Steroidogenic sertoli cells. Medical search. Frequent questions

Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
The rate-limiting step in steroid hormone production in the adrenal cortex and gonads, the translocation of cholesterol from the outer to the inner mitochondrial membranes, is mediated by the steroidogenic acute regulatory protein (StAR). (elsevierpure.com)

Furthermore, the nuclei of 90C95% granulosa cells of porcine MK-1775 manufacturer primordial, unilaminar, multilaminar, and antral follicles of different sizes stain positive for GATA4 [25]. (ap26113.com)
Primordial follicles of adult ovaries did not contain STAR, whereas antral follicles stained intensely in the thecal layer, with occasional staining of granulosa cells. (elsevierpure.com)
HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
Progesterone dose during synchronization treatment alters luteinizing hormone receptor and steroidogenic enzyme mRNA abundances in granulosa cells of Nellore heifers. (tamu.edu)

Lines of differentiation distinguish germ cell tumors. (medscape.com)
[ 1 ] Primitive, unipotential germ cells are the precursors to ovarian dysgerminomas, whereas pleuripotential germ cells diverge along several lines of differentiation. (medscape.com)
They further advised that because NUT protein appears to play a role in normal germ cell maturation, it may influence intestinal or hepatoid differentiation within malignant germ cell tumors. (medscape.com)
Enrichment of spermatogonial stem cells is important for studying their self-renewal and differentiation. (ap26113.com)
reported that GATA4 MK-1775 manufacturer localizes towards the coelomic epithelium of gonads also to the Sertoli and follicle cells before and after sex differentiation, [26] respectively. (ap26113.com)
An error during these developmental steps in females may lead to defective gonads, affecting the differentiation and/or function of the gonads and the development, differentiation, and maturity of the germ cells. (lidsen.com)
hCG was insufficient to facilitate Leydig cell differentiation, restore steroidogenesis and improve sperm yield. (elifesciences.org)
The evidence that the culture of testicular fragments of 6.5-day-old mouse testes does not allow optimal differentiation of steroidogenic cells is compelling and should enable further optimizations in the future. (elifesciences.org)
A gene in the sex-determining region of the short arm of the Y, now referred to as SRY , has been found to direct production of a protein which binds to DNA, inducing differentiation of cells derived from the genital ridges into testes. (en-academic.com)
European eel males treated with cold seawater (10 °C, T10) for 2 weeks showed an increase in the proliferation and differentiation of spermatogonial cells until the differentiated spermatogonial type A cell stage, and elevated testosterone and 11-ketotestosterone plasma levels. (biomedcentral.com)
In particular, our cold seawater treatment induces the synchronization and increased proliferation and differentiation of specific spermatogonial cells. (biomedcentral.com)

Piperine stimulates pubertal Leydig cell development by increasing Leydig cell number and promoting its maturation while it inhibits spermatogenesis in the rat. (frontiersin.org)
The objective of the present study is to investigate the modulation of antioxidant defence status in neonatal persistent hypothyroid rats before their sexual maturation and also to identify the specific testicular cell populations vulnerable to degeneration during neonatal hypothyroidism in immature rats. (hindawi.com)
During puberty, testosterone induces Sertoli cell maturation, and prevails over FSH on AMH regulation. (biomedcentral.com)
Testicular histology in azoospermic patients shows incomplete maturation arrest, with a Sertoli cell-only pattern in some areas (Arafat et al. (nih.gov)
During mitosis, cells undergo symmetrical cell division, while oocyte meiotic maturation undergoes two consecutive, asymmetric divisions that generate a totipotent haploid oocyte and two small polar bodies not involved in DNA replication. (bioone.org)

Piperine in vitro also increased androgen production and stimulated cholesterol side-chain cleavage enzyme and 17α-hydroxylase/20-lyase activities in immature Leydig cells. (frontiersin.org)
STUDY DESIGN, SIZE, DURATION: This comprehensive study examined testis morphology, Leydig cell and Sertoli cell number, steroidogenic enzyme expression, INSL3 expression and androgen secretion by testicular fragments in vitro. (bvsalud.org)
The presence of StAR in cells that do not express cholesterol side-chain cleavage enzyme cytochrome P450, including renal distal tubules, Sertoli cells, and fetal oocytes, suggests that StAR has roles in metabolic processes in addition to stimulating pregnenolone synthesis. (elsevierpure.com)
Moreover, our recent transcriptomic analysis reveals a decline in mRNA levels of Cyp17a1 , encoding a steroidogenic enzyme, in 4- to 30-day cultures of 6 d pp mouse testes ( 10 ). (elifesciences.org)

This compromised testicular antioxidant status might have contributed to poor growth and development by affecting the spermatogenesis and steroidogenesis in rats before puberty as indicated by reduced germ cell number, complete absence of round spermatids, decreased seminiferous tubule diameter, and decreased testosterone level. (hindawi.com)
In the ultrastructural study, it is shown that the seminiferous epithelium is structurally partitioned by the Sertoli cells into basal and adluminal compartments via the specialized tight junctions between the Sertoli cells. (ac.ir)
Studies on male rodents suggested that chronic ACR exposure resulted in testicular cytotoxicity indicated by vacuolization, multiple nuclei formation, abnormal giant cell, atrophy of the seminiferous tubules and apoptosis. (biomedcentral.com)
In the interstitial tissue, Leydig cells synthesize androgens and the insulin-like factor 3 (INSL3) [ 3 ], whereas in the seminiferous tubules, Sertoli cells regulate the nutrients and factors that reach the germ cells by means of the blood-testis barrier. (biomedcentral.com)
Seminiferous epithelium of both groups of rats displayed normal histology without any loss of germ cells. (biomedcentral.com)
In the testis, Sertoli cells serve as supporting cells and reside as a basal epithelial lining within the seminiferous epithelium. (biomedcentral.com)

After 10 weeks, exercised and non-exercised males were sampled to determine plasma 11-ketotestosterone levels, testicular mRNA expression levels of genes involved in steroidogenesis and gametogenesis by qPCR, as well as the relative abundance of germ cells representing the different spermatogenic stages by histological examination. (biomedcentral.com)
It upregulated the declined level of serum testosterone and the expression of steroidogenic genes such as CYP11A1 and 17β3-HSD with an obvious histologic improvement of the testes with re-establishment of the normal spermatogenic series, Sertoli and Leydig cells. (biomedcentral.com)
Contact with 10 mg/kg didn't affect advancement but decreased Sertoli cellular number and led to increased appearance of inhibin B. Contact with DEHP for 14 week affected steroidogenic genes appearance also. (cancerhugs.com)

also recognized in the cells of neonatal testes and total testicular cells, and that the manifestation of GATA4 was decreased in used older feeder cells. (ap26113.com)
Furthermore, GATA4 manifestation was more powerful in FFCs than in OFCs, and it had been recognized in Sertoli cells of neonatal pig testes. (ap26113.com)
Fetal testes displayed intense Leydig cell staining. (elsevierpure.com)
Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
The critical gene for male sex determination, SRY (sex-determining region Y), which is located on chromosome Yp11.3, initiates gonads to differentiate into testes, induces Leydig cells to secrete testosterone, develops Wolffian ducts, and forms male external genitalia. (e-kjgm.org)

Sertoli cell proliferation reaches its maximum level just before birth and ceases by the age of 3 weeks [ 24 ]. (hindawi.com)
These total outcomes claim that GATA4-positive cells MK-1775 manufacturer support GDC development in two-dimensional tradition which, during tradition with GDCs, the GATA4-expressing FFCs most likely are likely involved similar compared to that of somatic cells in the testessupporting germ cell development and proliferation. (ap26113.com)

[ 1 , 2 ] These are the most common types of malignant ovarian cell tumors (see the following image). (medscape.com)
Percentages of malignant germ cell tumors. (medscape.com)
Although germ cell tumors arise from primordial ovarian and testicular germ cells, the pathogenesis of the ovarian germ cell tumors is unknown. (medscape.com)
[ 1 ] Unusual for germ cell tumors, dysgerminomas occur bilaterally in 10%-20% of cases. (medscape.com)
However, a small percentage of mixed germ cell tumors occur. (medscape.com)
Sertoli cell tumors may be mistaken for dysgerminoma when tubules are indistinct and/or solid, especially if they are poorly fixed. (medscape.com)
A study that investigated nuclear protein in the testis (NUT) expression in ovarian germ cell tumors found that most malignant ovarian germ celll tumors express NUT protein, albeit focally. (medscape.com)
An ovarian Leydig cell tumor stained intensely, whereas granulosa cell tumors were negative. (elsevierpure.com)
Seminomas and testicular germ cell tumors were negative. (elsevierpure.com)
The present study also has its future implications in staging of cancer metastasis in the patients with Seminoma Testis and Leydig Cell Tumors and also in future xenografting of testicular tissue from an infant human donor. (ac.ir)
Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)
Finally, elevation of serum AMH above normal male prepubertal levels may be indicative of rare cases of sex-cord stromal tumors or Sertoli cell-limited disturbance in the McCune Albright syndrome. (biomedcentral.com)

It is very clear from these reviews that GATA4 takes on an important part in gonadal somatic cells that get excited about spermatogenesis and oogenesis. (ap26113.com)
5. Conclusions To conclude, isolated GATA4-positive somatic cells could be utilized as feeder cells for long-term tradition of porcine GDCs ( 4 weeks). (ap26113.com)
While sperm production has classically been the focus of adult reproductive function, somatic cells are crucial for the maintenance of spermatogenesis and gamete production. (biomedcentral.com)
Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
Culture of somatic cells isolated from frozen-thawed equine semen using fluorescence-assisted cell sorting. (tamu.edu)

and they express sex cord stromal markers such as calretinin, inhibin, and steroidogenic factor-1, and they lack germ cell markers. (medscape.com)
Fetal ovaries contained sporadic stromal cells displaying intense StAR staining, particularly in the hilar region. (elsevierpure.com)

To examine TCDD-induced biological consequences, we measured the changes in the secretion of progesterone and testosterone, as well as transcript levels of some selected steroidogenic enzymes (i.e. (edu.hk)
These abnormalities have already been connected with reductions in testosterone secretion and appearance of steroidogenic enzymes (Barlow et al. (cancerhugs.com)

In order to examine whether PIP affected spermatogenesis by interfering with Leydig cell testosterone production, in the current study we evaluated the effects of PIP on pubertal Leydig cell development. (frontiersin.org)
particularly the Sertoli cells, which play a major role in spermatogenesis and are the main cell type in the testis which expresses T 3 receptors [ 16 ]. (hindawi.com)
The immunohistological and ultrastructural features of the human testis with emphasis upon the process of spermatogenesis and the cytology of the Leydig cells were reviewed in this study. (ac.ir)
In vitro spermatogenesis could indeed be proposed to patients with testicular localization of residual tumor cells, for whom testicular tissue autografting is not indicated (about 30% of patients with acute leukemia). (elifesciences.org)
Sertoli cells not only regulate the inflow of external substances, but also produce several substances which are critical to the proper progression of spermatogenesis [ 4 ]. (biomedcentral.com)

As shown by examination of semi-thin and ultrathin sections, cell surface occupied by the basal ES connecting neighboring Sertoli cells and the number of gap and tight junctions coexisting with the basal ES were apparently reduced in flutamide-treated rats. (biomedcentral.com)

At the same time, Sertoli cells secrete Müllerian inhibiting factor that induces regression of Müllerian ducts that in females would differentiate into the uterus. (e-kjgm.org)

AMH is secreted in high amounts by Sertoli cells from fetal life until the onset of puberty. (biomedcentral.com)

Testosterone is essential for male fertility, mediating its biological effects through the androgen receptor (AR) present in somatic Leydig, peritubular, and Sertoli cells. (biomedcentral.com)
ERa was not expressed in Sertoli cells, peritubular myoid cells, blood vessels or germ cells at any time in either species. (endocrinology-journals.org)

We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)

We conclude that StAR is localized to normal and neoplastic cells in the gonads and adrenal cortex, which produce large amounts of pregnenolone. (elsevierpure.com)
Integration of single-cell transcriptome and chromatin accessibility of early gonads development among goats, pigs, macaques, and humans. (cas.cn)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)

SUMMARY ANSWER: Leydig cell number significantly decreases in parallel with INSL3 expression and Sertoli cell number in aged men, yet the in vitro Leydig cell androgenic potential does not appear to be compromised by advancing age. (bvsalud.org)

The main neoplasms in the differential diagnosis of ovarian dysgerminoma are lymphoma/leukemia, yolk sac tumor , embryonal carcinoma , and Sertoli cell tumor. (medscape.com)
It's been shown that binding of three transcription factors, steroidogenic factor 1 (SF1), specificity protein 1 (Sp1 transcription factor) and Wilms tumor protein 1 (WT1), to the human promoter sequence, influence expression of SRY. (wikipedia.org)
Testicular Leydig cells stained moderately to intensely, as did a testicular Leydig cell tumor. (elsevierpure.com)
Effect of heat stress on expression of junction-associated molecules and upstream factors androgen receptor and Wilms' tumor 1 in monkey sertoli cells. (cas.cn)

It has been reported that Nanog, Oct4, and Sox2, often used as stem cell markers, function cooperatively in the regulatory network of self-renewal and pluripotency [16]. (ap26113.com)

At the same time, in these groups, there was an increase in the level of aromatase, malondialdehyde, cholesterol, and steroidogenic factor-1 (SF-1) expression in the adrenal cortex and an enhancement in histological lesions. (biomedcentral.com)
Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. (thermofisher.com)

Sertoli cells stained weakly in some specimens. (elsevierpure.com)
In the rat, the adult generation of Leydig cells were also immunopositive for ERa whereas the comparable cells in the marmoset were only weakly immunopositive. (endocrinology-journals.org)

We analyzed a donor Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 polymorphism, hepatic expression of proteins involved in lipid metabolism by RT-PCR, hepatic stellate cell (HSC) activation by α-SMA immunohistochemistry and, one year after transplantation, histological progression of fibrosis due to Hepatitis C Virus (HCV) recurrence. (bvsalud.org)
The TSPO is present in virtually all mammalian peripheral tissues (Zisterer and Williams 1997), however highly prominent TSPO protein expression has been identified in steroidogenic tissues (R. R. Anholt et al. (aopwiki.org)
Administration of POS extract reversed the ACR-induced epididymides weight loss with improved semen quality and count, ameliorated the ACR-decreased testicular lesion scoring, testicular oxidative stress, testicular degeneration, Leydig cell apoptosis and the dysregulated PCNA and Caspase-3 expression in a dose-dependent manner. (biomedcentral.com)
We have previously demonstrated effects of TCDD in modulating the expression of rat Sertoli cell secretory products and markers for cell-cell interaction. (edu.hk)
Present study was designed to establish a causal connection between changes in the cell-cell junction protein expression at the blood-testis barrier and alterations in the adult rat testis histology following an anti-androgen flutamide exposure. (biomedcentral.com)
Dong F # , Chen M # , Chen M, Jiang L, Shen Z, Ma L, Han C, Guo X, Gao F. PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications. (cas.cn)
Chen M , Wang X, Wang Y, Zhang L, Xu B, Lv L, Cui X, Li W, Gao F. Wt1 is involved in leydig cell steroid hormone biosynthesis by regulating paracrine factor expression in mice. (cas.cn)
In vitro functional analyses of the novel variant suggested no impairment to NR5A1 mRNA or protein expression relative to wild-type, and immunofluorescence confirmed similar localization of NR5A1 mutant to the cell nucleus. (biomedcentral.com)

ERa was immunoexpressed in interstitial cells, including the fetal/neonatal generation of Leydig cells, in both the rat and marmoset. (endocrinology-journals.org)

In addition, the ACR-induced reproductive toxicity is associated with a dramatic reduction in testosterone level due to disruption of the Leydig cells steroidogenic pathway [ 10 ]. (biomedcentral.com)

The influence of gonadal steroid hormones on immunoreactive kisspeptin in the preoptic area and arcuate nucleus of developing agonadal mice with a genetic disruption of Steroidogenic factor-1. (arnes.si)

Transcript levels of the androgen receptor (AR)-regulated gene Rhox5 were decreased at the end of the culture period, suggesting that testosterone production by Leydig cells and/or AR transcriptional activity was impaired in organotypic cultures ( 8 ). (elifesciences.org)

In conclusion, this study reports the failure of adult Leydig cell development and altered steroid production and signaling in tissue cultures. (elifesciences.org)
The organotypic culture procedure, which preserves testicular tissue architecture, microenvironment and cell interactions, has been used successfully to obtain spermatozoa from fresh or frozen/thawed mouse prepubertal testicular tissues ( 3 - 6 ). (elifesciences.org)
Depending on the molecules and testis age, highly deleterious effects of phytocannabinoid exposure were observed on testis tissue after 14 days, including Sertoli and germ cell death. (biomedcentral.com)
Sodium nitrite causes the irritation of evolving male germ cells by disrupting hormonal balance and tissue anoxia, and by deforming the sperms, causes the reduction of their fertility. (biomedres.info)

For in vitro studies, immature Leydig cells were isolated from 35-day-old male rats and treated with 50 μM piperine in the presence of different steroidogenic stimulators/substrates for 24 h. (frontiersin.org)

Based on these reports, it seems that germ and stem cell markers are expressed in cultured germ cells of domestic animals. (ap26113.com)
In this study, cells of the colonies at each passage were found to be positive for GFR em /em -1 and PGP 9.5, as well as for stem cell markers, in RT-PCR, immunocytochemistry, MK-1775 manufacturer and flow cytometry analyses. (ap26113.com)
Despite a conserved density of Leydig cells after 30 days of culture (D30), transcript levels of adult Leydig cell and steroidogenic markers were decreased. (elifesciences.org)

They create a specialized microenvironment to support the germ cell development especially through the formation of the blood-testis barrier (BTB). (biomedcentral.com)

In the interstitial compartment, however, short-term exposure leads to both histological and functional changes of the Leydig cells. (biomedcentral.com)

Such a review cannot be comprehensive due to space constraints and I focused on the commitment of the female cell lineage and avoided discussing the male cell lineage. (lidsen.com)
Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. (philarchive.org)

When present, embryonal cell carcinoma exhibits more nuclear hyperchromasia and nuclear pleomorphism, amphophilic cytoplasm, high mitotic index, and necrosis than ovarian dysgerminomas. (medscape.com)
The Leydig cell cytoplasm contains an abundant supply of smooth endoplasmic reticulum and mitochondria with tubular cristae, both features being characteristic of steroidogenic cells. (ac.ir)
The molecule of MF, a small hydrophilic cation, is transported from the extracellular space to the cytoplasm of the target cell through organic cation transporters-1 and -2 (OCT1, OCT2), multidrug and toxin extrusion transporters (MATE), and ATM (ataxia telangiectasia mutated) transporter, and OCT1 and OCT2 are considered as the main functional units of MF transmembrane transport [ 7 ] . (encyclopedia.pub)

Late-stage pubertal development of Leydig cells is mainly involved in the transition of immature Leydig cells to adult Leydig cells. (frontiersin.org)

An ovarian dysgerminoma consists of primitive, undifferentiated germ cells. (medscape.com)

Leydig cell aplasia occurs when congenital absence of Leydig cells causes partially developed or ambiguous external genitals. (msdmanuals.com)
I don t want to bring femoral head increases from type i and ii) drug induced (antiepileptic, estrogen, thyroid cryptorchidism mutations) hyperthyroidism germinal aplasia (del castillo syndrome, sertoli-cell only and engagement. (ben.edu)

GATA4 can be an integral regulator of Sertoli cell function in adult mice [21]. (ap26113.com)
Embryonic GABAB Receptor Blockade Alters Cell Migration, Adult Hypothalamic Structure, and Anxiety- and Depression-Like Behaviors Sex Specifically in Mice. (arnes.si)
Altered position of cell bodies and fibers in the ventromedial region in SF-1 knockout mice. (arnes.si)
Selected oxidative stress parameters and testicular and adrenal steroidogenic capacities of adult mice were measured. (biomedcentral.com)
Mice XL765 shown prenatally to an individual dosage of 500 mg/kg of phthalates display germ cell abnormalities but testosterone creation isn't affected (Gaido et al. (cancerhugs.com)

The development of adult Leydig cell population was also analyzed 65 days postpartum. (frontiersin.org)

Copy number variants in patients with severe oligozoospermia and Sertoli-cell-only syndrome. (nih.gov)

check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

Recent research also has thrown lights upon a significant role of orexins, especially orexin A, in regulation of male reproductive functions owing to their receptor expressions in vital testicular cells, such as Leydig cells, Sertoli cells as well as spermatozoa at different developmental stages, even in the epididymis and penis. (researchgate.net)

The mechanistic action of TCDD was found to be via the reduction of cellular cAMP levels in the hCG-treated cells. (edu.hk)

Furthermore, GATA4 was also recognized in the nuclei of mouse and human being granulosa and thecal cells [23, 24]. (ap26113.com)
The cell bodies of these neurons are clustered in groups, called nuclei. (pharmaceuticalintelligence.com)

The now-induced Leydig cells of the testis then start secreting testosterone, while the Sertoli cells produce anti-Müllerian hormone. (wikipedia.org)
Fetal type Leydig cells disappear soon after birth (during first 2 weeks after birth) and are replaced by adult type Leydig cells [ 22 , 23 ]. (hindawi.com)
Mitochondria of human Leydig cells as seen by high resolution scanning electron microscopy. (ac.ir)
Cell biology of Leydig cells in the testis. (ac.ir)
Mature rat Leydig cells were purified by Percoll gradient centrifugation and the cell purity was determined by 3β-hydroxysteroid dehydrogenase (3β-HSD) staining and a testosterone induction assay. (edu.hk)
The data indicate that TCDD can modulate cAMP signaling in rat Leydig cells to affect the process of steroidogenesis. (edu.hk)
Appearance of Leydig cells. (en-academic.com)
These findings suggest that the main actions of oestrogens in the male reproductive tract, mediated by ERa, are related to the development and function of the efferent ducts and the Leydig cells. (endocrinology-journals.org)
NO is reactive oxygen radical that is produced in testicular vascular endothelial cells and leydig cells, and by affecting the hypothalamicpituitarygonadal axis causes a reduction in testosterone production and inhibits steroidogenesis [ 5 , 6 ]. (biomedres.info)

We have gained crucial insights into molecular factors and pathways of the cells generating either the supporting gonadal cells or germ cells of both sexes. (lidsen.com)

Nature Reviews Molecular Cell Biology. (arizona.edu)
Frontiers in Cell and Developmental Biology. (unab.cl)

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