)-4, IL-5 and IL-13 which all together orchestrate the migration of eosinophils, mast cells activation and Immunoglobulin E (IgE) production [ 5 , 6 ]. (biomedcentral.com)
The skin tissue was sectioned to measure the thicknesses of the epidermis and dermis, as well as the numbers of eosinophils, mast cells and CD8 infiltration by H&E, toluidine blue, Masson's trichrome and IHC staining. (spandidos-publications.com)

BALB/c mice exposed to triclosan (2%) had a higher number and frequency of neutrophils and lower number and frequency of dendritic cells in the skin compared to controls. (cdc.gov)

Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells. (bdbiosciences.com)
Interleukin-3Rα+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3. (bdbiosciences.com)
The enigmatic plasmocytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. (bdbiosciences.com)
Isolation and characterization of human tonsil dendritic cells. (bdbiosciences.com)
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature. (bdbiosciences.com)

It is well-known that mast cell activation is critically regulated by intracellular calcium ion (Ca 2+ ) concentrations. (figshare.com)
Collectively, our data suggests that MRGPRX2/MrgprB2 activation of mast cells is dependent on SOCE via STIM1, and further characterization of the MRGPRX2-SOCE-STIM1 pathway will lead to the identification of novel targets for the treatment of pseudo-allergic reactions in humans. (figshare.com)
These studies provide evidence that mast cells with their plethora of mediators may be involved in intestinal fibrosis, a notion supported by the observation of mast cell hyperplasia and activation in a variety of clinical and experimental situations in which fibrosis is prominent. (bmj.com)
c-KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. (signalchem.com)
Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth (2). (signalchem.com)
Activation of PAR2 can reduce the radiated U87 cell apoptosis via modulating the expression of p53. (biomedcentral.com)
that regulate the differentiation and activation of these cells. (cdc.gov)
Finally, TA decreased tIgE, OVA-IgE, and MCP-1 levels and subsequently inhibited mast cell activation and leukotriene release. (bvsalud.org)

c-KIT is a gene that encodes for a transmembrane receptor for a growth factor termed stem cell factor (scf). (wikipedia.org)
KitL, via its receptor cKit, supports primordial germ cell (PGC) growth, survival, migration and reprogramming to pluripotent embryonic germ cells (EGCs). (ca.gov)
Previous reports showed that store-operated Ca 2+ entry (SOCE) via the calcium sensor, stromal interaction molecule 1 (STIM1), regulates mast cell response induced by the high-affinity IgE receptor (FcεRI). (figshare.com)
4 It encodes a receptor tyrosine kinase involved in the development and homeostasis of several cell lines including melanocytic (pigment), hematologic (blood), mast, and germ cells. (creation.com)
The receptor makes a single pass through the cell membrane and contains an intracellular kinase catalytic region divided by a hydrophilic insert. (creation.com)
c-KIT is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). (signalchem.com)
This study aims to investigate the role of protease activated receptor-2 (PAR2) in regulation the apoptosis process in glioma cells. (biomedcentral.com)
CRTH2: Chemoattractant receptor-homologous molecule expressed includes nonallergic asthma phenotypes, such as asthma on TH2 cells associated with exposure to air pollution, infection, or obesity, ILC: Innate lymphoid cell that require innate rather than adaptive immunity. (cdc.gov)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

No cell acts independently," he said, "and differentiation is a continuous trajectory -- not a chain of discrete stages, as we once thought. (stanford.edu)
Continuing the research begun under her mentors Garry Nolan, PhD, and Sean Bendall, PhD, Good demonstrated the value of understanding T cell differentiation processes in order to then "guide T cells towards desired outcomes, such as steering T cells towards differentiation states that are more potent in combatting cancer. (stanford.edu)
Good described a method for deep single-cell phenotyping, measuring 30-plus features for every cell, across division states during critical differentiation periods in the context of cell expansion for immunotherapy. (stanford.edu)
We have an opportunity to intervene at the relevant time points, and perhaps guide T cell differentiation towards a desirable phenotype," Good said. (stanford.edu)
Leucocyte typing VI : white cell differentiation antigens : proceedings of the sixth international workshop and conference held in Kobe, Japan, 10-14 November 1996. (bdbiosciences.com)

In vitro, bone marrow derived mast cells from Socs7 -/- mice are hyperactive to IgE-mediated stimuli, with elevated production of pro-inflammatory cytokines (IL-13, IL-6, TNF-α). (johnshopkins.edu)

Based on the initial proof-of-concept success, Hoth intends to initially target mast cell neoplasms for development of HT-KIT, which is a rare, aggressive cancer with poor prognosis. (reachmd.com)
Meningiomas , as defined by the 2016 World Health Organization (WHO), are "a group of mostly benign, slow-growing neoplasms that most likely derive from the meningothelial cells of the arachnoid layer. (medscape.com)

Kraneveld AD, Sagar S, Garssen J and Folkerts G: The two faces of mast cells in food allergy and allergic asthma: The possible concept of Yin Yang. (spandidos-publications.com)
Her cutting-edge research provided the first true evidence that brain hormone serotonin has powerful influence over allergy cells (mast cells). (allergynk.com)

7 , 8 In systemic mast cell disease, association of fibrosis and mast cell infiltrates has been documented in the liver, spleen, lymph nodes, and bone marrow. (bmj.com)

The main constituent of the human thyroid stromal tissue was a CD34 positive reticular network involving fibroblasts, mononuclear cells and nerve terminals. (nih.gov)
Fibrosis is characterised by an excessive production of extracellular matrix components, and cells in the tissue are constantly interacting with these extracellular matrix proteins. (bmj.com)
Characterizing Microscopical Invasion Patterns in Canine Mast Cell Tumours and Soft Tissue Sarcomas. (oregonstate.edu)
This study aimed to define objective, quantifiable histomorphological invasive patterns in low-grade canine mast cell tumours (MCTs) and grade I/II soft tissue sarcomas (STSs), and correlate invasive patterns with overall excisional status. (oregonstate.edu)
Recently, the endocrine activity of adipose tissue cells has been intensively studied. (123dok.org)
We also point out a possible contribution of adipose tissue-associated mast cell secre- tory activity to the development of these diseases. (123dok.org)
Particular attention has been paid to elucidating how leukocytes can migrate through the stroma, the way these cells remodel their morphology and sense cues that guide them towards dysfunctional tissue areas. (hindawi.com)
The results showed that U87 cells and human glioma tissue expressed PAR2. (biomedcentral.com)
Description: tissue homogenates, cell lysates and other biological fluids. (worldcarecouncil.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Juxtaposed With Another Zinc Finger Protein 1 (JAZF1) in Tissue homogenates, cell lysates and other biological fluids. (worldcarecouncil.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Juxtaposed With Another Zinc Finger Protein 1 (JAZF1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (worldcarecouncil.org)

He is also creating detailed cell phenotypes and vivid images of cell neighborhoods from CyTOF, Codex and MIBI machines, allowing the visualization of cells and tissues with multiple markers and the development of network models of signaling pathways. (stanford.edu)

IL-5 is a homodimeric, disulphide-linked protein produced by T-cells. (biolegend.com)
It works by blocking the action of the abnormal protein that signals cancer cells to multiply. (medlineplus.gov)
CD117 is a protein that is found on the surface of certain cells. (flebo.in)
Description: A sandwich ELISA kit for detection of Juxtaposed With Another Zinc Finger Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (worldcarecouncil.org)
These targets can be a protein that the cancer cells is producing excessively or that has become altered by a gene mutation. (auravet.com)

In this study, using complementary pharmacologic and genetic ablation approaches we demonstrate that SOCE through STIM1 promotes MRGPRX2-induced human mast cell response in vitro. (figshare.com)
Subsequent in vitro and in vivo studies have demonstrated the initial steps of cancer cell invasion and dissemination by disrupting the integrity of the myoepithelial belt that encircles the LECs [ 7 , 8 , 9 , 10 , 11 ]. (biomedcentral.com)

1062 The c-KIT product/CD117 is expressed on ICCs and a large number of other cells, mainly bone marrow cells, mast cells, melanocytes and several others. (wikipedia.org)

1. To be able to describe the role of innate lymphoid cells (ILCs) in Date of Original Release: April 2014. (cdc.gov)
NKT: Natural killer T innate lymphoid cells and their role in asthma. (cdc.gov)
Although these changes were not observed in SKH1 mice, SKH1 mice exposed to triclosan had a higher number and frequency of type 2 innate lymphoid cells in the skin. (cdc.gov)

Interfollicular stromal fibroblasts also stained with CD34. (nih.gov)

Immunohistochemistry using a monoclonal antibody against Cx43 confirmed the distribution of gap junctions between stromal fibroblastic cells, which was compatible with the ultrastructural findings. (nih.gov)

Here, variation in a gene affecting the development and movement of pigment cells, KIT , is examined. (creation.com)

In addition, SNL significantly reduced the level of serum IgE and dermal thickness and the infiltration of mast cells and CD8 in the BALB/c mouse model of DNCB‑induced AD. (spandidos-publications.com)
There was a significant correlation between the cystoscopic aspect and inflammatory infiltration, mastocyte count in the detrusor muscle and stromal oedema. (uantwerpen.be)

Mast Cells Limit Ear Swelling Independently of the Chymase Mouse Mast Cell Protease 4 in an MC903-Induced Atopic Dermatitis-Like Mouse Model. (slu.se)
The present study aimed to investigate the effects of Solanum nigrum Linne (SNL) in a model of 1‑chloro‑2,4‑dinitrobenzene (DNCB)‑induced atopic dermatitis (AD) and in TNF‑α/IFN‑γ‑stimulated HaCaT cells. (spandidos-publications.com)
Extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-α/IFN-γ-induced chemokines production in HaCaT cells. (spandidos-publications.com)

The present study also examined the expression of various inflammatory cytokines, MAPK and NF‑κB in TNF‑α/IFN‑γ‑stimulated HaCaT cells. (spandidos-publications.com)
On the other hand, these barriers contain damaged or infected cells that are part of the inflammatory focus and the endpoint of the leukocyte migratory journey, so some sort of footprint, which is not completely understood, must exist in these cells to promote a preferential adhesion with infiltrated leukocytes. (hindawi.com)

Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin. (bdbiosciences.com)

Targeted therapy drugs work by blocking known "targets" on cancer cells, stopping them from dividing and making new cancer cells. (auravet.com)

and, in response to antigen, are subsequently secreted by plasma cells. (msdmanuals.com)

The aim of this study was to investigate whether mast cells accumulate in these tissues and whether their localisation is associated with extracellular matrix components. (bmj.com)

Cell-cell interaction (CCI) is a crucial event in the development and function of multicellular organisms. (bvsalud.org)
We constructed a cell-cell interaction database (CCIDB) containing the biological and clinical contexts involved in each interaction. (bvsalud.org)

METHODS Mast cells were visualised by immunohistochemical staining of the mast cell specific proteases chymase and tryptase. (bmj.com)

Since defective of apoptosis plays a crucial role in the pathogenesis of cancer, we hypothesized that PAR2 might be involved in the regulation of glioma cell apoptosis. (biomedcentral.com)

The white areas are depigmented due to the absence of melanocytes, the cell type which produces pigment. (creation.com)

Data obtained revealed that Socs7 -/- mice have increased serum IgE and IgG 1 production and exhibit an increased mast cell infiltrate, as well as un-provoked mast cell degranulation in the dermis as compared to controls. (johnshopkins.edu)

From the Greek cyto (cavity or cell) and kine (movement), cytokines are proteins involved in cell signaling and function as immunomodulating agents. (cdc.gov)
SNL significantly reduced the levels of cytokines released from HaCaT cells stimulated with TNF‑α/IFN‑γ. (spandidos-publications.com)

Hoth Therapeutics, Inc. (NASDAQ: HOTH), a patient-focused biopharmaceutical company , today announced that it has signed a Sponsored Research Agreement with North Carolina State University (" NC State ") to support the continued research and development of HT-KIT, a novel therapeutic for the treatment mast cell cancers. (reachmd.com)

Herein, we identified that vascular endothelial growth factor (VEGF)-C, a potent lymphangiogenic factor, is up-regulated in endometriotic cells and contributes to increased lymphangiogenesis. (endometriosistreatmentreport.com)

Anatomy21

Organisms6

Diseases14

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes17

Disciplines and Occupations1

Information Science1

Tumors22

Thymic3

GIST7

GISTs3

TSLP3

Tumor3

Mastocytosis2

Immune19

Epithelial19

Inflammation4

Sarcoma1

Mesenchymal3

Receptors2

Endothelial cells2

Proliferation3

Mutations2

Human mast cells1

Elevated mast cell numbers1

Cytokine1

Role of mast cells2

Eosinophils2

Neutrophils1

Dendritic cells5

Activation8

Receptor9

Differentiation5

Bone marrow-derived1

Neoplasms2

Allergy2

Systemic1

Tissue11

Phenotypes1

Protein5

Vitro2

CD1171

Innate lymphoid cells3

Fibroblasts1

Immunohistochemistry1

Gene1

Infiltration2

Atopic3

Inflammatory2

Myeloid1

Targets1

Antigen1

Tissues1

Interaction2

Proteases1

Involved in the regulation1

Melanocytes1

Degranulation1

Cytokines2

Therapeutic1

Growth1