Strategies anti bacterial agents. Medical search. Frequent questions

citation needed] The main classes of antimicrobial agents are disinfectants (non-selective agents, such as bleach), which kill a wide range of microbes on non-living surfaces to prevent the spread of illness, antiseptics (which are applied to living tissue and help reduce infection during surgery), and antibiotics (which destroy microorganisms within the body). (wikipedia.org)
To date, 11 different efflux pumps of the RND family in P. aeruginosa that enable the efflux of antibiotics/anti-microbial production have been detected. (ijmedrev.com)
Bacterial resistance to antibiotics: active efflux and reduced uptake. (ijmedrev.com)
Both natural and synthetic organic compounds are likely to remain important sources for new antibiotics - we will explore potentially significant new approaches and strategies for breakthrough molecules. (futurelearn.com)
Antibiotics play a pivotal role in modern medicine and agriculture, serving as powerful tools in combating bacterial infections. (dachengpharma.com)
Subsequent to the discovery of antibiotics during the last century, it was believed that these drugs would allow humans to conquer bacterial disease. (databasefootball.com)
The most common strategies employed by bacteria for resisting antibiotics include growing as biofilms, persisters, and small colony variants [1]. (databasefootball.com)
During bacterial infections involving biofilms, most of the existing antibiotics can kill the susceptible, planktonic bacterial population present in various body sites. (databasefootball.com)
This mechanism renders the lysins highly bactericidal, and their rates of bacterial killing are far superior to those of conventional antibiotics. (databasefootball.com)
In addition, because the site of action of lysins is on the external surface of the bacteria, these antibacterial agents do not encounter permeability or efflux issues which are known to affect the potency of conventional antibiotics. (databasefootball.com)
Multiple antibacterial effects of organosulfur compounds provide an excellent framework to develop them into novel antibiotics. (frontiersin.org)
These strategies can be divided into non-pharmacologic infection-control strategies (e.g., routine hand hygiene, infection-specific prevention protocols) and antibiotic management strategies (e.g., shorter courses of appropriate antibiotics, narrowing of the antimicrobial spectrum on the basis of culture results). (wustl.edu)
Developing various antibiotics led to the promising treatment of bacterial infectious diseases [ 1 ]. (hindawi.com)
Hydroxyapatite (HA)/nanotubular titanium dioxide (TiO 2) composite coatings loaded with antibiotics were developed to combine biocompatibility and antibacterial property.TiO 2 nanotubes were first fabricated on Ti plates using anodization techniques. (dymb.org)
Due to the resistance of some bacteria to antibiotics, research in the field of dealing with bacterial infections is necessary. (nature.com)
Over the years, antibiotics have played a crucial role in combating bacterial infections by benefiting from technological advancements and medical knowledge 13 . (nature.com)
However, excessive and indiscriminate use of antibiotics has resulted in the development of antibiotic resistance among bacterial strains 14 . (nature.com)

In order to ensure the long-term sustainability of country-level actions to combat antimicrobial resistance and build resilient systems to prevent and treat infections at scale, countries would benefit from integrating antimicrobial resistance initiatives in their national strategies for universal health coverage and health security. (who.int)
Antibacterials are used to treat bacterial infections. (wikipedia.org)
The discovery, development and use of antibacterials during the 20th century have reduced mortality from bacterial infections. (wikipedia.org)
Antibacterials are among the most commonly used drugs and among the drugs commonly misused by physicians, for example, in viral respiratory tract infections. (wikipedia.org)
Figures 1&2, modified from Kasmar AG, Hooper D. Pharmacology of bacterial infections: cell wall synthesis. (dentalcare.com)
In agriculture, it is commonly used to treat bacterial infections in livestock and, in some cases, applied to crops for disease control. (dachengpharma.com)
The SCVs too have been implicated in recurrence of various bacterial infections. (databasefootball.com)
Garlic ( Allium sativum ), a popular food spice and flavoring agent, has also been used traditionally to treat various ailments especially bacterial infections for centuries in various cultures around the world. (frontiersin.org)
Bacterial infections pose a significant threat to human health and cause various diseases. (nature.com)
Safety of Palivizumab Stewardship in Conjunction with Infection Prevention and Control Strategies for Healthcare-Associated Respiratory Syncytial Virus Infections. (medscape.com)
Des infections microbiennes ont été observées chez 30% (155/519) de l'ensemble des malades admis au service de soins intensifs pour adultes de l'Hôpital universitaire de Jordanie à Amman en 1993. (who.int)
In 1994, the U.S. Public Health Service (USPHS) and the Infectious Diseases Society of America (IDSA) recognized that, although strategies were available to reduce the frequency of opportunistic infections in patients who have human immunodeficiency virus (HIV) infection, information regarding prevention of both exposure and disease often was published in journals not regularly reviewed by health-care providers. (cdc.gov)
However, these decreases have not been observed among HIV-infected injecting-drug users, suggesting that more emphasis should be placed on providing currently recommended chemoprophylactic agents to all persons who have HIV infection and who meet appropriate criteria for prophylaxis for opportunistic infections. (cdc.gov)
The surveillance data also indicate that the incidence of some opportunistic infections is not decreasing among either men who have sex with men or injecting-drug users, indicating that preventive strategies need to be developed and applied to a wider spectrum of opportunistic infections. (cdc.gov)

Antibacterial agents can be further subdivided into bactericidal agents, which kill bacteria, and bacteriostatic agents, which slow down or stall bacterial growth. (wikipedia.org)
Prolonged use of certain antibacterials can decrease the number of enteric bacteria, which may have a negative impact on health. (wikipedia.org)
In parallel, there has been an alarming increase in antimicrobial resistance of bacteria, fungi, parasites and some viruses to multiple existing agents. (wikipedia.org)
8 The ability of antibacterial agents to diffuse into bacteria is also affected by these structural differences. (dentalcare.com)
An average adult harbors at least 300 oral bacterial species and more than 700 strains of bacteria have been isolated from test cases. (dentalcare.com)
There is an urgent need for new generations of antibacterial agents as antibiotic-resistant bacteria threaten everyone's health. (futurelearn.com)
Anti-infective agents are secondary metabolites produced and obtained from a different sources (plants, bacteria, virus, fungi, and marine oceans) with antibacterial or antiviral properties. (benthamscience.com)
To identify the bacteria, the researchers sequenced the DNA of 35 of the samples that had high amounts of bacterial DNA. (crunchtime-records.com)
They found large variations in the bacterial composition between different individuals, but also a greater presence of certain oral bacteria in fluid and tissue from cysts with high-grade dysplasia and cancer. (crunchtime-records.com)
If further studies show that the bacteria actually affects the pathological process it could lead to new therapeutic strategies using antibacterial agents. (crunchtime-records.com)
They found that the presence of bacterial DNA was higher in patients who had undergone invasive pancreas endoscopy, a procedure that involves the insertion of a flexible tube into the mouth to examine and treat pancreatic conditions thus the possible transfer of oral bacteria into the pancreas. (crunchtime-records.com)
However, bacteria present in biofilms can evade the antibacterial effect, forming a reservoir of infection. (databasefootball.com)
Thus, an ideal new antibacterial agent, in addition to its activity on drug-resistant strains of bacteria, should also be capable of killing bacteria in biofilms. (databasefootball.com)
Lysins are enzymes derived from bacteriophages (viruses which can kill bacteria) which can cleave bacterial peptidoglycan, a unique covering present in the cell wall of bacteria. (databasefootball.com)
The organosulfur compounds of garlic exhibit a range of antibacterial properties such as bactericidal, antibiofilm, antitoxin, and anti-quorum sensing activity against a wide range of bacteria including multi-drug resistant (MDR) strains. (frontiersin.org)
The antibacterial activity against various pathogenic and drug-resistant bacteria was tested using crude garlic extracts, garlic powder (GP), garlic extracts using various solvents, GO, and phytochemicals isolated from garlic. (frontiersin.org)
Additionally, there is currently a limited pipeline of new agents for the treatment of emerging bacteria with new resistance genes that pose an increasing threat to the ICU patient. (wustl.edu)

Microbial biofilms are resilient, immune-evasive, often antibiotic-resistant health challenges, and increasingly the target for research into novel therapeutic strategies. (jmb.or.kr)

The bacteriophages injected are specific to bacterial infection. (futurelearn.com)
This is particularly relevant in clinical settings where multiple bacterial species may be involved in an infection, and a combination therapy could provide comprehensive coverage. (dachengpharma.com)
Infected root canals of teeth with chronic periapical lesions have a mixed endodontic microbiota with predominance of strict anaerobic microorganisms 1-2 , and the reduction or eradication of the bacterial infection in these teeth seems to be the most relevant factor for the success of endodontic therapy 3 . (bvsalud.org)
Cost-Effectiveness of Competing Treatment Strategies for Clostridium difficile Infection: A Systematic Review. (medscape.com)
HAP is a common nosocomial bacterial infection and is most prevalent in medical and surgical intensive care units (ICUs). (medscape.com)

As a consequence of widespread and injudicious use of antibacterials, there has been an accelerated emergence of antibiotic-resistant pathogens, resulting in a serious threat to global public health. (wikipedia.org)
These are between-patient variation in clinical pharmacokinetics and the gamut of MIC values that reflect the susceptibility of pathogens to the anti-microbial drug. (benthamscience.com)
As bacterial pathogens evolve, combination therapies provide a dynamic approach to treatment. (dachengpharma.com)
Thus, there is a critical need to discover new antibacterial agents which can kill drug-resistant pathogens. (databasefootball.com)
The diameters (in millimeters) of the growth inhibition zones of four pathogens were measured, and a comparative assessment of their antibacterial activity was made. (researchgate.net)

To evaluate antibacterial behavior, we used two bacterial strains Gram-negative Escherichia coli ( E. coli ) and Gram-positive Staphylococcus aureus ( S. aureus ). (nature.com)
Aim: The present article aims to study and compare the antioxidant activity of aqueous solutions of leaves and flowers of Sambucus nigra L obtained at different exposure times and assess the antibacterial activity of these solutions against Escherichia coli ATCC 8739, Salmonella NCTC 6017, Listeria monocytogenes NCTC 11994, and Staphylococcus aureus ATCC 25093. (researchgate.net)

This reduction in peptidoglycans results in the loss of the integrity of the bacterial cell wall and ultimately culminates in cell damage caused by high internal osmotic pressure. (randox.com)
The reactive organosulfur compounds form disulfide bonds with free sulfhydryl groups of enzymes and compromise the integrity of the bacterial membrane. (frontiersin.org)

Background We have previously reported, in a systematic review of 181 studies, that restriction of antibiotic use in food-producing animals is associated with a reduction in antibiotic-resistant bacterial isolates. (bmj.com)
Antibacterial susceptibility testing was first performed for all isolates by a disk diffusion method on Mueller-Hinton agar [10]. (who.int)
Multiple bacterial isolates from a single patient with the same resistance patterns were considered as one isolate for studying minimum inhibitory concentration (MIC) using Micro Scan, Type TN dried panel (Baxter Health Care Corporation, West Sacramento, California, USA). (who.int)

Anti-infective agents (antibacterial or antiviral) possess either a bactericidal/virucidal or bacteriostatic /virustatic ability against microbes and viruses. (benthamscience.com)

Any suspicious or confirmed publicity to a biological weapons agent must be reported instantly to the native health department, local Federal Bureau of Investigation workplace, and the Centers of Disease Control and Prevention (770�488�7100). (atpobtvs.com)
Nikaido H. Prevention of drug access to bacterial targets: permeability barriers and active efflux. (ijmedrev.com)
The triennial 'VTEC' meetings provide a multidisciplinary forum for presentation of the latest research on all aspects of STEC, with sessions addressing epidemiology of human disease, animal reservoirs and transmission of STEC via the food chain, mechanisms of pathogenesis and host response, and control and prevention strategies. (edu.au)
Effective strategies for the prevention of antimicrobial resistance within ICUs are available and should be implemented aggressively. (wustl.edu)

Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy. (ox.ac.uk)
The results suggest that targeted nutraceutical support may help disrupt biofilm communities, offering new facets for integrative combinational treatment strategies. (jmb.or.kr)
A practical approach utilized in this study involves the preparation of an antibacterial thin film on the surfaces, which can effectively inhibit and reduce biofilm formation and bacterial adherence. (nature.com)

The Ti-Cu films displayed superior antibacterial ability, with a 99.9% reduction (equivalent to a 5-log reduction) in bacterial viability after 2 h compared to Ti alone against both bacterial strains. (nature.com)

The bold red markings of the species have been taken to represent some form of warning pattern against potential predators, but it is difficult to imagine how such a strategy would help a mainly fossorial and nocturnal species. (kingsnake.com)
However CH is not much effective against some bacterial species, especially Enterococcus faecalis 11,14-15 . (bvsalud.org)

The antimicrobial activity was assessed through the calculation of bacterial reduction against Posted May 22nd, 2019. (dymb.org)

Different strategies can be used to reduce antibiotic resistance [ 3 ]. (hindawi.com)

Stavri M, Piddock LJ, Gibbons S. Bacterial efflux pump inhibitors from natural sources. (ijmedrev.com)

Its mechanism of action involves inhibiting bacterial protein synthesis by binding to the 30S ribosomal subunit. (dachengpharma.com)
Therefore, the aim of the present chapter is to outline the world of anti- infective agents, along with their mechanism of action. (benthamscience.com)

furthermore, this structural unit is present as pharmacophore in a number of bioactive compounds, such as anti-cancer and anti-bacterial agents. (thieme.de)

The antibiotic era began with the therapeutic application of sulfonamide drugs in 1936, followed by a "golden" period of discovery from about 1945 to 1970, when a number of structurally diverse and highly effective agents were discovered and developed. (wikipedia.org)
Accordingly, this report will focus on papers presented at the meeting that addressed development of alternative therapeutic strategies. (edu.au)

Transcriptome-wide mapping of signaling pathways and early immune responses in lumpfish leukocytes upon in vitro bacterial exposure. (uib.no)

The risk for pneumonia was significantly increased with proton pump inhibitors, but not with histamine 2-blocking agents. (medscape.com)

All the isolated compounds, 1 showed anti-virulence activity by significantly inhibiting α-toxin (Hla) secreted by methicillin-resistant Staphylococcus aureus without its growth inhibition. (bvsalud.org)
Structures, morphological control, and antibacterial activity of silver-titanium dioxide (Ag/TiO 2 ) micro-nanocomposite materials against Staphylococcus aureus are investigated in this study. (dymb.org)
Field emission scanning electron microscopy (FE-SEM) images verified that both E. coli and S. aureus cells were physically deformed and damaged the bacterial cell ultrastructure was observed. (nature.com)

Though the term used to be restricted to antibacterials (and is often used as a synonym for them by medical professionals and in medical literature), its context has broadened to include all antimicrobials. (wikipedia.org)
The work presented here provides a guide to design strategies that reduce resistance and improve the activity of CRISPR-Cas antimicrobials. (dtu.dk)

Atta-ur-Rahman, M. Iqbal Chaudhary , " Frontiers in Anti-Infective Drug Discovery ", Bentham Science Publishers (2021). (benthamscience.com)
Gloria G. Guerrero Manriquez , " Frontiers in Anti-infective Agents ", Bentham Science Publishers (2020). (benthamscience.com)

Since 1980, the introduction of new antimicrobial agents for clinical use has declined, in part because of the enormous expense of developing and testing new drugs. (wikipedia.org)
The class of drugs that the anti-infective belongs to often determines the optimal choice of the metric for a given anti-microbial (and is empirically chosen based on pre-clinical data). (benthamscience.com)
Though teixobactin still has many clinical trials to undertake in order to ensure it is safe for human consumption there are high hopes that it can soon be added to our antibacterial arsenal. (futurelearn.com)

The anti-TB drugs commonly used are insufficient and have multiple adverse effects. (benthamscience.com)

Therefore, a new strategy to eradicate this infectious disease is required. (benthamscience.com)

So, the aim of this study is the synthesis, characterization, and antibacterial evaluation of vancomycin-containing soy protein nanoparticles (vancomycin-SPNs) as a new antimicrobial agent. (hindawi.com)

However, on solid surfaces, bacterial cells tend to grow together in a matrix secreted by the cells. (databasefootball.com)

Recently, the group of Dr. Raju Jannapu Reddy from the University College of Science, Osmania University (Hyderabad, India) reported a novel and versatile strategy for synthesizing the title compounds. (thieme.de)
The principal phytochemicals that exhibit antibacterial activity are oil-soluble organosulfur compounds that include allicin, ajoenes, and allyl sulfides. (frontiersin.org)
The review provides a focused and comprehensive portrait of the status of garlic and its compounds as antibacterial agents. (frontiersin.org)

Health benefits that are associated with the use of garlic are attributed to its anticancer, anti-inflammatory, antifungal, antiviral, and antibacterial activity. (frontiersin.org)

The total consumption of antibacterial agents was 414.1 DDD and 591.5 DDD at Thabet and Rafidia hospitals respectively. (who.int)

Drug exposure metrics, relative to the potency of the drug, are computed during the early stages of anti-infective drug development. (benthamscience.com)
Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly(I:C) exposure. (uib.no)
and secret IL-12p40 upon bacterial exposure. (uib.no)
Assessing the Ability of Hospital Diagnosis Codes to Detect Inpatient Exposure to Antibacterial Agents. (medscape.com)

This article provides a comprehensive exploration of the studies that examine combining oxytetracycline for enhanced antibacterial effects, covering the rationale, methods, potential benefits, challenges, and future implications of such combinations. (dachengpharma.com)
Antibacterial activity was evaluated by the radial diffusion assay (RDA) and absorbance methods. (hindawi.com)
Differential Effects of Chlorhexidine Skin Cleansing Methods on Residual Chlorhexidine Skin Concentrations and Bacterial Recovery. (medscape.com)

We have also demonstrated limited uptake of this strategy in current international colorectal practice. (lu.se)

The TiO2-PTFE coating also demonstrated extraordinary biocompatibility with fibroblast cells in culture, making it a prospective strategy to overcome current challenges in the use of metallic implants. (dymb.org)

The ability to adapt combinations based on emerging resistance patterns is a potential advantage in managing evolving bacterial threats. (dachengpharma.com)

Combining oxytetracycline with other antibacterial agents is a strategy to overcome resistance. (dachengpharma.com)

These efficiencies can lead to earlier and faster entry into full development for anti-microbials and aid optimal choice of dose regimen for phase 2/3 studies. (benthamscience.com)
By targeting different bacterial vulnerabilities simultaneously, the likelihood of resistance development may be reduced. (dachengpharma.com)

The implementation of new anti-TB drugs together with host-directed therapy (HDT) can decrease the duration of treatment and improve the TB patients' health. (benthamscience.com)
They can be new anti-TB drugs or agents for HDT. (benthamscience.com)
The search for new groups of anti-inflammatory and analgesic drugs is a topical issue of the current medicinal chemistry. (edu.ua)
This heterocyclic system is structurally close to 2H-1,2-benzothiazin-4-one 1,1-dioxide, which is the core of the famous non-steroidal anti-inflammatory drugs related to the "oxicam" group. (edu.ua)

Recent studies have delved into the possibilities of combining oxytetracycline with other antibacterial agents to enhance its effectiveness against resistant strains and broaden its spectrum of activity. (dachengpharma.com)
Researchers explore combinations to broaden the spectrum of antibacterial activity. (dachengpharma.com)
Calcium hydroxide (CH) is traditionally used in endodontics as the intracanal medication of choice for permanent teeth with pulp necrosis 10 , mainly because its highly alkaline pH (around 12.5) provides an excellent antibacterial activity 4,11 , and the capacity to inactivate bacterial endotoxin (LPS) 12-13 . (bvsalud.org)
The best drug loading (% entrapment efficiency = 90.2%), the fastest release rate (% release = 88.2%), and the best antibacterial activity were observed in ratio 10:30 of vancomycin:SPNs. (hindawi.com)
KW - Antibacterial activity. (dymb.org)
Antibacterial activity of the prepared sample was assessed by determining the number of colony-forming units per milliliter (CFU/ml) using a standard viable cell count assay. (nature.com)

These excluded publications, although found by the search strategy, were papers that did not discuss the main topic of this research. (surgicalneurologyint.com)
The terms used in the search strategies were validated and adapted for each database. (bvsalud.org)

Recently, however, pharmaceutical research has turned to examining natural microorganisms, which are 'uncultivatable' under laboratory conditions, that is to say bacterial or fungal colonies that will not grow in an artificial environment. (futurelearn.com)
However, the results of studies that evaluated the antibacterial efficacy of intracanal medications combining CH and CHX in permanent teeth are controversial 4,16 and little research has been carried out in primary teeth 2,14 . (bvsalud.org)
Since then, extensive research has been performed on the antibacterial effects of garlic. (frontiersin.org)

PBP is responsible for crosslinking between N-acetylmuramic acid and N-acetylglucosamine which forms the architecture of the bacterial cell wall. (randox.com)

Organisms2

Phenomena and Processes1

Antibiotics17

Infections14

Bacteria17

Biofilms1

Infection5

Pathogens5

Escherichia2

Integrity of the bacterial2

Isolates3

Bactericidal1

Prevention4

Biofilm4

Viability1

Species2

Reduction1

Antibiotic resistance1

Efflux1

Mechanism2

Bioactive compounds1

Therapeutic2

Vitro1

Inhibitors1

Aureus3

Antimicrobials2

Frontiers2

Clinical3

Adverse effects1

Infectious1

Synthesis1

Surfaces1

Compounds3

Antiviral1

Consumption1

Exposure4

Methods3

Uptake1

Challenges1

Resistance patterns1

Overcome1

Development2

Drugs4

Activity6

Search2

Research3

Cell1