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Sertoli Cell-Only SyndromeSertoli CellsSpermatogenesisTestisSyndromeSertoli Cell TumorSeminiferous TubulesSeminiferous EpitheliumStem CellsBlood-Testis BarrierDown SyndromeMetabolic Syndrome XSpermatidsSpermatogoniaFollicle Stimulating HormoneSpermatocytesCells, CulturedLeydig CellsSexual MaturationNephrotic SyndromeReceptors, FSHSpermatozoaSjogren's SyndromeCell DifferentiationTestosteroneAndrogen-Binding ProteinRNA, MessengerImmunohistochemistryTesticular HormonesGerm CellsTurner SyndromeInhibinsHematopoietic Stem CellsPlant StemsMolecular Sequence DataMyelodysplastic SyndromesStem Cell TransplantationEncyclopedias as TopicLoveCoitusCourtshipAdolescent BehaviorInterpersonal Relations
Spermatogonial stem cellsSpermatogenesisSperm2018DifferentiateEmbryonicOvarianHaploid cellsMitosisHormonesDifferentiationTesticularGerm cellOccursSeminiferous tubulesFormationNucleiGeneticViabilityVitroSomaticPancreaticBacterialTestisMammalianHomeostasisCumulusChromosomesAdjacentBasalMRNAsRegulationMechanismAdultMutationsPatientsTypesDonorReceptorProductionDivisionCancer stemVivoMeiosisFundamentalHumansDevelopmentCrucialRecognitionMiceGametesRoleEffectsDemonstrateFunctionBrain
Spermatogonial stem cells3
  • These cells are called spermatogonial stem cells. (wikipedia.org)
  • The seminiferous tubules of the testes are the starting point for the process, where spermatogonial stem cells adjacent to the inner tubule wall divide in a centripetal direction-beginning at the walls and proceeding into the innermost part, or lumen-to produce immature sperm. (wikipedia.org)
  • NANOS2 has also been identified as a key stem cell regulator in Spermatogonial Stem Cells (SSC) of mature individuals by maintaining the stem cell fate during spermatogenesis in mice 10 . (nature.com)
Spermatogenesis8
Sperm5
  • These develop into mature spermatozoa, also known as sperm cells. (wikipedia.org)
  • Stem cells for sperm are found in the walls of the semeniferous tubules. (ivf1.com)
  • when the cells divide, they go through a process called meiosis which gives the sperm the correct number of chromosomes and another process which gives the sperm it characteristic appearance. (ivf1.com)
  • during the final changes of cell division, the nearly mature sperm call is deposited into the lumen of the semeniferous tubule. (ivf1.com)
  • In order to produce sperm, testosterone production form other cells in the testicles is needed. (ivf1.com)
20184
  • Chollangi T, Clabault H, Thibeault A, Yong HE, Narula S, Menkhorst E, Sanderson JT, Vaillancourt C, Murthi P (2018) An electrical impedance-based assay to examine functions of various placental cell types in vitro. (hudson.org.au)
  • de Kretser DM, Stanton P, O'Donnell L (2018) Structure/Cells overview. (hudson.org.au)
  • Funder JW (2018) Mineralocorticoids and Mineralocorticoid Excess Syndromes: Pathophysiology. (hudson.org.au)
  • Lyons VG, Payne NL, McCoy CE (2018) Optimization techniques for miRNA expression in low frequency immune cell populations. (hudson.org.au)
Differentiate2
  • Type A cells replenish the stem cells, and type B cells differentiate into primary spermatocytes. (wikipedia.org)
  • Signs and symptoms of a blocked shunt are sometimes tough to differentiate from these of tethered cord syndrome or twine compression related to Chiari kind 2 malformation. (ehd.org)
Embryonic1
  • In mouse, only epiblast cells can be directly converted into cultured pluripotent embryonic stem cells, capable of forming all adult cell types. (bioone.org)
Ovarian4
  • Collins K , Segura S, Hwang M. Endocrine cell micronests in an ovarian mucinous borderline tumor: a potential diagnostic pitfall for microinvasion. (iu.edu)
  • Ovarian cancer stem cells that reside within the tumor play a role in cancer recurrence and progression. (biomedres.us)
  • Although some reviews are available on this topic, this review is comprehensive and provides novelty as it includes the role of cancer stem cells in ovarian cancer development in addition to other risk factors. (biomedres.us)
  • Incidence and severity of ovarian hyperstimulation syndrome (OHSS) in high responders after gonadotropin-releasing hormone (GnRH) agonist trigger in "freeze-all" approach. (ivi-rmainnovation.com)
Haploid cells2
  • Thus, the primary spermatocyte gives rise to two cells, the secondary spermatocytes, and the two secondary spermatocytes by their subdivision produce four spermatozoa and four haploid cells. (wikipedia.org)
  • and the unique differentiation of haploid cells (spermiogenesis) (Figure 1 ). (jci.org)
Mitosis2
  • C ) Expansion of both the undifferentiated (A spermatogonia) and differentiated (A1 spermatogonia) spermatogonial populations occurs by mitosis of these cell types, regulated in part by FSH. (jci.org)
  • During mitosis, cells undergo symmetrical cell division, while oocyte meiotic maturation undergoes two consecutive, asymmetric divisions that generate a totipotent haploid oocyte and two small polar bodies not involved in DNA replication. (bioone.org)
Hormones4
  • The production of these hormones increases gradually until sexual maturation is met. (wikipedia.org)
  • The blood carries the hormones to target cells that contain specific receptor proteins for the hormones, and which therefore can respond in a specific fashion to them. (50webs.org)
  • These hormones are made in the cell bodies and then transported to the axon terminals. (pharmaceuticalintelligence.com)
  • The gland consists of numerous cell types, which specialize in making and releasing specific hormones. (pharmaceuticalintelligence.com)
Differentiation1
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Testicular1
  • Acosta AM, Al-Obaidy KI, Sholl LM, Dickson BC, Lindeman NI, Hirsch MS, Collins K , Fletcher CD, Idrees MT. Sarcomatoid Yolk Sac Tumor Harbors Somatic Mutations That Are Otherwise Rare in Testicular Germ Cell Tumors. (iu.edu)
Germ cell3
  • Nanos are RNA-binding proteins playing crucial roles in germ cell development and maintenance. (nature.com)
  • Nanos1A was strongly expressed in brain and also localized in all germ cell types in the polarized testis. (nature.com)
  • The Nanos proteins family regroups highly conserved RNA-binding proteins in higher eukaryotes implicated in germ cell development and maintenance. (nature.com)
Occurs1
Seminiferous tubules1
  • B ) Histological cross section through an adult mouse testis depicting seminiferous tubules, the peritubular myoid cells, and the interstitium (space between tubules). (jci.org)
Formation1
  • Compared to vehicle controls, 2i conditions increased the abundance of cumulus cells in bovine IVF cultures, which compromised blastocyst formation. (bioone.org)
Nuclei2
  • In addition, Nanos1B protein was predominantly located in the nuclei of male germinal cells. (nature.com)
  • The cell bodies of these neurons are clustered in groups, called nuclei. (pharmaceuticalintelligence.com)
Genetic3
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
  • It is organized into sections by subtype of condition (e.g., infections, genetic syndromes, medication-caused) and includes a section of variants of acne that may be misdiagnosed. (nshealth.ca)
  • Genetic Syndromes Mimicking Acne Vulgaris -- 25. (nshealth.ca)
Viability2
  • Although pentastatin reduced the viability of endothelial cells, smooth muscle cell proliferation was induced. (bvsalud.org)
  • Environmental stress or suboptimal growth conditions reduce cell viability and put cells at risk. (prolekarniky.cz)
Vitro3
  • In vitro, treatment with pentastatin induced transcription of immediate early genes and proinflammatory cytokines and led to a functional loss of endothelial barrier integrity in pulmonary arterial endothelial cells. (bvsalud.org)
  • Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)
  • Endometrial Cells Acutely Exposed to Phthalates In Vitro Do Not Phenocopy Endometriosis. (ivi-rmainnovation.com)
Somatic1
  • In the ovary, both paralogs were detected in germinal and somatic cells. (nature.com)
Pancreatic2
  • the endocrine portion of the pancreas is composed of clusters of cells called the pancreatic islets (islets of Langerhans). (50webs.org)
  • Lysosomes in nutrient signalling: A focus on pancreatic β-cells. (uni-bielefeld.de)
Bacterial1
  • Boosting NAD+ production increased NAD+ levels in immortalized and primary cells and decreased bacterial replication upon infection. (bvsalud.org)
Testis1
  • The structure, regulation, and cell types of the mouse testis. (jci.org)
Mammalian1
  • Mammalian CDs are surrounded by a cell membrane and contain cytoplasm that houses the cytosol and cytoskeletal network [ 7 ]. (biomedcentral.com)
Homeostasis2
  • Mutations in shelterin components cause Dyskeratosis Congenita (DC) and related disease syndromes due to the inability to maintain telomere homeostasis. (prolekarniky.cz)
  • Cells maintain their internal homeostasis by adequate reprogramming of metabolic activities at all levels of gene expression, including chromatin remodeling, mRNA expression and degradation, translation and protein degradation. (prolekarniky.cz)
Cumulus3
  • HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
  • Following cumulus removal, 2i accelerated blastocyst development and increased inner cell mass (ICM) and trophoblast cell numbers by 30% and 27%, respectively. (bioone.org)
Chromosomes1
  • To preserve the number of chromosomes in the offspring - which differs between species - one of each gamete must have half the usual number of chromosomes present in other body cells. (wikipedia.org)
Adjacent1
  • check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)
Basal1
  • FGF10 treatment triggered an initial increase in the number of alveolar type 2 cells that gradually returned to the basal level when the FGF10-mediated repair process progressed. (bvsalud.org)
MRNAs1
  • Given the considerable time needed to activate new genes and/or de novo synthesize mRNA, the translation of existing mRNAs provides the necessary plasticity for the cell to selectively and rapidly respond to stress [1] , [2] . (prolekarniky.cz)
Regulation1
  • We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
Mechanism2
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • Through this mechanism the eukaryotic cell dynamically represses and reactivates translation at low metabolic costs. (prolekarniky.cz)
Adult1
  • A role of this gene in Germinal Stem Cells maintenance may be evolutionarily conserved as Nanos2 is specifically expressed both in oogonia and in spermatogonia of adult medaka 11 and in a subpopulation of undifferentiated A spermatogonia in juvenile and spermiating male trout 12 . (nature.com)
Mutations1
  • Functional impact and targetability of PI3KCA, GNAS, and PTEN mutations in a spindle cell rhabdomyosarcoma with MYOD1 L122R mutation. (iu.edu)
Patients1
  • Clinically diagnosed by the mucocutaneous abnormalities, DC patients are prone to developing bone marrow failure, multiple types of cancers and a spectrum of diseases collectively characterized as "telomere syndromes" [ 24 ]. (prolekarniky.cz)
Types1
  • The mitotic division of these produces two types of cells. (wikipedia.org)
Donor2
  • In mice, fibroblast growth factor (FGF) 10 is essential for lung morphogenesis, and in humans, polymorphisms in the human FGF10 gene correlate with an increased susceptibility to develop COPD.We analysed FGF10 signalling in human lung sections and isolated cells from healthy donor, smoker, and COPD lungs. (bvsalud.org)
  • An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response. (lookformedical.com)
Receptor2
  • or actively by prior immunization of the recipient with graft antigens which evoke specific antibodies and form antigen-antibody complexes which bind to the antigen receptor sites of the T-cells and block their cytotoxic activity. (lookformedical.com)
  • Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody [NBP2-22523] - Analysis of 25 ug of mouse thyroid (lane 1), NIH-3T3 (lane 2) and A431 (lane 3) cell lysates onto an SDS polyacrylamide gel. (novusbio.com)
Production3
  • We found the NAD+ salvage pathway to be dysregulated upon infection in a cell line model, primary human lung tissue and in vivo in rodents, leading to a reduced production of NAD+. (bvsalud.org)
  • Recombinant human/mouse/rat BMP-2 (355-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. (novusbio.com)
  • Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. (novusbio.com)
Division2
  • This process starts with the mitotic division of the stem cells located close to the basement membrane of the tubules. (wikipedia.org)
  • In the following table, ploidy, copy number and chromosome/chromatid counts are for one cell, generally prior to DNA synthesis and division (in G1 if applicable). (wikipedia.org)
Cancer stem2
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
  • Epidemiologic factors were discussed under five subheadings including hereditary factors, cancer stem cells, hormonal influences, environmental factors, and lifestyle choices. (biomedres.us)
Vivo1
  • These effects on the pulmonary vascular cells were recapitulated ex vivo in the isolated-perfused lung model, where treatment with pentastatin-induced swelling of the endothelium accompanied by occasional endothelial cell apoptosis. (bvsalud.org)
Meiosis1
  • These cells then proceed through meiosis II, wherein sister chromatids are separated into individual cells. (jci.org)
Fundamental1
  • Because it is such a diverse population of cells, a fundamental question is whether they have a common precursor or whether each macrophage population develops from a different precursor. (frontiersin.org)
Humans1
Development1
  • From development to aging and disease, the brain parenchyma is under the constant threat of debris accumulation, in the form of dead cells and protein aggregates. (frontiersin.org)
Crucial1
  • Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. (prolekarniky.cz)
Recognition1
  • Then, we will discuss several principles that govern macrophage phagocytosis of apoptotic cells (efferocytosis), including the existence of redundant recognition mechanisms ("find-me" and "eat-me") that lead to a tight coupling between apoptosis and phagocytosis. (frontiersin.org)
Mice1
  • In mice, the suppression of Nanos3 expression in PGC resulted in the complete loss of germ cells in both sexes 9 . (nature.com)
Gametes1
  • These cells have the potential to become gametes but have not yet committed to the process. (jci.org)
Role1
  • Collagen IVα5 harbors a functionally active fragment within its C-terminal noncollageneous (NC1) domain, called pentastatin, whose role in pulmonary endothelial cell behavior remains unknown. (bvsalud.org)
Effects1
  • If these needs go undetected and remain unaddressed, the results can derail physical and social maturation and include life-long effects on health. (nshealth.ca)
Demonstrate2
  • Here, we demonstrate that pentastatin serves as a mediator of pulmonary endothelial cell dysfunction, contributing to pulmonary hypertension. (bvsalud.org)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Function1
  • Deposition of basement membrane components, such as collagen IVα5, is associated with altered endothelial cell function in pulmonary hypertension. (bvsalud.org)
Brain1
  • Microglial phagocytosis of apoptotic cells (efferocytosis) is at the core of the brain regenerative response. (frontiersin.org)