• Sertoli cell tumour. (wikipedia.org)
  • This tumour produces both Sertoli and Leydig cells. (wikipedia.org)
  • A very rare tumour producing both ovarian (granulosa and/or theca) and testicular (Sertoli and/or Leydig) cells or tissues. (wikipedia.org)
  • citation needed] Granulosa cell tumors and Sertoli-Leydig cell tumors have specific genetic mutations that are characteristic and can help support the diagnosis. (wikipedia.org)
  • A retrospective study of 83 women with sex cord-stromal tumours (73 with granulosa cell tumour and 10 with Sertoli-Leydig cell tumour), all diagnosed between 1975 and 2003, reported that survival was higher with age under 50, smaller tumour size, and absence of residual disease. (wikipedia.org)
  • Sex cord-stromal tumors are groups of tumors composed of granulosa cells, theca cells, Sertoli cells, Leydig cells, and fibroblasts of stromal origin, singly or in various combinations. (medscape.com)
  • These data support the concept that this tumor likely arises from ectopic primitive gonadal tissue and/or stromal cells with capacity to transdifferentiate to ovarian cortical cells. (johnshopkins.edu)
  • Sex cord tumour with annular tubules, abbreviated SCTAT. (wikipedia.org)
  • The tumour is almost exclusively benign and unilateral. (wikipedia.org)
  • The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)
  • Leydig cell tumors are usually benign, but malignant variants also occur. (medscape.com)
  • We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. (ijpmonline.org)
  • Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. (lookformedical.com)
  • Leydig cell tumour. (wikipedia.org)
  • This tumour produces Leydig cells, which normally are found in the testicle and tend to secrete androgens. (wikipedia.org)
  • Low magnification micrograph of a Leydig cell tumour. (wikipedia.org)
  • Leydig cell tumors (see the image below) are rare testicular tumors of the male gonadal interstitium that may be hormonally active and lead to feminizing or virilizing syndromes. (medscape.com)
  • Leydig cell tumors may be an incidental finding of a testicular mass on scrotal ultrasonography performed for other conditions. (medscape.com)
  • Radical orchiectomy was once the primary treatment for Leydig cell tumors, and it remains in use for malignant cases. (medscape.com)
  • When Leydig cell tumors are diagnosed and treated early, testicle-sparing surgery has proved to be a feasible and safe choice and could be regarded as first-line therapy. (medscape.com)
  • In a study of 20 patients with Leydig cell tumors who were treated with conservative surgery, follow-up for a mean of 15 years found 100% disease-free survival, with no local recurrences or metastases. (medscape.com)
  • Leydig cell tumors are rare testicular tumors of the male gonadal interstitium. (medscape.com)
  • Although uncommon, Leydig cell tumors comprise 1-3% of all testicular neoplasms. (medscape.com)
  • Leydig cell tumors were once managed primarily with radical orchiectomy . (medscape.com)
  • The etiology of Leydig cell tumors remains unknown. (medscape.com)
  • Unlike germ cell testicular tumors, Leydig cell neoplasms are not associated with cryptorchidism . (medscape.com)
  • In the United States, Leydig cell testicular neoplasms are the most common sex cord-stromal tumors and comprise 1-3% of all testicular neoplasms. (medscape.com)
  • Sex cord-stromal tumors account for approximately 8% of all ovarian tumors. (medscape.com)
  • The International Federation of Gynecology and Obstetrics (FIGO) staging of ovarian tumors is outline below. (medscape.com)
  • Epithelial ovarian tumors are the most common tumor subtype. (amboss.com)
  • In contrast, the epithelial cells originate from the outer epithelial lining surrounding the gonad while the germ cell tumors arise from the precursor cells of the gametes, hence the name germ cell. (wikipedia.org)
  • Deregulation of this balance leads to branching inhibition or excessive branching and increased maturation of the stroma surrounding the differentiating epithelial ducts. (bvsalud.org)
  • Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. (ijpmonline.org)
  • Sex cord-gonadal stromal tumour is a group of tumors derived from the stromal component of the ovary and testis, which comprises the granulosa, thecal cells and fibrocytes. (wikipedia.org)
  • This tumour produces granulosa cells, which normally are found in the ovary. (wikipedia.org)
  • Although both cell types normally occur in the testicle, this tumour can occur in the ovary. (wikipedia.org)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • For diagnosis of granulosa cell tumour, inhibin is under investigation. (wikipedia.org)
  • Although various markers have been reported to stain sex cord-stromal tumors (eg, CD99, CD56, A103, müllerian inhibiting factor, vimentin), inhibin and calretinin have proven to be the most helpful to date. (medscape.com)
  • CD56 is a sensitive marker of ovarian sex cord-stromal tumors and may also be useful in the diagnosis of this group of neoplasms, especially in cases that are inhibin or calretinin negative, and the differential diagnosis includes neoplasms that are CD56 negative. (medscape.com)
  • Results: Mucinous cystic neoplasm of the liver exhibited significantly increased RNA expression of ovarian stromal markers WT1, PR, and ER2 and sex cord stromal markers SF-1, inhibin-α, and calretinin compared with nonneoplastic liver. (johnshopkins.edu)
  • Arise from sex cord cells (e.g. (amboss.com)
  • GU tract pathologies can arise potentially at any stage of a person's life: newborns and infants can start showing signs and symptoms of congenital GU abnormalities, early or delayed puberty can become a burden for adolescents, STDs remain a major public health concern in sexually active teens and adults, and the potential for gonadal or cervical malignancy is constantly looming in particular cases. (lecturio.com)
  • Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)
  • This tumour produces theca of follicle, a tissue normally found in the ovarian follicle. (wikipedia.org)
  • Now, surrounding the glandular tissue is the stroma, which contains adipose or fat tissue , and this makes up the majority of the breast. (osmosis.org)
  • An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
  • A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
  • C: Tumor either Stage IA or Stage IB, but with tumor on the surface of one or both ovaries, or with capsule ruptured, or with ascites containing malignant cells or with positive peritoneal washings. (medscape.com)
  • Tumor involving one or both ovaries with peritoneal implants outside the pelvis and/or positive retroperitoneal or inguinal nodes. (medscape.com)
  • B. Tumor of one or both ovaries with histologically confirmed implants of abdominal peritoneal surfaces, none exceeding 2 cm in diameter. (medscape.com)
  • Nests of endometrial stroma, glands or both are found in the myometrium, in between muscle bundles. (brainscape.com)
  • Characterized by the presence of endometrial glands and stroma in a location outside the endomyometrium. (brainscape.com)
  • It typically secretes estrogen, and as a result women with this tumour often present with postmenopausal bleeding. (wikipedia.org)
  • Immunohistochemical studies have shown that the ovarian-type stroma expresses estrogen receptor, suggesting potential hormonal responsiveness. (johnshopkins.edu)
  • Evidence for sex hormone biosynthesis was identified by significant overexpression of multiple estrogen biosynthetic enzymes. (johnshopkins.edu)
  • Although these tumors usually secrete testosterone, the production of estrogen, progesterone, and corticosteroids has also been described. (medscape.com)
  • Estrogen excess and feminizing syndromes may occur from the peripheral aromatization of testosterone or from the direct production of estradiol by the tumor itself. (medscape.com)
  • A sex cord-gonadal stromal tumor that has_material_basis_in granulosa cells and arises from the sex cord stroma. (jax.org)
  • Rupture of a mucinous cystadenoma or cystadenocarcinoma leading to the spread of tumor cells throughout the peritoneum . (amboss.com)
  • Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma. (brainscape.com)
  • Characterized byvtche presence of tumor necrosis, cytologic atypia and mitotic activity. (brainscape.com)
  • Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. (ijpmonline.org)
  • The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor. (ijpmonline.org)
  • CD56 may be useful for distinguishing sex cord-stromal tumours from some other types of tumours, although it does not distinguish them from neuroendocrine tumours. (wikipedia.org)
  • Objectives: Mucinous cystic neoplasm of the liver is characterized by neoplastic mucinous and/or biliary epithelium surrounded by ovarian-type stroma. (johnshopkins.edu)
  • A. Tumor grossly limited to the true pelvis with negative nodes but with histologically confirmed microscopic seeding of abdominal peritoneal surfaces. (medscape.com)
  • Conclusions: Mucinous cystic neoplasm of the liver recapitulates ovarian stroma at the morphologic, DNA, RNA, and protein levels. (johnshopkins.edu)
  • The International Ovarian and Testicular Stromal Tumor Registry is studying these rare tumors and collecting data on them to further research. (wikipedia.org)
  • Uncommonly, a similar but possibly distinct tumour, juvenile granulosa cell tumour, presents in pre-pubertal girls with precocious puberty. (wikipedia.org)
  • Molecular genetics and immunopathologic analysis of bladder cancer have shown some abnormalities in a number of genes and proteins that have been implicated in the development and progression of such tumors, mainly in the p53 pathway. (ijpmonline.org)
  • Adults with androgen-secreting tumors are generally asymptomatic. (medscape.com)
  • Their diagnosis is histological: only a biopsy of the tumour can make an exact diagnosis. (wikipedia.org)