• They found multiple small molecule inhibitors of the HIV-1 Tat-TAR system that recognized the bulge, lower stem, or loop region of the TAR RNA. (wikipedia.org)
  • Tocriscreen Kinase Inhibitor 3.0 library is a collection of 210 kinase inhibitors supplied pre-dissolved in DMSO (100 μL 10 mM solution). (tocris.com)
  • To identify small-molecule inhibitors of SKP2, Chan and colleagues performed high-throughput in silico screening of an in-house chemical library and discovered a compound that potently and specifically inhibited SKP2 but not other F-box proteins. (aacrjournals.org)
  • The screening library consist of small molecule agonists, antagonists, and inhibitors. (invivochem.com)
  • Indeed, DNA methyltransferase inhibitors reduce the stem-like properties of ALDH1A1 positive cells in EOC. (ocrahope.org)
  • In my preliminary studies, I screened a library of small molecule inhibitors of epigenetic regulators to identify compounds that suppress ALDH1A1 activity in multiple EOC cell lines. (ocrahope.org)
  • Therefore, I hypothesize that targeting BRD4 using clinically applicable small molecule BET inhibitors is sufficient to overcome platinum resistance of EOC by eradicating CSCs. (ocrahope.org)
  • A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. (uclahealth.org)
  • They have a wide range of functions such as providing pig mentation to flowers, fruits, and seeds in order to attract pollinators and seed dispersers, protecting against ultraviolet light, providing defence Inhibitors,Modulators,Libraries against phytopathogens, playing a role in plant fertility and germi nation of pollen and acting as signal molecules in plant microbe interactions. (chk1inhibitor.com)
  • Enhancing the Inhibitors,Modulators,Libraries production of flavonoids in crop plants Inhibitors,Modulators,Libraries can there fore give an important boost to their Inhibitors,Modulators,Libraries nutritional value, which makes knowledge of expression and regulation of the flavonoid pathway important. (chk1inhibitor.com)
  • Otherwise, for those systems obtained by using a mixture between solid and liquid DAPT secretase Notch lipids, that is NLC C and NLC D samples, PDI values are acceptable in all investigated Inhibitors,Modulators,Libraries media. (chk1inhibitor.com)
  • In fact, a critical advantage in treat Inhibitors,Modulators,Libraries ing tumors with nanoparticulate systems comes from the unique patho physiological characteristics of solid tu mors extensive angiogenesis and hence hypervasculari zation, coupled with poor lymphatic drainage, which allow a facilitate extravasation into the tumor Inhibitors,Modulators,Libraries and EPR effect of colloidal systems. (chk1inhibitor.com)
  • Increasing evidences supporting the potential use of SIRT inhibitors (SIRTi) for the treatment of cancer, HIV infection, and muscular diseases and of SIRT activators (SIRTa) for age-related disorders have led to the identification of many SIRT modulators over recent years, mainly through chemical library screening and catalytic mechanism-based design approaches, often combined with structure-activity relationship (SAR) investigations. (biomedcentral.com)
  • Identification of small molecule inhibitors that target key post-transcriptional events will unlock the door for discovery of novel compounds. (genomeweb.com)
  • RNA-targeting small molecules represent a class of small molecules, organic compounds with traditional drug properties (e.g. (wikipedia.org)
  • Research Objective We propose to use a lung stem cell based organoid to identify a new compound for COVID-19 by screening a library of FDA approved compounds that could be repurposed for COVID-19 infection. (ca.gov)
  • The TSRI researchers, including lead author Michael J. Bollong, Ph.D., currently a Scripps Fellow in the Department of Chemistry, discovered FiVe1 by screening a library of about 50,000 small-molecule compounds for activity against EMT-transformed breast cancer cells. (scripps.edu)
  • Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. (chemscene.com)
  • Bioactive Compound Library Plus, with more powerful screening capability, further complements Bioactive Compound Library (HY-L001) by adding some compounds with low solubility or solution stability (Part B) and some novel, rare or exclusive compounds (Part C) to this library. (chemscene.com)
  • Screening libraries are a collection of different bioactive compounds that are Ready-to-use. (invivochem.com)
  • It is also demonstrated that the compounds in the libraries are stable, pure, and soluble. (invivochem.com)
  • Moreover, you can customize your library by selecting the compounds, sizes, quantities, format (powder or solution), and plate map that you want in our personalized bioactive screening libraries. (invivochem.com)
  • By screening large chemical libraries, scientists at these companies have identified compounds that activate neurogenesis from adult neural stem cells both in the lab and in mouse models of various neurodegenerative disorders. (biotechprimer.com)
  • Neuronascent's first focus is the development of small molecule compounds that promote neurogenesis for the treatment of Alzheimer's disease. (biotechprimer.com)
  • We employed this phenotypic screening strategy to uncover modulators of human synaptogenesis from a small molecule library and successfully identified a set of diverse compounds that increase the synaptic network connectivity in human neural co-culture. (mcgill.ca)
  • Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regeneration of heart muscle following myocardial infarction. (biomedcentral.com)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • By screening chemical diversity libraries and siRNA libraries, the technology allows simultaneous identification of both chemical compounds that are the starting point for drug development as well as pathways and new drug discovery targets and biomarkers," Robert Finney, president of PanGenex, said in a statement. (genomeweb.com)
  • Compounds of interest include not only classical "drug-like" organic small molecules, but also peptides, proteins, and other bioactive chemical classes. (cancer.gov)
  • The EMT also can be triggered by inflammation in adult tissues to transform epithelial cells into stem-like mesenchymal cells that aid wound healing. (scripps.edu)
  • Oct-4 (POU5F1) is a transcription factor that is critically involved in the self-renewal of pluripotent stem cells, and its expression is commonly used as a marker for pluripotency. (stemcell.com)
  • Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Huang et al. (stemcell.com)
  • Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. (stemcell.com)
  • Although hematopoietic stem cells (HSC) are the best characterized and the most clinically used adult stem cells, efforts are still needed to understand how to best ex vivo expand these cells. (stemcell.com)
  • Research Objective Greenstone Biosciences will use patient-derived stem cells to discover safe and effective drugs for cardiovascular disease. (ca.gov)
  • Impact The use of patient-derived stem cells to discover novel drug targets for cardiovascular disease, identify drug candidates, and establish clinical trial in a dish to evaluate drug safety and efficacy. (ca.gov)
  • Research Objective Intramuscular delivery of 2 repurposed FDA approved drugs to activate diaphragm stem cells to augment regeneration and restore strength to COVID-19 patients with diaphragm atrophy from ventilation. (ca.gov)
  • Research Objective Alveolar type II cells are the stem cells of the lung, and they are killed by SARS-CoV-2. (ca.gov)
  • Research Objective A vaccine booster to induce antigen-specific T memory stem cells that will help enhance the long-term immunity against cancer recurrence Impact Cancer recurrence presents an unmet medical need. (ca.gov)
  • We will induce T memory stem cells (TMSCs) to boost the long-term immunity. (ca.gov)
  • Lung tumor stem cells are a subpopulation of cells important for lung tumor development, metastasis, and medication resistance. (immune-source.com)
  • through targeting lung cancer stem cells. (immune-source.com)
  • In the latest years, people discovered that there is certainly a little subpopulation of cells in tumors, which play a essential function in the resistance of cancer to radiotherapy and chemotherapy. (immune-source.com)
  • Some combined groups screened the anticancer stem cells medication through little molecule screen. (immune-source.com)
  • Sphere Formation The lung cancer stem cells were accumulated by sphere formation. (immune-source.com)
  • In previous studies, scientists had demonstrated that the EMT process enables carcinoma cells to adopt the properties of cancer stem cells, namely chemotherapy resistance and the ability to migrate in the body to form metastases. (scripps.edu)
  • Researchers have become aware in just the last decade that breast, colon and other epithelial-derived tumor cells sometimes exploit the EMT to detach from a primary tumor and acquire stem-like properties. (scripps.edu)
  • The cells express FOXC2, a transcription factor gene that promotes the EMT and makes cancer cells more stem-like, more prone to metastasis and more resistant to treatment. (scripps.edu)
  • One compound performed particularly well at curbing the growth of the FOXC2-expressing cells without affecting non-FOXC2-expressing cells, and had other properties that make it potentially suitable as a small-molecule drug. (scripps.edu)
  • Pharmacologic blockade of SKP2 may eliminate cancer stem cells and overcome chemoresistance. (aacrjournals.org)
  • Intriguingly, depletion or pharmacologic inhibition of SKP2 also diminished the accumulation and self-renewal potential of prostate cancer stem cells (CSC), likely via suppression of AKT-mediated glycolysis and stimulation of senescence, and enhanced the sensitivity of prostate cancer cells to chemotherapeutic drugs. (aacrjournals.org)
  • Cell Signaling in Human Monocytes White blood cells collected by apheresis from G-CSF-mobilized normal stem cell donors were obtained from the Stem Cell Assay Laboratory/Hematology Cell Bank of the British Columbia Cancer Agency. (morainetownshipdems.org)
  • Recent data suggest that one mechanism for chemotherapy resistance is the presence of a population of cells with stem cell-like characteristics termed cancer stem cells (CSCs). (ocrahope.org)
  • Headlines touting stem cells often claim the therapies heal everything from hair loss to hearing loss. (biotechprimer.com)
  • Stem cells are unspecialized cells that have the ability to develop (differentiate) into 1 of 200 cell types in the body. (biotechprimer.com)
  • Embryonic stem cells, found only in developing embryos, can become any cell type within the adult body. (biotechprimer.com)
  • Adult stem cells, found within organs of a fully developed body, can become only certain cell types. (biotechprimer.com)
  • Embryonic stem cells have the most therapeutic potential. (biotechprimer.com)
  • The billion dollar market: grow and transplant stem cells into patients who have lost tissue due to acute trauma. (biotechprimer.com)
  • Since embryonic stem cells may come from unrelated donors, there is the likelihood of tissue rejection. (biotechprimer.com)
  • Thus there is considerable interest in developing therapies using a patient's own adult stem cells. (biotechprimer.com)
  • In certain tissues such as bone marrow, muscle, liver, and skin, damaged or worn out areas are naturally and regularly replaced by activated adult stem cells. (biotechprimer.com)
  • In other tissues such as heart and brain/spinal cord, adult stem cells exist in such small numbers, our body cannot readily activate them to replace tissue. (biotechprimer.com)
  • Progenitor Therapeutics is focused on discovering small molecule drugs that will nudge adult stem cells down the differentiation pathway. (biotechprimer.com)
  • They do this by testing hundreds of thousands of drugs on stem cells to see which bring out progenitor cell types. (biotechprimer.com)
  • Neuronascent (Clarksville, MD) and Neuralstem (Germantown, MD) are leading the charge in developing small-molecule activators of neurogenesis, or the generation of neurons (brain cells) from stem cells. (biotechprimer.com)
  • The differentiation of mesenchymal stem cells towards an osteoblastic fate depends on numerous signaling pathways, including activation of bone morphogenetic protein (BMP) signaling components. (medsci.org)
  • BMP signaling also has a critical role in the processes by which mesenchymal stem cells undergo commitment to the adipocyte lineage. (medsci.org)
  • In this study, we used dorsomorphin, a selective small molecule inhibitor of BMP signaling, to investigate whether BMP signaling is involved in the positive effects of PPARγ agonists on osteogenic phenotypes of cultured human periosteum-derived cells. (medsci.org)
  • This protocol describes an assay to quantify the uptake of these aggregates by neuronal cells by monitoring the uptake of fluorescently labelled α-synuclein preformed fibrils (PFFs) in dopaminergic (DA) neural progenitor cells (NPCs) derived from induced pluripotent stem cells (iPSCs). (zenodo.org)
  • The California Institute for Regenerative Medicine awarded Rubedo Life Sciences a $1.5 million grant to support research and development of a regenerative therapy for the treatment of idiopathic pulmonary fibrosis targeting senescent lung stem cells. (globalgenes.org)
  • The grant funding will enable Rubedo to characterize senescence cells, including senescent stem and progenitor cells in the lung of patients affected by IPF, a novel therapeutic opportunity to develop disease-modifying interventions for this chronic degenerative disease, as well as screen a library of senolytic small molecule prodrugs on IPF primary cells. (globalgenes.org)
  • While diverse brain cell types can now be generated from human pluripotent stem cells in vitro, knowledge of human synaptogenesis remains incomplete. (mcgill.ca)
  • Our results demonstrate the power of phenotyping assay in human neurons derived from pluripotent stem cells and provide a robust platform for the interrogation of neuronal connectivity in developmental and degenerative diseases. (mcgill.ca)
  • Nearly 70 years ago, Professor Charles Leblond led McGill in regenerative medicine with the first report of mammalian stem cells. (mcgill.ca)
  • Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. (lu.se)
  • To elucidate regulatory mechanisms governing the maintenance and propagation of human HSCs ex vivo, we screened libraries of annotated small molecules in human cord blood (CB) cells using an optimized assay for detection of functional HSCs during culture. (lu.se)
  • The physician scientists sought to identify glioblastoma subtype-specific cancer stem cells. (neurosciencenews.com)
  • This study shows that the mesenchymal subtype is the most aggressive subtype, that it has the poorest prognosis among affected patients, and that cancer stem cells isolated from the mesenchymal subtype have significantly higher levels of the enzyme ALDH1A3 compared with the proneural subtype. (neurosciencenews.com)
  • Our study suggests that ALDH1A3 is a potentially functional biomarker for mesenchymal glioma stem cells, and that inhibiting that enzyme might offer a promising therapeutic approach for high-grade gliomas that have a mesenchymal signature," says principal investigator Ichiro Nakano, MD, PhD, associate professor of neurosurgery at the OSUCCC - James. (neurosciencenews.com)
  • For this study, Nakano and his collaborators used cancer cells from 40 patients with high-grade gliomas, focusing on tumor cells with a stem-cell signature. (neurosciencenews.com)
  • Inhibiting ALDH1A3-mediated pathways slows the growth of mesenchymal glioma stem cells and might provide a promising therapeutic approach for glioblastomas with a mesenchymal signature. (neurosciencenews.com)
  • Overall, our data suggest that a novel signaling mechanism underlies the transformation of proneural glioma stem cells to mesenchymal-like cells and their maintenance as stem-like cells," Nakano says. (neurosciencenews.com)
  • These perturbations are applied to various types of human cells including induced pluripotent stem cells from patients, differentiated into various lineages such as neurons or cardiomyocytes. (my-mooc.com)
  • They tested the effects of A11 doses on the function of human microglia-like cells cultured from patient stem cells. (scientificinquirer.com)
  • When they exposed the microglia-like cells to immune molecules that typically trigger inflammation, cells dosed with A11 exhibited reduced expression and secretion of inflammatory cytokines and less of the cell body shape changes associated with microglia inflammatory responses. (scientificinquirer.com)
  • The cells also showed less accumulation of lipid molecules, another sign of inflammatory activation. (scientificinquirer.com)
  • Thus, small molecules capable of influencing the fate decisions and differentiation programs of multipotent progenitor cells could facilitate therapeutic regeneration of lost myocardium. (biomedcentral.com)
  • Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft model. (go.jp)
  • Pancreatic cancer is enriched with cancer stem cells (CSCs), which contribute to its high metastatic tendency and resistance to treatments. (ku.edu)
  • Our data showed that knockdown of HuR in pancreatic cancer cells significantly inhibited cell migration, invasion, and stem-like features. (ku.edu)
  • Camilla Forsberg studies how the different types of blood cells develop from hematopoietic stem cells in the bone marrow. (ucsc.edu)
  • Kim uses stem cells and mouse models of cancer to examine how lncRNAs are involved in epigenetic reprogramming. (ucsc.edu)
  • PanGenex, a subsidiary of drugmaker Cell Therapeutics, said this week that it has introduced a library of over 50,000 gene sequences and vectors that can be used to produce gene expression reporters and gene knockouts in human cells. (genomeweb.com)
  • PanGenex said that its scientists demonstrated at the International Conference on Molecular Targets and Cancer Therapeutics how gene expression reporter cells derived from the library can be used to screen siRNA reagents to identify key pathways associated with cancer. (genomeweb.com)
  • Similarly, single cell methods are vital in stem cell research and cancer biology, where isolated populations of primary cells are heterogeneous due to limitations in purification protocols, and it is often a minority cell population that is the most relevant. (justia.com)
  • Existing methods for measuring transcript levels in single cells include RT-qPCR (1), single molecule counting using digital PCR (2) or hybridization probes (3, 4), and next generation sequencing (5). (justia.com)
  • Mesenchymal Stem Cells (MSCs) are a heterogeneous subset of stromal stem cells that originate from the mesoderm layer of the fetus. (tocris.com)
  • Tocris offers the following scientific literature for Mesenchymal Stem Cells to showcase our products. (tocris.com)
  • Stem cells have potential as a source of cells and tissues for research and treatment of disease. (tocris.com)
  • Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids. (tocris.com)
  • Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. (tocris.com)
  • In the absence of SAP, interaction of CD48 on EBV-infected cells with 2B4 (a receptor belonging to the immunoglobulin superfamily that is found on natural killer [NK] cells as well as a small subset of T cells) on NK cells inhibits their ability to kill the EBV-infected cell. (medscape.com)
  • Application of the Pluripotent Stem Cells and Genomics in Cardiovascular Research-What We Have Learnt and Not Learnt until Now. (cdc.gov)
  • In early blood cells, called hematopoietic stem cells, the methylation patterns established by DNA methyltransferase 3 alpha promote maturation (differentiation) into different blood cell types. (medlineplus.gov)
  • they are typically found in a small percentage of cells and the mutations are not inherited. (medlineplus.gov)
  • Researchers speculate that the altered gene activity prevents hematopoietic stem cells from differentiating normally, which leads to the overproduction of abnormal, immature white blood cells characteristic of acute myeloid leukemia. (medlineplus.gov)
  • That includes research on things as small as molecules and cells and as large as whole organisms and entire populations and ecosystems. (medlineplus.gov)
  • Much of our current understanding of how small-molecule ligands interact with proteins stems from X-ray crystal structures determined at cryogenic (cryo) temperature. (rcsb.org)
  • Small molecules that behave like drugs can be used to explore the function of various proteins and large molecules, acting as chemical probes. (news-medical.net)
  • Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning. (go.jp)
  • CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules. (cdc.gov)
  • promotes the conversion of induced pluripotent stem cell-derived endoderm to a hepatic fate and regulates HNF4A turnover. (musc.edu)
  • Book] Cre/loxP, Flp/FRT systems and pluripotent stem cell lines. (nii.ac.jp)
  • The Tocriscreen Kinase Inhibitor 3.0 library is suitable for high-throughput screening (HTS), cell based high-content screening (HCS) and chemical biology applications. (tocris.com)
  • A selective inhibitor of SKP2 E3 ligase impairs cancer stem cell self-renewal and tumor growth. (aacrjournals.org)
  • Chapter 6) We then developed a small molecule inhibitor of HuR, KH-3, and evaluated the activities of KH-3 on pancreatic cancer EMT and CSCs. (ku.edu)
  • This protocol provides the details and methods we used for other researchers to screen small molecule libraries for actives that modulate the uptake of fluorescently labelled PFFs uptake in NPCs. (zenodo.org)
  • Currently, the only definitive treatment available for XLP1 patients is allogeneic hematopoietic stem cell transplantation (HSCT). (medscape.com)
  • Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. (aacrjournals.org)
  • Our ready-to-use ChemScene compound libraries consist of over 4000 small molecules with validated biological and pharmacological activities. (chemscene.com)
  • More than 10, 000 small molecules with verified pharmacological and biological activities are included in the libraries. (invivochem.com)
  • One researcher in Singapore is developing probes in reverse, starting with synthesized fluorescent molecules and then finding the targets that they label. (acs.org)
  • Lomenick B, Olsen RW, Huang J. Identification of direct protein targets of small molecules. (uclahealth.org)
  • Finally, we introduce crowdsourcing/citizen-science projects where students can work together in teams to extract expression signatures from public databases and then query such collections of signatures against LINCS data for predicting small molecules as potential therapeutics. (my-mooc.com)
  • Small molecules that are directed against RNA are slowly making their appearance as therapeutics, with one drug targeting non-ribosomal RNA approved a few months ago to help patients with spinal muscular atrophy (SMA). (news-medical.net)
  • Epigenetic aberrations are common in cancer and epigenetic regulators play a major role in stem cell differentiation. (ocrahope.org)
  • Inevitably, there are fundamental and applied questions, such as those relating to transcriptional control of stem cell differentiation, intrinsic noise in gene expression, and the origins of disease, that may only be addressed at the single cell level. (justia.com)
  • Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. (tocris.com)
  • This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. (tocris.com)
  • Before you can test antibodies functionally, you have to enrich them from phage display libraries that house billions of antibodies. (lu.se)
  • If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service . (tocris.com)
  • This initiative is one of the integrated components of the NIH Molecular Libraries Roadmap initiative that offers biomedical researchers access to large-scale automated high throughput screening (HTS) centers in the MLPCN, diverse compound libraries in the Small Molecule Repository (MLSMR) and information on biological activities of small molecules in the PubChem BioAssay public database. (nih.gov)
  • Compound libraries are useful professional tools for drug discovery and new indication research. (chemscene.com)
  • MCE 96-well storage plates are the ideal storage plate for compound library. (chemscene.com)
  • citation needed] There are limited examples of small molecules that target RNA and are approved drugs for the treatment of human disease. (wikipedia.org)
  • The team therefore screened more than 58,000 small molecules from libraries of FDA-approved drugs and novel chemicals to see if any could safely and significantly reduce key inflammation and Alzheimer's related genes regulated by by PU.1 in cell cultures. (scientificinquirer.com)
  • This molecule is from a class of pyridazine small molecules and enhances the inclusion of exon 7, resulting in a full-length and functional protein product. (wikipedia.org)
  • 2018). Here, we have performed two RT crystallographic screens of PTP1B using many of the same fragments, representing the largest RT crystallographic screens of a diverse library of ligands to date, and enabling a direct interrogation of the effect of data collection temperature on protein-ligand interactions. (rcsb.org)
  • Huang's research in stem cell gene regulation (including the regulation of neural stem cell fate) is related to her interest in protein interaction network mapping. (uclahealth.org)
  • Such regulation may occur through protein-RNA interactions or allosteric RNA-RNA effects between stem-loops on the 5'-UTR. (news-medical.net)
  • Codiscovery by other groups led to the other designations, DSHP and SAP (signaling lymphocytic activation molecule [SLAM]-associated protein). (medscape.com)
  • CRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays. (cdc.gov)
  • This entropy largely stems from the fluctuation of the protein and ligand. (lu.se)
  • These molecules were only modestly selective and showed unfavorable toxicity levels at relevant therapeutic concentrations. (wikipedia.org)
  • Previously, we showed that small-molecule fragments cluster in putative allosteric sites using a cryo crystallographic screen of the therapeutic target PTP1B (Keedy et al. (rcsb.org)
  • However, instead of using modified virus, Juventas relies on plasmids - small, circular pieces of DNA engineered to contain the therapeutic gene. (biotechprimer.com)
  • The researchers say this heralds the application of these molecules as chemical probes to explore viral biology and produce specific antivirals targeting RNA regions of the coronavirus genome. (news-medical.net)
  • citation needed] Branaplam represents the first mechanistic study of splicing modulation using a sequence-selective small molecule. (wikipedia.org)
  • Furthermore, recent interest focusing on sirtuin modulators as epigenetic players in the regulation of fundamental biological pathways has prompted increased efforts to discover new small molecules able to modify sirtuin activity. (biomedcentral.com)
  • A second major area of interest in Huang's lab is the screening of small molecule libraries (including natural product banks, combinatorial chemical libraries and drug collections) to identify probes for human and other proteomes. (uclahealth.org)
  • Daniel Kim's lab studies the role of long noncoding RNA molecules (lncRNAs) in gene expression and cancer. (ucsc.edu)
  • The NIH Molecular Libraries Roadmap Initiative wishes to solicit HTS assay applications from the scientific community from investigators who have the interest and capability to work with the Molecular Libraries Probe Production Centers Network (MLPCN) in support of chemical probe development. (nih.gov)
  • In addition, in the absence of SAP, SLAM molecules interact with SHP-2, resulting in an inhibitory effect on T-cell function. (medscape.com)
  • Gizmo Warm-up Atoms are tiny particles of matter that are made up of three particles: protons, neutrons, and electrons. (telefoninternetanbieter.de)
  • This enzyme is involved in DNA methylation, which is the addition of methyl groups, consisting of one carbon atom and three hydrogen atoms, to DNA molecules. (medlineplus.gov)
  • Biologists use them to stain specific cell types, biochemists rely on them to monitor enzyme activity, and analytical chemists use them to detect molecules in the environment. (acs.org)
  • A great amount of synthetized small molecules have also been studied in targeting regulating factors of EMT and CSCs. (ku.edu)
  • I suppose the real change is that organic chemists are now used to being able to get results with smaller crystals, get absolute structure determination, marry up the results with other techniques. (rsc.org)
  • Developed in-house, this poster summarizes how small molecules have been used in protocols across the stem cell workflow. (tocris.com)
  • This is largely due to improved chemotherapy protocols and stem cell transplantion, as well as improved monitoring and supportive care. (medscape.com)
  • By screening a library of siRNA reagents, the pathways and genes implicated in the regulation of PGXA001 D3 were identified, said PanGenex. (genomeweb.com)
  • In 2012, through known molecule your local library display screen, Sachlos et al. (immune-source.com)
  • A small-molecule screen reveals that HSP90? (musc.edu)
  • Fluorescent small molecules are workhorses for scientists from many disciplines. (acs.org)
  • Joints (typically the small joints of the limbs) become painful and have stiffness that persists for more than 60 minutes on awakening and after inactivity. (msdmanuals.com)
  • This Funding Opportunity Announcement (FOA) will utilize the NIH Resource Access award (X01) mechanism and runs in parallel with FOA (the reissue of PAR-08-035 (R03) that solicits applications for MLPCN under the R03 Small Research Grant mechanism. (nih.gov)
  • This library is a useful tool for signal pathway research, drug discovery and drug repurposing, etc. (chemscene.com)
  • Stem cell research and cloning, and egg procurement. (stanford.edu)
  • Our guide highlights the use of small molecules in stem cell research and cell therapy and lists relevant products. (tocris.com)
  • The human production of tritium mainly stems from atmospheric testing of nuclear weapons in the 1950ies and 1960ies, but also from nuclear power reactors, research reactors and research laboratories.Tritium is e.g. used as a tracer in research. (lu.se)
  • Screening libraries are usually employed in drug discovery, laboratory drug screening, drug target identification, and other pharmaceutically related fields. (invivochem.com)
  • The human body contains small amounts of radioactive substances. (lu.se)
  • As tritium is bound into water molecules, it is spread to the human body through the hydrological cycle. (lu.se)