Strain mice crosses genetic. Medical search. Frequent questions

Recombinant inbred strains derived from crosses between high and low activity strains exhibit segregation characteristic of a single allele difference. (jci.org)
Southern analyses using a 5'DI probe identified a restriction fragment length variant that segregated with 5'DI activity in 33 of 35 recombinant inbred strains derived from four different pairs of high and low activity parental strains. (jci.org)
The Collaborative Cross (CC) is a mouse reference population with high allelic diversity that is being constructed using a randomized breeding design that systematically outcrosses eight founder strains, followed by inbreeding to obtain new recombinant inbred strains. (ornl.gov)
Initially, the founder strains, which include five common laboratory and three wild-derived strains, were selected to establish the Collaborative Cross (CC), a panel of high diversity recombinant inbred strains. (jax.org)

Hepatic and renal 5'DI mRNA in a high (C57BL/6J) and low (C3H/HeJ) strain paralleled enzyme activity and concentration, in agreement with a recent report. (jci.org)
Past studies have mapped four susceptibility loci (Pas1-4) for pulmonary adenoma in which A/J and C57BL/6J (B6) mice have different alleles that affect incidence and multiplicity of tumours. (bmj.com)
6 Inbred mouse strains vary in their susceptibility to cancer and two extreme strains are A/J (susceptible) and C57BL/6J (B6, resistant). (bmj.com)
Mouse pulmoary adenoma susceptibility loci (Pas) as mapped in crosses of strains A/J and C57BL/6. (bmj.com)
The C57BL/6J (B6) and DBA/2J (D2) inbred strains of mice exhibit an age-related hearing loss (AHL) due to a recessive gene (Ahl) that maps to Chromosome 10. (cdc.gov)
One of the most common strains in mouse modeling is C57BL/6. (biomedcentral.com)
To determine if the phenotype of rTg4510 mice was similarly affected by the introduction of the C57BL/6 background, we compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 mice on an F1 FVB/N x C57BL/6NTac (B6/NTac) background, herein termed rTg4510 B6 . (biomedcentral.com)
Overall, our data shows that introduction of the C57BL/6 strain into the rTg4510 mouse background modestly alters the tau pathology that was originally reported in rTg4510 on the F1 FVB/129 background. (biomedcentral.com)
These studies support the use of the rTg4510 mouse model on a partial C57BL/6 strain background without losing fidelity of the phenotype and suggest that the C57BL/6 background does not inherently protect against tauopathy. (biomedcentral.com)
To test the hypothesis that crossing rTg4510 mice to a C57BL/6 strain background is protective against tauopathy, we have compared rTg4510 mice on the original F1 FVB/N x 129S6 background to rTg4510 on an F1 FVB/N x C57BL/6NTac background (rTg4510 B6 ) (Figure 1 ). (biomedcentral.com)
Breeding scheme used to produce rTg4510 mice on an F1 FVB/N x C57BL/6 (FVB/B6) strain background (rTg4510 B6 ) (Left) compared to the original rT4510 mice on an F1 FVB/N x 129S6 (FVB/129) strain background (Right). (biomedcentral.com)
METHODS: We performed cardiac gene expression, whole genome sequencing (WGS), and cardiac function analysis in 40 strains of BXD recombinant inbred mice derived from C57BL/6J (B6) and DBA/2J (D2) strains. (bvsalud.org)
The chimeric mice are bred to C57BL/6J albino mice to generate F1 heterozygous animals. (mmrrc.org)
On rare occasions, for example when very few F1 mice are obtained from the chimera, F1 heterozygous mice are crossed to 129/SvEvBrd x C57BL/6 hybrid mice to yield additional heterozygous animals for the intercross to generate the F2 mice. (mmrrc.org)
Reproductive performance consisting of mean litter size, number of pups that wean (wean: born ratio) and mean reproductive index of three inbred mice strains, which are BALB/cMlac, C57BL/6Mlac and DBA/2Mlac, were investigated to provide some basic information on the breeding and maintaining of a foundation colony. (mahidol.ac.th)
The original genetic background used for the K18-hACE2 mice (C57Bl/6J) proved to be among the most susceptible, while the F1 crosses from a strain known as PWK were highly resistant to disease. (omniaeducation.com)

Sequencing the DNA of each animal allows the researchers to peg physiological and behavioral characteristics (phenotypes, in the vernacular) to specific genetic variants. (jax.org)
Inbred mouse lines vary in their ability to mount protective antiretroviral immune responses, and even closely related strains can exhibit opposing phenotypes upon retroviral infection. (ebsco.com)
We will determine whether this approach can induce ALS phenotypes in the wild type mice and/or modulate the disease phenotypes and pathology in the mutant ALS transgenic mice. (neurodegenerationresearch.eu)
Genetic reference populations in model organisms are critical resources for systems genetic analysis of disease related phenotypes. (ornl.gov)
The strains are highly useful for trait correlation studies, as phenotypes from a CC panel can be compared across experiments and laboratories. (jax.org)
We and others have previously reported that this strain background alters the phenotypes of various models, including the JNPL3 model of tauopathy. (biomedcentral.com)
Here we compare the phenotypes of both young and old rTg4510 mice on each strain background. (biomedcentral.com)
By maximizing the genetic diversity of mouse strains, researchers can identify the gene variants responsible for various phenotypes and behaviors. (spectrumnews.org)
In another study, researchers documented the various phenotypes and behaviors visible in Collaborative Cross strains. (spectrumnews.org)
These strains show a much wider variety of phenotypes, such as body length or level of anxiety, than those documented for BXD mice, an existing inbred lab strain 2 . (spectrumnews.org)
Phenotypes determination, genetic segregation test crosses and histological study of kidneys were also performed. (mahidol.ac.th)
We have adopted a PCR-based, DNA pooling method for mice with 'extreme' phenotypes (small testes versus normal-sized testes) to identify a candidate linkage to the Ter locus. (jax.org)
The Collaborative Cross (CC), developed by intercrossing eight genetically diverse mouse strains, is a powerful translational tool for systems genetic analyses of complex phenotypes including diseases elicited by viruses. (keystonesymposia.org)
We correlated phenotypic observations with haplotypes of genomic regions previously linked to TMEV susceptibility to test the hypothesis that genomic diversity within CC mice results in variable disease phenotypes in response to TMEV. (keystonesymposia.org)
However, comparisons of QTL mapping results between phenotypes suggested some possible genetic overlap for these traits, both putative measures of ethanol reward. (elsevierpure.com)

In 2004 JAX Professor Gary Churchill, together with JAX Professor Elissa Chesler when she was at Oak Ridge National Laboratory and dozens of other leading laboratory mouse experts around the world (known collectively as the Complex Traits Consortium), devised the Collaborative Cross: a mouse population established with eight different founder strains, including standard inbred strains but also some wild-type mice. (jax.org)
In the review, Chesler and colleagues focus on two reference populations based on the same eight founder strains. (jax.org)
The other population, Diversity Outbred (DO), is bred to produce individual mice whose genetics derive equally from the eight founder strains but in a random configuration. (jax.org)
We demonstrate that the genetic diversity of the CC, which derives from random mixing of eight founder strains, results in high phenotypic diversity and enhances our ability to map causative loci underlying complex disease-related traits. (jax.org)

The Collaborative Cross, a community resource for the genetic analysis of complex traits. (jax.org)
Today the Collaborative Cross concept (as well as a further refinement, Diversity Outbred mouse populations) is a big idea in the research community, with more than 1,400 citations in the scientific literature. (jax.org)
We leveraged the genetically diverse Collaborative Cross (CC) mouse panel in conjunction with a library of Mtb mutants to create a resource for associating bacterial genetic requirements with host genetics and immunity. (elifesciences.org)
A study of the influence of genetic variance and sex on the density and thickness of the calvarial bone in collaborative cross mice. (ebsco.com)
Genetic analysis in the Collaborative Cross breeding population. (ornl.gov)
Founding fathers: Using just eight strains of mice, the Collaborative Cross initiative is planning to generate thousands of strains of genetically diverse mice. (spectrumnews.org)
Researchers are creating a population of inbred lab mice, called the Collaborative Cross , with the potential to produce thousands of genetically diverse strains. (spectrumnews.org)
To address this issue, in 2004, researchers launched a project called the Collaborative Cross to create 1,000 inbred mouse strains from 5 lab strains and 3 derived from wild populations 4 . (spectrumnews.org)
Further breeding among the Collaborative Cross strains has the potential to produce unlimited numbers of genetically diverse mice. (spectrumnews.org)
Genetic analysis of complex traits in the emerging Collaborative Cross" by David L Aylor, William Valdar et al. (jax.org)
Genetic analysis of complex traits in the emerging Collaborative Cross. (jax.org)
The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a resource for mammalian systems genetics. (jax.org)

METHODS: Transgenic mice were generated in which the bcl-2 or bcl-XL transgenes were expressed in photoreceptor cells under the transcriptional control of a rhodopsin gene promoter. (arvojournals.org)
Bcl-2 and bcl-XL transgenic mice also were tested for possible resistance to light-induced photoreceptor damage under two different experimental conditions. (arvojournals.org)
RESULTS: Bcl-2 or bcl-XL transgenes were expressed in photoreceptor cells of all lines of transgenic mice. (arvojournals.org)
Twelve days after exposure to 2 hours of high-intensity light, bcl-2 transgenic mice retained approximately four rows of photoreceptor cells in the central retina as compared to none in littermate controls, whereas bcl-XL transgenic mice showed no increased resistance to light damage. (arvojournals.org)
Resistance to light damage seen in the bcl-2 transgenic mice is likely from a reduction in rhodopsin content rather than an anti-cell death activity of Bcl-2. (arvojournals.org)
However, this process is slow because of the low yield of double or triple transgenic mice and the multigenerational crosses that are necessary to bring different transgenic lines to the same genetic background. (neurodegenerationresearch.eu)
We will inject the rAAV into several mouse strains including the normal wild type and mutant transgenic mice that develop ALS phenotype. (neurodegenerationresearch.eu)
Cross-breeding of transgenic mice is commonly used to assess gene-gene interactions, particularly in the context of disease. (biomedcentral.com)
Numerous transgenic mice expressing wild-type or mutant human tau have been created to model the neuropathology of tauopathies-a group of neurodegenerative diseases characterized by the accumulation of tau protein aggregates. (biomedcentral.com)
The strain background of transgenic mice can also alter disease progression and presentation. (biomedcentral.com)

However, this is difficult to model in mice because loss of one TBK1 allele in mice does not cause an overt phenotype but a complete knockout of this gene causes embryonic lethality. (neurodegenerationresearch.eu)
RESULTS: WGS identified compound splicing and missense T659I Tnni3k variants in the D2 parent and some BXD strains (D allele) and these strains had significantly lower Tnni3k expression than those carrying wild-type Tnni3k (B allele). (bvsalud.org)
In this report, we show that New Zealand black (NZB) mice express a variant CD23 allele, with mutations in both the C-lectin-binding domain and stalk region, which fails to bind IgE at high affinity and has reduced expression on the cell surface. (ox.ac.uk)
These results suggest that NZB mice or mice carrying the variant allele will be useful models for studying both allergy and quantitative traits associated with atopy. (ox.ac.uk)
Genome-wide analysis of the incipient strains reveals high genetic diversity, balanced allele frequencies, and dense, evenly distributed recombination sites-all ideal qualities for a systems genetics resource. (jax.org)

In humans, the wide variety of carcinogens and varying degrees of exposure make identifying the predisposing genes difficult, but in a mouse model, such confounding variables can be controlled. (bmj.com)
With the release of a genome wide SNPs database, it has become feasible to analyse these genetically determined QTLs for genes polymorphic in these strains. (bmj.com)
Identification of the genes predisposing to mouse lung cancer could have considerable implications for diagnosis, treatment, or chemoprevention of lung cancer in humans. (bmj.com)
We used recombinant congenic mouse strains to map asthma susceptibility genes on mouse chromosome 17. (rug.nl)
In addition, we found that isolated islets from Chop -/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. (jci.org)
To identify functional categories overrepresented in the differentially expressed genes, we used integrated gene-network analysis, gene ontology enrichment and mouse phenotype ontology analysis. (biomedcentral.com)
Our data indicate, for the first time, a requirement for MAPK signaling in the developing XY gonad in order to facilitate normal expression of SRY and the downstream testis-determining genes and also suggest that reduced dosage of MAP3K4 may be the cause of a previously described autosomal sex-reversing mutation in the mouse. (plos.org)
Researchers typically use inbred mouse strains, which have identical genes on each chromosome and whose genetics are well established. (spectrumnews.org)
Analysis based on inferred haplotypes improves power, reduces false discovery, and provides information to identify and prioritize candidate genes that is unique to multifounder crosses like the CC. The number of expression QTLs discovered here exceeds all previous efforts at eQTL mapping in mice, and we map local eQTL at 1-Mb resolution. (jax.org)
Together, these components hone in on target genes and carry out precise molecular "surgery" to create a genetic change. (kkartlab.in)
The study of TMEV-induced pathologies using conventional inbred mouse strains with limited genetic diversity has revealed little about non-H2 genes involved in TMEV pathogenesis, and these strains may not sufficiently represent the disease diversity seen in humans. (keystonesymposia.org)
Two of these genes, arginase 1 and eotaxin 1 are the focus of continuing investigations in mouse models of asthma regarding differences in mechanistic pathways depending on the allergen. (cdc.gov)

Casp7 knockout mice were crossed to two different RP mouse models with significantly different rod and cone death kinetics: the rd1 mouse model, which carries a mutation in the Pde6b gene, and the rhodopsin knockout mouse model ( Rho-KO or Rho -/- ). (molvis.org)
NIH acquires knockout mice. (mmrrc.org)

Strain background changes can influence the phenotype of mouse models and can confound crossbreeding studies. (biomedcentral.com)
We sought to determine if changing the strain background of a commonly used mouse model of tauopathy (rTg4510) would significantly impact the originally reported phenotype. (biomedcentral.com)
The phenotype of the L1 mutant mouse indicates that it is a potentially valuable model for the human CRASH syndrome. (jneurosci.org)

Moving forward, the diverse mouse strains will allow scientists to model patient variation in COVID-19 outcome and provide a platform for discovering biomarkers of disease severity, characterizing antiviral immune responses and evaluating countermeasures. (omniaeducation.com)

Viruses in the genus Hantavirus , similar to other mem- been classifi ed as a hantavirus by virtue of its ultrastruc- bers of the family Bunyaviridae , have a negative- tural features ( 8 ) and overall genetic similarities with well- sense, single-stranded RNA genome in 3 segments desig- characterized rodentborne hantaviruses ( 9 , 10 ). (cdc.gov)
Both immunological and bacterial traits can be associated with genetic variants distributed across the mouse genome, making the CC a unique population for identifying specific host-pathogen genetic interactions that influence pathogenesis. (elifesciences.org)
Numerous genetic loci contributing to atherosclerosis have been identified in human genome-wide association studies, but thes. (ebsco.com)
Variations in abundance: genome-wide responses to genetic variation. (biomedcentral.com)
Here I review recent work in yeast, flies, mice and primates that examines the influences of naturally occurring sequence variation, chromosomal order and speciation on genome-wide expression profiles of both RNA and protein. (biomedcentral.com)

Transcriptome analysis has been used in autism spectrum disorder (ASD) to unravel common pathogenic pathways based on the assumption that distinct rare genetic variants or epigenetic modifications affect common biological pathways. (biomedcentral.com)
Expression quantitative trait locus (eQTL) mapping reveals genomic regions harboring genetic variants that influence transcript abundance. (ebsco.com)
Several mice show remarkable resistance to infection, allowing the researchers to hone in on the gene variants responsible for resistance 3 . (spectrumnews.org)
The relevance of TMEV infection as a tool for studying virus-induced neurological conditions in humans identifies a critical need to determine genetic variants and their mechanisms to link TMEV infection to disease outcome. (keystonesymposia.org)

New genetically diverse mouse populations mirror human genetic variation, providing a powerful new experimental platform to complement human data insights, particularly for complex trait and complex disease research. (jax.org)
In "Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19," a paper published in Nature Communications , the team shows that the resulting F1 (first generation crossed) mice indeed modeled human COVID-19 severity, ranging from asymptomatic to lethal. (omniaeducation.com)

Recombination frequencies using previously mapped loci allowed assignment of the 5'DI gene to mouse chromosome 4 and identified its approximate chromosomal position. (jci.org)
4, 5 Four QTLs identified as pulmonary adenoma susceptibility (Pas) loci 1-4 have been mapped, respectively, to mouse chromosomes 6, 17, 19, and 9. (bmj.com)
2. Li R, Lyons MA, Wittenburg H, Paigen B, Churchill GA. Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping. (jax.org)
Quantitative trait loci analyses (log of the odds=15) indicated association of the genetic factor within a few centiMorgan of the best evidence for Ahl [Johnson et al. (cdc.gov)

Cheverud JM, Ehrich TH, Kenney JP, Pletscher LS, Semenkovich CF. Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains. (jax.org)
These populations are powering a revolution in model organism research that will enable major advancements in the understanding of complex genetic traits. (jax.org)
When investigated within diverse mouse populations, traits show a range similar to those observed in human populations, and they can be genetically mapped with high precision. (jax.org)
DO mice have profound trait differences between individual mice, providing a powerful genetic mapping platform to identify associations between the traits and specific genomic regions. (jax.org)
Although progress with research methods has only recently made work with DO mouse populations readily feasible, DO studies have already successfully mapped complex traits related to cardiovascular function, addiction, metabolic syndrome, cancer, behavior and more. (jax.org)
The CC, DO and founder mice as well as associated analysis tools will greatly improve mouse-based research into complex traits and disease and complement human genetic analyses. (jax.org)
As the authors conclude, "These diversity mice can be used to dissect complex traits at multiple levels by establishing heritability, identifying coregulation with other traits, finding interesting model strains, and making mechanistic genetic insights. (jax.org)
Rodents have been extensively utilized to study ethanol's rewarding and aversive effects, and to demonstrate the existence of genetic influences on traits such as free- choice ethanol-consumption, ethanol-conditioned place preference and ethanol- conditioned taste aversion. (elsevierpure.com)
Genetic correlations were estimated from BXD RI strain means, and QTL maps for these traits were compared to evaluate the possibility of a genetic association. (elsevierpure.com)

Conserved linkage between this segment of mouse chromosome 4 and human HSA1p predicts this location for human Dio1. (jci.org)
The present study demonstrates segregation for the putative Ahl gene and mapping of such a gene to Chromosome 10, consistent with other independent mapping of Ahl for AHL in 10 strains of mice [Johnson et al. (cdc.gov)
A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18. (jax.org)
Two independent mapping approaches confirmed this evidence for Ter linkage near D18Mit62 on mouse chromosome 18, and suggest a possible human homologue on chromosome 5q. (jax.org)

The present study was based on a conventional cross between two inbred strains, CBxB6.F(1) backcrossed to B6 with segregation for the putative +/Ahl:Ahl/Ahl. (cdc.gov)

At a multiplicity of infection of 0.1, infection and to ascertain whether susceptibility of small intracytoplasmic, virus-specifi c granular fl uorescence ap- laboratory animals to disseminated TPMV infection is age- peared somewhat later in Vero E6 cells infected with TPMV dependent, we infected NIH Swiss mice and Mongolian than in those cells infected with HTNV or PUUV. (cdc.gov)
JAX changed science 90 years ago with the advent of inbred laboratory mouse models and a genetic theory of cancer. (jax.org)
Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press announced the release of Genetic Counseling: Clinical Practice and Ethical Considerations, available on its website in Hardcover and Paperback formats. (cshlpress.com)
Five of the eight founders are common laboratory strains, and three are wild-derived. (ornl.gov)
A stringent program for clinico-pathology, microbiology, genetic monitoring of the laboratory rodents and animal feed ensures quality control of the animals. (actrec.gov.in)
Laboratory mice have been at the center of biomedical research for almost a century. (jax.org)
Researchers at The Jackson Laboratory have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection. (omniaeducation.com)
To see whether the variable human response could be replicated in mice, a team of researchers led by The Jackson Laboratory (JAX) Scientific Director and Professor Nadia Rosenthal , Ph.D., F.Med.Sci. (omniaeducation.com)
The Ter mutation in laboratory mice is novel in that it acts codominantly to reduce germ cell numbers on many inbred strain backgrounds and to enhance dramatically inherited predisposition to spontaneous testicular teratocarcinomas in strain 129 inbred mice. (jax.org)
We retrieved data on all laboratory-confirmed cases the behaviour of this coronavirus strain (3,4) . (who.int)

Our analysis of published and un- pect Hill virus (PHV) with the meadow vole ( M . pennsyl- published data on the experimental host range, genetics, vanicus ), and Sin Nombre virus (SNV) with the deer mouse and molecular phylogeny of TPMV supports coevolution of ( Peromyscus maniculatus ). (cdc.gov)
These strains show different intensities and types of asthmatic response, which indicates that this approach could successfully be used for asthma genetics. (rug.nl)
Gene expression genetics of the striatum of Diversity Outbred mice. (ebsco.com)
Research with inbred mouse strains-that is, mice inbred for generations until their genetics are identical, or as nearly so as possible-has yielded countless biological discoveries and led to significant medical progress. (jax.org)

Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global understanding of the mouse microbiota landscape. (nih.gov)
After enterotype stratification, we find that genetic, caging and inter-individual variation contribute on average 19%, 31.7% and 45.5%, respectively, to the variance in the murine gut microbiota composition. (nih.gov)
Enter mouse populations with stupendous quantities of genetic variation. (jax.org)
The construction of this population provided a unique opportunity to observe phenotypic variation as new allelic combinations arose through intercrossing and inbreeding to create new stable genetic combinations. (ornl.gov)
Phenotypic variation in the CC breeding population exceeds that of existing mouse genetic reference populations due to both high founder genetic diversity and novel epistatic combinations. (ornl.gov)
The result is more genetic diversity within a reasonable population size than is observed across the human population, with detectable genetic variation in every gene and pathway. (jax.org)
However, available strains are strikingly genetically identical to one another, greatly limiting the amount of genetic variation that researchers are able to study. (spectrumnews.org)
Competing causes of mortali- or all of the animal species tested genetic variation, health status, life ty may prevent the development of experimentally. (who.int)
Recent work to map genetic sources of expression variation has shown a surprising balance between cis and trans effects. (biomedcentral.com)
A series of recent papers has taken a complementary approach by examining the sources of variation in expression profiles between strains of model organisms. (biomedcentral.com)

Recombinant congenic strains are series of strains which have inherited one or more chromosomal fragments from a donor strain and all other DNA from the background strain. (rug.nl)
We then started to map asthma susceptibility in the Lmr series of recombinant congenic and subcongenic strains. (rug.nl)
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. (mmrrc.org)

Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency. (jci.org)

CONCLUSIONS: Overexpression of bcl-2 or bcl-XL transgenes does not rescue photoreceptor cells from apoptosis caused by the two genetic mutations tested. (arvojournals.org)
The cone-enriched apoptotic protease caspase-7 ( Casp7 ) is thought to be triggered by endoplasmic reticulum (ER) stress and plays a pivotal role in mice deficient in the cone cyclic nucleotide-gated channels, a deficiency that causes achromatopsia in humans and in mice with autosomal dominant rhodopsin mutations, in particular the T17M mutation. (molvis.org)
Targeted or gene trap mutations are generated in strain 129/SvEvBrd-derived embryonic stem (ES) cells. (mmrrc.org)
For instance, a percentage of people carry genetic mutations for certain diseases. (kkartlab.in)
The researchers wanted to see if, among these people, there were any individuals who remained healthy despite carrying certain genetic mutations linked to severe childhood disorders. (kkartlab.in)

Translating discoveries to humans and leveraging them for therapeutic development will remain difficult, however, and modeling genetic diversity is essential. (jax.org)

The B6xD2.F(1) hybrid mice (Ahl/Ahl) are more susceptible to NIHL than the CBxB6.F(1) mice (+/Ahl) [Erway et al. (cdc.gov)
In contrast, F1 crosses with the more susceptible strains exhibited relatively inefficient IFN-1 expression in the lung, failed control of virus replication, and dysregulated pro-inflammatory responses. (omniaeducation.com)

When administered shortly after endotoxin treatment, the selective NOS2 inhibitor L-NIL preserved HPV in wild-type mice. (nih.gov)

Photoreceptor cell death in mice expressing one of the bcl transgenes and carrying either the rd mutation homozygously or the rhodopsin mutation heterozygously was examined by histologic and electroretinographic measurements. (arvojournals.org)
Using a forward genetic screen, we identified the recessive boygirl ( byg ) mutation. (plos.org)
Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation. (ox.ac.uk)

Crossing these animals shuffles the genetic deck to yield populations of mice with greater genetic diversity than is present in the entire human race. (jax.org)
For this reason, researchers are increasingly focusing on mouse populations with high genetic diversity. (jax.org)
The JAX Genetic Diversity Initiative is a strategic effort to increase the awareness and availability of diversity mouse populations and associated tools across the research community. (jax.org)
Interpreting the functional significance of genetic polymorphisms in natural populations poses a major challenge. (biomedcentral.com)

Mycobacterium tuberculosis isolates from previously treated patients ( n = 88) from all regions of Syrian Arab Republic were characterized in terms of antibiotic sensitivity and genotyping using double-repetitive- element polymerase chain reaction (DRE-PCR) method for the proximity of the repetitive DNA elements IS 6110 (a mobile genetic element) and PGRS. (who.int)

Developing a preclinical platform for linking disease outcome to patient genetic features promises to bridge the knowledge gap in our understanding of the underlying differences in COVID-19 susceptibility, facilitating the development of precise models for rapid diagnoses, mechanistic studies and therapeutic intervention strategies. (omniaeducation.com)
Since route of allergen exposure can influence mechanistic pathways, mice were sensitized by identical routes with a high molecular weight occupational allergen ovalbumin and a low molecular weight occupational allergen trimellitic anhydride (TMA). (cdc.gov)

If successful, this experiment will establish a new mouse model for ALS and a new method that is faster than the conventional gene knockout approach for construction of mouse models for ALS and for studying mutant gene interactions in vivo. (neurodegenerationresearch.eu)
The weekly sampling schedule is devised such a way that every 12 weeks representative animal from all the strains are covered under the conventional microbiology testing. (actrec.gov.in)

Previously, classical genetic studies involving cross breeding of mouse strains with differing susceptibilities have identified chromosomal areas associated with predisposition to developing spontaneous and chemically induced lung adenomas. (bmj.com)

The ground floor houses the service areas (washing, autoclaving and animal feed) and also various laboratories (biochemistry, microbiology, genetic monitoring and histology) and quarantine room. (actrec.gov.in)

Breeding scheme for comparison of rTg4510 mice on different strain backgrounds. (biomedcentral.com)

We report here that the Fgf2 null mutant mice show an ∼40% decrease in cortical glutamatergic pyramidal neurons. (jneurosci.org)
In both the rd and the rhodopsin mutant mice, expression of either bcl-2 or bcl-XL transgenes did not prevent or measurably delay photoreceptor degeneration. (arvojournals.org)
The majority of the homozygous mutant mice exhibited retinal depigmentation spots in the fundus test. (mmrrc.org)
RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. (mmrrc.org)
In the motor, somatosensory, and visual cortex, many pyramidal neurons in layer V exhibited undulating apical dendrites that did not reach layer I. The hippocampus of L1 mutant mice was smaller than normal, with fewer pyramidal and granule cells. (jneurosci.org)

Here, we investigate the variability of the healthy mouse microbiota of five common lab mouse strains using 16S rDNA pyrosequencing. (nih.gov)
The project involves interbreeding these strains to maximize their genetic variability. (spectrumnews.org)
With the mouse panel, the team was able to further investigate differences in the innate immune responses that had been implicated in human patient variability. (omniaeducation.com)

known in mice as the H2 region) correlate with different susceptibilities to TMEV persistence and clinical disease. (keystonesymposia.org)

and Rocky Mountain National Laboratories Chief of Innate Immunity and Pathogenesis Sonja Best, Ph.D., crossed the original K18-hACE2 line with other mouse strains that represent broad genetic diversity. (omniaeducation.com)

Integrative analysis of hepatic transcriptional profiles reveals genetic regulation of atherosclerosis in hyperlipidemic Diversity Outbred-F1 mice. (ebsco.com)

In both genetic and diet-induced models of insulin resistance, CHOP deficiency improved β cell ultrastructure and promoted cell survival. (jci.org)
To assess the role of NO and NOS2 in the impairment of HPV during endotoxemia, we measured in vivo the distribution of total pulmonary blood flow (QPA) between the right (QRPA) and left (QLPA) pulmonary arteries before and after left mainstem bronchus occlusion (LMBO) in mice with and without a congenital deficiency of NOS2. (nih.gov)

Here, we found that 129S mice inherit a previously unknown mechani. (ebsco.com)
Previously, a low incidence of mild hydronephrosis was observed mostly in male mice and found only on the right kidney. (mahidol.ac.th)
All regions of the country showed high levels of genotype diversity, suggesting a low level of transmission of M. tuberculosis strains in previously treated patients. (who.int)

We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)

Cerebellar and hippocampal tissue samples from three En2 -/- and wild type (WT) littermate mice were assessed for differential gene expression using microarray hybridization followed by RankProd analysis. (biomedcentral.com)

Cre mice (Jax labs strain 003651) and backcrossed again to generate LSD1 FL/FL, ZP3Cre+ and - mice. (nih.gov)
It also shows that genetic research in mice can generate data relevant to human. (rug.nl)

Nonetheless, inbred mouse strains have limitations, and findings in them often don't translate well to humans or for clinical applications. (jax.org)
These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
For example, researchers tested 371 mice from 66 new strains for their susceptibility to the fungus Aspergillus fumigatus , which can also infect humans. (spectrumnews.org)

Many of the behaviors and pathologies reported for these mouse models, even those that express the same tau protein, are different. (biomedcentral.com)
Infection by a given virus can cause diverse neurological outcomes and disease pathologies, influenced by the genetic background of the host. (keystonesymposia.org)

Non-transgenic (NT) littermates of rTg4510 B6 (NT B6 ) mice also had greater amounts of cortical and hippocampal phospho-tau at 10.5 months of age when compared to NT littermates of rTg4510 mice. (biomedcentral.com)

A large series of evidence clearly indicates that neuropathological features and behavioral deficits of ASD have a primarily genetic origin. (biomedcentral.com)

In contrast, no change in pyramidal or granule cell number is detected in the hippocampus of Fgf2 −/− mice. (jneurosci.org)
however, 10.5-month-old rTg4510 B6 mice had greater amounts of phospho-tau in the cortex and hippocampus when compared to age-matched rTg4510 mice. (biomedcentral.com)

1. Wittenburg H, Lyons MA, Li R, Churchill GA, Carey MC, Paigen B. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. (jax.org)

We assessed the effect of Chop deletion in multiple mouse models of type 2 diabetes and found that Chop -/- mice had improved glycemic control and expanded β cell mass in all conditions analyzed. (jci.org)
Genetic diversity is particularly important when it comes to complex diseases such as Alzheimer's disease, diabetes, cancer and more. (jax.org)
A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. (lu.se)

Researchers are also conducting experiments on many of the existing 'nearly inbred' strains of mice. (spectrumnews.org)
The researchers also show that classic lab mouse strains have been selected for domesticity, by documenting wild-like behaviors in those bred from the wild-derived strains. (spectrumnews.org)
In a recent study, a group of researchers looked at the genetic data of about 589,000 people. (kkartlab.in)
To that end, it will be engaged in grant writing to obtain funds so that researchers studying aging will be able to conduct lifespan studies in mice and rats. (transhumanist-party.org)

Despite these inescapable pressures, high diversity and precision for genetic mapping remain. (ornl.gov)

Future studies on Many other rodent-hantavirus associations are known, the epizootiology of TPMV and investigations of new shrew- including the recent discovery of a hantavirus in the Afri- borne hantaviruses will provide additional insights into the can wood mouse ( Hylomyscus simus ) ( 6 ). (cdc.gov)
Research using inbred (genetically nearly identical) mice has provided countless biological insights and has been vital for medical progress, but translation to clinical application has been difficult and inconsistent. (jax.org)

Anatomy12

Organisms57

Diseases11

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes101

Disciplines and Occupations7

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture3

Information Science4

Health Care14

Geographicals1

Recombinant inbred strains4

C57BL16

Phenotypes15

Founder strains4

Collaborative Cross12

Transgenic mice10

Allele5

Genes12

Knockout mice2

Phenotype3

Diverse mouse strains1

Genome5

Variants4

Genetically diverse mouse2

Loci4

Traits9

Chromosome4

Segregation1

Laboratory10

Genetics4

Variation10

Congenic3

Analyses1

Mutations5

Modeling genetic diversity1

Susceptible2

Wild-type mice1

Mutation3

Populations4

Polymerase chain re1

Mechanistic2

Conventional2

Chromosomal1

Microbiology1

Backgrounds1

Mutant mice5

Variability3

Susceptibilities1

Pathogenesis1

Reveals1

Deficiency2

Previously3

Embryonic1

Gene expression1

Generate2

Humans3

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Littermates1

Behavioral1

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Quantitative trait1

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High diversity1

Insights2