Stem bone regeneration. Medical search. Frequent questions

Here, by developing injectable, void-forming hydrogels that decouple pore formation from elasticity, we show that mesenchymal stem cell (MSC) osteogenesis in vitro , and cell deployment in vitro and in vivo , can be controlled by modifying, respectively, the hydrogel's elastic modulus or its chemistry. (nature.com)
Heterotopic ossification (HO) is a dynamic, complex pathologic process that often occurs after severe polytrauma trauma, resulting in an abnormal mesenchymal stem cell differentiation leading to ectopic bone growth in soft-tissues including tendons, ligaments, and muscles. (nih.gov)

Background: Connective tissue progenitors (CTPs) from native bone marrow (BM) or their culture-expanded progeny, often referred to as mesenchymal stem/stromal cells, represents a promising strategy for treatment of cartilage injuries. (whiterose.ac.uk)
Bone is a plastic tissue with a large healing capability. (oregonstate.edu)
However, extensive bone loss due to disease or trauma requires tissue-engineering applications. (oregonstate.edu)
Presently, bone grafting is the gold standard for bone repair, but presents serious limitations including donor site morbidity, rejection, and limited tissue regeneration. (oregonstate.edu)
Hutmacher, D. W. Scaffolds in tissue engineering bone and cartilage. (nature.com)
They developed a way to regenerate human bone and tissue using non-scale structures. (stemcellscourse.com)
Recently, we observed that NGF (Nerve growth factor)-responsive TrkA (Tropomyosin receptor kinase A)-expressing nerves invade sites of soft-tissue trauma, and this is a necessary feature for heterotopic bone formation at sites of injury. (nih.gov)
In the future, modulation of TrkA signaling may represent a potent means to prevent the trauma-induced heterotopic bone formation and improve tissue regeneration. (nih.gov)
Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. (gazi.edu.tr)
As is the case in most scientific pursuits, these accomplishments might be applied to other forms of regeneration and vice versa as scientists continue to study tissue engineering. (wikipedia.org)
In the last decade, there have been notable accomplishments in utilizing extracellular matrices (ECM) and stem cells to reconstruct lost tissue. (wikipedia.org)
May 2012 Barnard, E. and Wilhite M. Patent application number: 20120136287 "Regeneration of Vaginal Tissue with non-systemic vaginal administration of Estrogen" May 2009 Lyle, J. Patent application number: 20090124584 "Surgical Techniques: Reconstructive Surgery of the Clitoris after Ritual Excision. (wikipedia.org)
Thus, we show that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals. (kl.ac.at)
Data demonstrate MSC seeded POCfs support partial regeneration of bladder tissue in vivo. (northwestern.edu)
Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. (utwente.nl)
The features of BFPSCs were compared with bone marrow-derived stem cells (BMSCs) as a well known cell source for bone tissue engineering. (utwente.nl)
These results define BFP as a new, rich, and accessible source of stem cells for tissue engineering purposes. (utwente.nl)
The researchers believe that OCR stem cells will be found in human bone tissue, as mice and humans have similar bone biology. (sciencedaily.com)
The plasmid-seeded bio patch grew 44-times more bone and soft tissue in the affected area than with the scaffold alone, and was 14-fold higher than the affected area with no manipulation. (sciencedaily.com)
To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. (routledge.com)
Current approaches of regenerative therapies constitute strategies for bone tissue reparation and engineering, especially in the context of genetical diseases with skeletal defects. (hindawi.com)
Bone regeneration using electrospun nanofibers' implant has the following objectives: bone neoformation induction with rapid healing, reduced postoperative complications, and improvement of bone tissue quality. (hindawi.com)
The clinical purpose of these methods is the reparation or guided regeneration of damaged tissue, in our case, jaw bone affected by genetical diseases. (hindawi.com)
Different sources of living cells are described, as mesenchymal stem cells (MSCs), adipose-tissue derived stem cells, skin derived multipotent stem cells, or oral cavity MSCs, presenting compatible immunophenotype or morphology [ 2 , 3 ]. (hindawi.com)
Thus, the strategy of functionalization of nanofibers by nanoreservoirs of BMP-2 or BMP-7 showed a great efficiency for bone regeneration and increased the differentiation of MSCs (mesenchymal stem cells), accelerating the tissue regeneration in vivo [ 9 , 10 , 13 , 14 ]. (hindawi.com)
In this context, tissue engineering becomes relevant for the treatment of large bone defects, where cells or growth factors are incorporated into a three-dimensional scaffold to mimic native tissue architecture and function in terms of osteoconduction, osteoinduction and osteointegration. (amrita.edu)
MSCs have the ability to differentiate into adipocytes and chondrocytes forming fat tissue and cartilage as well as into bone cells - called osteocytes. (nature.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
Tamaddon M, Samizadeh S, Wang L, Blunn G, Liu C. Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering. (scielo.br)
are used to develop new bone substitutes that restore, improve or prevent the deterioration of compromised tissue function [ 8 8. (scielo.br)
Her research is focused on developing biomaterials and harnessing their potential for tissue regeneration. (southampton.ac.uk)
During her PhD, she focused on enhancing macrophage recruitment to defects and modulating the macrophage phenotype by drug delivery to accelerate the tissue regeneration process. (southampton.ac.uk)
She joined the Bone and Joint Research Group at the Centre for Human Development, Stem cells, and Regenerative Medicine in 2016 and focused on developing clay nanoparticles for stem cell-driven tissue regeneration funded by Dr Dawson's EPSRC fellowship ( Nanoclay group ). (southampton.ac.uk)
Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
2 , 3 Bone tissue engineering (BTE) attempts to solve the referred problems mentioned. (dovepress.com)
These include molecular and cellular materials that tissue engineer the bone. (allenpress.com)
2 , 3 Bone engineering involves the delivery of cells or biologic molecules such as growth factors to a defect site for tissue regeneration. (allenpress.com)
It is often necessary to use a scaffold for transplanting these cells to enhance the regeneration of the affected tissue or organ. (allenpress.com)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
ASCs are present in a number of posnatal tissues and are responsible for normal tissue renewal as well as for regeneration and healing after injuries. (bvsalud.org)
Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)

TGFβ3 recruited endogenous MSCs to initiate bone formation. (biomedcentral.com)
Researchers have identified a subpopulation of mesenchymal stem cells (MSCs) that boost the healing of bone fractures and show an ability to differentiate into various cell types. (lifeboat.com)
2018) that a subpopulation of MSCs, as well as sinusoidal endothelial cells (sECs) in the bone marrow (BM) of CD73-EGFP reporter mice, could be labeled in vivo. (lifeboat.com)
We took advantage of this model to explore the plasticity and osteogenic potential of CD73-EGFP+ MSCs in vitro and their role in the regenerative response upon bone lesion in vivo. (lifeboat.com)
When the hydrogels were used to transplant MSCs, the hydrogel's elasticity regulated bone regeneration, with optimal bone formation at 60 kPa. (nature.com)
Mesenchymal stem/progenitor cells (MSCs) are a multipotent population of cells that can differentiate into muscle, bone, fat, and other cell types in context-specific manners. (kl.ac.at)
Here, we show that Bzb induces MSCs to preferentially undergo osteoblastic differentiation, in part by modulation of the bone-specifying transcription factor runt-related transcription factor 2 (Runx-2) in mice. (kl.ac.at)
Mice implanted with MSCs showed increased ectopic ossicle and bone formation when recipients received low doses of Bzb. (kl.ac.at)
The results of a number of experimental animal studies also showed that cell therapy (bone marrow cells (BMCs), hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs)) might have the potential to rescue animals from organ injuries. (tmu.edu.tw)
It is known that MSCs can contribute to renal tubular regeneration after ATN, although the exact mechanism, either transdifferentiation or effects of paracrine/cytokines, is uncertain. (tmu.edu.tw)
The study also showed that the adult OCRs are distinct from mesenchymal stem cells (MSCs), which play a role in bone generation during development and adulthood. (sciencedaily.com)
Researchers presumed that MSCs were the origin of all bone, cartilage, and fat, but recent studies have shown that these cells do not generate young bone and cartilage. (sciencedaily.com)
The CUMC study suggests that OCR stem cells actually fill this function and that both OCR stems cells and MSCs contribute to bone maintenance and repair in adults. (sciencedaily.com)
New treatment strategies have pursued the idea of using mesenchymal stromal cells (MSCs) in combination with osteoinductive materials to guide differentiation of MSCs into bone cells ensuring complete bone regeneration. (nature.com)
After bone fractures mesenchymal stromal cells (MSCs) take on a key role in the in vivo bone repair process 1 . (nature.com)
The use of donor derived MSCs for triggering the bone regeneration in vivo is a promising tool for assisting the healing process. (nature.com)
Interaction of MSCs with bone morphogenic proteins (BMPs) in an alginate scaffold mimicking the extracellular matrix (ECM) in vivo enhances their differentiation into bone cells 9 . (nature.com)
Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
MSCs can be isolated from different locations, such as bone marrow, umbilical cord, placenta, adipose and dental tissues. (bvsalud.org)

But the cartilage regeneration capacity of these cells remains unpredictable because of cell heterogeneity. (whiterose.ac.uk)
Hypothesis: The harvest technique of BM may highly influence stem cell heterogeneity and, thus, cartilage formation because these cells have distinct spatial localization within BM from the same bone. (whiterose.ac.uk)
Clinical Relevance: The harvest technique of BM may be of major importance in determining the clinical success of BM mesenchymal stem/stromal cells in cartilage repair. (whiterose.ac.uk)
A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. (sciencedaily.com)
Using this marker, the researchers found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes. (sciencedaily.com)
If you make a fracture in the mouse, these cells will come alive again, generate both bone and cartilage in the mouse--and repair the fracture. (sciencedaily.com)
Several therapeutic applications are developed in the field of bone and cartilage defect treatments, based on the osteoinductive and osteoconductive properties of these materials but also on the intrinsic physiological regenerative properties of bone [ 3 ]. (hindawi.com)
GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)
The superior osteoinductive properties of BMP-2/7 are a consequence of its direct positive effect on progenitor cell homing at the implantation site, which consequently leads to upregulation of cartilage and bone related genes and biochemical markers. (lu.se)

Marrow-derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness. (nature.com)
Bladder regeneration studies have yielded inconclusive results possibly due to the use of unfavorable cells and primitive scaffold design. (northwestern.edu)
The team created a scaffold seeded with plasmids containing the genetic information for producing bone. (sciencedaily.com)
We can make a scaffold in the actual shape and size of the defect site, and you'd get complete regeneration to match the shape of what should have been there," Elangovan says. (sciencedaily.com)
The plasmid does its work by entering bone cells already in the body -- usually those located right around the damaged area that wander over to the scaffold. (sciencedaily.com)
When cells migrate into the scaffold, they meet with the plasmid, they take up the plasmid, and they get the encoding to start producing PDGF-B, which enhances bone regeneration. (sciencedaily.com)
Leader of the DIGITORR (Digital Oral Rehabilitation Research) team, focusing on validation of the digital workflow in prosthodontics and implant dentistry, 3D printed bone scaffold, bruxism monitoring etc. (researchgate.net)
For this purpose, we developed a fibrous scaffold resembling the bone/bone marrow extracellular matrix (ECM) based on protein without addition of synthetic polymers. (nature.com)
Incorporation of hydroxyapatite (HA) in a collagen scaffold dramatically improves bone morphogenic protein (BMP) sequestration via biophysical interactions with BMP, thereby providing more controlled BMP release compared with pristine collagen. (lu.se)

The use of scaffolds in combination with ASC and growth factors provides a valuable tool for guided bone regeneration, especially for complex anatomic defects. (oregonstate.edu)
Bone regeneration within the defects was evaluated after 1 month using histology and histomorphometry. (bvsalud.org)
There was no difference in bone regeneration between the bone defects treated with oADSC vs. just blood clot . (bvsalud.org)
After 1-month healing, the use of autologous oADSC did not improve bone regeneration in defects containing titanium devices with different surfaces. (bvsalud.org)
It also can be used to repair birth defects where there's missing bone around the head or face. (sciencedaily.com)
In vivo implantation of polycaprolactone (PCL) biomembrane functionalized with BMP-2/Ibuprofen in mouse maxillary defects was followed by bone neoformation kinetics evaluation using microcomputed tomography. (hindawi.com)
Segmental bone defects resulting from trauma or pathological conditions represent formidable clinical challenges in orthopaedic surgery. (amrita.edu)
Large bone defects can often not sufficiently be repaired by the body itself and require new clinical therapies 1 . (nature.com)
The association of scaffolds to repair extensive bone defects can contribute to their evolution and morphophysiological recomposition. (scielo.br)
The objective of this experiment was to evaluate the effects of PBM therapy on critical size defects filled with xenogenic bone substitute associated with fibrin biopolymer. (scielo.br)
Biocomplex favored the insertion and permanence of the particulate material in bone defects, creating a favorable microenvironment for accelerate repair process. (scielo.br)
Most bone defects such as fractures have the capacity for spontaneous regeneration, which leads to treatment by conventional therapies. (scielo.br)
However, in cases of large defects, fractures with loss of segment and resection of tumors, the use of grafts (autografts, allografts and xenografts) or bone substitutes may be indicated to contribute to healing [ 1 1. (scielo.br)
Regeneration of large bone defects is a common clinical problem. (dovepress.com)
To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)
however, we hypothesize that the VSM can be used to deliver osteoblastic progenitors into bone defects. (allenpress.com)
The pretreatment of osteoblastic cells with PDGF-BB before transplantation into osseous defects is investigated in the present study to further investigate the role of this growth factor in bone regeneration. (allenpress.com)

Aerial and cross-sectional scans showed the plasmid-encoded scaffolds had spurred enough new bone growth to nearly close the wound area, the researchers report. (sciencedaily.com)
Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues. (routledge.com)
These biomembranes or scaffolds constitute a support for osteoblastic adhesion and proliferation, but also microenvironment for stem cells' chemotactism and differentiation [ 1 ]. (hindawi.com)
These different nanofiber scaffolds with nanoreservoirs are efficient proregenerative biomimicking implants for bone regeneration. (hindawi.com)
Traditional BTE involves three-dimensional biodegradable scaffolds, stem cells, and osteoinductive growth factors. (dovepress.com)
7 However, the scaffolds still face the problem of biocompatibility, mechanical properties, and bioresorbability, which are not adaptable to the properties of natural bone. (dovepress.com)
To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)

The challenge for existing stem cell-based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo , because stem cells are rather sensitive to even minute changes in their environment. (routledge.com)
This pure protein-based and chemically modifiable, fibrous ECM model allows the investigation of MSC behavior on biomimetic materials to unfold new vistas how to direct cells' differentiation for the development of new bone regenerating strategies. (nature.com)
Therefore, it is important to understand how MSC differentiation into bone cells is controlled and how this process can be guided or improved by externally added factors. (nature.com)
According to Korea Biomedical Review , the team found that nanoparticles displayed the potential to promote osteogenic differentiation (the process by which skeletal stem cells form, develop, repair, and maintain) of human mesenchymal (skeletal) stem cells (hMSCs) - adult cells obtained from bone marrow, not fetal cell lines - and subsequently enhance bone regeneration. (aleteia.org)
This sustained intracellular drug delivery capability is important because it could help direct stem cell differentiation , a pivotal aspect of stem cell therapy that directs the pliant stem cells to turn into the desired cell. (aleteia.org)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)

Since the iliac crest remains a frequent site of BM harvest for musculoskeletal regeneration, the authors also compared the spatial distribution of these subsets in trabeculae of femoral head and iliac crest and found CD2711CD561 bone-lining cells in both tissues. (whiterose.ac.uk)
A topical cream developed by Lyle Corporate Development, Inc., claims to encourage regeneration of tissues in the vulva that have undergone cellular hypoxia. (wikipedia.org)
Bone marrow transplantation and organ transplantation studies suggest that bone marrow cells can differentiate into a variety of non-hematological tissues, including renal cells. (tmu.edu.tw)
In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)

Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. (lu.se)

We delivered the DNA to the cells, so that the cells produce the protein and that's how the protein is generated to enhance bone regeneration," explains Aliasger Salem, professor in the College of Pharmacy and a co-corresponding author on the paper, published in the journal Biomaterials . (sciencedaily.com)

In order to do this, doctors have experimented with stem cells and extracellular matrix to provide a framework for regenerating missing structures. (wikipedia.org)
Nanofibrous and microporous membranes are very suitable to promote bone regeneration as a mimetic extracellular matrix. (hindawi.com)
Further evaluation of the molecular mechanisms responsible for this increased osteoinductivity at an early stage in the regeneration process indicated that the CHA+BMP-2/7 enhanced progenitor cell homing at the implantation site, upregulated the key transcriptomic determinants of bone formation, and increased the production of bone extracellular matrix components. (lu.se)

The aim of this study was to investigate the capacity of adipose-derived stem cells (ADSC), grown in serum -free conditions, to regenerate bone around titanium discs with different titanium surfaces. (bvsalud.org)
Researchers at the University of Iowa have created a bio patch to regenerate missing or damaged bone by putting DNA into a nano-sized particle that delivers bone-producing instructions directly into cells. (sciencedaily.com)
The experimental treatment was shown to regenerate the bone at a much faster rate than normal and the rat recovered completely. (aleteia.org)
The ability of osteoprogenitor cells to regenerate bone was significantly reduced upon pretreatment with PDGF-BB in vitro. (allenpress.com)

Stem Cell Training Inc.'s mission is to equip physicians with the latest and best in regenerative medicine techniques and technology, enabling them to offer these cutting-edge treatments to their patients. (stemcellscourse.com)
Some organizations which perform research into, or conduct regeneration procedures, include the Wake Forest Institute for Regenerative Medicine, the United States Department of Defense, and the California Institute for Regenerative Medicine. (wikipedia.org)
Drug targeting of adult stem cells has been proposed as a strategy for regenerative medicine, but very few drugs are known to target stem cell populations in vivo. (kl.ac.at)
This book presents the latest micro- and nanotechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. (routledge.com)
She is currently focused on modulating macrophage and stem cell responses to bioactive Nanoclay for bone regeneration in collaboration with Kyoto University, Japan, funded by MRC-AMED Regenerative Medicine and Stem Cell Research Initiative grant. (southampton.ac.uk)
Stem Cell Treatment in Puerto Vallarta Mexico presents regenerative medicine solutions based on proven medical innovation and research. (placidway.com)

1 The obstacles of current bone substitutes include the limited amounts of donor bone, the bone resorption of autografts, the risk of disease transmission and graft rejection of allografts, and the shortage of osteoinductive property for synthetic grafts. (dovepress.com)
Various materials have been used to promote bone regeneration around dental implants, including autografts, allografts, xenografts, and alloplasts. (allenpress.com)

The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells. (nature.com)
It also stimulated new growth in human bone marrow stromal cells in lab experiments. (sciencedaily.com)

By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration. (frontiersin.org)

Within the Collaborative Research Centre (CRC) 1149 "Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma", we offer an exciting interdisciplinary project to understand the cellular and molecular mechanisms of glucocorticoid action in skeletal stem/progenitor cells during bone regeneration. (hotdailytrends.com)
Unraveling mechanisms of GC signaling in skeletal stem/progenitor cells will provide rationales for therapeutic approaches in the field of bone regeneration. (hotdailytrends.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
We isolated bone marrow from mice at 8 time points after transplantation and examined the reconstitution dynamics and transcriptional profiles of stem and progenitor populations. (lu.se)

These problems can be partially circumvented by using macroporous biomaterials that improve the survival of transplanted stem cells and provide molecular cues to direct cell phenotype. (nature.com)
Published in the November issue of Biomaterials , these groundbreaking findings represent the first successful attempt to use saponin-based nanoparticles in stem cell therapy. (aleteia.org)
Bone grafts and biomaterials substitutes for bone defect repair: A review. (scielo.br)

Osteoblasts dissipate calcium and phosphate ions into the subjacent collagenous bone for the formation of hydroxyapatite (Ca 5 (PO 4 ) 3 (OH)) for bone stiffening 5 , 6 . (nature.com)
The team was able to create a concoction based on the saponin nanoparticles that successfully directed the human mesenchymal stem cells to differentiate into osteoblasts, or cells responsible for bone formation . (aleteia.org)
Cells used in bone engineering are the osteoblasts, osteoprogenitor cells, periosteal cells, and stem cells. (allenpress.com)

1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)

Bone marrow stem cell therapy for renal regeneration after acute tubular necrosis: A dream or a reality? (tmu.edu.tw)
Dive into the research topics of 'Bone marrow stem cell therapy for renal regeneration after acute tubular necrosis: A dream or a reality? (tmu.edu.tw)

In vivo bone regeneration on titanium devices using serum-free grown adipose-derived stem cells, in a sheep femur model. (bvsalud.org)

Cranial bone regeneration via BMP-2 enco. (gazi.edu.tr)
Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. (gazi.edu.tr)

Further study could provide greater understanding of how to prevent and treat osteoporosis, osteoarthritis, or bone fractures. (sciencedaily.com)
Large or complex bone fractures often need clinical treatments for sufficient bone repair. (nature.com)
In the neck, fractures of the posterior elements and dislocations can damage the vertebral arteries, causing a syndrome resembling a brain stem stroke. (msdmanuals.com)

Their findings are published in the journal Bone Reports in a paper titled, " Bone marrow CD73 + mesenchymal stem cells display increased stemness in vitro and promote fracture healing in vivo ," and led by researchers from the University of Tsukuba, in collaboration with the University of Bonn, Germany. (lifeboat.com)
Researchers also showed that OCR stem cells, when transplanted to a fracture site, contribute to bone repair. (sciencedaily.com)
Oct. 8, 2021 Researchers have identified a subpopulation of mesenchymal stem cells in the bone marrow that express the marker CD73. (sciencedaily.com)
Researchers have created an implantable bio patch that regrows bone in a living body, using existing cells. (sciencedaily.com)
The study is novel in that the researchers directly delivered bone-producing instructions (using piece of DNA that encodes for a platelet-derived growth factor called PDGF-B) to existing bone cells in vivo, allowing those cells to produce the proteins that led to more bone production. (sciencedaily.com)
The researchers then loaded the bio patch with synthetically created plasmids, each of which is outfitted with the genetic instructions for producing bone. (sciencedaily.com)
A team of researchers from the Catholic University of Korea School of Medicine recently revealed that they have been developing a method of stem cell therapy which allows for more efficient drug delivery at the cellular level, and it could also play a part in bone regeneration . (aleteia.org)
The study found that the unique properties of the saponin enabled nanoparticles to be absorbed into the stem cells without any prompting (electrical charge) from the researchers and facilitated the formation of cellular pores. (aleteia.org)
Researchers found success in testing their data on a defective femur bone of a rat. (aleteia.org)
At the end of 2023, researchers at Lund Stem Cell Center received funding amounting to SEK 77.5 million from the Swedish Research Council, the Swedish Cancer Society, and the Swedish Childhood Cancer Fund. (lu.se)
At Lund Stem Cell Center, researchers are using innovative approaches to advance the field, offering exciting possibilities for the future. (lu.se)

We hypothesized that human mesenchymal stem cells seeded onto poly(1,8-octanediol-co-citrate) elastomeric thin films would provide a suitable milieu for partial bladder regeneration. (northwestern.edu)

Fracture healing and bone repair. (scielo.br)
Nonunion and segmental bone loss after fracture, reconstructive surgery, or lesion excision can present complex orthopedic problems, and the multiple surgical procedures often needed are associated with patient morbidity and reduced quality of life. (who.int)
Extraction may also be contraindicated when it is adjacent to the site of jaw fracture, because the teeth may be required for stabilization of the fractured bone. (medscape.com)
Osteoporotic bones and degenerative joint disease may increase the risk of cord injury at lower impact velocities due to angulations formed by the degenerated joints, osteophytes impinging on the cord, and brittle bone allowing for easy fracture through critical structures. (msdmanuals.com)

Wild-Type (WT) and Tabby (Ta) mice were used to compare effects on a normal phenotype and on a mutant model of ectodermal dysplasia (ED). After 21 days, no effect on bone neoformation was observed in Ta treated lesion (4% neoformation compared to 13% in the control lesion). (hindawi.com)
In conclusion, PCL functionalized biomembrane promoted bone neoformation, this effect being modulated by the Ta bone phenotype responsible for an alteration of bone response. (hindawi.com)

These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Mice homozygous for a null allele exhibit incomplete prenatal lethality, decreased osteoclast cell number, decreased angiogenesis, increased long bone epiphyseal plate size, and short long bones. (jax.org)

However, the scarce locations available for autogenous bone harvesting as well as donor site morbidity require the search for other alternatives. (allenpress.com)

This review examines data that provides strong support for the clinical translation of ASC for bone regeneration. (oregonstate.edu)
Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. (uib.no)
Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
Recently, stem cell- and gene-based therapy has been applied in BTE and achieved some good clinical results. (dovepress.com)
However, conflicting results indicate the clinical use of β-TCP for bone repair remains questionable in several specific experiment models. (frontiersin.org)
Despite the glimmer of hope provided by the discovery and commercialization of bone morphogenetic protein-2 (BMP-2) as a bone graft substitute, side effects related to the use of supraphysiological doses have hindered its clinical usage. (lu.se)

This Autologous treatment is when you take the stem cells from the patient who is currently being treated. (stemcellscourse.com)
The following therapies do not rely on autologous cells: A vibration technique developed by Ellen L. Barnard and Myrtile Wilhite claims to promote regeneration in the vaginal cell lining. (wikipedia.org)
The bone regenerative capacity of autologous oADSC was evaluated in vivo on titanium discs in a sheep femur epicondyle model. (bvsalud.org)
The autologous graft is still considered the gold standard, as it has the necessary properties for bone regeneration, in terms of combined osteoconduction, osteoinduction and osteogenesis [ 5 5. (scielo.br)

Strategies for regeneration of the bone using porcine adult adipose-derived mesenchymal stem cells. (oregonstate.edu)
However, it has been shown that adipose-derived stem cells (ASC) have similar immunophenotype, morphology, multilineage potential, and transcriptome compared to BMSC. (oregonstate.edu)
To help relieve the pain, the doctors attending our courses are taught to use the equipments for PRP and Adipose derived stem cells isolation and processing. (stemcellscourse.com)

In summary, these studies further link injury site hyper-innervation with increased vascular ingrowth and ultimately heterotopic bone after trauma. (nih.gov)
Intense vascular proliferation and bone deposition around the biomaterial particles were observed in the animals of the groups in which biocomplex was applied (XS and XS-PBM). (scielo.br)

That prospect would be a "life-changing experience" for patients who need implants and don't have enough bone in the surrounding area, says Satheesh Elangovan, assistant professor in the UI's College of Dentistry and a joint first author, as well as co-corresponding author, on the paper. (sciencedaily.com)
Holistic Care is one of the best stem cell clinics in Mexico and the top conventional and alternative medicine offering Stem Cell Therapy and Biological dentistry. (placidway.com)
Objective: the aim of this study was to conduct a literature review of the types of stem cells of dental origin and their applications in Dentistry. (bvsalud.org)
Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
In the Dentistry field, stem cells derived situated in red and near-infrared region of electromagnetic from dental pulp have been isolated and investigated as spectrum. (bvsalud.org)

To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)

Currently, the bone autograft is the most frequently used strategy to manage large bone loss. (frontiersin.org)
Large bone loss as a result of trauma, tumor removal, infection, and developmental congenital disorders, often leads to delayed healing or non-union, and remains a critical challenge for orthopedic surgeons. (frontiersin.org)

The bone-regeneration kit relies on a collagen platform seeded with particles containing the genes needed for producing bone. (sciencedaily.com)
PBM therapy allowed an improvement in the formation of new bone, with a more organized deposition of collagen fibers in the defect area. (scielo.br)

Figure 2: Manipulating stem cell osteogenesis and proliferation by controlling the elasticity of the bulk phase of void-forming hydrogels. (nature.com)

Furthermore, this treatment increased bone formation and rescued bone loss in a mouse model of osteoporosis. (kl.ac.at)
With the formation of a bone callus and organization of the new bone in lamellae, the process can progress to complete remodeling and total repair. (scielo.br)
The results indicated that the BMP-2-producing cell sheet group was more efficient than other groups in promoting bone formation in the defect area. (dovepress.com)
Endochondral bone formation seems to be affected in MPS IV. (medscape.com)

Large segmental bone loss and bone resection due to trauma and/or the presence of tumors and cysts often results in a delay in healing or non-union. (frontiersin.org)

Stem Cells Int, 2017, 5718608. (lu.se)

Of these materials, autogenous bone grafts remain the gold standard for bone regeneration. (allenpress.com)

The functionalization of these matrices enhances the bone regenerative process. (hindawi.com)

Experience top stem cell treatments in Nuevo Progreso, Mexico by Dr. Omar Gonzalez Integra Medical Center. (placidway.com)
We hope that this new method will foster a culture of proactive health management and shift the paradigm towards preventive care, in addition to paving the way for more effective treatments," says Sandra Linstedt, research group leader at Lund Stem Cell Center. (lu.se)

Anatomy48

Organisms15

Diseases17

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes34

Disciplines and Occupations3

Technology, Industry, Agriculture22

Health Care1

Mesenchymal stem2

Tissue42

MSCs20

CARTILAGE9

Scaffold9

Defects18

Scaffolds7

Differentiation7

Tissues4

Hematopoietic Stem1

Enhance bone regeneration1

Extracellular matrix3

Regenerate4

Regenerative medicine6

Autografts2

Stromal cells2

Promote bone1

Progenitor4

Biomaterials3

Osteoblasts3

Embryonic stem1

Renal regeneration2

Vivo bone regeneration1

Cranial bone2

Fractures3

Researchers11

Human mesenchymal stem1

Fracture4

Phenotype2

Angiogenesis2

Donor site morbidity1

Clinical6

Autologous4

Adipose3

Vascular2

Dentistry5

Morphogenetic1

Large bone2

Collagen2

Osteogenesis1

Formation4

Segmental1

20171

Autogenous bone1

Enhances1

Treatments2