• binds
  • STAT1 and STAT2 form a complex with IFN-regulatory factor 9 (IRF) forming the transcription factor complex ISGF3, which then translocates to the nucleus and binds to IFN-stimulated response elements (ISREs) in the promoters of IFN-regulated genes (IRGs). (wikipedia.org)
  • immunization
  • These antigens can be used for the immunization of patients, and epitopes from them can be used in one of the recently developed and very sensitive assays for the detection of antigen-specific T-cell activity, such as ELISpot, intracellular cytokine induction, and tetramer analysis. (aacrjournals.org)
  • 1. Artificially Acquired Active Immunity: Immunity: Antigens are introduced in vaccines (immunization). (scribd.com)
  • signaling pathway
  • IFNγ suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, which otherwise stimulates the production of NF-κB. (wikipedia.org)
  • vaccine
  • According to our results this construct could be proposed to investigate as a new subunit vaccine candidate in order to stimulate immune system against Brucellosis in future studies. (g3m.ir)
  • formerly known as BLP25 or EMD 531444) is a synthetic lipopeptide that is used as antigen in an investigational therapeutic cancer vaccine (formerly known as Stimuvax, L-BLP25, BLP25 liposomal vaccine or BLP25 liposome vaccine). (wikipedia.org)
  • Nonproprietary/generic names: International Nonproprietary Name (INN): Tecemotide United States Adopted Name (USAN): Emepepimut-S Formerly known as: BLP25 (Biomira lipopeptide 25) or EMD 531444 Function: Tecemotide is the antigen of the cancer vaccine Tecemotide is a synthetic lipopeptide 27 amino acids long. (wikipedia.org)
  • protein
  • In the current study, we compared the production of these two cytokines by PBMC of HIV-LTBI+ and HIV + LTBI+ individuals in response to Mtb antigens CFP-10 (culture filtrate protein) and ESAT-6 (Early Secretory Antigenic Target). (springer.com)
  • adjuvant
  • Moreover, Brucella Lumazine Synthase (BLS) as another main antigen can be used as an adjuvant when covalently attached to a foreign antigen. (g3m.ir)
  • Infection
  • In the current study, designing and production of a chimeric construct as a primary step to stimulate the immune system against Brucella infection is investigated. (g3m.ir)
  • Active TB infection in HIV+ individuals further inhibited antigen specific IL-17 and IL-22 production compared to those with LTBI. (springer.com)
  • genes
  • In addition, canonical type I IFN signalling may activate STAT1 homodimers that bind to interferon-gamma-activating factor (GAF), which also translocates to the nucleus and activates transcription of IFN-stimulated genes. (wikipedia.org)
  • The virus-induced expression of IFNA/IFNB genes is primarily controlled at the gene transcription level, by the interferon regulatory factors (IRFs) and IFN-stimulated genes. (wikipedia.org)
  • inhibits
  • In the current study we found that increased PD1 expression in HIV + LTBI+ and HIV+ active TB patients inhibits IL-17, IL-22 production and IL-23R expression in response to Mtb antigens CFP-10 and ESAT-6. (springer.com)
  • response
  • To evaluate the effects of PLUSCOMs containing Leishmaniamajor antigens (SLA) on the type of immune response generated in the murine model of leishmaniasis. (ac.ir)
  • The success of therapy directed at EBV antigens in transplant patients suggests that under ideal circumstances, this type of response can indeed be effective ( 1 ). (aacrjournals.org)
  • No immune response to antigens. (scribd.com)
  • When analyzing blood samples using a peripheral blood mononuclear cell proliferation assay, they discovered that B. oleronius stimulated an immune system response in 79 percent of 22 patients with subtype 2 (papulopustular) rosacea, compared with only 29 percent of 17 subjects without the disorder. (wikipedia.org)
  • The non-specific immune response is an immediate antigen-independent response, however it is not antigen-specific. (wikipedia.org)
  • human
  • Mouse CD1d ( 24 ) and human CD1a ( 25 ) have glycolipid-binding capacities different from CD1b and it has been proposed that each CD1 molecule has evolved the capacity to present unique types of lipid antigens ( 18 ). (rupress.org)
  • In recent years numerous target antigens have been defined in human tumors. (aacrjournals.org)
  • The first signal is the major histocompatibility complex (MHC), which in humans is also called the human leukocyte antigen (HLA). (wikipedia.org)