• Conus
  • All ω-conotoxins identified to date have been found in piscivorous cone snails ranging from the small Conus catus to the large Conus geographus ( Figure 1 ). (mdpi.com)
  • Hao H, Bandyopadhyay P, Olivera B, Yandell M. Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct. (springer.com)
  • species
  • This group, drawn from cephalopod biologists, neuroscientists, developmental and evolutionary biologists, materials scientists, bioinformaticians and researchers active in sequencing, assembling and annotating genomes, agreed on a set of cephalopod species of particular importance for initial sequencing and developed strategies and an organization (CephSeq Consortium) to promote this sequencing. (standardsingenomics.org)
  • One successful and often unexploited strategy in biomedical research is to examine naturally occurring variations in animal species that are adapted to extreme environments. (ahajournals.org)
  • channels
  • These polypeptides known as conopeptides or conotoxins act selectively at a wide variety of ion channels and receptors in their prey, as well as in mammals. (mdpi.com)
  • In neurons, native Ca V 2.3 is referred to as R-type current, which is poorly defined as the current remaining after blocking the activity of T channels (Ca V 3) with nickel, L channels (Ca V 1) with dihydropyridines, and N, P, and Q channels with ω-conotoxins. (rupress.org)
  • Aside from adaptations to the broader potassium channel family, we suggest that this strategy of comparative docking can be extended to other channels of interest with known structure, especially in cases where a critical motif exists to improve docking effectiveness. (mdpi.com)
  • target
  • Many of these conotoxins have been used to gain further information about their target, either at the pharmacological, physiological or structural level. (mdpi.com)