• Dubbed as "smart hydrogels" or "stimuli-responsive hydrogels", these gels are able to dynamically respond to external or internal stimuli in addition to possessing similar swelling-deswelling properties of traditional hydrogels. (wikipedia.org)
  • Various examples of external stimuli that have been used to control smart hydrogels in drug delivery systems include temperature, pH, light, ultrasound, and enzymes. (wikipedia.org)
  • Additional considerations in designing smart hydrogels involve fundamental understanding of bond strength, molecular weight, degree of polymerization, polymer structure, and molecular assembly. (wikipedia.org)
  • Similar to conventional hydrogels, the polymeric chain (or backbone) of the smart hydrogels is derived from polysaccharides, polypeptides, and polynucleotides. (wikipedia.org)
  • First-generation silicone hydrogel contact lenses may be more prone to GPC development, perhaps because of their mechanical stiffness or their higher propensity for lipid deposition. (medscape.com)
  • Silicone hydrogel lenses tend to induce more local GPC (similar to the changes seen with rigid lenses), whereas hydrogel lenses tend to induce more generalized GPC reactions in the palpebral conjunctiva. (medscape.com)
  • Synthetic hydrogels are made from synthetic polymers, such as polyacrylamide, poly(ethylene glycol), and poly(N-isopropylacrylamide). (thewitfire.in)
  • Synthetic hydrogels can be designed to release drugs in a controlled manner, making them ideal for pharmaceutical dosing applications. (thewitfire.in)
  • Injectable hydrogels are a class of hydrogels that can be administered through a syringe and needle, forming a gel in situ upon injection. (thewitfire.in)
  • This includes bioactive scaffolds, bioresorbable implants, injectable hydrogels, "organ-on-a-chip" organ models, and self-healing biomaterials. (boydbiomedical.com)
  • [xii] Also, SiHy fits are usually tighter than conventional hydrogels to prevent « fluting » or excessive edge lift. (envisionmagazine.ca)
  • [xiii] The hypothetical pathophysiology may explain why some studies paradoxically show a two-fold greater risk for CIEs with silicone hydrogels than with conventional hydrogels. (envisionmagazine.ca)
  • Various examples of hydrogel type designs include nanoparticles, nanogels, and microgels. (wikipedia.org)
  • proposed gelatin-based hydrogel nanoparticles that were stimulated by magnetic forces. (wikipedia.org)
  • To assess antimicrobial effects of hybrid hydrogel implants containing gold nanoparticles and albucide and developed for reconstructive surgery in the orbit and periorbital area. (ozhurnal.com)
  • The synthesized hydrogels and hydrogel nanocomposites with incorporated Au nanoparticles demonstrated bacteriostatic effects against E. Coli ATCC 25922, E. Faecalis ATCC 29213, and S. Aureus ATCC 25923 strains, and bactericidal effects against P. Aeruginosa ATCC 27853 strain. (ozhurnal.com)
  • This study also demonstrated marked bactericidal effects of hybrid hydrogel implants incorporating both Au nanoparticles and albucide. (ozhurnal.com)
  • Our findings of bacteriostatic and bactericidal effects of the synthesized hydrogels and hydrogel nanocomposites containing Au nanoparticles and albucide against bacterial strains of interest will allow for the absence of, or low probability of bacterial contamination in applications of these hydrogels in implants. (ozhurnal.com)
  • El-Gendy, A. A.* Green synthesized superparamagnetic iron oxide nanoparticles for water treatment with alternative recyclability , J Mol Liq 2022, 356, 118983. (utep.edu)
  • In this study, a porous piezoelectric hydrogel bone scaffold was fabricated by incorporating polydopamine (PDA)-modified ceramic hydroxyapatite (PDA-hydroxyapatite, PHA) and PDA-modified barium titanate (PDA-BaTiO 3 , PBT) nanoparticles into a chitosan/gelatin (Cs/Gel) matrix. (biomedcentral.com)
  • Indeed, the project led to the development of multimaterial and hybrid fibers able to react to stimuli like tempereature, pH, light, and electricity, and either respond through the delivery of drugs, monitor the changes in the environment, transport and transform the signal and to interact with cells or tissues. (empa.ch)
  • Owing to their unique properties, hydrogels have found applications in a wide range of fields, including tissue engineering, wound healing , drug delivery systems, and contact lenses. (thewitfire.in)
  • Natural hydrogels have been extensively used in drug delivery and tissue engineering applications due to their excellent biocompatibility and biodegradability. (thewitfire.in)
  • These hydrogels have excellent properties such as tissue adhesion, swelling, and water absorption. (biomedcentral.com)
  • Self-assembled rosette nanotube/hydrogel composites for cartilage tissue engineering. (universityorthopedics.com)
  • The piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation, angiogenesis, and osteogenesis functions may be used as a substitute in periosteum injuries, thereby offering the novel strategy of applying piezoelectric stimulation in bone tissue engineering for the enhancement of combat effectiveness in grassroots troops. (biomedcentral.com)
  • [ 63 ] Rather, the system is designed to describe the degree of tissue damage observed at a specific time of examination and is meant to facilitate communication among the various disciplines involved in the study and care of patients with these lesions. (medscape.com)
  • Hydrogels are three dimensional structures consisting of hydrophilic polymers (i.e., polymers, colloids, etc.) that form networks through cross-linking processes. (wikipedia.org)
  • The main examples of natural polymers used to derive hydrogels include polysaccharides, polypeptides, and polynucleotides. (wikipedia.org)
  • Hydrogels are three-dimensional, cross-linked networks of hydrophilic polymers that can absorb and retain large amounts of water or biological fluids. (thewitfire.in)
  • Responsive polymers could offer an elegant solution to this problem, by allowing the kinetics of delivery be tailored on-demand by the application of an external, non-contact stimulus such as light, magnetic, or electric field. (empa.ch)
  • This study presents an in-silico model replicating a microfluidic assay where endothelial cells sprout into a biomimetic extracellular matrix, specifically, a large-pore, low-concentration fibrin-based porous hydrogel, influenced by chemotactic factors. (ibecbarcelona.eu)
  • The main safety concerns in formulating hydrogels include bacterial infection and biocompatibility. (wikipedia.org)
  • Other variables considered in hydrogel design include safety, biodegradability, drug loading capacity, and on-demand control of drug release [23]. (wikipedia.org)
  • The macromolecules involved in the formation of hydrogels are able to absorb and retain large amounts of water and other aqueous substances. (wikipedia.org)
  • It is important to develop orbital hydrogel implants capable of depositing drugs (particularly, antimicrobial and anticancer drugs). (ozhurnal.com)
  • Antimicrobial activity of synthesized hydrogels was determined using Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29213, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853 strains. (ozhurnal.com)
  • Hydrogels have been explored as carriers for the controlled release of drugs in the gastrointestinal tract. (thewitfire.in)
  • The pH range of fluids in various segments of the gastrointestinal tract may provide environmental stimuli for responsive drug release. (scialert.net)
  • Mechanical stimulation led to a significant increase in chondrogenic gene expression, while histological analysis detected sulphated glycosaminoglycans and collagen II only in loaded specimens, confirming MC hydrogel suitability to support load induced MSCs chondrogenesis. (nature.com)
  • These formulations offer greater control over their physical and chemical properties, such as swelling behavior, mechanical strength, and stimuli responsiveness. (thewitfire.in)
  • Hydrogels have been widely studied for drug delivery applications due to their unique characteristics, such as high water content, tunable mechanical properties, and stimuli-responsive behavior. (thewitfire.in)
  • Ultrasound-triggered drug delivery using stimuli-responsive hydrogels refers to the process of using ultrasound energy for inducing drug release from hydrogels that are sensitive to acoustic stimuli. (wikipedia.org)
  • This method of approach is one of many stimuli-responsive drug delivery-based systems that has gained traction in recent years due to its demonstration of localization and specificity of disease treatment. (wikipedia.org)
  • Protease-responsive biosensors for siRNA and drug delivery in vitro and in vivo, advanced materials for immunomodulation devices for sepsis treatment. (vanderbilt.edu)
  • The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. (mdpi.com)
  • Treatment can range from simple monitoring to prescribing topical ocular steroids, such as Lotemax or Pred Forte, or a combination antibiotic/steroid preparation, such as Tobradex, to decrease the microbial load. (envisionmagazine.ca)
  • Therefore, there is a critical unmet need for a topically applied material that (1) is easily applied and forms in situ, (2) is of sufficient mechanical flexibility to accommodate complex wound contours and volumes, (3) can be easily and atraumatically removed under controlled conditions for definitive surgical care, and (4) is non-toxic. (biomedcentral.com)
  • From circumstantial evidence, the initiating event is believed to be mechanical irritation and/or antigenic stimulus of the tarsal conjunctiva of the upper lids by a contact lens surface or edge (rigid or flexible) or deposit. (medscape.com)
  • Besides the cell source choice, also mechanical stimuli are crucial in the development and maintenance of articular cartilage. (nature.com)
  • The crosslinking mechanism of the hydrophilic macromolecules are driven by covalent bonding, resulting in a physical- or chemical-type hydrogel. (wikipedia.org)
  • Effective treatment of cartilage defects represents a challenging problem, mainly due to the tissue's limited intrinsic self-repair capacity. (nature.com)
  • All the synthesized samples of orbital hydrogel implants were sterile. (ozhurnal.com)
  • Orbital hydrogel implants were found to be sterile after being sealed into polypropylene bags and steam sterilized at 121 °C for 20 minutes. (ozhurnal.com)
  • The lack of any hydrogel-derived immunoreaction was demonstrated in vivo by mice subcutaneous implantation. (nature.com)
  • Cell and animal experiments were performed to characterize the immunomodulatory, angiogenic, and osteogenic capabilities of the piezoelectric hydrogel scaffold in vitro and in vivo. (biomedcentral.com)
  • The in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury model. (biomedcentral.com)
  • His clinical focus is the full-spectrum mental health care of sexual and gender minorities, with particular interest in depression, anxiety, and the complex effects of trauma in this population. (stanford.edu)
  • The underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis, and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 polarization. (biomedcentral.com)
  • Hydrogels are generally classified based on the following characteristics: material, crosslinking mechanism, physical structure, electric charge, and response to stimuli. (wikipedia.org)
  • Physical hydrogels contain reversible matrices of hydrogen and non-covalent bonds, while chemical hydrogels are composed of irreversible matrices that are molecularly held together by covalent bonds. (wikipedia.org)
  • In addition, these hydrogels have a distinctive capacity to form in situ and dissolve on-demand via physical or chemical reactions. (biomedcentral.com)
  • Therefore, we summarize here the recent advances of hydrogels that dissolve on demand, covering both chemical cross-linking cases and physical cross-linking cases. (biomedcentral.com)
  • FBS suppresses TGF-?1-induced chondrogenesis in synoviocyte pellet cultures while dexamethasone and dynamic stimuli are beneficial. (universityorthopedics.com)
  • A few examples of hydrogel use include organ regeneration, wound healing, and drug delivery. (wikipedia.org)
  • Being able to think and act effectively in response to changes in stimuli, environments, and surprises signifies a healthy level of cognitive flexibility. (medicalnewstoday.com)
  • The high water content of hydrogels can help to solubilize hydrophilic drugs, while their tunable properties allow for the incorporation of various drugs with different physicochemical characteristics. (thewitfire.in)
  • The actual visualization final results show the value of peri-lesional characteristics in treatment-planning MRI in projecting nearby outcome following radiotherapy. (azd8931inhibitor.com)
  • This work proposes a microfibers-hydrogel assembled composite as delivery vehicle able to combine into a single system both burst and prolonged release of lactate. (ibecbarcelona.eu)
  • Natural hydrogels are derived from biological sources and are biodegradable, biocompatible, and often possess cell-adhesive properties. (thewitfire.in)
  • Cells, proteins, and therapeutic drugs are the main payloads used in hydrogel-based drug delivery platforms. (wikipedia.org)
  • if they do not, consider changing the lens care solution to another MPS or hydrogen peroxide system before loosening the fit or refitting to another SiHy or conventional hydrogel. (envisionmagazine.ca)
  • Dressings have long been considered as a critical part of wound care, and many of dressings can indeed be useful for topical therapies. (biomedcentral.com)
  • The instillation option is indicated for patients who can benefit from vacuum-assisted drainage and controlled administration of solutions and suspensions for topical wound treatment at the wound bed ( 1-4) . (medichub.ro)
  • Since its discovery in 1960, hydrogels have become a crucial component in biomedical research and applications. (wikipedia.org)
  • A tough and anti-fouling three-network hydrogel has been prepared by integrating a zwitterionic polymer network into a robust double-network hydrogel. (edu.au)
  • Hydrogels: Pharmaceutical dosing and drug delivery systems have been evolving over the years to improve patient outcomes, enhance drug efficacy, and minimize side effects. (thewitfire.in)
  • This article delves into the world of hydrogels, discussing their types, applications in pharmaceutical dosing, advantages, and potential challenges. (thewitfire.in)
  • 11] V. Torchilin, "Multifunctional and stimuli-sensitive pharmaceutical nanocarrier," Eur. (fujipress.jp)
  • Although recent developments in this field highlight its potential in treating certain diseases such as COVID-19, there remain many major challenges that need to be addressed and overcome before more related biomedical applications are clinically translated into standard of care. (wikipedia.org)
  • We believe that continuous exploration of dissolution strategies will uncover new mechanisms of dissolution and extend the range of applications for hydrogel dressings. (biomedcentral.com)
  • The Global Market for Hydrogels 2024-2034 provides a comprehensive analysis of the global hydrogel landscape, technologies, companies, and applications across major industry verticals. (researchandmarkets.com)
  • This study serves as a strategic guide for companies and investors looking to capitalize on the major growth opportunities for hydrogels across a diverse set of high-potential markets and applications. (researchandmarkets.com)
  • Hydrogel size and type are the two main properties considered in designing hydrogels when seeking the optimal delivery route for drug administration. (wikipedia.org)
  • Health initiatives worldwide demand affordable point- of-care devices to aid in the reduction of morbidity and mortality rates of high-incidence infectious and noncommunicable diseases. (upc.edu)
  • Orthopaedic war injuries from combat casualty care to definitive treatment: a current review of the basic science, clinical advances and research opportunities. (universityorthopedics.com)
  • The bond strength describes the cross-linking strength of the hydrogel, which is considered in designing drug release mechanisms of hydrogel-based platforms. (wikipedia.org)
  • They are soft, flexible, and capable of swelling or shrinking in response to changes in their environment, such as temperature, pH, or the presence of specific chemical stimuli. (thewitfire.in)
  • Response of orbital and auricular soft tissues to the developed hydrogel implant in rabbits]. (ozhurnal.com)
  • The poorer tear exchange, along with the absence of the blinking process on the back surface of the lens, allows debris, deposits and microbial biofilm, including released endotoxins, to build up and become additional stimuli for an immunological response. (envisionmagazine.ca)
  • However, scientific studies about the association involving TMB along with the response to ICI treatments within intestines cancer by yourself are still missing. (tie-2signaling.com)
  • Chapter 4 investigates the conductivity signal in response to short-duration visual stimulus, compares the signal and functional activation pathway with that of BOLD, and tests the consistency of functional conductivity imaging (funCI) with visual stimulation across participants. (edu.au)
  • Modern solutions to wound management include hydrogels that dissolve on demand, and the development of such hydrogels is of keen research interest. (biomedcentral.com)
  • The treatment of burn injuries has received more attention over the years, leading to the development of artificial skin or various medical devices to facilitate the care of burn patients and to prevent some of the acute or chronic phase complications such as post-traumatic stress, vicious scarring or malignant skin tumors on burn scars. (medichub.ro)
  • Since traditional hydrogels were able to encapsulate and carry materials, research into drug-loaded hydrogels began to expand in the field of drug delivery. (wikipedia.org)
  • One of the most promising materials that have emerged in this field is hydrogels. (thewitfire.in)
  • Li, X.* Microfluidic platforms integrated with nano-sensors for point-of-care bioanalysis , TRAC - Trend Anal Chem 2022, 157, 116806. (utep.edu)
  • Hydrogel-based transdermal patches are an attractive alternative to traditional patches as they can provide controlled drug release, enhanced drug permeation, and improved patient comfort. (thewitfire.in)
  • PSDDS wherein the drug release is controlled primarily by the delivery system, stimuli induced PSDDS in which release is controlled by the stimuli, such as the pH present in the intestinal tract. (scialert.net)
  • In this review, we show that the application of MSC-derived EV for the treatment of CSU has positive effects, including accelerating healing and decreasing scar formation. (frontiersin.org)
  • Interestingly, their potential application in the treatment of CSU opens the door for the design of new highly effective therapeutic strategies. (frontiersin.org)
  • Hydrogels classified based on this property fall under three main categories: cationic, anionic, and amphoteric. (wikipedia.org)
  • demonstrated the stimulated release of gallic acid from chitin-based hydrogel via ultrasound induction. (wikipedia.org)
  • By encapsulating drugs within hydrogel networks, the release rate can be modulated, improving drug bioavailability and reducing side effects. (thewitfire.in)
  • In this area, the use of EV for the treatment of chronic skin ulcers (CSU) has been proposed. (frontiersin.org)
  • Prompt diagnosis and appropriate treatment decrease the duration of healing and chronic complications. (medichub.ro)
  • MedicineNet does not provide medical advice, diagnosis or treatment. (medicinenet.com)