• vivo
  • We conclude that ASphCs possess a pronounced in vivo activity to regenerate the bone injury. (scitechnol.com)
  • In vivo formation of new bone was observed under all conditions. (uminho.pt)
  • They isolated bone marrow stromal/stem cell (BMSC)-derived EVs through gradient ultracentrifugation and ultrafiltration, and tested the influence of the EVs on osteogenesis both in vivo and in vitro . (exosome-rna.com)
  • We aimed at evaluating the effect of transportation conditions on cell function, including the ability to form bone in vivo, using procedures suited to clinical application. (nih.gov)
  • Moreover, cGMP-hBM-MSC transported from a production facility under clinical-grade conditions of 4% HSA in 0.9% saline to a destination 18 h away showed prompt adhesion to HA/β-TCP 3D scaffold and subsequent in vivo bone formation. (nih.gov)
  • Cartilage
  • This particular type of stem cell has the future potential to differentiate into a variety of other cell types including: Myocardiocytes to repair damaged cardiac tissue following a heart attack Neuronal to generate nerve and brain tissue Myocytes to repair muscle Osteocytes to generate bone Chondrocytes to generate cartilage Adipocytes to generate fat Bone and tissue from the oral cavity. (wikipedia.org)
  • Articular cartilage is a connective tissue overlying the ends of bones that provides smooth joint surfaces. (wikipedia.org)
  • Published descriptions of the articular cartilage stem cell paste grafting technique are readily available. (wikipedia.org)
  • tissues
  • A topical cream developed by Lyle Corporate Development, Inc., claims to encourage regeneration of tissues in the vulva that have undergone cellular hypoxia. (wikipedia.org)
  • Regeneration in humans is the regrowth of lost tissues or organs in response to injury. (wikipedia.org)
  • Some tissues such as skin and large organs including the liver regrow quite readily, while others have been thought to have little or no capacity for regeneration. (wikipedia.org)
  • However ongoing research, particularly in the heart and lungs, suggests that there is hope for a variety of tissues and organs to eventually become regeneration-capable. (wikipedia.org)
  • Advances in research have enabled the induced regeneration of many more tissues and organs than previously thought possible. (wikipedia.org)
  • In 2009, the regeneration of hollow organs and tissues with a long diffusion distance, was a little more challenging. (wikipedia.org)
  • defects
  • Three bone defects, measuring 3.75 x 7.0mm (diameter x deep) were prepared on each side of the edentulous areas in beagle dogs. (nii.ac.jp)
  • The results showed that a larger area of regenerated bone was seen in the defects that were filled with PRP+MSC and PRP. (nii.ac.jp)
  • In the next experiment, two bone defects were created at the buccal side of each edentulous area. (nii.ac.jp)
  • Then the defects were filled with one of the following four materials : 1) blood clot (Controls), 2) PRP, 3) AB graft and 4) autogeneous bone (AB) graft with PRP. (nii.ac.jp)
  • Ten weeks after surgery, new bone formation at the buccal defects was assessed using histological and histomorphometrical methods. (nii.ac.jp)
  • Histologically, all defects were filled with newly formed bone with some variation. (nii.ac.jp)
  • Reconstruction of large size cranial bone defects in rats. (wikipedia.org)
  • therapies
  • Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. (wikipedia.org)
  • This complicates the design of drugs, for instance neural stem cell targeted therapies for the treatment of clinical depression. (wikipedia.org)
  • regrowth
  • In less than one month following surgery, x-ray analysis showed the regrowth of bone while macroscopic observation showed the regrowth of nail and skin. (wikipedia.org)
  • myocardial
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • MSCs
  • Human leukocyte antigen testing has been utilised to confirm that the MSCs stem from the fetus and not from the mother. (wikipedia.org)
  • Comparison of amniotic fluid-derived MSCs to bone-marrow-derived ones showed that the former has a higher expansion potential in culture. (wikipedia.org)
  • However, the cultured amniotic fluid-derived MSCs have a similar phenotype to both adult bone-marrow-derived MSCs and MSCs originating from second trimester fetal tissue. (wikipedia.org)
  • humans
  • Every species is capable of regeneration, from bacteria to humans. (wikipedia.org)
  • Due to the ethical constraints of conducting stem cell research on humans, the use of mice has been for advances in this field of study. (wikipedia.org)
  • cellular
  • There are rudimentary techniques of promoting cellular division to alter the structure of the penis, often referred to as foreskin restoration, and are not to be confused with regeneration. (wikipedia.org)
  • Regeneration in biology, however, mainly refers to the morphogenic processes that characterize the phenotypic plasticity of traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states. (wikipedia.org)
  • Above the genetic level, regeneration is fundamentally regulated by asexual cellular processes. (wikipedia.org)
  • Liver
  • however, the impact of this process in liver tissue maintenance and regeneration remains controversial. (hindawi.com)
  • Stem cell replacement strategies are therefore being investigated as an attractive alternative approach to liver repair. (hindawi.com)
  • Limbs
  • salamanders and newts), an order of tailed amphibians, is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)
  • Limited regeneration of limbs occurs in most fishes and salamanders, and tail regeneration takes place in larval frogs and toads (but not adults). (wikipedia.org)
  • research
  • Successful preliminary studies have encouraged a more translational phase for stem cell research. (nih.gov)
  • An article collection in Stem Cell Research & Therapy . (biomedcentral.com)
  • Contributing authors were nominated by members of the Stem Cell Research & Therapy Editorial Board. (biomedcentral.com)
  • Dr Chung is a prominent leader in the field of stem cell research with over 20 years of experience. (wikipedia.org)
  • Her current research focuses on systematic studies of the effect of biomaterial properties on stem cell differentiation. (wikipedia.org)
  • As stem cell research continues, scientists will need a database to store and share their information and research. (wikipedia.org)