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  • 1880
  • Staphylococcus was first identified in 1880 in Aberdeen, Scotland, by surgeon Sir Alexander Ogston in pus from a surgical abscess in a knee joint. (wikipedia.org)
  • adherence
  • Protein A facilitates the adherence of S. aureus to human von Willebrand factor (vWF)-coated surfaces, thus increasing the bacteria's infectiousness at the site of skin penetration. (wikipedia.org)
  • extracellular
  • S. aureus has numerous surface proteins that promote attachment to host proteins such as laminin and fibronectin that form part of the extracellular matrix. (news-medical.net)
  • gene
  • Staphopain A is largely co-expressed with the other three major proteases of S. aureus: aureolysin, glutamyl endopeptidase, and staphopain B. The transcription of scp occurs via a promoter controlled by "housekeeping" sigma factor σA and up-regulated by accessory gene regulator agr. (wikipedia.org)
  • The hla gene on the S. aureus chromosome encodes the 293 residue protein monomer, which forms heptameric units on the cellular membrane to form a complete beta-barrel pore. (wikipedia.org)
  • homologous
  • Natural (or native) protein A can be cultured in Staphylococcus aureus and contains the five homologous antibody binding regions described above and a C-terminal region for cell wall attachment. (wikipedia.org)
  • bloodstream
  • during the 1980s some tampons allowed the rapid growth of S. aureus, which released toxins that were absorbed into the bloodstream. (wikipedia.org)
  • protein
  • S aureus can be confirmed by testing colonies for agglutination with latex particles coated with immunoglobulin G and fibrinogen which bind protein A and the clumping factor, respectively. (news-medical.net)
  • Protein A uniformly coats surface of S. aureus and is usually oxidase negative. (news-medical.net)
  • Protein A is a surface protein of S aureus which binds immunoglobulin G molecules by the Fc region. (news-medical.net)
  • Protein A has been shown to cripple humoral (antibody-mediated) immunity which in turn means that individuals can be repeatedly infected with S. aureus since they cannot mount a strong antibody response. (wikipedia.org)
  • symptoms
  • Common symptoms of Staphylococcus aureus food poisoning include: a rapid onset which is usually 1-6 hours, nausea, explosive vomiting for up to 24 hours, abdominal cramps/pain, headache, weakness, diarrhea and usually a subnormal body temperature. (wikipedia.org)