• pluripotent
  • established a protocol for isolating and identifying the subpopulations of dental pulp pluripotent-like stem cells (DPPSC). (wikipedia.org)
  • 2000 First discovery of DPSCs reported by Dr. Songtao Shi of NIH 2005 NIH announces discovery of DPSCs by Dr. Irina Kerkis 2006 IDPSC Kerkis reported discovery of Immature Dental Pulp Stem Cells (IDPSC), a pluripotent sub-population of DPSC using dental pulp organ culture. (wikipedia.org)
  • However, foetal stem cells attained from the amniotic fluid are more stable and more plastic than their adult counterparts making it easier for them to be reprogrammed to a pluripotent state. (wikipedia.org)
  • defects
  • Three bone defects, measuring 3.75 x 7.0mm (diameter x deep) were prepared on each side of the edentulous areas in beagle dogs. (nii.ac.jp)
  • The results showed that a larger area of regenerated bone was seen in the defects that were filled with PRP+MSC and PRP. (nii.ac.jp)
  • In the next experiment, two bone defects were created at the buccal side of each edentulous area. (nii.ac.jp)
  • Then the defects were filled with one of the following four materials : 1) blood clot (Controls), 2) PRP, 3) AB graft and 4) autogeneous bone (AB) graft with PRP. (nii.ac.jp)
  • Ten weeks after surgery, new bone formation at the buccal defects was assessed using histological and histomorphometrical methods. (nii.ac.jp)
  • Histologically, all defects were filled with newly formed bone with some variation. (nii.ac.jp)
  • Furthermore, the researchers constructed an EVs delivery system to stimulate bone formation in Sprague Dawley (SD) rats with calvarial defects. (exosome-rna.com)
  • They found that BMSC-derived EVs led to more bone formation in the critical-size calvarial bone defects. (exosome-rna.com)
  • Reconstruction of large size cranial bone defects in rats. (wikipedia.org)
  • alveolar
  • The purpose of this study was to determine whether a combination of platelet-rich plasma (PRP) and mesenchymal stem cells (MSC) would accelerate new bone formation in a canine alveolar defect model. (nii.ac.jp)
  • differentiate
  • This study highlights the presence of stem cells in DF, their potential to adhere and differentiate into osteoblasts on different types of titanium surfaces. (biomedcentral.com)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • This should not be confused with the transdifferentiation of cells which is when they lose their tissue-specific characteristics during the regeneration process, and then re-differentiate to a different kind of cell. (wikipedia.org)
  • Discoveries in recent years have suggested that adult stem cells might have the ability to differentiate into cell types from different germ layers. (wikipedia.org)
  • Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which are derived from endoderm and mesoderm. (wikipedia.org)
  • cellular
  • The Food and Drug Administration (FDA) has warned Parcell Laboratories that it mischaracterized its stem cell-based bone regeneration product as a human cell, tissue and cellular or tissue-based product, when the product is actually a drug or a biologic and must conform to applicable regulations. (lexology.com)
  • There are rudimentary techniques of promoting cellular division to alter the structure of the penis, often referred to as foreskin restoration, and are not to be confused with regeneration. (wikipedia.org)
  • Regeneration in biology, however, mainly refers to the morphogenic processes that characterize the phenotypic plasticity of traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states. (wikipedia.org)
  • Above the genetic level, regeneration is fundamentally regulated by asexual cellular processes. (wikipedia.org)
  • regrowth
  • In less than one month following surgery, x-ray analysis showed the regrowth of bone while macroscopic observation showed the regrowth of nail and skin. (wikipedia.org)
  • myocardial
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • Liver
  • however, the impact of this process in liver tissue maintenance and regeneration remains controversial. (hindawi.com)
  • Whether BM-HSC are involved in liver regeneration or not would be of particular interest as the cells have been suggested to be an alternative donor source for the treatment of liver failure. (hindawi.com)
  • Stem cell replacement strategies are therefore being investigated as an attractive alternative approach to liver repair. (hindawi.com)
  • therapies
  • Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. (wikipedia.org)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • This complicates the design of drugs, for instance neural stem cell targeted therapies for the treatment of clinical depression. (wikipedia.org)
  • Osteogenic
  • Additional BMP-2 in the medium did not allow DF stem cells to develop a more mature phenotype, leaving them in a pre-osteogenic stage. (biomedcentral.com)
  • Long term culturing (70 days) on titanium surfaces of DF stem cells in standard medium without soluble osteogenic inducers, indicated that HA coating is more favorable, with the acquisition of a more mature osteoblastic phenotype as shown by immunocytochemical staining. (biomedcentral.com)
  • These findings demonstrated that even in absence of exogenous osteogenic factors, TiHA implants and in a lesser extent TiCtrl and TiSiO 2 implants can induce and sustain osteogenic differentiation of DF stem cells, by their chemical and topographical properties. (biomedcentral.com)
  • Our research demonstrated that DF stem cells have a spontaneous tendency for osteogenic differentiation and can be used for improving bone regeneration on titanium implants surfaces. (biomedcentral.com)
  • Bone tissue engineering strategies require cells with high proliferative and osteogenic potential as well as a suitable scaffold to support the development of these as they form new bone tissue. (uminho.pt)
  • Limbs
  • salamanders and newts), an order of tailed amphibians, is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)
  • Limited regeneration of limbs occurs in most fishes and salamanders, and tail regeneration takes place in larval frogs and toads (but not adults). (wikipedia.org)
  • research
  • Successful preliminary studies have encouraged a more translational phase for stem cell research. (nih.gov)
  • Research has been conducted on the effects of stem cells on animal models of brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease. (wikipedia.org)
  • Dr Chung is a prominent leader in the field of stem cell research with over 20 years of experience. (wikipedia.org)
  • Her current research focuses on systematic studies of the effect of biomaterial properties on stem cell differentiation. (wikipedia.org)
  • By having this information openly available to the public, it gives researchers a place to meet and share information that could possibly enhance the experimental success of stem cell research as well as provide techniques to influence stem cells down specific pathways. (wikipedia.org)
  • In order to reduce the length of time for regeneration, further research is being conducted to speed regeneration such as nerve grafts and stem cells. (wikipedia.org)
  • Adult stem cell research has been focused on uncovering the general molecular mechanisms that control their self-renewal and differentiation. (wikipedia.org)
  • human
  • Human bone marrow-derived MSCs were seeded at a density of 2.0 × 10 5 cells/well into 24-well plates and cultured with growth medium supplemented with 50 μg/mL L-ascorbic acid for 4 days. (biomedcentral.com)
  • A subpopulation of dental pulp stem cells has been described as human immature dental pulp stem cells (IDPSC). (wikipedia.org)
  • Human leukocyte antigen testing has been utilised to confirm that the MSCs stem from the fetus and not from the mother. (wikipedia.org)
  • This is one of the earliest recorded examples of adult human digit-tip regeneration. (wikipedia.org)
  • Currently, the database only includes human and mouse stem cell lineages, but the database hopes to expand into more species. (wikipedia.org)
  • markers
  • Isolated cells from the harvested DF tissue from impacted canine/molars, expressed stem cells markers. (biomedcentral.com)
  • citation needed] Several publications have stressed the importance of the expression of pluripotentiality associated markers: the transcription factors Nanog, SOX2, Oct3/4, SSEA4, CD13, are indispensable for the stem cells to divide indefinitely without affecting their differentiation potential, i.e., maintaining their self-renovation capacity. (wikipedia.org)
  • One of the major factors that separates SCLD from other stem cell databases is that it allows users to edit information pertaining to cell types, markers, and lineages. (wikipedia.org)