Strand chromosomes human pair 14. Medical search. Frequent questions

The latest company targeted by Myriad Genetics for offering a genetic diagnostic test encompassing the human BRCA 1 and BRCA 2 genes is Invitae Corp. located in San Francisco. (patentdocs.org)
The primary goal was determining the sequence of chemical base pairs which make up DNA, and identifying and mapping the approximately 20,000-25,000 genes of the human genome from both a physical and functional standpoint. (web3.lu)
The EBI hosts the The Protein and Nucleotide Database Group (PANDA) providing all its sequence resources and The HUGO Gene Nomenclature Committee (HGNC), the only worldwide authority that assigns standardised nomenclature to human genes. (web3.lu)
Genes are organized and packaged in units called "chromosomes. (achievingthedream.org)
Human genetics is the study of the human genome and the transmission of genes from one generation to the next. (amboss.com)
Using a combination of miRNA hairpin predictions and co-mapping with miRBase entries, we identified a highly conserved cluster of miRNA genes on the X chromosome in the tammar and a total of 94 other predicted miRNA producing genes. (biomedcentral.com)
Mapping all miRNAs to the tammar genome and comparing target genes among tammar, mouse and human, we identified 163 conserved target genes. (biomedcentral.com)
An additional nine genes were identified in tammar that do not have an orthologous miRNA target in human and likely represent novel miRNA-regulated genes in the tammar. (biomedcentral.com)
The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)
The inactivation of MMR genes, usually hMSH2 or hMLH1, is associated with human colorectal cancers and is responsible for the characteristic microsatellite instability (MSI)+ phenotype of these tumors. (aacrjournals.org)
The protein-coding component of these genes makes up just a small fraction of the human genome - 1.5 percent to 2 percent. (nih.gov)
The candidate interval was shown to exhibit an extraordinary level of alternate splicing - 19 transcripts were identified for the 5 protein coding genes, but it appears that a significant portion (14/19) of these alternate transcripts did not have an open reading frame, hence their functional role is questionable. (biomedcentral.com)
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (ucsc.edu)
In 1944 it was realized that genetic transformation in bacteria was due to DNA and not protein and that DNA was the molecule responsible for heredity in genes and chromosomes [ 8 ]. (biomedcentral.com)
Multiple miRNA-mRNA prediction databases were searched by differentially expressed genes (DEGs) to obtain pairs of a miRNA-DEG regulatory network. (frontiersin.org)
Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. (homologyeffects.org)

Illustration Credit: Image modified from original illustration of Li et al, 2023 Cell 186, 1-14. (sflorg.com)

The team also found that the MCM2-7 DHs are loaded onto DNA at tens of thousands of sites across the human genome, which are mutually exclusive with loci of active transcription. (sflorg.com)
Short tandem repeats (STRs) compose approximately 3% of the genome, and mutations at STR loci have been linked to dozens of human diseases including amyotrophic lateral sclerosis, Friedreich ataxia, Huntington disease, and fragile X syndrome. (biomedcentral.com)
It is possible that each of these mechanisms contributes to the high mutation rate of STRs, but strand slippage is the mechanism proposed for generating most observed mutations in STR loci [ 19 ]. (biomedcentral.com)
Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)

Humans have 23 pairs of chromosomes - 22 pairs of numbered chromosomes, called autosomes, and one pair of sex chromosomes, X and Y. As you probably already know, males have XY sex chromosomes and females have XX sex chromosomes. (achievingthedream.org)
Human cells contain 22 pairs of homologous autosomes. (amboss.com)
Here, we consider counting and choice in the context of pairing, both of the X and of the autosomes. (homologyeffects.org)

Each human's chromosome has two arms that are separated by a centromere. (aslansplace.com)
We now recognize that, following DNA replication, the metaphase chromosome consists of two chromatids held together by a centromere and by cohesin. (biomedcentral.com)

Scientists from The Hong Kong University of Science and Technology (HKUST), The University of Hong Kong (HKU) and Institut Curie, France have jointly uncovered a new mechanism of the human MCM2-7 complex in regulating replication initiation, which can be used as a novel and effective anticancer strategy with the potential for selective killing of cancer cells. (sflorg.com)
The replication process requires the DNA duplex to be first melted and then separated into two single-stranded templates for DNA polymerases to synthesize as complement strands. (sflorg.com)
In cells, to initiate DNA replication, MCM2-7 complex must be first assembled into a head-to-head double hexamer (DH) encircling duplex DNA at thousands of places along each chromosome. (sflorg.com)
Topoisomerases are nuclear enzymes that modify the topological state of DNA and participate in fundamental metabolic processes such as replication, transcription, repair, recombination, and chromosome segregation (1) . (aacrjournals.org)
and elements that maintain the structure of chromosomes and mediate the dynamics of their replication. (nih.gov)
Promising new inhibitors that target the viral helicase-primase complex have been reported to block replication of herpes simplex and varicella-zoster viruses, but they have no activity against human cytomegalovirus (HCMV), another herpesvirus. (frontiersin.org)

The resulting recombinase-coated ssDNA filaments can invade the homologous chromosome dsDNA, searching for a complementary sequence (chromosome pairing), which will foster genetic material exchange. (nature.com)
DNA is made out of two long, twisted strands that contain complementary genetic information (like a picture and its negative). (achievingthedream.org)
Human genetic data is becoming more prevalent and easy to obtain. (achievingthedream.org)
Each human cell contains 23 pairs of homologous chromosomes (corresponding in structure and genetic information, i.e., 23 chromosomes are inherited from each parent). (amboss.com)
The table below shows the correlation of maternal age (mother's age) and the potential risk of human genetic abnormalities in children. (edu.au)
ENCODE Research Consortium Uncovers Surprises Related to Organization and Function of Human Genetic Blueprint. (nih.gov)
Morgan, Sturtevant, Bridges and Muller constructed the first genetic linkage maps from recombination studies in crosses made in the fruit fly and from cytological preparations of its polytene salivary gland chromosomes [ 4 - 6 ]. (biomedcentral.com)
The sequence of base pairs in DNA/RNA is thus the universal genetic code in all forms of life that descended from a common progenitor 4.5 billion years ago. (biomedcentral.com)
Since the genetic code was deciphered much has been learnt about the chromosome structure shared by all organisms from yeast to human. (biomedcentral.com)
Genetic polymorphism in the intergenic region (HBS1L-MYB) between GTP-binding elongation factor HBS1L and myeloblastosis oncogene MYB on chromosome 6q is associated with high fetal hemoglobin levels. (scirp.org)
Sickle cell disease is an inherited genetic disorder, resulting from homozygous and compound heterozygote mutation in the β globin gene as a single base-pair point mutation (GAG to GTG) results in the substitution of glutamic acid (hydrophilic) to Valine (hydrophobic) in the 6th position of the β-chain of hemoglobin resulting in hemoglobin S formation [7]. (scirp.org)
Early clonal genetic events in benign hyperplastic lesions show losses at chromosomes 9p21 and 3p. (medscape.com)

Repair of mitomycin-C-induced chromosomal aberrations was impaired in RAD51B/Rad51b-c.92delT human and mouse somatic cells in vitro and in explanted mouse bone marrow cells. (nature.com)
In most cases, a known chromosomal abnormality may be searched using any search engine in order to find the location of the abnormality or problem on the chromosome(s). (aslansplace.com)
Telomeres are protective DNA structures that are located at the end of chromosomes, and proper telomere maintenance is indispensable for chromosomal integrity and overall genomic stability. (oncotarget.com)
We also identify multiple cases of catastrophic chromosomal rearrangements known as chromoanagenesis, including somatic chromoanasynthesis, and extreme balanced germline chromothripsis events involving up to 65 breakpoints and 60.6 Mb across four chromosomes, further defining rare categories of extreme cxSV. (biomedcentral.com)
The first column shows maternal age, the second column shows the most common human chromosomal abnormality, trisomy 21 (Down syndrome), the third column shows all chromosomal abnormalities. (edu.au)

A DNA molecule consists of two strands wound around each other, with each strand held together by bonds between the bases. (achievingthedream.org)
A DNA molecule consists of two strands that wind around each other like a twisted ladder. (achievingthedream.org)
By contrast, RNA is a single-stranded molecule. (databasefootball.com)
Each chromatid is a single molecule of DNA attached to protein matrix fibres that forms its scaffold or axial filament [ 14 ]. (biomedcentral.com)

Each strand of DNA is terminated at both ends by a sort of aglet (the little plastic cap on the ends of shoe laces), called a telomere . (religiousnaturalism.org)
The critical telomere length was 12.8 repeats (of six base pairs) long, they found - any shorter and the chromosomes began to fuse together at their ends (R. Capper et al. (stackexchange.com)
2007). Baird suggests that without sufficiently long telomere caps, the cell may perceive the chromosome ends as broken strands of DNA and attempt to piece them together. (stackexchange.com)
I thought it had to do with the ability for the telomere to loop over on itself and form a T-Loop with strand invasion into the D-loop. (stackexchange.com)

The aim of the present study was to search for mutations in the ventricular regulatory myosin light chain gene (MYL2), located on chromosome 12q23q24.3, in a panel of 42 probands presenting a classical phenotype of familial hypertrophic cardiomyopathy. (nih.gov)
Single-strand conformation polymorphism analysis was used to search for mutations in the coding segments of the MYL2 gene, and the abnormal products were sequenced. (nih.gov)
Mutations occur rarely, and in order for a cell to become cancerous - this is calculated for human fibroblasts - about 100 divisions must occur (this number of divisions usually occurs in a person at about the age of 40) [5]. (vechnayamolodost.ru)
13 14 Although p16 INK4a is most frequently inactivated by homozygous deletion, point mutations or somatic methylation of 5′ regulatory regions are also important mechanisms of gene inactivation. (bmj.com)
These had all been previously screened for the presence of p53 mutations in exons 2 and 4-11 by single strand conformational polymorphism (SSCP) analysis and DNA sequencing as previously described. (bmj.com)
β-thalassemia results from numerous mutations or rarely deletions of the β globin gene on chromosome 11. (scirp.org)

Monkeys have served as one of the most valuable models for understanding DNA methylation dynamics during early embryogenesis in human due to their similarities in genetics and early embryonic development 17 , 18 . (nature.com)
Despite the term Genetics started being employed a few centuries ago, its practice is ancient and responsible for thriving of the human society to the point we see now. (bvsalud.org)

DNA is famous for its "double helix" structure, two intertwining strands with complementary bases. (databasefootball.com)

21(14)2020 Jul 16. (bvsalud.org)

It is located on chromosome 9p21 and its three exons encode a 156 amino acid, 15.8 kDa protein. (bmj.com)

Rad51b c.92delT/c.92delT mice exhibited meiotic DNA repair defects due to RAD51 and HSF2BP/BMRE1 accumulation in the chromosome axes leading to a reduction in the number of crossovers. (nature.com)
Mediates attachment of the chromosome to the meiotic or mitotic spindle . (amboss.com)
The review provides a brief account of the structure of somatic and meiotic chromosomes, stressing the high conservation of structure in plants and animals, with emphasis on aspects that require further research. (biomedcentral.com)

Transmembrane protein 251, also known as C14orf109 or UPF0694, is a protein that in humans is encoded by the TMEM251 gene. (wikipedia.org)
There are 2 transcript variants that encode for the TMEM251 protein, with the longer one being 169 base pairs in length, and the shorter one being 131 base pairs in length. (wikipedia.org)
The mature miRNA is then loaded onto an Argonaute protein (Ago2 in humans) where it then interacts with and regulates the mRNA target. (biomedcentral.com)
Only 1.5% of nucleic acids in human genome are used for protein encoding, but other 98.5% of the genome does not encode proteins. (jcancer.org)
Some eight years later it was discovered that triplets of the base pairs specified each amino acid in the polypeptide chain of each protein [ 11 , 12 ]. (biomedcentral.com)
Klapholz-Brown Z, Walmsley GG, Nusse YM, Nusse R, Brown PO "Transcriptional program induced by wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. (openwetware.org)
Protein oligomerization is key to countless physiological processes, but also to abnormal amyloid conformations implicated in over 25 mortal human diseases. (bvsalud.org)

Each strand of DNA forms a structure called a chromosome and human body cells contain 23 pairs of chromosomes (=46 in total) in their nuclei. (thosenutfreeladies.com)

[ 7 , 8 ] Sister chromatid exchanges are considered a sensitive indicator for cell genome instability, as they are thought to be the outcome of DNA double-strand breaks resulting from homologous recombination repair. (medscape.com)
Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)

Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. (homologyeffects.org)

The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
Diehn M, Bhattacharya R, Botstein D, Brown PO "Genome-Scale Identification of Membrane-Associated Human mRNAs. (openwetware.org)

Adenine pairs with thymine, and cytosine pairs with guanine. (achievingthedream.org)
Attached to each sugar is one of four bases: adenine (A), cytosine (C), guanine (G), or thymine (T). The two strands are held together by bonds between the bases, adenine forming a base pair with thymine, and cytosine forming a base pair with guanine. (achievingthedream.org)
Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most extensively studied guanine quadruplex (G-quadruplex). (bvsalud.org)

The human genome consists of 23 pairs of chromosomes ( 22 pairs of homologous chromosomes and one pair of sex chromosomes ). (amboss.com)
The three-dimensional structure of bovine pancreatic DNase has been determined and it consists of two 6 stranded beta sheets forming a sandwich structure (35). (pancreapedia.org)
consists of an approximate 1 megabase chromosome and multiple linear and circular plasmids. (cdc.gov)

Structural variation (SV) influences genome organization and contributes to human disease. (biomedcentral.com)
Each parent contributes one chromosome to each pair so offsprings get half of their chromosomes from their mother and half from their father. (achievingthedream.org)

Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)

To the extent that these reports are true, they are remarkable examples of cross-species altruism by animals without previously existing alliances with humans. (religiousnaturalism.org)
purified DNase 1 from 14 different tissues of humans and multiple animal species. (pancreapedia.org)
For amplification of non-human mtDNA, the REPLI-g Human mt Primer Mix needs to be substituted with an appropriate primer mix suitable for that species (not provided with the kit). (qiagen.com)
However, to denature DNA sample from non-human species, the REPLI-g Human mt Primer Mix should be substituted with the appropriate primer mix for that species (not included in the kit). (qiagen.com)
Phylogenomic studies using chromosome painting confirms the high conservation of DNA between even distantly related species [ 13 ]. (biomedcentral.com)
A related, often sympatric species is Borrelia bissettii , but this species has not been associated with human disease. (cdc.gov)

Each strand has a backbone made of alternating groups of sugar (deoxyribose) and phosphate groups. (achievingthedream.org)
It also serves as part of the backbone of chromosomes. (databasefootball.com)

This kit provides DNA polymerase, buffers, and reagents for specific and uniform whole genome amplification from small samples of human and non-human mitochondrial DNA in total DNA samples. (qiagen.com)
Total DNA preparations typically comprise approximately 0.1% of mitochondrial DNA (e.g., 0.1 ng of total human DNA contains 0.1 pg of mitochondrial DNA). (qiagen.com)
The REPLI-g Mitochondrial DNA Kit provides specific amplification of the whole human mitochondrial genome, and yields approximately 4 µg of amplified mitochondrial DNA per reaction. (qiagen.com)

In one day, equipment in Pfrender's lab can determine the sequences of some 50 million strands of DNA. (snexplores.org)
This could have significant implications for efforts to identify the DNA sequences involved in many human diseases. (nih.gov)
begingroup$ I suppose you might want to rephrase your question to ask whether the chromosomes are sometimes shortened enough so that coding sequences or regulatory sequences get stripped. (stackexchange.com)

Unlike in rodents, X chromosome inactivation is not observed during monkey pre-implantation development. (nature.com)
respiratory tract effects in rodents are not relevant for human risk assessment. (cdc.gov)

When evaluated by EM immunocytochemistry using antibody raised against purified pancreatic proteins, pancreatic DNase was concentrated in the secretory pathway similar to other pancreatic secretory proteins with the highest amount in the Golgi and zymogen granules (2,14). (pancreapedia.org)

Furthermore, due to ethical and legal concerns, very limited techniques can be applied to human embryos to validate some of significant conclusions drawn from descriptive studies regarding human embryonic development. (nature.com)
Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos. (homologyeffects.org)

By making small adjustments to the architecture of a genome, epigenetic changes give human beings the flexibility they need to develop from a single cell to a complex multi-cellular organism, and to continue responding to a dynamic environment across the lifespan. (umich.edu)

The recent completion of the LB-2001 genome sequence revealed a distinct number of plasmids (n=12) that differed from CT13-2396 (n=14). (cdc.gov)
Therefore, we re-evaluated the original CT13-2396-derived multiplex PCR primer pairs and determined their location in the LB-2001 plasmids. (cdc.gov)

The ENCODE consortium's major findings include the discovery that the majority of DNA in the human genome is transcribed into functional molecules, called RNA, and that these transcripts extensively overlap one another. (nih.gov)

Despite these discoveries, the patterns, rates, and properties of cxSVs have primarily been the focus of cancer genomics and such rearrangements remain largely underappreciated in the human germline. (biomedcentral.com)
13 p16 INK4a is a cyclin dependent kinase inhibitor that is frequently mutated or deleted in many human cancer cell lines 14-16 and some sporadic malignancies, including sarcomas, breast cancer, leukaemia, and brain tumours, which are all component tumours of LFS. (bmj.com)
Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides that function as regulatory factors in many human diseases, including cancer. (jcancer.org)

Cyril Darlington pioneered plant cytogenetics in 1920-30 and made important advances in our understanding of mechanisms of chiasma formation and the behavior of sex chromosomes in meiosis [ 7 ]. (biomedcentral.com)

The structure of the human and mouse gene contains eight coding exons and is located on chromosome 16 (28,41). (pancreapedia.org)

The gene size is 1,277 base pairs. (wikipedia.org)
According to Genomatix's ElDorado program, the promoter region of TMEM251 is predicted to be 680 base pairs in length. (wikipedia.org)
The promoter region starts 500 base pairs upstream of the 5' UTR of TMEM251 mRNA transcript and contains part of this 5' UTR. (wikipedia.org)
I shut each door that has been opened to allow evil to affect each base, base pair, gene, chromosome, and my entire DNA. (aslansplace.com)
I ask You to open all doors that should be opened to each base, base pair, gene, chromosome, and my entire DNA so the righteous gates cannot be closed. (aslansplace.com)
I declare the correction of each base, base pair, gene, chromosome, and my entire DNA is accomplished by the finished work of Jesus Christ on the cross. (aslansplace.com)
In 24 hours, DNA-sequencing equipment at Notre Dame can read up to 15 billion DNA base pairs on the chip being held by biologist Melissa Stephens. (snexplores.org)
DNase 1 binds to about 10 base pairs across the DNA minor groove. (pancreapedia.org)
Short tandem repeats (STRs), or microsatellites, are 1-6 base pair (bp) motifs of repeating units of DNA. (biomedcentral.com)
The collaborative study focused on 44 targets, which together cover about 1 percent of the human genome sequence, or about 30 million DNA base pairs. (nih.gov)
As of 2003, 99% of the chemical base pairs that make up human DNA had been sequenced to within 99.99% accuracy. (medscape.com)

Our results reveal important principles about the organization of functional elements in the human genome, providing new perspectives on everything from DNA transcription to mammalian evolution. (nih.gov)
Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans -homolog interactions in a Drosophila hybrid cell line and investigate complex types of pairing and functional roles. (homologyeffects.org)

These data are discussed in terms of three exposure periods: acute (14 days or less), intermediate (15-364 days), and chronic (365 days or more). (cdc.gov)

Human infections are sporadic and almost entirely caused by strains of biotype 1, while biotype 2 strains have been reported to cause disease mainly among eels and rarely infect humans ( 9 ). (cdc.gov)

The PBPK model predicts that humans do not gener- toxicity, and nasal olfactory lesions. (cdc.gov)

In mammals, this process relies on the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) that generates crossover recombination events (COs) [ 1 ]. (nature.com)

Various transcription factors are predicted to bind within the conserved parts of the promoter (upstream regulatory) region, on both the plus and minus strands. (wikipedia.org)

These studies reaffirmed that chromosome structure and behavior in somatic and germ cell divisions were common to all plants and animals. (biomedcentral.com)

Each cell carries roughly 2 meters of DNA organized into 23 pairs of chromosomes. (sflorg.com)
At an early stage of human development ( blastocyst ), each cell has the potential to become many different kinds of tissue ( pluripotency ), which are incorporated into many different organs. (umich.edu)
Most, but not all , of the cells in the human adult body have lost the ability to transform into other cell types and instead maintain a stable identity. (umich.edu)
A chromosome is an organized package of DNA found in the nucleus of the cell. (achievingthedream.org)
When a cell divides, it must first duplicate its genome so that each daughter cell winds up with a complete set of chromosomes. (achievingthedream.org)
In addition, some of the MMR components participate in recombination and double-strand break repair as well as cell cycle regulation and apoptosis. (aacrjournals.org)
Sickle cell disease ( SCD ) is considered as one of the commonest gene disorders of human beings. (scirp.org)
Palmer C, Diehn M, Alizadeh AA, Brown PO "Cell-type specific gene expression profiles of leukocytes in human peripheral blood. (openwetware.org)
Soen Y, Mori A, Palmer TD, Brown PO "Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. (openwetware.org)
This technologic and biologic revolution continued through the 1960s to today, and the explosion in technology has fueled the current expansion of knowledge into the working of the human cell. (medscape.com)

The Biological Basis for Behavior - The Biological Basis for Behavior The Human Brain * Reptilian brain AKA the R-complex brain consist of the central core or brainstem. (powershow.com)
The Biological Foundations of Behavior - The Biological Foundations of Behavior The nervous system: the most complicated system in human body where billions of interconnected cells radiate all over the body. (powershow.com)
The origins of this emergent infectious disease have not been fully understood, although it was originally thought to arise mostly from human behavior and work practices ( 10 ). (cdc.gov)
The mechanisms of transmission of both discontinuous and continuous characteristics across the generations were unknown before Mendel's laws were explained at the turn of the 20th Century by the behavior of chromosomes in germ cells [ 2 , 3 ]. (biomedcentral.com)

Human life begins with a single fertilized egg in the mother's womb. (sflorg.com)
Claim 16: A pair of single-stranded DNA primers for determination of a nucleotide sequence of a BRCA1 gene by a polymerase chin reaction, the sequence of said primers being derived from human chromosome 17q, wherein the use of said primers in a polymerase chain reaction results in the synthesis of DNA having all or part of the sequence of the BRCA1 gene. (patentdocs.org)
A pair of single-stranded DNA primers of at least 15 nucleotides in length for determination of the nucleotide sequence of a BRCA2 gene by a polymerase chain reaction, the sequence of said primers being isolated from human chromosome 13, wherein the use of said primers in a polymerase chain reaction results in the synthesis of DNA comprising all or at least 15 contiguous nucleotides of the BRCA2 gene. (patentdocs.org)
Multicellular organisms, such as human beings, begin as single cells. (umich.edu)
Comparison with the human genome reveals a single copy of CAT in the human genome. (tanakalab.org)

During this process, each chromosome associates with its corresponding homologue (pairing) whose ultimate physical hallmark is a chiasma. (nature.com)

An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
Rubins KH, Hensley LE, Wahl-Jensen V, Daddario Dicaprio KM, Young H, Reed DS, Jahrling PB, Brown PO, Relman DA, Geisbert TW "The temporal program of peripheral blood gene expression in the response of non-human primates to Ebola hemorrhagic fever. (openwetware.org)
Sood R, Zehnder JL, Druzin ML, Brown PO "Gene expression patterns in human placenta. (openwetware.org)

An initial open structure (IOS) is formed upon binding of human MCM double hexamer (hMCM-DH) to origin DNA. (sflorg.com)
Recently, the researchers successfully purified the MCM2-7 DH from cultured human cells and determined its structure at 2.59 Å. (sflorg.com)
The future of molecular cytogenetics is likely to depend on a better knowledge of chromosome structure and function. (biomedcentral.com)
One of the purposes of this review is to encourage research into chromosome structure as this could help advance molecular cytogenetics. (biomedcentral.com)

LOAELs or NOAELs should also help in determining whether or not the effects vary with dose and/or duration, and place into perspective the possible significance of these effects to human health. (cdc.gov)

Germ cells only carry one-half of a somatic cell's chromosomes . (amboss.com)

results from their study show the importance of the RAD51 nucleoprotein filament conformation for stimulating DNA pairing by BLM . (medscape.com)

Claim 17: The pair of primers of claim 16 wherein said BRCA1 gene has the nucleotide sequence set forth in SEQ ID NO:1. (patentdocs.org)
This i-motif is formed by two strands, associated head-to-head, and featuring zero-nucleotide loops which have not been previously observed. (bvsalud.org)

It turned out that cells in human fibroblast culture live for a limited time under good conditions and are able to double approximately 50±10 times, and this number was called the Hayflick limit [6, 7]. (vechnayamolodost.ru)
All living things are composed of cells, which then further subdivide based on the presence or absence of the nucleus, into two types: eukaryotic cells (Greek, Eu=true, karyo=nut, nucleus) - these cells are present in all the human, animal and plants with a clear, distinct nucleus. (thosenutfreeladies.com)
There are tens of trillions of cells in my body and every one of them has about an arm's length of DNA, packed as 23 pairs of chromosomes. (religiousnaturalism.org)
For instance, H19 is the first lncRNA transcribed by RNA polymerase II and is expressed mainly in human embryonic cells. (jcancer.org)
DNA in (regular) cells (in human and some other organisms) are protected by telomers. (stackexchange.com)
This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
The MC3T3-E1 cells were cultured and incubated in the osteogenic differentiation medium for 14 days. (frontiersin.org)
There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)
Trans -homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. (homologyeffects.org)

The Human Genome Project (HGP) was a 13-year international scientific research project coordinated by the U.S. Department of Energy (DOE) and the National Institutes of Health (NIH). (web3.lu)
The completion of the Human Genome Project in April 2003 was a major achievement, but the sequencing of the genome marked just the first step toward the goal of using such information to diagnose, treat and prevent disease. (nih.gov)

Anatomy61

Organisms6

Diseases21

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology1

Phenomena and Processes174

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Health Care1

Genes16

20231

Loci4

Autosomes3

Centromere2

Replication6

Genetic12

Chromosomal5

Molecule4

Telomere4

Mutations6

Genetics2

Complementary1

20201

9p211

Meiotic3

Protein7

Nuclei1

Chromatid2

Somatic cells1

MRNAs2

Guanine3

Consists3

Contributes2

Segregation1

Species6

Backbone2

Mitochondrial3

Sequences3

Rodents2

Proteins1

Embryos2

Epigenetic1

Plasmids2

Transcripts1

Cancer3

Meiosis1

Exons1

Base11

Functional2

Chronic1

Sporadic1

Lesions1

Homologous recombination1

Transcription1

Divisions1

Cell10

Behavior4

Single5

Chiasma1

Gene expression3

Structure4

Significance1

Germ1

RAD511

Nucleotide2

Cells9

Genome Project2