Steroid gene nuclear receptor subfamily 6 group a member 1. Medical search. Frequent questions

This study identifies a non-canonical EcR-corepressor complex with the potential for a direct regulation of ATP-dependent nucleosome remodelling by a nuclear hormone receptor. (sdbonline.org)

Nuclear receptor 4A1 and the rest of the NR4A family are structurally similar to other nuclear receptor superfamily members, but contain an extra intron. (wikipedia.org)
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)
The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors. (guidetopharmacology.org)
Unlike receptors found on the cell surface, members of the nuclear hormone receptor (NR) superfamily are restricted to metazoan organisms such as nematodes, insects, and vertebrates. (indigobiosciences.com)
Các câu ví dụ - Cambridge Dictionary Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily. (edu.vn)
All insect order, suborder, superfamily, family and subfamily names are given, together with the diagnostic features of orders and families. (edu.vn)
MRP4 is an ATP-dependent, unidirectional efflux transporter belonging to the C subfamily of the ABC protein superfamily. (solvobiotech.com)

The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 gene. (wikipedia.org)
The protein has an atypical ligand-binding domain that is unlike the classical ligand-binding domain in most nuclear receptors. (wikipedia.org)
Avian species do not have brown adipose tissue (BAT), and lack Uncoupling Protein 1 ( UCP1 ) [ 12 ]. (biomedcentral.com)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
The human GR protein is produced from 9 exons of the GR gene and is composed of 3 major subdomains, each of which has specific structural and functional properties. (brainimmune.com)
Variants in the SMCHD1 gene on chromosome 18, which encodes a protein known as structural maintenance of chromosomes flexible hinge domain containing 1, have been associated with FSHD2. (arkansasbluecross.com)
Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. (embl.de)
To test our hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, H4R3 and H3R17 protein arginine (R) methyltransferases 1 and 4 (PRMT1 and PRMT4) were investigated. (embl.de)
We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the marks to different functional consequences of E2F-1 activity. (embl.de)
The Tudor domain protein p100-TSN reads the symmetric methylation mark, and binding of p100-TSN downregulates E2F-1 apoptotic activity. (embl.de)
Identification and characterization of new molecular partners for the protein arginine methyltransferase 6 (PRMT6). (embl.de)
Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. (embl.de)
events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)
Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. (stanford.edu)
Also, this region may contain nuclear localization signals and protein-protein interaction sites. (indigobiosciences.com)
RAS family proteins include 23 genes coding for at least 25 proteins that are divided into eight paralog groups based on sequence identity, structure, and function: RAS, RAS-like (RAL), RAS-related protein (R-RAS), RAS-like protein in tissues (RIT), RAS-related protein Rap (RAP), RAS homolog enriched in brain (RHEB), Dexamethasone-induced RAS-related protein (RASD), and GTP-binding protein Di-RAS (DIRAS) [ 5 ] . (encyclopedia.pub)
High-confidence identification of ~2,000 proteins, including cytoplasmic, nuclear, plasma membrane, extracellular and unknown/unclassified proteins, was obtained by separating tryptic peptides of renal cortical proteins into 60 fractions by SCX prior to LC-MS/MS. The identified proteins represented the renal cortical proteome with no discernible bias due to protein physicochemical properties, subcellular distribution, biological processes, or molecular function. (biomedcentral.com)
Additional protein domains found at their C termini have been used to classify TRIM proteins into subfamilies. (elifesciences.org)
In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)
arginine and serine rich protein 1 [So. (gsea-msigdb.org)
adhesion G protein-coupled receptor E5. (gsea-msigdb.org)
Limb-girdle muscular dystrophy (LGMD) protein defects occur in several pathways involved in the biologic function of muscle and can be divided into groups based on cellular localization. (medscape.com)

According to the bimodal switch model, steroid hormone receptors recruit corepressors in the absence of hormone and coactivators in its presence. (sdbonline.org)
Contrary to the prevalent model, recruitment of the dMi-2 corepressor increases upon hormone addition to constrain gene activation through chromatin remodelling. (sdbonline.org)
This study examined the roles of hormone-dependent transcription factors (Nuclear Receptors), in accessory gland development, function and male fertility of a genetically tractable insect model, Drosophila melanogaster. (sdbonline.org)
First, an RNAi screen was carried out involving 19 hormone receptors, individually and specifically, in a male reproductive tissue (accessory gland) for their requirement in Drosophila male fertility. (sdbonline.org)
The objective of this study was to assess the thyroid hormone disruption and reproductive dysfunction effects of the bioaccumulation and rate of mechanism in zebrafish exposed to tris(1,3-dichloro-2-propyl) phosphate (TDCPP), with stress responsiveness. (bvsalud.org)
The thyroid hormone (triiodothyronine [T3] and thyroxine [T4]) levels and sex steroid (i.e., estrogen, androgen, and progesterone) levels were significantly increased only in female zebrafish exposed to TDCPP, and no significant difference was observed in male zebrafish, although their cortisol levels increased. (bvsalud.org)
Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. (mcw.edu)
Bernal J. (2007) Thyroid hormone receptors in brain development and function. (guidetopharmacology.org)
2011) Membrane receptor for thyroid hormone: physiologic and pharmacologic implications. (guidetopharmacology.org)
2010) Mini-review: Cell surface receptor for thyroid hormone and nongenomic regulation of ion fluxes in excitable cells. (guidetopharmacology.org)
2009) Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors. (guidetopharmacology.org)
Grover GJ, Mellström K, Malm J. (2007) Therapeutic potential for thyroid hormone receptor-beta selective agonists for treating obesity, hyperlipidemia and diabetes. (guidetopharmacology.org)
Liu YY, Brent GA. (2010) Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. (guidetopharmacology.org)
We used logistic regression to estimate odds ratios for allelic effects in ethnic-pooled analyses as well as in subgroups defined by disease stage and steroid hormone receptor status. (biomedcentral.com)
We also investigated effect modification by established breast cancer risk factors that are associated with steroid hormone exposure. (biomedcentral.com)
Cataloging and testing of coding variants in coactivator and corepressor genes should continue and may serve as a valuable resource for investigations of other hormone-related phenotypes, such as inter-individual response to hormonal therapies used for cancer treatment and prevention. (biomedcentral.com)
Cellular response to estrogens is mediated through estrogen receptors (ERα and ERβ), which upon binding to ligand and DNA hormone response elements, recruit coactivator and corepressor proteins that regulate the expression of steroid hormone target genes. (biomedcentral.com)
HRT or SERMs) estrogens and lead to differences in steroid hormone sensitivity which could alter one's risk of developing breast cancer. (biomedcentral.com)
In this study, we systematically screened the coding exons of steroid hormone receptor coactivator and corepressor genes in a multiethnic panel of women with breast cancer in an attempt to identify and catalogue potentially functional coding polymorphisms that may serve as genetic markers of breast cancer risk. (biomedcentral.com)
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). (avivasysbio.com)
Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody [NBP2-22523] - Analysis of 25 ug of mouse thyroid (lane 1), NIH-3T3 (lane 2) and A431 (lane 3) cell lysates onto an SDS polyacrylamide gel. (novusbio.com)
Thyroid Hormone Receptor alpha is encoded by this gene is a nuclear hormone receptor for triiodothyronine. (novusbio.com)
It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. (novusbio.com)
Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. (novusbio.com)

Given the established role of estrogens in breast cancer, we hypothesized that coding variation in steroid receptor coactivator and corepressor genes may alter inter-individual response to estrogen and serve as markers of breast cancer risk. (biomedcentral.com)
Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). (avivasysbio.com)
The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding. (bindingdb.org)

It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating transcription in response to retinoids. (wikipedia.org)
In addition, chromatin immunoprecipitation analysis of livers from mice showed that injection of 1,25(OH)2D3 increased recruitment of Vdr and rodent retinoid X receptor to the Shp promoter. (nih.gov)
Once activated by a ligand, the receptor acts as a transcription factor either as a monomer, homodimer or heterodimer with members of the retinoid X receptor family. (guidetopharmacology.org)

Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. (wikipedia.org)
Understand Nuclear Receptors through our introduction to this family of intracellular transcription factors that regulate gene expression. (indigobiosciences.com)

Furthermore, phylogenetic analyses identified molluscan-specific gene expansions of key enzymes involved in catecholamine biosynthesis. (exeter.ac.uk)
However, exposure to MK-801 did not alter the expression of selected key enzymes, suggesting that NMDA receptors do not regulate the biosynthesis of catecholamines via gene expression. (exeter.ac.uk)
Estrone is only a weak agonist of estrogen receptor but it serves as a precursor for biosynthesis of 17β-estradiol, 16α-hydroxyestrone and catechol estrogens. (helsinki.fi)

ATP binding cassette subfamily D membe. (gsea-msigdb.org)

Gene regulation by steroid hormones plays important roles in health and disease. (sdbonline.org)
Glucocorticoids, steroid hormones secreted from the adrenal cortex, play essential roles in the maintenance of internal homeostasis by influencing virtually all organs and tissues. (brainimmune.com)
Glucocorticoids are steroid hormones secreted from the zona fasciculata of the adrenal cortex, and play numerous important roles in the maintenance of internal homeostasis by influencing activities of virtually all organs and tissues, such as the brain, liver, skeletal muscles and the immune-related organs and cells [1]. (brainimmune.com)
Breast cancer risk is related to lifetime exposure to steroid hormones. (biomedcentral.com)
The ovary is a dynamic female reproductive organ that undergoes many structural and functional transformations as it fulfills its two significant roles of producing female gametes and synthesizing sex steroid hormones [ 1 ] . (encyclopedia.pub)

The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)

12 , 13 ] Polymorphic variants in these mediators of hormonal responsiveness could affect the functional activity of estrogen receptors following stimulation by endogenous or exogenous (i.e. (biomedcentral.com)
While 16α-hydroxyestrone has relatively weak affinity for estrogen receptor, it has prolonged effect due to covalent binding to the receptor. (helsinki.fi)

Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
It binds and inactivates the 140 kDa subunit of RNA polymerase II, blocking all gene expression leading to proteins. (helmberg.at)
These proteins are intracellular transcription factors that directly regulate gene expression in response to lipophilic molecules. (indigobiosciences.com)
The paralog group of RAS proteins is composed of four isoforms (H-RAS, N-RAS, K-RAS4A, and K-RAS4B) that are encoded by three genes, H-RAS , N-RAS , and K-RAS [ 6 ] . (encyclopedia.pub)
RAS family proteins mediate extracellular signals, transduced through their receptors, with multiple signaling pathways, and consequently regulate a wide array of cellular processes [ 8 ] . (encyclopedia.pub)
While progress has been made in establishing a renal cortical proteome using 1-D or 2-DE and mass spectrometry, the number of proteins definitively identified by mass spectrometry has remained surprisingly small. (biomedcentral.com)

The microtiter plate provided in this kit has been pre-coated with an antibody specific to Androgen Receptor (AR). (avivasysbio.com)
Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Androgen Receptor (AR). (avivasysbio.com)
After TMB substrate solution is added, only those wells that contain Androgen Receptor (AR), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (avivasysbio.com)

Trends Endocrinol Metab , 27 (6): 404-414. (guidetomalariapharmacology.org)

The concentration of Androgen Receptor (AR) in the samples is then determined by comparing the O.D. of the samples to the standard curve. (avivasysbio.com)
Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Androgen Receptor (AR) were tested 20 times on one plate, respectively. (avivasysbio.com)
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Androgen Receptor (AR) were tested on 3 different plates, 8 replicates in each plate. (avivasysbio.com)
This assay has high sensitivity and excellent specificity for detection of Androgen Receptor (AR). (avivasysbio.com)
No significant cross-reactivity or interference between Androgen Receptor (AR) and analogues was observed. (avivasysbio.com)
High-Load Resistance Exercise Augments Androgen Receptor-DNA Binding and Wnt/Î²-Catenin Signaling without Increases in Serum/Muscle Androgens or Androgen Receptor Content. (avivasysbio.com)
AIS;androgen receptor;AR8;DHTR;dihydrotestosterone receptor;HUMARA;HYSP1;KD;NR3C4;nuclear receptor subfamily 3 group C member 4;SBMA;SMAX1;TFM. (avivasysbio.com)

Subsequently, we cloned three NMDA receptor subunits CgNR1, CgNR2A and CgNR2B, with sequence analysis suggesting successful assembly of functional NMDA receptor complexes and binding to natural occurring agonists and the channel blocker MK-801. (exeter.ac.uk)

The Wnt genes encode secreted glycoprotein ligands that regulate a wide range of developmental processes, including axis elongation and segmentation. (biomedcentral.com)

The CYP2J2 gene encodes an enzyme responsible for the oxidative metabolism of various exogenous and endogenous compounds and is involved in various physiological and pathological processes in the human body [ 9 ]. (hindawi.com)
Unlike mammals that have four TIF1 members, Drosophila only encodes one member of the family, Bonus. (elifesciences.org)

A sub-family of steroid receptor-related orphan nuclear receptors that have specificity for a variety of DNA sequences related to AGGTCA. (bvsalud.org)

Thus, organisms cannot survive in the absence of glucocorticoid action, as observed in the mouse model in which the glucocorticoid receptor (GR) gene is genetically deleted [3]. (brainimmune.com)

The C-terminal ligand-binding domain is conserved to a lesser extent at 60% and the N-terminal AB region is not conserved, differing in each member. (wikipedia.org)
They are immediate early genes activated in a ligand-independent manner that bind at the homologous sites on response elements. (wikipedia.org)
However, the vast majority of known receptors do not have an identifiable physiologically relevant ligand, and are deemed orphan receptors. (indigobiosciences.com)

Our findings suggest that common coding variation in these candidate genes do not make a substantial contribution to breast cancer risk in the general population. (biomedcentral.com)
In this study, we employed a high-density single nucleotide polymorphism (SNP) chip to genotype 386 Nellore steers, a Bos indicus breed and, a Bayesian approach to identify genomic regions and putative candidate genes that could be involved with deposition and composition of IMF. (biomedcentral.com)

Furthermore, the Spätzle (Spz) family ligands for the Toll receptor are transcriptionally upregulated by activated JNK signalling in a non-cell-autonomous manner, providing a molecular mechanism for JNK-induced Toll pathway activation. (sdbonline.org)
Early classification of these receptors was based on ligands, DNA binding properties or other functional characterization. (indigobiosciences.com)

It belongs to a group of three closely related orphan receptors, the NR4A family (NR4A). (wikipedia.org)

Nuclear receptor 4A1 has the systematic HUGO gene symbol NR4A1. (wikipedia.org)

Ecdysone-regulated genes are bound by a heterodimer of Ecdysone receptor (EcR) and Ultraspiracle . (sdbonline.org)

NR4A1 may play a role in Drug-induced gingival overgrowth associated with exposure to phenytoin, nifedipine, and cyclosporine A. Nuclear receptor 4A1 binds as a monomer or homodimer to response element NBRE and as a homodimer to NurRE. (wikipedia.org)
Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
However, the amount of energy that can be stored in this way is limited: for their hydroxyl groups, glucose units are very hydrophilic: 1 g of glycogen binds 2.7 g of water. (helmberg.at)
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. (affbiotech.com)

We explored 36 mRNA-seq libraries in order to study transcriptome dynamics during proliferation and differentiation processes at 6 time points. (biomedcentral.com)

Two such genes in Drosophila encode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple) . (sdbonline.org)

Furthermore, a functional analysis of differentially expressed genes revealed enriched gene ontology terms involved in the regulation of circadian rhythm, histone modification, meiotic nuclear division, and others. (biomedcentral.com)
In addition, using invitro methylation assay we identified 4 new substrates for PRMT6, extending the involvement of this enzyme to other cellular processes beyond its well-established role in gene expression regulation. (embl.de)
Cytochrome P450 family 2 subfamily J member 2 (CYP2J2), a member of the monooxygenase cytochrome P450 (CYP) family and the only member of the human CYP2J subfamily, has many functions, including regulation of oxidative stress, inflammation, apoptosis, and immune responses. (hindawi.com)
This important study advances our understanding of the functions and regulation of the Drosophila transcriptional regulator Bonus, an ortholog of mammalian TIF1 family members. (elifesciences.org)
Epigenetic regulation of gene expression is an essential mechanism that guides cell differentiation during development. (elifesciences.org)

A poor outcome was defined as a score of 3-6 (functional dependence or death) on the modified Rankin Scale. (bvsalud.org)

Notably, the separate overexpression of EcR-B1 or a transforming growth factor- β receptor Baboon , whose activation can upregulate the EcR-B1 expression, in MB neurons rescued the miR-34 -induced gamma axon pruning phenotype. (sdbonline.org)
The technique of GWAS exploits differences in allele frequencies of thousands of polymorphic markers available in unrelated individuals who possess different phenotypes (for example, deposition and composition of intramuscular fat), and leads to the identification of markers associated with a given phenotype [ 6 ]. (biomedcentral.com)
Overlap exists with Congenital Muscular Dystrophy (CMD) as several gene mutations can cause both a LGMD and CMD phenotype. (medscape.com)
These diseases are discussed here in part because mutations in 2 genes can present with either an LGMD or a myofibrillar myopathy phenotype. (medscape.com)

According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways. (guidetomalariapharmacology.org)
Calkin AC, Tontonoz P. (2010) Liver x receptor signaling pathways and atherosclerosis. (guidetomalariapharmacology.org)

Generally, subfamily UGT1A enzymes conjugate the 3-hydroxyls of estrogens, while the activity of subfamily UGT2B is directed towards 16- and 17-hydroxyls. (helsinki.fi)
Otherwise, Foxo1 drives the transcription of enzymes involved in gluconeogenesis (PEPCK, glucose-6-phosphatase). (helmberg.at)

This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. (cancerindex.org)
Nuclear positioning, germinal vesicle breakdown, spindle migration, spindle rotation, chromosome segregation, and polar body extrusion are the most critical cellular processes during oocyte meiosis I and II, and a growing number of studies primarily using the mouse oocyte model revealed that actin filaments were critical for these processes, especially for spindle migration. (bioone.org)
Actin filaments widely involve into multiple cellular processes such as nuclear positioning, germinal vesicle breakdown, spindle migration, chromosome segregation, spindle rotation and polar body extrusion in oocyte mammalian meiosis. (bioone.org)

In a subsequent study, we examined how neurons in CA1 and CA3 responded differentially to OS increases in terms of the neuronal gene expression patterns and we identified genes whose expression distinguished the responses of CA1 from those of CA3 neurons [ 21 ]. (biomedcentral.com)
Transcriptomes from the tissues of the brain-pituitary-gonad (BPG) axis of T10 samples revealed a differential gene expression profile compared to the other experimental groups, with clustering in a principal component analysis and in heat maps of all differentially expressed genes. (biomedcentral.com)
This thermoception may have caused the observed effects through epigenetic mechanisms, since all analysed tissues further revealed differentially expressed genes involved in histone modification. (biomedcentral.com)

The NR4A1 gene contains seven exons. (wikipedia.org)
The DNA-binding domain at exons 3 and 4 of the NR4A1 gene is conserved among all members of the nuclear receptor. (wikipedia.org)

Chen WD, Wang YD, Meng Z, Zhang L, Huang W. (2011) Nuclear bile acid receptor FXR in the hepatic regeneration. (guidetomalariapharmacology.org)
Ding L, Yang L, Wang Z, Huang W. (2015) Bile acid nuclear receptor FXR and digestive system diseases. (guidetomalariapharmacology.org)

This process is mediated by the NF-κB (nuclear factor-kappa B) complex, a ubiquitous transcription factor involved in cellular response to stress. (wikipedia.org)
Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. (affbiotech.com)

Further, the data point to a novel ecdysone receptor that does not include Ultraspiracle but is probably comprised of EcR isoforms in Drosophila male accessory glands. (sdbonline.org)

The download advanced mass spectrometry reticulum city receptors very explore the businesses in elongation at the phosphorylates of valine. (evakoch.com)

Mechanistically, NR4A1 is preferentially recruited to binding sites of the transcription factor AP-1, where it represses effector gene expression by inhibiting AP-1 function. (wikipedia.org)
Intriguingly, the miR-34 -induced γ axon pruning defect resulted from downregulating the expression of ecdysone receptor B1 (EcR-B1) in differentiated MB γ neurons. (sdbonline.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancerindex.org)
GeneChip-based transcriptomic analyses revealed that vulnerable neurons had higher expression of genes related to stress and immune response, and lower expression of energy generation and signal transduction genes in comparison with resistant neurons. (biomedcentral.com)
FSHD is likely to be caused by inappropriate expression of the gene DUX4 in muscle cells. (arkansasbluecross.com)
Reductions in SMCHD1 gene product levels have been associated with D4Z4 contraction-independent DUX4 expression, suggesting that SMCHD1 acts as an epigenetic modifier of the D4Z4 allele (Lemmers, 2012b). (arkansasbluecross.com)
NMDA receptor subunits are expressed in competent larvae, during metamorphosis and in spat, but this expression is neither self-regulated nor regulated by catecholamines. (exeter.ac.uk)
Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. (affbiotech.com)
In this study, expression levels of CYP2J2 in various cancer types were determined using the Oncomine, the Gene Expression Profiling Interactive Analysis (GEIPA), DriverDBv3, UALCAN, and Tumor Immune Estimation Resource (TIMER) databases. (hindawi.com)
However, prognostic stratification by molecular markers (such as expression of specific genes) can improve the accuracy of prognostic prediction [ 8 ]. (hindawi.com)
We found that knockdown of Bonus in early oogenesis results in severe defects in ovarian development and in ectopic expression of genes that are normally repressed in the germline, demonstrating its essential function in the ovary. (elifesciences.org)
Together, our work identified Bonus as a regulator of tissue-specific gene expression and revealed the importance of SUMOylation as a regulator of complex formation in the context of transcriptional repression. (elifesciences.org)
One potential mechanism underlying the persistent effects of stress on visceral sensitivity could be epigenetic modulation of gene expression. (frontiersin.org)
Some of the receptors are cation channels, which can directly depolarize the nociceptor upon activation, while other receptors activate second messenger systems to change neuronal excitability by changing expression of, or modifying the function of, other cation channels. (frontiersin.org)
MRP4 (recently reviewed in [1] is found in a variety of human tissues, with high levels of mRNA expression in the kidney and prostate, and lower levels in the liver, testis, ovary, lung, parotid gland, adrenal gland, and in various neurons and blood cells. (solvobiotech.com)

Overexpression of Nuclear receptor 4A1 inhibits effector T cell differentiation, whereas deletion of NR4A1 overcomes T cell tolerance and exaggerates effector function, as well as enhancing immunity against tumor and chronic virus. (wikipedia.org)

GR versus RXR) and among receptor subtypes (RXRα versus RXRβ). (indigobiosciences.com)
Renal cell carcinoma (RCC), a tumor whose origin is the renal epithelium [ 1 ], can be grouped into various subtypes based on its histological characteristics, with KIRC accounting for the vast majority of renal cell carcinoma subtypes. (hindawi.com)

Polymorphisms in UGT genes have been linked to excretion of steroids and risk of some cancers. (helsinki.fi)

Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)

Furthermore, the information generated will allow future investigations of specific genes involved in particular stages of duck adipogenesis. (biomedcentral.com)

In mice fed normal diets and given injections of 1,25(OH)2D3, liver and plasma concentrations of 1,25(OH)2D3 increased and decreased in unison. (nih.gov)
Bełtowski J, Semczuk A. (2010) Liver X receptor (LXR) and the reproductive system--a potential novel target for therapeutic intervention. (guidetomalariapharmacology.org)
Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. (affbiotech.com)
In the liver, choroid plexus, prostatic acinar cells, and the GIT, MRP4 is expressed at the basolateral membrane, while in the brain capillary endothelium and renal proximal tubule cells it is expressed at the apical membrane [2-6]. (solvobiotech.com)

The genes present in these regions were identified and some can help explain the genetic basis of deposition and composition of fat in cattle. (biomedcentral.com)
The genomic regions and genes identified contribute to a better understanding of the genetic control of fatty acid deposition and can lead to DNA-based selection strategies to improve meat quality for human consumption. (biomedcentral.com)

In-situ hybridisation of CgNR1 in competent larvae identified NMDA receptor presence in the apical organ/cerebral ganglia area with a potential sensory function, and in the nervous network of the foot indicating an additional putative muscle regulatory function. (exeter.ac.uk)

Pramfalk C, Pedrelli M, Parini P. (2011) Role of thyroid receptor β in lipid metabolism. (guidetopharmacology.org)

Further, the GR gene expresses a splicing variant GRbeta, which does not bind glucocorticoids but functions as a dominant negative isoform for GRalpha. (brainimmune.com)

The intra- and intertumor heterogeneity of cell types and gene mutations as well as the complexity of the microenvironment contribute to limiting the efficacy of the current therapeutic options for high grade glioma. (mdpi.com)

for example, it accounts for only 6% of LGMD cases in Denmark. (medscape.com)
Improved diagnostic methods have demonstrated that a large group of neuromuscular disorders, including some that were not truly LGMD, were included in this definition. (medscape.com)

Three transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)
We identified 45 coding variants with frequencies ≥ 1% in any one ethnic group (43 non-synonymous variants). (biomedcentral.com)

Anatomy11

Organisms7

Chemicals and Drugs123

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes53

Disciplines and Occupations1

Information Science4

Remodelling by a nuclear hor1

Superfamily8

Protein23

Hormone24

Coactivator3

Retinoid3

Family of intracellular transcription factors2

Biosynthesis3

Cassette subfamily1

Hormones5

Target genes1

Estrogen2

Proteins6

Antibody3

Trends Endocrinol Metab1

Androgen receptor7

Agonists1

Regulate1

Encodes2

Specificity1

Glucocorticoid receptor1

Ligand3

Candidate genes2

Ligands2

Orphan receptors1

Systematic1

Heterodimer1

Binds4

Proliferation and differentiation1

Encode1

Regulation5

Functional1

Phenotype4

Pathways3

Enzymes2

Chromosome3

Differentially3

Exons2

Bile Acid2

Cellular2

Drosophila1

Mass spectrometry1

Expression16

Differentiation1

Subtypes2

Polymorphisms1

Human genes1

Specific genes1

Liver4

Genetic2

Apical1

Thyroid1

Glucocorticoids1

Mutations1

LGMD2

Variants2