Strain vaccines synthetic. Medical search. Frequent questions

DEKnull has reduced immunogenicity to polymorphic regions responsible for strain-specific immunity while retaining conserved protein folds necessary for induction of strain-transcending blocking inhibitory antibodies. (rcsb.org)
We also observed that seasonal vaccination is able with closely related strains, but they are ineffective against to raise neutralizing immunity against infl uenza (H5N1) in a viruses with major antigenic divergence. (cdc.gov)
N1 may possibly be a target for both cellular and humoral probable infl uenza A and B virus strains thought to be cir- cross-type immunity, but additional experiments are needed culating in the next seasonal outbreak ( 5 , 7 ). (cdc.gov)
Waning of vaccine-induced immunity plays a role, but antigenic differences between vaccine and mumps outbreak strains could also contribute to reduced vaccine effectiveness. (mdpi.com)
NEW YORK (REUTERS) - Immunity from Moderna's Covid-19 vaccine should last at least a year, the company said on Monday (Jan 11) at the JP Morgan Healthcare conference. (straitstimes.com)
Create a contagious synthetic pathogen that's relatively benign, but induces immunity to the major pathogen -- and spread it actively. (kateva.org)
It is thus important to develop vaccines which induce protective immunity to a broad spectrum of influenza viruses. (rki.de)
This trial is designed to evaluate the immunogenicity and safety of FLU-v, a vaccine composed of four synthetic peptides with conserved epitopes from influenza A and B strains expected to elicit both cell mediated immunity (CMI) and humoral immunity providing protection against a broad spectrum of influenza viruses. (rki.de)
We have a longstanding interest in understanding immunological mechanisms underlying protective immunity and the application of this knowledge to the development of new or improved vaccines. (pirbright.ac.uk)
HSV is highly adapted to evade host immunity, making it difficult for a vaccine to prevent the virus from reaching the ganglia , which is the site of latency . (precisionvaccinations.com)
Assuming that we immunize with a synthetic molecule containing the regions conserved among many strains of influenza, then this material will be able to provide immunity against many strains of the virus. (jpost.com)
A synthetic DNA vaccine may be a reasonable candidate because it is non-live, nonviral, and able to drive humoral and T-cell immunity along with establishing a long-term immunologic memory. (infectiousdiseaseadvisor.com)
While a weakened strain provides almost life-long immunity, it can pose a high risk for people with a weak immune system. (makatimed.net.ph)
Once the research is complete, the candidate vaccine will be tested to determine its immunogenicity, or the ability to produce immunity. (makatimed.net.ph)

The live attenuated vaccine BPZE1 was developed to mimic immunogenicity of natural infection without causing disease, and in preclinical models protected against pertussis disease and B. pertussis colonization after a single nasal administration. (mdpi.com)
As of 2013, Flucelvax had shown similar levels of vaccine efficacy and immunogenicity as traditional egg-based vaccines. (wikipedia.org)
And to support the development of COVID-19 vaccine candidates by utilising the pig as a preclinical model to study vaccine immunogenicity. (pirbright.ac.uk)
We are supporting the UK response to the COVID-19 pandemic by evaluating a range of vaccine candidates for immunogenicity in pigs to inform further clinical development. (pirbright.ac.uk)
GSK launched the first-time-in-human phase 1 clinical study to assess the reactogenicity, safety, and immunogenicity of four different dose levels of an experimental herpes simplex virus type 2 (HSV-2) vaccine when administered intramuscularly on a 0, 2-month schedule to healthy participants aged 18-40 years. (precisionvaccinations.com)
Of note, when the anti-Ebola virus glycoprotein DNA vaccine was by 2 injections delivered intradermally followed by electroporation, a strong immunogenicity was generated and was also 100% protective against the lethal Ebola virus-Makona challenge. (infectiousdiseaseadvisor.com)
Further, although reports of long-term immunogenicity following DNA or other experimental vaccine administration are lacking, results showed that the anti-Ebola virus glycoprotein DNA vaccine induced long-term immune responses in the nonhuman primates. (infectiousdiseaseadvisor.com)

Here's what's intriguing about Gritstone's approach: The company's investigational vaccine includes the coronavirus spike protein and parts of other viral genes. (fool.com)
The potential use of cell culture techniques in developing viral vaccines has been widely investigated in the 2000s as a complementary and alternative platform to the current egg-based strategies. (wikipedia.org)
To produce viral vaccines, candidate vaccine viruses are grown in mammalian, avian or insect tissue culture of cells with a finite lifespan. (wikipedia.org)
In addition, cell-based vaccines may allow for multiple viral vaccines be produced in the same production platforms and facilities in a more sterile environment. (wikipedia.org)
They envision a system where, if a new strain such as H1N1 emerged, developing a vaccine would be as straightforward as shuffling genes encoding the relevant viral fragments into a synthetic genome. (technologyreview.com)
Current vaccines do not provide sufficient levels of protection against divergent porcine reproductive and respiratory syndrome virus (PRRSV) strains circulating in the field, mainly due to the substantial variation of the viral genome. (unl.edu)
Can engineering subdue viral vaccine reversion? (microbe.tv)
Again I wonder if some of the sickest patients have multiple viral inflections or more aggressive strains. (kateva.org)
The vaccine, which contains one additional flu strain - all existing multivalent flu shots currently on the market contain only three strains - presumably also contains one-third more poison in the form of extra viral fragments, synthetic adjuvants, and other deadly chemicals. (naturalnews.com)
The Institute has also pioneered a synthetic biology platform which is now integral to fighting current and emerging viral threats. (jcvi.org)
Viral vector-based vaccines offer the potential to provide protection against virulent pathogens entering via the mucosal route. (pirbright.ac.uk)
We are evaluating a range of recombinant vaccine candidates, based on protein subunits as well as viral and mRNA vectors. (pirbright.ac.uk)
Pfizer's viral vaccine scientist, Philip Dormitzer said that they have tested 16 different mutations and none had a significant impact against their vaccines which is good news. (journaltranscript.com)
Based on the state-of-play in Belgium, this chapter discusses examples of regulatory journeys of applications with genetically modified viral vectors and novel vaccine candidates that have been reviewed by GMO national competent authorities in Belgium and in Europe. (intechopen.com)

DEKnull is a synthetic DBP based antigen that has been engineered through mutation to enhance induction of blocking inhibitory antibodies. (rcsb.org)
Immunization of cynomolgus macaques with the S-VLP nanoparticles induced high antibody titers with potent neutralizing activity against the vaccine strain, Alpha, Beta, and Gamma variants and TH1 CD4+ biased T cell responses.Upon the first and second immunization, antibodies were most mostly generated against the receptor binding domain (RBD), which is immunodominant, while the third immunization boosted non-RBD antibody titers. (ibs.fr)
Background: Current influenza vaccines, based on antibodies against surface antigens, are unable to provide protection against newly emerging virus strains which differ from the vaccine strains. (rki.de)
We are deploying cutting edge technologies to identify and characterise naturally occurring porcine monoclonal antibodies capable of broadly neutralising PRRSV strains. (pirbright.ac.uk)
These antibodies will then be used to identify highly conserved vaccine targets that may be engineered to induce cross-protection. (pirbright.ac.uk)
In the first phase test of the two vaccines, high titers of neutralizing antibodies can be induced, and strong CD4+ and CD8+ reactions are produced, accompanied by mild to moderate adverse reactions. (medicaltrend.org)
Results indicated that individuals that had received the vaccine produced antibodies that effectively neutralized a key mutation in two highly contagious coronavirus variants. (journaltranscript.com)

Experts predict the coronavirus -- and new strains -- will be around well into the future. (fool.com)
The following three companies are tackling new variants of concern -- strains that are more transmissible or more dangerous than the original coronavirus. (fool.com)
The company reported 96% efficacy against the original coronavirus, 86.3% efficacy against the U.K. strain, and 55.4% efficacy against the South African variant. (fool.com)
The advantage of Novavax is its original coronavirus vaccine candidate is close to market. (fool.com)
The company's vaccine uses synthetic mRNA to mimic the surface of the coronavirus. (straitstimes.com)
The drugmaker said it was confident that the messenger RNA (mRNA) technology it used was well suited to deploy a vaccine based on the new variant of the coronavirus which has emerged in a handful of countries. (straitstimes.com)
The company's vaccine, mRNA-1273, uses synthetic mRNA to mimic the surface of the coronavirus and teach the immune system to recognise and neutralise it. (straitstimes.com)
A study by Pfizer Inc. (NYSE:PFE) And BioNTech SE (NASDAQ:BNTX ) researchers has established that their COVID-19 vaccine is effective against a mutation in highly transmissible new coronavirus variants discovered in South Africa and the UK. (journaltranscript.com)

Several recently published studies have emphasized the potential efficacy of mRNA vaccines in the treatment of different types of malignant tumors and infectious diseases, where traditional vaccine strategies cannot elicit a protective immune response. (medicaltrend.org)
Although there have been significant breakthroughs in the Ebola virus disease vaccine development field, there remains an important need for prophylactic anti-Ebola virus vaccine candidates that elicit long-lasting immune responses. (infectiousdiseaseadvisor.com)
Both biopharmaceuticals are regarded as vaccines because they elicit an immune response, either against a pathogenic microorganism or against the host's own tumour cells. (intechopen.com)

Ubiquitous sequencing will allow for the near real-time characterization of pathogen biology, including determinations of virulence, transmissibility, sensitivity or resistance to medicines or vaccines. (slideshare.net)
Synthetic biology is being used in the hunt for a vaccine for H7N9, the new strain of bird flu emerging in China, with hopes it could shave a vital two weeks off the development process. (progress.org.uk)
My training spans computer science, systems and synthetic biology, health economics, and technology policy. (mit.edu)
Systems biology may be able to yield insights into how to design a HIV vaccine or cure. (mit.edu)
Synthetic biology, a particular field in biological engineering, uses what is already known in biology to redesign or design from scratch biological systems to carry out useful functions. (mit.edu)
Research in synthetic biology can also provide insights into the workings of and common network motifs in biological networks. (mit.edu)
Since synthetic biology is such a new discipline, how does one go about engineering biology? (mit.edu)
Lastly, there are many framework issues in synthetic biology that are currently unanswered. (mit.edu)
In a series of commentaries in the journal Nature, scientists from a variety of disciplines and institutions hailed the creation of a synthetic genome as an important, historic advance in biology. (voanews.com)
Building on excellent preliminary studies expressing the Campylobacter jejuni N-linked pgl glycan, we will combine novel synthetic biology approaches to develop a new platform technology for optimal glycan expression using (i) 'refactoring' of glycan clusters (deconstructing and rebuilding in a tunable modular format) and combinatorial optimisation, (ii) engineered regulation, and (iii) our bank of rationally designed E. coli host strains. (ukri.org)
Many of these companies are embracing synthetic biology and the power of microbes to help meet these challenges, and Ginkgo's end-to-end services are empowering them from R&D discovery to manufacturing scale up. (ginkgobioworks.com)
Ginkgo's synthetic biology platform, enables you to develop functional proteins, enzyme biocatalysts, small molecule ingredients, and microbial strains for a variety of applications in the nutrition and wellness markets. (ginkgobioworks.com)
We talk to Dr. Barrick about the famous long-term evolution experiment in the Lenski lab, evolutionary failure in synthetic biology, tools for engineering the bee gut microbiome, and more. (buzzsprout.com)
And then when I started my lab here at the University of Texas at Austin, I started getting more and more into synthetic biology and combining it with some of those interests. (buzzsprout.com)

Vaccination is a key element to PRRS control and while both inactivated and live attenuated PRRS vaccines are widely used neither provides sufficiently effective protection against the diversity of circulating PRRSV strains. (pirbright.ac.uk)
Evaluating whether a synthetic live attenuated PRRSV expressing 'consensus sequence' glycoproteins provides enhanced cross-protection. (pirbright.ac.uk)
We are also exploring the potential for live attenuated PRRSV and pseudorabies virus to act as vaccine vectors for Nipah and thus provide a bivalent vaccine. (pirbright.ac.uk)
RVx201 is a live-attenuated HSV-2 vaccine candidate conducting an observational clinical study RVx-001-PSS in England designed to have a specific degree of attenuation through specifically designed mutations in the ICP0 protein. (precisionvaccinations.com)
These recommendations represent the first statement by the Advisory Committee on Immunization Practices (ACIP) on the use of live, attenuated varicella virus vaccine -- VARIVAX -- manufactured by Merck and Company, Inc. and licensed in March 1995 for use in healthy persons greater than or equal to 12 months of age. (cdc.gov)

Right now, 82 vaccine candidates are in clinical development and 182 are in preclinical development, according to the World Health Organization. (fool.com)
The company also is investigating strain-specific candidates. (fool.com)
In the present study, sequences of 40 CD8 + T cell epitope candidates, including previously and newly identified, obtained from Jeryl-Lynn mumps vaccine strains were compared with genomes from 462 circulating MuV strains. (mdpi.com)
They are pairing this with a rapid, modular reverse genetic system to assess genomic variants identified in the wealth of global sequencing data, develop and test vaccine candidates, and generate needed reagents, including fluorescent and tagged virus strains. (jcvi.org)
This information is crucial to the design and evaluation of diagnostics and vaccine candidates. (jcvi.org)
Various herpes vaccine candidates are based on DNA, modified mRNA, protein subunit, killed virus, and attenuated live virus vaccine technologies . (precisionvaccinations.com)
When developing herpes vaccines, candidates conduct clinical trials called phase 1, phase 2, phase 3, and phase 4. (precisionvaccinations.com)
Most SARS-CoV-2 vaccine candidates produce an immune response to the spike protein on the surface of the virus. (medicaltrend.org)
As of June 18, 2021, 185 CVID-19 vaccine candidates are in the preclinical development stage, and another 102 have entered clinical trials. (medicaltrend.org)
This is particularly true for applications concerning vaccine candidates containing or consisting of genetically modified organisms (GMOs). (intechopen.com)

For many years scientists have used the characteristic sugar molecules on the surface of bacteria as a component of vaccines. (mpg.de)
For decades, scientists have been on the hunt for a universal common cold vaccine-and they're still searching. (popsci.com)
When it comes to manufacturing universal vaccines, scientists hunt for the lowest common denominator-a common trait that the vaccine can target-shared by all variants of a virus. (popsci.com)
In the culmination of a project spanning 15 years, scientists at the J. Craig Venter Institute have engineered the first cell controlled by a synthetic genome. (technologyreview.com)
Scientists rebooted bacterial cells by transplanting a synthetic version of the Mycoplasma mycoides genome manufactured in the lab. (technologyreview.com)
Scientists at the University of Surrey have developed a novel vaccine and complementary skin test to protect cattle against bovine tuberculosis (bovine TB). (surrey.ac.uk)
The discovery may also have implications for other influenza virus strains and help scientists understand why flu outbreaks hit some populations harder than others. (progress.org.uk)
Informed Consent demands full disclosure of ingredients-and it is very clear at this point that all the top COVID vaccine manufacturers have concealed numerous ingredients in the vaccines, which are now being unearthed by research scientists and being found to be supremely harmful, toxic, and distinctly threatening to human health. (republicbroadcasting.org)
Using laboratory chemicals, scientists have produced what they are calling the world's first 'synthetic cell. (voanews.com)
In the medical field, Venter says, the technology might allow scientists to make vaccines in a matter of days instead of months. (voanews.com)
Further, some respected scientists who examined H1N1 say the virus contains strains of the 1918 Spanish Pandemic flu. (worldnewstrust.com)
6.Scientists have developed a vaccine for the Zika virus. (encyclopediaoffacts.com)
In August, scientists announced that they had developed a vaccine for the Zika virus. (encyclopediaoffacts.com)
The Independent' reports that scientists have created a yeast cell with 50% synthetic DNA, coming one step closer to creating complex "artificial" life. (newsr.in)

Another video has surfaced online showing a Polish doctor speaking about a finding made in a sample of the Pfizer vaccines, of an aluminium-carbon lifeform with a head and three legs in different colors, comprising, he says, aluminium, carbon, and bromine. (republicbroadcasting.org)
Dr. Zalewski states that he examined five vials of the Pfizer Comirnaty vaccine and found only a saline solution with drying NaCl (Sodium Chloride or Common Salt) crystals in a couple before discovering the "Thing" with a head and three legs in a third vial. (republicbroadcasting.org)
Pfizer and BioNTech have jointly developed five mRNA candidate vaccines, which encode variants of the spike protein antigen. (medicaltrend.org)
Although the vaccines produced by Pfizer and Moderna have proven to have good efficacy and safety, their demand for cold chain storage has brought huge difficulties to guarantee. (medicaltrend.org)
Since the Pfizer/BioNTech vaccine uses synthetic messenger RNA tech, they can easily be adjusted where necessary to address new mutations. (journaltranscript.com)
CDC, our planners, and presenter wish to disclose they have no financial relationships within eligible companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients with the exception of Dr. Elizabeth Moulton, who would like to disclose that she is a sub-investigator for SARS-CoV-2 pediatric vaccine trials with Pfizer and that funds went to institution. (cdc.gov)

Addition of the synthetic sugar molecule to the current pneumococcal vaccine Prevnar 13, expanded the protection in vaccinated animals from 13 to 14 serotypes including the dangerous ST8 pathogen. (mpg.de)
Cattle that are vaccinated with the BCG vaccine, which contains a harmless strain of the bovine TB pathogen Mycobacterium bovis, produce a positive PPD test for TB making it impossible to distinguish, with the PPD skin test, if the animal has TB or has simply been vaccinated. (surrey.ac.uk)
During this innovative study, researchers sought to make a new BCG vaccine strain that lacks some of the proteins that are shared with the pathogen Mycobacterium bovis by identifying genes that contain encoded immunogenic proteins that could be removed from BCG without affecting its ability to work as a live vaccine. (surrey.ac.uk)
The oral vaccine was an active contagious pathogen that was excreted in stool. (kateva.org)
Currently no satisfactory vaccine exists for either pathogen. (ukri.org)
In the future, we plan to continue the study of strains of the anthrax pathogen and anthrax bacilli on the sensitivity to disinfectants and to determine the relationship between the toxigenic characteristics of the strains. (ujecology.com)
These antigens may include weakened strains of the virus itself, virus-like particles, weakened bacterial toxins, and other substances derived from the pathogen. (makatimed.net.ph)

The Plasmodium vivax vaccine candidate Duffy Binding Protein (DBP) is a protein necessary for P. vivax invasion of reticulocytes. (rcsb.org)
While the pneumococcal protein conjugate vaccines reduce the incidence in invasive pneumococcal disease (IPD), serotype replacement remains a major concern. (jcvi.org)
Once optimal glycan expression is established, we will use our proprietary Protein Glycan Coupling Technology or alternative membrane vesicle technology to produce much needed, low-cost S. suis and Brucella vaccines. (ukri.org)
Since the gp90 protein of Reticuloendotheliosis virus (REV) plays vital roles in virus neutralization, so detailed analysis of REV-gp90 epitopes is important for the development of epitope based marker vaccines and diagnostic tools for REV infections. (bvsalud.org)
Already in my PhD, I studied synthetic polymers in order to look at their universal properties and to see whether there is a correlation between the structure of the protein-like polymers and immunological properties," Arnon said. (jpost.com)
Her studies subsequently led to the development of a synthetic polymer of amino acids, similar to a protein involved in multiple sclerosis. (jpost.com)
Generally, the antigen encoded by vaccine mRNA is either the full-length spike protein or the receptor binding domain of the spike protein. (medicaltrend.org)
CureVac's candidate vaccine CVnCoV can be stored stably for 3 months at 5°C. CVnCoV uses ionizable lipids from Acuitas Therapeutics (probably ALC-0315) and unmodified mRNA encoding a full-length spike protein with two proline substitutes. (medicaltrend.org)
The vaccine may consist of a protein found on the virus's surface, an inactivated toxin from a bacteria, or a bacteria's polysaccharide coating. (makatimed.net.ph)
The vaccine neutralized the N501Y mutation of the spike protein in the vaccinated individuals. (journaltranscript.com)

Collectively, our data demonstrate that PRRSV-CON can serve as an excellent candidate for the development of a broadly protective PRRSV vaccine. (unl.edu)
Discussion: Broadly protective influenza vaccines able to provide protection against multiple strains of influenza are urgently needed. (rki.de)
The utility and technical advantages of synthetic nucleic acid platforms (SNAP), including their efficacy, safety, speed of development, and ease of vaccine manufacture, were revealed during the COVID-19 pandemic, thus instilling hope that these technologies can be leveraged for the development of an effective HIV vaccine and broadly neutralizing antibody (bNAb) delivery. (nih.gov)

The protective efficiency of the new strain was tested in guinea pigs. (surrey.ac.uk)
By dissecting the pathological and protective immune responses evoked by PRRSV, we will be able to design safer and more effective vaccines. (pirbright.ac.uk)
Developing protective herpes simplex virus ( HSV ) vaccines has been an ongoing challenge for decades. (precisionvaccinations.com)
Results showed that multiple-injection regimens of the anti-Ebola virus glycoprotein DNA vaccine delivered by intramuscular administration followed by electroporation were 100% protective against the lethal Ebola virus-Makona challenge. (infectiousdiseaseadvisor.com)

And that means countries will need to buy vaccine doses beyond the pandemic. (fool.com)
Cell-based antigen production offer a faster and more stable production of vaccines compared to embryonic chicken eggs, which produce 1-2 vaccine doses per chicken egg. (wikipedia.org)
The company said on Monday it expects to deliver between 600 million doses and 1 billion doses of its vaccine in 2021 and forecast vaccine-related sales of US$11.7 billion (S$15.5 billion) for the year, based on advance purchase agreements signed with governments. (straitstimes.com)
In a phase III trial involving 30,420 volunteers, the prevention rate of two 100μg doses of vaccine was 94.1%, and local pain at the injection site was the most common side effect. (medicaltrend.org)

These are key components to detecting and responding to new influenza strains and containing outbreaks before they start. (cdc.gov)
The company is now in the final stage of human clinical trials, with studies to date showing the vaccine to be safe, well-tolerated and immunogenic to a broad range of influenza strains. (jpost.com)
The recommended influenza vaccine matched the circulating influenza strains. (who.int)

These dispensable genes encoding immunogenic proteins were then deleted from the BCG chromosome to make a BCG-minus strain. (surrey.ac.uk)
The deleted immunogenic proteins were then used to develop a new synthetic skin test that, like PPD, will be positive for animals that have been exposed to TB but, unlike PPD, will be negative for animals that have been vaccinated with the BCG-minus strain. (surrey.ac.uk)
A year later I wondered if there were multiple strains circulating , all mutually immunogenic, some more toxic than others. (kateva.org)
Intradermal-electroporation delivery is an alternate route for vaccine administration that is immunogenic and potentially dose sparing, which are potential advantages for vaccine delivery in an outbreak setting and for more sensitive populations. (infectiousdiseaseadvisor.com)

Considering there are more than 100 types of A and B rhinoviruses," notes Yury Bochkov, a respiratory virus specialist at the University of Wisconsin School of Medicine and Public Health , "you would have to put all 100 types in one vial of vaccine in order to enable protection" against just A and B rhinoviruses. (popsci.com)
by a researcher at McGill University's Dept of Medicine illustrates, but there is no excuse whatsoever for a vaccine manufacturer to insert a biological life form, synthetic or natural, in a vial of vaccine of any kind, particularly one that is currently being forced and coerced onto people worldwide. (republicbroadcasting.org)

Further epitope mapping revealed mAb 3E7 recognized the epitope 108LALGDGLE115 in Fiber-2, which was highly conserved among DAdV-3 strains. (bvsalud.org)
Moreover, homology analysis indicated that mAbs defined epitopes are highly conserved among REV strains used in this study. (bvsalud.org)

A week later, Moderna vaccine mRNA-1273 was also authorized for use in the United States. (medicaltrend.org)

To distinguish their synthetic genome from the naturally occurring version, the researchers encoded a series of watermarks into the sequence. (technologyreview.com)
In order to distinguish their synthetic genome from a natural one, Venter says researchers inserted 'watermarks' into the new genetic code. (voanews.com)

CVVs are flu viruses that have been prepared for vaccine manufacturers to aide them in producing a flu vaccine. (cdc.gov)
It may also help to design new vaccines against different types of viruses , not just influenza. (progress.org.uk)
We think these tools can affect vaccines to diseases that haven't been possible to date - things where the viruses rapidly evolve, such with rhinovirus. (voanews.com)
In addition, we are applying our expertise in porcine immunology and vaccinology to contribute to the development of vaccines to combat new and emerging zoonotic viruses, such as the Nipah virus and SARS-CoV-2. (pirbright.ac.uk)
Growing viruses in cell cultures allowed preparation of purified viruses for the manufacture of vaccines . (wikipedia.org)
NanoVax is an adjuvant platform to develop a vaccine candidate to protect against the two viruses that can cause genital herpes. (precisionvaccinations.com)
With a vaccine, antigens-molecules present in all forms of viruses and bacteria-are injected into the body. (makatimed.net.ph)

The researchers at the Max Planck Institute in Potsdam combined a series of experiments to identify the surface molecules of the pneumococcal strain ST8 that are currently a serious threat. (mpg.de)
Researchers now aim to further develop it into a vaccine for humans. (mpg.de)
In order to keep the synthesis effort for the vaccine managable, the researchers identified the smallest possible sugar for immunization. (mpg.de)
Currently, the researchers aim to develop a vaccine for humans together with Vaxxilon AG, a Max Planck Institute spin-off company. (mpg.de)
Beyond practical applications, Venter also hopes that synthetic cells will help elucidate the basics workings of life, perhaps allowing researchers to decipher exactly what every component of a bacterial cell does. (technologyreview.com)
Publishing their findings in the journal Scientific Reports, researchers reveal they have for the first time created a vaccine that is compatible with a synthetic form of the tuberculin skin test (PPD), a legally required test used for the surveillance of TB in cattle throughout the UK. (surrey.ac.uk)
A gene therapy technique can protect mammals from lethal strains of influenza, according to US researchers. (progress.org.uk)
Now that they have shown it is possible to control a cell with a synthetic genome, researchers say they will try to use the technology to solve complex environmental and energy problems. (voanews.com)
In this study, researchers at the IBS (EBEV, CAID, MEM et M&P groups), in collaboration with IDMIT, Amsterdam University and Institut Pasteur, develop synthetic SARS-CoV2 S glycoprotein-coated liposomes that resemble virus-like particles. (ibs.fr)
Today, BiondVax is building on Arnon's immunology research and making encouraging strides toward developing a universal, multi-season and multi-strain flu vaccine that has eluded researchers for decades. (jpost.com)
But researchers were delighted by the effectiveness of the vaccine against N501Y mutations as well as 16 other previously tested mutations. (journaltranscript.com)
Researchers will run more tests to establish if the vaccine is effective against the mutations in the South African and UK strains in the coming weeks. (journaltranscript.com)

The main benefit of cell-based vaccines is the ability to rapidly produce vaccine supplies during an impending pandemic. (wikipedia.org)
She alleges that the H1N1 "swine flu" pandemic is a hoax designed to sell vaccines. (worldnewstrust.com)
She alleges that officials conspired to use a virus - the H1N1 "swine flu" - that was engineered in a lab to create a flu pandemic in order to sell vaccines. (worldnewstrust.com)
She also warns of plans to make the vaccines compulsory in several countries in reaction to the manufactured pandemic. (worldnewstrust.com)
Due to its high pathogenicity, pandemic potential, and lack of therapeutics or approved vaccines, its study requires biosafety level 4 (BSL4) containment. (cdc.gov)

The identification of this component can be tedious, and complicates the development of this new generation of synthetic vaccines. (mpg.de)
The production of conventional vaccines against ST8 is difficult,' explains Max Planck Director Peter Seeberger, 'therefore, the development of a synthetic vaccine would be an enormous medical advance. (mpg.de)
The polymorphic nature of DBP induces strain-specific immune responses that pose unique challenges for vaccine development. (rcsb.org)
That was considered the major obstacle in development of those vaccines," Bochkov says. (popsci.com)
The resulting synthetic product will form the basis for the development of attenuated HCMV vaccines. (sbir.gov)
The principles and technology developed in this study will be more widely applied for diagnostic and vaccine development for a range of human and animal diseases. (ukri.org)
Thus, the S-VLP nanoparticle vaccine candidate is efficient and safe, based on a proven classical approach for further development and clinical testing. (ibs.fr)
INO with The PATH Malaria Vaccine Initiative (MVI) today announced a follow-on collaboration to advance malaria vaccine development and new vaccination delivery technologies. (smallcapbiotech.com)
Our major research focus is the development of improved vaccines for porcine reproductive and respiratory syndrome (PRRS). (pirbright.ac.uk)
We are working with colleagues and collaborators on ambitious complimentary approaches aimed at the development of improved PRRS vaccines. (pirbright.ac.uk)
Development of a Nipah virus vaccine to eliminate porcine reservoirs and safeguard human health. (pirbright.ac.uk)
The mAbs and their epitopes identified in this study may have potential applications in development of diagnostic techniques and epitope-based marker vaccines for control of REV infections. (bvsalud.org)
The WHO , the U.S. National Instuties of Health ( NIH ), and global partners launched STI Watch , a portal containing updated information on vaccine development status. (precisionvaccinations.com)
The purpose of this Notice of Funding Opportunity (NOFO) is to advance synthetic nucleic acid platforms for the rapid development and iterative testing of active and passive immunization strategies for HIV prevention, treatment, and cure. (nih.gov)
As of now, more than 100 DNA- and RNA-based vaccines have advanced to clinical development for SARS-CoV-2, HIV, other infectious diseases, and cancers. (nih.gov)
In the next few months, the development, manufacturing and deployment of mRNA vaccines have entered a stage of rapid leapfrogging. (medicaltrend.org)

In the 1950s, however, flush with the success of Jonas Salk's polio vaccine , virologists were convinced it would be just a handful of years before the common cold would be eradicated by vaccine. (popsci.com)
The injectable polio vaccine developed by Jonas Salk was one of the first products mass-produced using cell culture techniques. (wikipedia.org)
Polio, hepatitis A, and rabies vaccines were made this way. (makatimed.net.ph)

Evermore, the results from an ongoing trial of the company's H1N1 influenza "construct" vaccine are expected in Q1 2013. (smallcapbiotech.com)

The main differences are in release specifications for measuring vaccine lots' safety, efficacy, and quality, mostly due to differences between U.S. and European regulatory standards and tests. (wikipedia.org)
EXD-12 is a vaccine candidate currently in preclinical testing for safety and efficacy as a prophylactic and therapeutic vaccine for both Herpes Simplex Virus-1, HSV-1, and Herpes Simplex Virus-2, HSV-2. (precisionvaccinations.com)
GSK's Simplirix HerpeVac was in a double-blind, randomized, controlled phase 3 clinical study to assess the prophylactic efficacy and safety of gD-Alum/MPL vaccine in preventing genital herpes disease in young women who are herpes simplex virus (HSV)-1 and -2 seronegative. (precisionvaccinations.com)

This virus replicon particle system provides a vital tool to the field and demonstrates utility as a highly efficacious and safe vaccine candidate that can be administered parenterally or mucosally to protect against lethal Nipah disease. (cdc.gov)

Determining if and how these potent immune responses lead to protection against infection with the most deadly form of malaria is a high priority in our efforts to develop a next generation malaria vaccine. (smallcapbiotech.com)

Cell-based vaccines are developed from mammalian or more rarely avian or insect cell lines rather than the more common method which uses the cells in embryonic chicken eggs to develop the antigens. (wikipedia.org)
The focus on vaccines that deliver multiple antigens simultaneously is a leading approach to developing highly effective malaria vaccines. (smallcapbiotech.com)
Most mRNA vaccines currently undergoing preclinical trials and clinical use are injected into the skin, muscle or subcutaneously in a single dose, where they are absorbed by immune or non-immune cells and converted into antigens, which are displayed to T cells And B cells. (medicaltrend.org)
Intensive research is done-usually taking 2-4 years-to identify the natural or synthetic antigens to help prevent or treat a certain disease. (makatimed.net.ph)

Variants with the potential for increased transmissibility, more severe disease, diagnostic detection failures, or reduced response to available treatments and/or vaccines are tracked as Variants of Concern and are commonly referred to by their WHO-designated Greek alphabet label or their Pango lineage number. (msdmanuals.com)

We also aim to develop a safe and efficacious Nipah virus vaccine for pigs that will aid the prevention and control of Nipah outbreaks. (pirbright.ac.uk)
Availability of a safe and efficacious vaccine is critical for restricting outbreaks and preventing disease in endemic countries. (cdc.gov)

Lastly, cell-based vaccines may be more effective given that, with egg-based vaccines, there is a risk that the virus may mutate (antigenic drift) during its long growth phase in the chicken egg, thus causing the immune system to produce a different antibody than originally intended. (wikipedia.org)
The N501Y mutation is responsible for transmissibility with concerns that it can make the virus escape antibody neutralization produced by the vaccine. (journaltranscript.com)

Dating back to the 19th century, a slew of vaccines have been developed for many of humanity's most pervasive pathogens, from the very first vaccine in 1798 for smallpox to cholera and typhoid in 1896 to the COVID-19 vaccines in 2020-but no common cold vaccine. (popsci.com)
On December 11, 2020, Pfizer's BNT162b2 vaccine received emergency authorization from the FDA and became the first mRNA drug approved for use in humans. (medicaltrend.org)

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection. (ibs.fr)
Delta gD-2 (∆gD-2) is a vaccine candidate based on an HSV-2 virus genetically deleting glycoprotein D (gD-2) . (precisionvaccinations.com)

We are here today to announce the first synthetic cell -- a cell made by starting with the digital code in the computer, building the chromosome from four bottles of chemicals, assembling that chromosome in yeast, transplanting it into a recipient bacterial cell and transforming that cell into a new bacterial species,' he said. (voanews.com)
In the study of the disinfecting effect of 96% ethanol and sterile on the B. anthracis K-79Z strain, it was found that after exposure for 30, 60, 120 minutes and 24 hours, bacterial growth is recorded when using the native and disinfectant. (ujecology.com)
Wait until Abx Tx complete to administer live bacterial vaccine. (medscape.com)

The liposomes were mannosylated in two ways, by covalent attachment of p-aminophenyl-α-D-mannopyranoside to the preformed liposomes and by incorporation of synthetic mono-, di- and tetramannosyl-lipoconjugates into the lipid bilayer of liposomes. (srce.hr)
The vaccine uses the ionizable lipid SM-102 to prepare LNP, which encapsulates N1 methylpseudouridine-modified mRNA. (medicaltrend.org)

The team electronically transferred the sequence data to CDC, where a synthetic candidate vaccine virus (CVV) was developed before the first human case of the outbreak strain was identified. (cdc.gov)

With more than a billion cases each year in the US alone -far more than any other virus, including COVID-19 and the flu combined-it's hard to overstate the uplift a universal common cold vaccine would have. (popsci.com)
When will a new Covid-19 Vaccine be available to the U.S. Public? (anh-usa.org)
The last thing I want is a case of the Covid-19 after I received the Vaccine, like I experienced back in the 1970's with the FLU Vaccine, who got the flu? (anh-usa.org)
World's first needleless Covid-19 vaccine, ZyCov-D, manufactured by Zydus Cadila, will be first introduced in 7 states in India. (newsr.in)

Both vaccines are injectable, and both have been approved for young children. (naturalnews.com)

A molecule consisting of only three adjoined sugars was sufficient to protect against the pneumococcal strain ST8 in mice. (mpg.de)

Moderna said in December it would run tests to confirm the vaccine's activity against any strain. (straitstimes.com)
Moderna stated on September 13, 2023, that the latent and other vaccine market is estimated at approximately $10 billion to $25 billion. (precisionvaccinations.com)

They are more precise, effective and easier to manufacture than conventional vaccines. (mpg.de)
Other potential applications include designing synthetic microbes that could purify water or manufacture chemicals or food ingredients. (technologyreview.com)

This result was confirmed by ELISA using synthetic peptides. (bvsalud.org)

Vaccines work to prepare an immune system to fight off disease by generating an immune response to disease-causing agents. (wikipedia.org)
FLU-v is a promising vaccine which has shown to trigger the cell-mediated immune response. (rki.de)

Verorab, developed by Sanofi Pasteur, is a mammalian vero cell based rabies vaccine approved by the World Health Organization. (wikipedia.org)

We are working with colleagues and partners to develop a prototype Nipah virus vaccine for pigs. (pirbright.ac.uk)

Coupled with carrier proteins, these molecules are effective vaccines that are much simpler to prepare in the laboratory than the isolation of conventional vaccines from bacteria. (mpg.de)

DEKnull is an iterative improvement of DBP as a vaccine candidate. (rcsb.org)
The candidate vaccine virus strain will replicate using the mammalian cells. (wikipedia.org)
As a result, a method is needed which can both monitor the long-term epidemiology of the pneumococcus among a large number of isolates, and analyze vaccine-candidate genes, such as pspA, for mutations and recombination events that could result in 'vaccine escape' strains. (jcvi.org)
mRNA-1608 is an mRNA vaccine candidate against HSV-2 disease. (precisionvaccinations.com)
BNT163 is an mRNA-based HSV vaccine candidate that encodes three HSV-2 glycoproteins to help prevent HSV cellular entry and spread and counteract HSV immunosuppressive properties of HSVs. (precisionvaccinations.com)
As of the end of 2019, 15 candidate mRNA vaccines for infectious diseases have entered clinical trials. (medicaltrend.org)
The two candidate vaccines are well tolerated and effective, but only the BNT162b2 vaccine entered the phase II/III trial due to its milder systemic and local adverse reactions. (medicaltrend.org)
If the candidate vaccine passes the pre-clinical stage, a sponsor-often, a private company-will submit an application for an Investigational New Drug (IND) to the U.S. Food and Drug Administration (FDA). (makatimed.net.ph)

Infectious disease vaccines are currently the leading application of mRNA therapy. (medicaltrend.org)

As of September 2023, the U.S. Food and Drug Administration ( FDA ), Europe , Canada , China , India , and the U.K. had not authorized herpes prevention or therapeutic vaccines. (precisionvaccinations.com)
The Sexually Transmitted Disease vaccine summary was updated in 2023. (precisionvaccinations.com)

With no withdrawal time, Deccox can be used in the latter stages of growth and also where a flock is thinned during the growing cycle, offering producers the opportunity to benefit from a chemical clean up of coccidia in their flocks.Deccox is a synthetic anticoccidial used as a feed additive in control programs. (wattagnet.com)
Synthetic compounds are routinely used in such programs, along with different ionophores (monovalent or divalent) and sometimes anticoccidial vaccines, to reduce the chance of resistance developing in the coccidial population. (wattagnet.com)

On Friday BioNTech said that there was a need or more data to monitor the effectiveness of the vaccines against new virus strains. (journaltranscript.com)

Cytotoxic T lymphocytes play a central role in the human and avian infl uenza (H5N1) strains in healthy donors clearance of primary infl uenza virus infection, peaking af- vaccinated for seasonal infl uenza A (H1N1)/(H3N2). (cdc.gov)

One of the key points of Burgermeister's suit is that the new strain of flu is a synthetic structural recombinant containing genes from birds, humans, and pigs from different continents. (worldnewstrust.com)

FDA approves new multi-strain flu shot from Sanofi: One-third more poison in every jab! (naturalnews.com)

Venter hopes that in the future, the synthetic genomic technology can be used to design and develop entirely new organisms, with wide-ranging practical applications. (technologyreview.com)
DESCRIPTION (provided by applicant): The goal of this project is to synthesize, based on genomic sequence information, a human cytomegalovirus (HCMV) strain with demonstrated ability to establish persistent infection in sero-positive individuals. (sbir.gov)

Since the first reports of HIV infection in the early 1980s, multiple clinical trials have tested potential vaccines against the virus, but unfortunately, HIV has numerous defense mechanisms that prevent a person's immune system from mounting an effective response following HIV vaccination. (sciencedaily.com)
In clinical trials, 19 are mRNA vaccines. (medicaltrend.org)

ACAM2000 is a smallpox vaccine approved by the Food and Drug Administration in 2007. (wikipedia.org)

However, the findings from the research are limited since they have not tackled all the mutations found in the new strains of the quickly spreading virus. (journaltranscript.com)

Anatomy10

Organisms31

Diseases16

Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes47

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science4

Health Care11

Immunity14

Immunogenicity7

Viral14

Antibodies7

Coronavirus8

Elicit3

Biology14

Live attenuated5

Candidates10

Scientists14

Pfizer6

Pathogen7

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Broadly3

Protective4

Doses4

Influenza strains3

Immunogenic4

Vial of vaccine2

Highly conserved2

MRNA-12731

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Viruses7

Researchers12

Pandemic5

Development16

Polio3

Company's1

Efficacy3

SAFE VACCINE1

Malaria vaccine1

Antigens4

Variants of concern1

Outbreaks2

Antibody2

20202

Glycoprotein2

Bacterial3

Lipid2

Outbreak1

COVID4

Injectable1

Pneumococcal1

Moderna2

Manufacture2

Peptides1

Immune response2

Rabies1

Virus vaccine1

Effective vaccines1

Candidate8

Infectious disease1

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Anticoccidial2

BioNTech1

Avian1

Recombinant1

Multi-strain flu1

Genomic2

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Smallpox1

Findings1