Degree of stenosisAtherosclerosisArteriesLuminalProgression of atherosclerotic lesionsRuptureSeverity of coronary arteryOcclusionStenoticThrombosisArterialComplex lesionsBurdenBifurcationIntracranial atherosclerotic diseaseLumenVesselCharacteristicsDiameter stenosisAngiographyAtherectomySevere stenosesCarotid atheroscleroticBalloon angioplastyAsymptomaticAngiographicSymptomatic carotidVascularVulnerable plaquesAtheromaPrevalenceStentLess than 50LipidAssessmentExtracranialMorphologyIntermediate lesionsThrombusCommonlyAccumulationMyocardial infarctionClinicalEarly lesionsAtheromatous plaquesComputed tomographyPatientsCoronary vesselsClassification
Degree of stenosis7
- Computational modeling of atherosclerotic plaque progression in carotid lesions with moderate degree of stenosis. (tum.de)
- IVUS is of use to determine both plaque volume within the wall of the artery and/or the degree of stenosis of the artery lumen. (wikipedia.org)
- Treatment is with statins, anti-hypertensive and antiplatelet agents, and, in some cases (depending on the degree of stenosis and associated symptoms) , surgical revascularization. (lecturio.com)
- Within the ulcerated plaque group, there was a correlation between degree of stenosis and high HDJ-2 mRNA expression (r = 0.896, P = .016). (wustl.edu)
- However, there was no correlation between degree of stenosis and high HDJ-2 mRNA expression within the nonulcerated plaque group (r = 0.530, P = .076) or within the entire group of patients (r = 0.0085, P = .97). (wustl.edu)
- The following plaque characteristics were monitored: the echogenic patterns (soft, intermediate, hard, and mixed), the surface aspects, and the degree of stenosis. (unipg.it)
- Significantly more often there was an increase in the degree of IA stenosis, and hence migration to groups with a more severe degree of stenosis, in persons not taking statins ( p =0.000), in smokers ( p =0.005), and in patients suffering from diabetes ( p =0.015). (angiol.ru)
Atherosclerosis22
- The term atherosclerosis is derived from the Greek "athero," meaning gruel, or wax, corresponding to the necrotic core area at the base of the atherosclerotic plaque, and "sclerosis" for hardening, or induration, referring to the fibrous cap of the plaque's luminal edge. (medscape.com)
- The etiology of atherosclerosis is unknown, but there are multiple factors that contribute to atherosclerotic plaque progression. (medscape.com)
- During atherosclerosis, the narrowing of the arterial lumen is observed through the accumulation of bio compounds and the formation of plaque within artery walls. (springer.com)
- Atherosclerosis is a progressive disease, with a characteristic increase in lipid accumulation, inflammation, and plaque formation within the arterial walls [ 1 ]. (springer.com)
- Therefore, we investigated the possible association of ACE gene insertion/deletion (I/D) polymorphism and the severity of atherosclerosis, estimated on the basis of the number of coronary stenoses and critical arterial occlusions observed during coronary angiography. (degruyter.com)
- When compared with the TID-negative control cohort, TID-positive patients had no significant differences in the presence and extent of atherosclerosis, the degree of coronary artery stenosis, or the calcium score at cardiac CT. (snmjournals.org)
- For scientists and clinicians who carry out research about the genesis of atherosclerosis, it has always been compelling to somehow quantify the grade of severity of coronary artery calcification and stenosis. (dovepress.com)
- Presence of atherosclerosis (stenosis), increased the resistance and therefore blood flow reduced inside the artery and also the remarkable change occurred in pressure distribution and wall shear stress. (scirp.org)
- This phenotypic switch is central to many vascular illnesses, which include atherosclerosis, re-stenosis, and vascular aging (332). (adenosine-kinase.com)
- Immune mechanisms are thought to play a pivotal role in atherosclerosis, 1, 2 and inflammatory mediators are thought to be instrumental in early atherosclerotic lesion formation, plaque progression, and plaque rupture. (bmj.com)
- Atherosclerosis imaging has been traditionally based on the evaluation of coronary luminal narrowing and stenosis. (encyclopedia.pub)
- Magnetic resonance angiography (MRA) was used to detect cervical and/or intracranial plaque, and ultrasonography was used to quantify carotid intima-media thickness (IMT) as an index of subclinical atherosclerosis. (biomedcentral.com)
- To gain insight into the role of glycemic variability in the different stages of atherosclerosis, we used both ultrasonography and MRA to determine preclinical atherosclerosis and plaque formation. (biomedcentral.com)
- and (ii) to explore the role of glycemic variability in both the subclinical stage and plaque formation stage of atherosclerosis in this population. (biomedcentral.com)
- Arteries: Histology (ICAs) secondary to atherosclerosis Atherosclerosis Atherosclerosis is a common form of arterial disease in which lipid deposition forms a plaque in the blood vessel walls. (lecturio.com)
- ABCDE Assessment and fatal stroke (with atherosclerosis Atherosclerosis Atherosclerosis is a common form of arterial disease in which lipid deposition forms a plaque in the blood vessel walls. (lecturio.com)
- The development of atherosclerosis which can progress silently during decades is characterized by the thickening and loss of elasticity of the arteries owing to the formation of atherosclerotic plaques in lesion-prone areas. (icmub.com)
- Since atherosclerosis is involved in most cardiovascular diseases which are the leading cause of morbidity and death in the world, the identification of vulnerable plaques (i.e. rupture-prone plaques) constitutes an urgent need which would result in health benefits. (icmub.com)
- Although the histopathology of intracranial atherosclerotic disease resembles extracranial atherosclerosis, there are some notable differences in the onset and severity of atherosclerosis. (j-stroke.org)
- Atherosclerosis is characterised by an alteration of the vascular endothelium and the formation of atherosclerotic plaques that decrease the lumen of blood vessels. (pocketdentistry.com)
- Small vessel disease was the most common stroke etiology for single small lacunar lesion while large artery atherosclerosis was associated with single large lesion and multiple lesions in the posterior circulation. (scirp.org)
- It is widely acknowledged that inflammatory reactions contribute considerably to the production of atherosclerosis, from original atherosclerotic plaque to subsequent destabilization and eventual rupture [ 1 ]. (biomedcentral.com)
Arteries23
- IVUS is used in the coronary arteries to determine the amount of atheromatous plaque built up at any particular point in the epicardial coronary artery. (wikipedia.org)
- Atherosclerotic plaques eventually lead to the blockage of blood flow, causing in extreme cases, the eventual rupture of the arteries [ 2 ]. (springer.com)
- Percutaneous transluminal coronary rotational atherectomy (PTCRA) debulks atherosclerotic plaque from coronary arteries using an abrasive burr. (cochrane.org)
- To assess the effects of PTCRA for coronary artery disease in patients with non-complex and complex lesions (e.g. ostial, long or diffuse lesions or those arising from in-stent re-stenosis) of the coronary arteries. (cochrane.org)
- The invention relates to devices and methods for removing tissue from body passageways, such as removal of atherosclerotic plaque from arteries, utilizing a rotational atherectomy device. (justia.com)
- A frequent objective of such techniques and instruments is the removal of atherosclerotic plaques in a patient's arteries. (justia.com)
- Such procedures are used most frequently to initiate the opening of calcified lesions in coronary arteries. (justia.com)
- In another study, 1 they used a more precise system by classifying the coronary vessels as non/slightly/moderately/severely/totally obstructed depending on the grade of obstruction in percental gradations from no to total stenosis, but they concentrated on the major arteries and branches. (dovepress.com)
- By the development of atherosclerotic plaques that protrude into the lumen, arteries get narrowed and stenosed arteries are formed. (scirp.org)
- In atherosclerotic plaques, which represent chronically inflamed parts of arteries, SMCs reside predominantly within the superficial components of lesions. (adenosine-kinase.com)
- Recently, CRP was identified within early atherosclerotic lesions in human coronary arteries obtained at necropsy. (bmj.com)
- Carotid artery stenosis is a chronic atherosclerotic disease resulting in narrowing of the common and internal carotid arteries. (lecturio.com)
- Carotid Artery Stenosis is a narrowing of the common and internal carotid arteries Arteries Arteries are tubular collections of cells that transport oxygenated blood and nutrients from the heart to the tissues of the body. (lecturio.com)
- There was no significant difference in hsp60 expression between carotid artery plaques and normal arteries (21.0 ± 0.9 vs 20.6 ± 0.8, P = .65). (wustl.edu)
- As a result, the luminal narrowing (stenosis) of the modified arteries occurs and limits therefore the blood flow which can lead to tissue ischaemia. (icmub.com)
- CAD, also known as ischaemic heart disease, involves the reduction of sufficient blood flow to the heart muscles due to atherosclerotic lesions in coronary arteries. (pocketdentistry.com)
- In this way, vital arteries become progressively narrow and this results in stenosis. (pocketdentistry.com)
- At the initial degree of IA stenosis up to 50% and 50-69%, patients should be recommended to correct any risk factors (primarily diabetes, smoking, hypercholesterolemia, arterial hypertension), and to undergo duplex scanning of the brachiocephalic arteries with a frequency of 1-2 times a year. (angiol.ru)
- In the progression of atherosclerotic lesions of the brachiocephalic arteries, disturbances occur interdependently in the venous system, its extra- and intracranial sections. (angiol.ru)
- Changes in the structural and functional parameters of the internal jugular veins with varying degrees of stenosis of the carotid arteries were studied in fragments. (angiol.ru)
- To study the venous outflow through the internal jugular veins at different degrees of the internal carotid arteries stenosis. (angiol.ru)
- Here we show, that carotid arteries expressed intimal neovascularization associated with CD105-positive endothelial cells, concomitant with increased inflammation in early stage lesions, preatheroma (I-III) whilst they were not present in coronary plaques of the same grade. (biomedcentral.com)
- In high-grade lesions, neovessel proliferation was similar in both arterial types and significantly higher numbers of CD105-positive vasa vasorum were associated with plaque regions in coronary arteries. (biomedcentral.com)
Luminal4
- A modified version of the AHA classification was developed by our laboratory to include important pathologic lesions responsible for luminal thrombosis other than plaque rupture, such as plaque erosion and calcified nodule. (medscape.com)
- 3. Zhao X, Underhill HR, Cai J, Zhao Q, Li F, Oikawa M, Dong L, Ota H, Hatsukami TS, Yuan C. Discriminating Carotid Atherosclerotic Lesion Severity by Luminal Stenosis and Plaque Burden: A Comparison Utilizing High-Resolution Magnetic Resonance Imaging at 3.0 Tesla. (tsinghua.edu.cn)
- The level of expression of HDJ-2 mRNA was also correlated to the presence of plaque ulceration and the degree of luminal stenosis associated with the lesion. (wustl.edu)
- Conclusion: These results demonstrate that expression of HDJ-2 is significantly increased in atherosclerotic carotid artery plaques as compared with hsp60 and hsp70 and correlates with luminal stenosis in ulcerated atherosclerotic carotid artery plaques. (wustl.edu)
Progression of atherosclerotic lesions1
- Intravascular ultrasound provides a unique method to study the regression or progression of atherosclerotic lesions in vivo. (wikipedia.org)
Rupture13
- Some plaques remain quiescent and stable for years and others become unstable and vulnerable, ultimately leading to plaque rupture. (nature.com)
- Lesion reference to AHA types V and VI was discarded, because it failed to account for the 3 different morphologies (rupture, erosion, and calcified nodule) that give rise to acute coronary thrombosis. (medscape.com)
- This may increase vulnerability to plaque rupture and thrombosis, with subsequent clinical sequelae. (bmj.com)
- Most acute coronary events are triggered by plaque rupture or erosion. (encyclopedia.pub)
- Hence, atherosclerotic plaque imaging has generally focused on the detection of vulnerable plaque prone to rupture. (encyclopedia.pub)
- However, most acute coronary events occur from atherosclerotic plaque rupture or erosion causing arterial thrombosis [ 3 ] . (encyclopedia.pub)
- This objective is based on the identification of coronary atherosclerotic burden, its extent and pathological characteristics which are closely associated with progression and rupture of vulnerable plaques. (encyclopedia.pub)
- Extensive calcification is associated with higher risk of CAD, because the presence of more plaques increases the chance that one may rupture. (encyclopedia.pub)
- However the most severe complications arise from the rupture of the atherosclerotic plaques which accounts for 70% of heart attacks. (icmub.com)
- This strategy carries the promise to significantly improve the detection of vulnerable plaques and therefore to prevent from the dramatic issue of their rupture. (icmub.com)
- Since intimal neovascularization contributes significantly to subsequent plaque instability, haemorrhage and rupture. (biomedcentral.com)
- Neovessel growth occurs in regions of atherosclerotic lesions undergoing remodelling, plaque 'shoulders' prone to rupture. (biomedcentral.com)
- The formation of atheromatous plaques in the carotid artery - also called calcified carotid atheromatous plaques (CCAP) - is not a simple and inevitable degenerative process resulting from advanced age, but rather a chronic inflammatory disease that can develop into an acute clinical condition owing to plaque rupture, rendering the patient susceptible to thromboembolism or stroke 2 . (bvsalud.org)
Severity of coronary artery2
- The ACE I/D polymorphism influences individual differences in severity of coronary artery disease and the D allele promotes generation of numerous and critical atherosclerotic lesions. (degruyter.com)
- In this study, cardiac CT was used to evaluate the prevalence of atherosclerotic lesions and the severity of coronary artery stenosis in patients with TID of the left ventricle with or without associated myocardial perfusion defects on SPECT MPI. (snmjournals.org)
Occlusion3
- These complications are caused by thrombotic arterial occlusion localized at the site of high-risk atherosclerotic plaques, of which early detection and therapeutic stabilization are urgently needed. (nature.com)
- 16 In addition, the management of patients with acute symptomatic carotid artery occlusion remains controversial, though the angiographic finding of ICA occlusion reveals a spectrum of ICA occlusions, as well as a tandem lesion in the intracranial artery in addition to the level (below or above the ophthalmic artery) and type (atherosclerotic or embolic) of lesion. (ajnr.org)
- We sought to evaluate the safety and efficacy of the Tigertriever device in patients with large vessel occlusion (LVO) and underlying intracranial atherosclerotic disease (ICAD). (bmj.com)
Stenotic5
- Such atheromas restrict the flow of blood, and therefore often are referred to as stenotic lesions or stenoses, the blocking material being referred to as stenotic material. (justia.com)
- As renal atherosclerotic disease is continuously increasing, especially in the elderly population, it is important to implement a preventive analysis to identify patients with potential renal stenotic lesions. (gsdinternational.com)
- For several years, the treatment of stenotic lesions by percutaneous angioplasty (PTA) has been considered the revascularization procedure of first choice, reserving the use of conventional surgery (aorto-renal bypass) only in cases where percutaneous treatment has proved ineffective. (gsdinternational.com)
- Intravascular ultrasound (IVUS) is superior to coronary angiography in terms of accurate assessment of lumen area and plaque burden and thus is commonly applied to evaluate intermediate stenotic lesions and guide the decision about revascularization in real-world practice [ 4 , 7 ]. (hindawi.com)
- Patients that are ideal for CAS include patients that have a high surgical risk, such as patients with prior neck irradiation, aberrant neck anatomy, contralateral recurrent laryngeal nerve injury, prior ipsilateral CEA, significant coronary artery disease, high cervical stenotic lesion location, and tracheostomy. (radiologykey.com)
Thrombosis3
- The earliest pathologic descriptions of atherosclerotic lesions focused on morphologies of fatty streaks to fibroatheromas (FAs) and advanced plaques complicated by hemorrhage, calcification, ulceration, and thrombosis. (medscape.com)
- and type VI, complicated plaques with surface defects, and/or hematoma-hemorrhage, and/or thrombosis. (medscape.com)
- As a rule, percutaneous coronary intervention (PCI) with drug-eluting stent implantation for every intermediate lesion could increase the risk of stent thrombosis or restenosis, whereas deferral revascularization of high-risk intermediate lesions might be associated with a higher risk of long-term events [ 5 , 6 ]. (hindawi.com)
Arterial11
- such as for the lumen of ostial lesions or where angiographic images do not visualize lumen segments adequately, such as regions with multiple overlapping arterial segments. (wikipedia.org)
- As a chronic inflammatory condition, one of its hallmarks is the narrowing of the arterial lumen through plaque buildup within the inner lining of artery walls. (springer.com)
- In the initial phase of plaque burden development, minimal build-up of plaque is observed in the intima of the artery, allowing the arterial lumen to remain unaffected. (springer.com)
- As the plaque expands, remodelling is observed to push the vessel wall outwards to maintain the volume of the arterial lumen. (springer.com)
- Treatment of coronary intermediate lesions remains a controversy, and the role of arterial remodeling patterns determined by intravascular ultrasound in intermediate lesion is still not well known. (hindawi.com)
- The aim of this study was to investigate the impact of arterial remodeling of intermediate coronary lesions on long-term clinical outcomes. (hindawi.com)
- Arterial remodeling patterns were assessed in 212 deferred intermediate lesions from 162 patients after IVUS examination. (hindawi.com)
- Furthermore, previous studies have shown that arterial remodeling assessed by IVUS in vivo affects hemodynamic stress on the lesion site [ 8 - 10 ] and is correlated with clinical presentation [ 11 , 12 ]. (hindawi.com)
- Accordingly, we sought to investigate the impact of arterial remodeling of intermediate lesions on long-term prognosis in patients with stable coronary artery disease. (hindawi.com)
- More recent techniques focus on the high-resolution visualization of the arterial wall and the coronary plaques. (encyclopedia.pub)
- History of arterial hypertension ( p =0.007), smoking ( p =0.03), as well as hemodynamically significant stenosis of IA ( p =0.000) had statistically significant effect on the dynamics of initial cerebrovascular insufficiency. (angiol.ru)
Complex lesions6
- Current clinical uses of IVUS technology include checking how to treat complex lesions before angioplasty and checking how well an intracoronary stent has been deployed within a coronary artery after angioplasty. (wikipedia.org)
- For those with complex lesions, PTCRA may provide some benefit in comparison to balloon angioplasty. (cochrane.org)
- In certain circumstances (e.g. patients ineligible for cardiac surgery, those with architecturally complex lesions, or those with lesions that fail PTCA), PTCRA may achieve satisfactory re-vascularisation in subsequent procedures. (cochrane.org)
- There was no evidence of the effectiveness in improving patient outcomes of PTCRA in non-complex lesions. (cochrane.org)
- Morphological characteristics distinguishing complex lesions have not been examined in parallel-arm randomised controlled trials. (cochrane.org)
- Prof Gil has wide scientific and research interests including the evaluation of atherosclerotic plaque characteristic and distribution, coronary stenosis significance, treatment of complex lesions, notably bifurcation lesions using invasive diagnostic techniques that include IVUS, OCT or iFR/FFR. (radcliffecardiology.com)
Burden5
- Additionally, IVUS examinations, as they were done more frequently, served to reveal and confirm the autopsy research findings of the late 1980s, showing that atheromatous plaque tends to cause expansion of the internal elastic lamina, causing the degree of plaque burden to be greatly underestimated by angiography. (wikipedia.org)
- BACKGROUND: Computed tomography-adapted Leaman score (CT-LeSc) was developed to quantify coronary CT angiography information about atherosclerotic burden (lesion localization, stenosis degree, and plaque composition). (who.int)
- Imaging techniques provide direct assessment of coronary atherosclerotic burden and pathological characteristics of atherosclerotic lesions which may predict the progression of disease. (encyclopedia.pub)
- It is recommended that in aircrew with non-obstructive coronary artery disease or obstructive coronary artery disease not deemed haemodynamically significant, nor meeting the criteria for excessive burden (based on plaque morphology and aggregate stenosis), a return to flying duties may be possible, although with restrictions. (bmj.com)
- It is recommended that aircrew with haemodynamically significant coronary artery disease (defined by a decrease in fractional flow reserve) or a total burden of disease that exceeds an aggregated stenosis of 120% are grounded. (bmj.com)
Bifurcation3
- In these videos, Prof Robert Gil and Dr Tomasz Pawlowski perform three cases, incorporating the treatment of OM-CX with bifurcation - dedicated stent, Bifurcation stenting and Complex PCI in distal LM stenosis. (radcliffecardiology.com)
- Further references and insights to this bifurcation campaign can be found by clicking here for the "Performing PCI in Coronary Bifurcation lesions in 2021" white paper and clicking here to view the "How to Perform PCI in Coronary Bifurcation Lesions in 2021" webinar. (radcliffecardiology.com)
- Stents are used frequently for acute myocardial infarction, ostial or left main disease, chronic total occlusions, and bifurcation lesions. (msdmanuals.com)
Intracranial atherosclerotic disease1
- Current understanding of intracranial atherosclerotic disease has been advanced by the high-resolution magnetic resonance imaging (HRMRI), a novel emerging imaging technique that can directly visualize the vessel wall pathology. (j-stroke.org)
Lumen5
- yet considerable plaque was within the newly widened lumen and the lumen remained partially obstructed. (wikipedia.org)
- This recognition promoted more frequent use of stents to hold the plaque outward against the inner artery walls, out of the lumen. (wikipedia.org)
- The range of lumen stenosis locations at which myocardial infarctions occurred ranged from areas of mild dilation all the way to areas of greater than 95% stenosis. (wikipedia.org)
- This leads to vascular remodeling resulting inside the plaque formation and narrowing in the vessel lumen. (adenosine-kinase.com)
- Patients were enrolled if they had de novo lesions with a visual estimation of lumen DS of 50-70% and without revascularization (balloon angioplasty and/or stent implantation) after IVUS examination. (hindawi.com)
Vessel6
- Angiotensin II is produced primarily by angiotensin I-converting enzyme (ACE) within atherosclerotic lesions and ACE level in plaques correlates with the severity of vessel wall damage. (degruyter.com)
- D allele carriers ( DD+ID genotypes) were more frequent in the subgroup of patients with stenoses in at least four coronary vessels than in other patients including subjects with one-, two- and three-vessel disease (97.4% vs. 74.4%, OR=13.05, 95% CI: 1.81-100.00, χ 2 =9.84, p=0.0017). (degruyter.com)
- These plaques are built from the accumulation of fatty materials within the vessel walls and by the modification of the connective tissue of the vessel walls. (icmub.com)
- The aim of the study was to evaluate plaque evolution, in relation both to the degree of vessel stenosis produced and to the echostructural characteristics of the lesion. (unipg.it)
- It is defined as thickening of blood vessel walls due to the accumulation of lipids, inflammatory cells and fibrous components, forming the so called atheromatous plaque. (pocketdentistry.com)
- A lesion in the LAD can have severe consequences, as suggested by the common nickname given to this vessel: "widow maker. (medscape.com)
Characteristics5
- It is unknown whether gender influences the atherosclerotic plaque characteristics (APCs) of lesions of varying angiographic stenosis severity. (bvsalud.org)
- For example, in one of their studies, Proudfit et al 3 concentrated on the number of severe stenoses and correlated them to clinical characteristics such as duration of the history of angina pectoris, distribution of pain, and serum cholesterol. (dovepress.com)
- Importantly, OCT identified a culprit lesion in 46% of patients most commonly via characteristics of a ruptured or "active" plaque, consistent with atherosclerotic pathophysiology of infarction although not low limiting. (doximity.com)
- However, the pathological validation of HRMRI signal characteristics remains a key step to depict the plaque components and vulnerability in intracranial atherosclerotic lesions. (j-stroke.org)
- Relation of Gender to Atherosclerotic Plaque Characteristics by Differ" by Rebecca Jonas, Toral Patel et al. (gwu.edu)
Diameter stenosis1
- Risk stratification and management strategy of intermediate coronary lesions, defined as 50-70% diameter stenosis (DS) at coronary angiography [ 1 , 2 ], remain a challenging issue [ 3 , 4 ]. (hindawi.com)
Angiography7
- Arguably the most valuable use of IVUS is to visualize plaque, which cannot be seen by angiography. (wikipedia.org)
- In the early 1990s, IVUS research on the re-stenosis problem after angioplasty lead to recognition that most of the re-stenosis problem (as visualized by an angiography examination) was not true re-stenosis. (wikipedia.org)
- Perhaps the greatest contribution to understanding, so far, was achieved by clinical research trials completed in the United States in the late 1990s, using combined angiography and IVUS examination, to study which coronary lesions most commonly result in a myocardial infarction. (wikipedia.org)
- This study evaluated the imaging data of 303 symptomatic patients from the derivation arm of the CREDENCE (Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia) trial, all of whom underwent coronary computed tomographic angiography and clinically indicated nonemergent invasive coronary angiography upon study enrollment. (bvsalud.org)
- Coronary CT angiography was used to evaluate each coronary segment for the presence and composition of atherosclerotic plaque and the degree of coronary stenosis. (snmjournals.org)
- Non-invasive visualization of the morphology of coronary atherosclerotic lesions is performed using computed tomography (CT), computed tomography coronary angiography (CTCA), and cardiac magnetic resonance (CMR). (encyclopedia.pub)
- There was no significant difference between the three groups as regard presence of significant intracranial stenosis in magnetic resonance angiography (MRA). (scirp.org)
Atherectomy3
- ELCA coronary laser atherectomy catheters are designed to cross, prepare and treat the most complex coronary lesions. (philips.ie)
- This non-mechanical atherectomy catheter can be delivered over any .014" wire and can de-bulk and modify plaque of multiple morphologies and is approved for the broadest range of coronary indications in atherectomy. (philips.ie)
- n = 18) underwent directional coronary atherectomy for coronary lesions. (bmj.com)
Severe stenoses1
- Only 14% of heart attacks occurred at locations with 75% or more stenosis[citation needed], the severe stenoses previously thought by many to present the greatest danger to the individual. (wikipedia.org)
Carotid atherosclerotic3
- Evolutionary trends in carotid atherosclerotic plaques: results of a two-year follow-up study using an ultrasound imaging system. (unipg.it)
- In this review, the authors concentrate their discussion on the treatment of carotid atherosclerotic disease with particular attention on the endovascular treatment. (radiologykey.com)
- Endovascular therapy for the treatment of carotid atherosclerotic disease has advanced over the last decade and is now considered to be a viable alternative to carotid endarterectomy (CEA) in appropriately selected patients. (radiologykey.com)
Balloon angioplasty1
- For non-calcified lesions, balloon angioplasty most often is used alone to open the artery, and stents often are placed to maintain patentcy of the opened artery. (justia.com)
Asymptomatic3
- Successful implementation of best medical treatment for patients with asymptomatic carotid artery stenosis within a randomized controlled trial (SPACE-2). (tum.de)
- Renal artery stenosis is usually asymptomatic for a considerable period of time. (gsdinternational.com)
- In the groups with 50-69% and 70-99% stenosis, differences between the number of asymptomatic and symptomatic patients at the beginning and end of the follow-up period were significant ( p =0.000). (angiol.ru)
Angiographic2
- This assessment must incorporate angiographic findings, a detailed risk assessment and a nuanced management plan that must include aggressive control of the atherosclerotic disease process to ensure safety of flight. (bmj.com)
- Mean peak troponin was 17 times the upper limit of normal with angiographic assessment showing maximal stenosis of 30% (26-37%) in patients of whom 44% had abnormal echo segmental wall motion abnormalities. (doximity.com)
Symptomatic carotid1
- 70%) symptomatic carotid stenosis have up to a 20% risk of an ipsilateral stroke over the following 3-month time period, with 30% to 35% risk of ipsilateral stroke over 2 to 3 years' time when treated with optimum medical management. (radiologykey.com)
Vascular3
- The reason behind the malfunction of cardio-vascular system is the presence of fats, cholesterol and lipoproteins at the sites of atherosclerotic lesion in the artery. (scirp.org)
- C reactive protein (CRP), an important serum marker of atherosclerotic vascular disease, has recently been reported to be active inside human atherosclerotic plaques. (bmj.com)
- Aneurysms: congenital and acquired vascular aneurysm (atherosclerotic, aortitis and syphilitic aneurysm). (unibo.it)
Vulnerable plaques3
- In high-risk patients, intravascular imaging provides accurate assessment of vulnerable plaques and early stage of their development. (encyclopedia.pub)
- Although these multifunctional gold nanoparticles exhibit the potential for a targeted imaging, they are handicapped by a too rapid renal clearance which should impede a sufficient accumulation in the vulnerable plaques. (icmub.com)
- Besides a greater circulation time, the accumulation of these golden nanoflowers designed for multimodal imaging (MRI/PET and CT) will be ensured by the avidity of macrophages for nanoparticles which are present in a large amount in the vulnerable plaques and by the specific interaction between the peptides coated to the golden nanoflowers and cell adhesion molecules (VCAM-1). (icmub.com)
Atheroma1
- The studies revealed that most myocardial infarctions occur at areas with extensive atheroma within the artery wall, however very little stenosis of the artery opening. (wikipedia.org)
Prevalence1
- Unfortunately, the early macroscopic examination only described the prevalence and severity of ICAS by characterizing the surface involvement of fatty streak, plaque, ulcerated lesion, and calcification changes, failing to provide the detailed features of individual intracranial atherosclerotic lesions. (j-stroke.org)
Stent2
- There is limited published evidence and no long-term data to support the routine use of PTCRA in in-stent re-stenosis. (cochrane.org)
- In the presence of a hemodynamically significant stenosing lesion, a short hospitalization is proposed for the performance of transluminal angioplasty (PTRA) or endovascular stent placement. (gsdinternational.com)
Less than 503
- However the average or typical stenosis at which myocardial infarctions occurred were found to be less than 50%, describing plaques long considered insignificant by many. (wikipedia.org)
- The incidence of increasing grade of IA stenosis in the groups with initial stenosis less than 50% and 50-69% was statistically significant ( p =0.001 and p =0.000, respectively). (angiol.ru)
- In the groups with less than 50% stenosis and occlusions the dynamics of initial cerebrovascular insufficiency was insignificant ( p =0.643). (angiol.ru)
Lipid2
- A non-linear optical imaging modality (NLOM), coherent anti-stokes Raman scattering (CARS) microscopy, can be used to image lipid-rich structures commonly found in atherosclerotic plaques. (springer.com)
- Lipid deposition is a key phenomenon in atherogenesis and plaques are formed by an LDL cholesterol core and a fibrous capsule ( Fig 2-1 ). (pocketdentistry.com)
Assessment1
- The aim of performing imaging diagnostic tests is the assessment of patients at risk of acute coronary events associated with plaque formation, before atherosclerotic complications occur. (encyclopedia.pub)
Extracranial1
- A two-year follow-up on 118 atherosclerotic lesions of the extracranial carotid tract observed in 70 patients was carried out using real-time high-resolution echotomography. (unipg.it)
Morphology1
- Valvular heart disease: morphology and pathogenesis of rheumatic heart disease, aortic stenosis, mitral valve prolapse, infective endocarditis, non-bacterial thrombotic endocarditis. (unibo.it)
Intermediate lesions1
- Quantitative flow ratio was assessed for evaluating the functional significance of intermediate lesions. (hindawi.com)
Thrombus2
- Echocardiogram, cardiac magnetic resonance, and computed tomography showed mitral stenosis and a left atrial thrombus. (bvsalud.org)
- Left atrial thrombus formation is a well-known complication of severe mitral stenosis that can lead to systemic thromboembolism. (bvsalud.org)
Commonly1
- Carotid artery stenosis is commonly diagnosed via carotid duplex ultrasound. (lecturio.com)
Accumulation3
- The progressive accumulation of plaque within the artery wall over decades is the setup for vulnerable plaque which, in turn, leads to heart attack and stenosis (narrowing) of the artery (known as coronary artery lesions). (wikipedia.org)
- The most common type of gingivitis involves the marginal gingiva and is brought on by the accumulation of microbial plaques in persons with inadequate oral hygiene. (medscape.com)
- The initial stage of an acute exudative inflammatory response begins within 4 or 5 days of plaque accumulation. (medscape.com)
Myocardial infarction1
- Characteristic electrocardiographic pattern indicating a critical stenosis high in left anterior descending coronary artery in patients admitted because of impending myocardial infarction. (medscape.com)
Clinical2
- Since the late 1960s, the severity of coronary stenosis was suspected to be a prognostic factor for patients with coronary artery disease (CAD), 1 - 3 and this hypothesis was proven in several clinical studies with long follow-up periods. (dovepress.com)
- IVUS-derived negative remodeling is associated with adverse long-term clinical outcome in stable patients with intermediate coronary artery stenosis. (hindawi.com)
Early lesions2
- Gingivitis proceeds through an initial stage to produce early lesions, which then progress to advanced disease. (medscape.com)
- At approximately 1 week, transition to early lesions is marked by the change to predominately lymphocytic infiltrates. (medscape.com)
Atheromatous plaques1
- In the mid 1990s the terminology used to define atheromatous plaques was refined by the American Heart Association (AHA) Consensus Group headed by Dr. Stary. (medscape.com)
Computed tomography2
- Fluorescence emission computed tomography detecting near-infrared autofluorescence allows in vivo monitoring of intraplaque hemorrhage, establishing a preclinical technology to assess and monitor plaque instability and thereby test potential plaque-stabilizing drugs. (nature.com)
- Facing the real and urgent need, the CARGOLD project aims at developing nanoprobes for early detection of vulnerable atherosclerotic plaques and therapy by magnetic hyperthermia from multifunctional nanostructures whose physical and chemical properties render possible the specific targeting of these plaques, their follow-up by integrated MRI/PET device and also by computed tomography (CT) after intravenous injection, a therapeutic activity and their removal by bio-degradation and renal clearance. (icmub.com)
Patients15
- We suggest that near-infrared autofluorescence imaging is a novel technology that allows identification of atherosclerotic plaques with intraplaque hemorrhage and ultimately holds promise for detection of high-risk plaques in patients. (nature.com)
- Besides establishing fluorescence emission tomography (FLECT) as a preclinical tool for the detection of plaques with intraplaque hemorrhage and its potential use in testing and monitoring of plaque-stabilizing drugs, our report has the potential to support technical developments for imaging technologies that will ultimately allow to risk stratify atherosclerotic plaques in patients and, in particular, to identify plaques that are prone to cause cardiovascular events. (nature.com)
- 72 intermediate remodeling lesions were present in 66 patients, whereas 77 negative remodeling lesions were present in 71 patients, and 63 positive remodeling lesions were present in 55 patients. (hindawi.com)
- The presence of CRP, complement, and oxLDL in a high proportion of plaque tissue from patients with unstable coronary artery disease implies that these surrogate markers have important proinflammatory effects inside atherosclerotic plaques. (bmj.com)
- Identifying patients at increased risk of coronary artery disease, before the atherosclerotic complications become clinically evident, is the aim of cardiovascular prevention. (encyclopedia.pub)
- One hundred and fifty-three patients (70.8%) presented with cervical and/or intracranial lesions on MRA among 216 patients in the study. (biomedcentral.com)
- In patients without stenosis ( n = 63), SDBG ( r = 0.412, P = 0.001) and MAGE ( r = 0.365, P = 0.005) were both correlated with carotid IMT and these relationships remained significant in multiple linear regression analysis (multiple R 2 = 0.314 for the model including SDBG and multiple R 2 = 0.268 for the model including MAGE). (biomedcentral.com)
- However, SDBG and MAGE were not significantly different among patients with different stenosis degrees. (biomedcentral.com)
- Overall, 44% of patients were identified as not having an atherosclerotic case suggesting spasm, thromboembolism and or a missed culprit lesion. (doximity.com)
- Compared to the late onset of intracranial atherosclerotic lesions in Caucasians, various degrees of ICAS were detected in patients with younger age in Asians [ 12 - 15 ]. (j-stroke.org)
- Patients with type II and III aortic arches, tortuous common carotid artery (CCA), or young patients with otherwise normal anatomy and a low-lying cervical lesion location precluding mandibular disarticulation are best served with CEA. (radiologykey.com)
- Carotid artery stenosis in patients is usually discovered after an ischemic event (either a transient ischemic attack [TIA] or a permanent stroke). (radiologykey.com)
- Patients were classified according to infarction patterns into a single small lacunar lesion (group I), a single large lesion (group II), and multiple scattered lesions (group III) 20 patients in each group. (scirp.org)
- The study included 82 patients with atherosclerotic lesions of the IA observed for various diseases in A.V. Vishnevsky National Medical Research Center of Surgery for the period from 2010 to 2022. (angiol.ru)
- Patients with initial or developed hemodynamically significant IA lesions had the development of strokes in half of the cases (53.5%) ( p =0.000), and every third case was fatal ( p =0.009). (angiol.ru)
Coronary vessels2
- The frequencies of DD genotype, D allele carrier-state ( DD+ID genotypes) and the D allele increased with the number of stenoses in coronary vessels. (degruyter.com)
- PTCRA utilises small rotating devices to selectively remove the build-up of atherosclerotic plaques from within coronary vessels. (cochrane.org)
Classification3
- In contrast, our study demonstrates that autofluorescence in the NIR range uniquely characterizes atherosclerotic plaques with intraplaque hemorrhage and may allow classification of atherosclerotic plaques into lesions of low or high risk for future cardiovascular events. (nature.com)
- [ 1 ] In this modified classification, numeric AHA lesions types I to IV are replaced by descriptive terminology to include adaptive intimal thickening, intimal xanthoma, pathologic intimal thickening (PIT), and fibroatheroma, as shown in the table below. (medscape.com)
- Through the combination of CARS microscopy and computational methods, a powerful classification tool was developed to identify the progression of atherosclerotic plaque in an automated manner. (springer.com)