• Three TOF related QTL were stable and four TOF QTL were detected in the corresponding genomic locations of the flowering QTL of M. truncatula , an indication of possible evolutionarily conserved regions. (biomedcentral.com)
  • In Escherichia coli and related bacteria, we believe that both plasmids and the bacterial chromosome use site-specific recombination to convert multimers to monomers. (gla.ac.uk)
  • QTL mapping of four seed related traits revealed two stable QTL regions on chromosomes 2 and 16, which not only facilitate fine mapping and cloning these genes, but also provide opportunity for molecular breeding of new peanut cultivars with improved seed weight and size. (biomedcentral.com)
  • Now based at the Baylor College of Medicine, Monica's research exploits the remarkable conservation in genes and whole chromosome regions between the mouse and human. (biologists.com)
  • The Additional sex combs (Asx) gene of Drosophila is a member of the Polycomb group of genes, which are required for maintenance of stable repression of homeotic and other loci. (ox.ac.uk)
  • 4) Asx is an Enhancer of position-effect variegation and (5) Asx displays tissue-specific derepression of target genes. (ox.ac.uk)
  • A comparison of human and chimpanzee genes in the region of this inversion indicates that two genes-ROCK1 and USP14-that are adjacent on chimpanzee chromosome 17 (which corresponds to human chromosome 18) are more distantly positioned on human chromosome 18. (schleiden-eifel.de)
  • Because even small segments of chromosomes can span many genes, chromosomal disorders are characteristically dramatic and often fatal. (schleiden-eifel.de)
  • In the human genome, which is estimated to contain 25 000 genes, DNA is arranged into 24 distinct chromosomes (courtesy U.S. Department of Energy, Genome Management Information System). (thecanadianencyclopedia.ca)
  • She developed the technique for visualizing maize chromosomes and used microscopic analysis to demonstrate many fundamental genetic ideas. (wikipedia.org)
  • One of those ideas was the notion of genetic recombination by crossing-over during meiosis-a mechanism by which chromosomes exchange information. (wikipedia.org)
  • She produced the first genetic map for maize, linking regions of the chromosome to physical traits. (wikipedia.org)
  • She demonstrated the role of the telomere and centromere, regions of the chromosome that are important in the conservation of genetic information. (wikipedia.org)
  • Genetic correlations between loci on different chromosomes can be high and can generate false positive linkage. (nervenet.org)
  • Through genetic linkage studies, we showed X-linked dominant inheritance of RTT and mapped the disease trait to the Xq28 region of the X chromosome. (neurology.org)
  • Changes in the structure or quantity of chromosomes , which are strands of condensed genetic material, are known as chromosomal aberrations or abnormalities. (schleiden-eifel.de)
  • This patient series confirms the high frequency of MeCP2 gene mutations causative of RTT in females and provides data concerning the molecular basis for clinical variability (mutation type and position and X-inactivation patterns). (neurology.org)
  • Because so much information had to be packed into every cell, it must be packed into what Schrödinger called a 'hereditary code-script' embedded in the molecular fabric of chromosomes. (nobelprize.org)
  • Five quantitative trait loci (QTLs) on chromosomes 1A, 2B, 7B, and 7D overlapped or were in close proximity to previously reported QTLs based on the consensus and physical maps using the reference sequence of bread wheat (IWGSC RefSeq v1.0). (unboundmedicine.com)
  • Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)
  • The other two QTLs were potential novel QTLs given their physical positions. (unboundmedicine.com)
  • Five environmentally stable QTLs were detected in at least three environments. (beds.ac.uk)
  • Five environmentally stable QTLs related to grain number and spikelet number per spike were identified. (beds.ac.uk)
  • In addition, 55 QTL coincidence regions representing more than 60 % of total QTLs were found on 22 chromosomes, which indicated that several earliness-related traits might be simultaneously improved. (biomedcentral.com)
  • Fine-mapping of a 2-Mb region on chromosome D3 associated with five stable QTLs between Marker25958 and Marker25963 revealed that lines containing alleles derived from CCRI36 in this region exhibited smaller phenotypes and earlier maturity. (biomedcentral.com)
  • Studies using a derivative of chromosome conformation capture (3C) known as 'Hi-C' have revealed that long-range genomic contacts segregate TADs into an active (A) and inactive (B) compartment [ 37 ]. (biomedcentral.com)
  • Derivative chromosomes are indicated with arrows. (schleiden-eifel.de)
  • One acatalesemic mutation was mapped to position 3-47.0 which resides within the catalase dosage sensitive region. (lookformedical.com)
  • The ADGRE2 gene mutation that causes vibratory urticaria, written as Cys492Tyr or C492Y, replaces the protein building block (amino acid) cysteine with the amino acid tyrosine at position 492 of the protein sequence. (medlineplus.gov)
  • 3] Mutation at position 20210 of the gene results in thrombophilia. (medscape.com)
  • Eleven markers located on chromosomes 1A, 2B, 5A, 5D, 7B, and 7D by the genome-wide association studies analysis showed significant associations with at least two resistance-associated traits in two of the environments. (unboundmedicine.com)
  • Two stable QTL regions were identified on chromosomes 2 and 16, and gene content within these regions provided valuable information for further functional analysis of yield component traits. (biomedcentral.com)
  • The structural gene for catalase in Drosophila melanogaster has been localized to region 75D1-76A on chromosome 3L by dosage responses to segmental aneuploidy. (lookformedical.com)
  • examples include aneuploidy (atypical chromosome number), deletion (loss of part of a chromosome), duplications (extra copies of a region of a chromosome), inversion (when part of a chromosome breaks off and reattaches in reverse. (schleiden-eifel.de)
  • Amlodipine besylate tablets are indicated for the symptomatic treatment of chronic stable angina. (nih.gov)
  • Angina: The recommended dose for chronic stable or vasospastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency. (nih.gov)
  • One special type of plasmid used for genome sequencing is a bacterial artificial chromosome (BAC) , which can contain DNA fragments of about 150 kb. (learner.org)
  • During the last decade, the non-random spatial arrangement of the genome into the nucleus of eukaryotic cells, as emerged as a key regulator of genome functions and notably of the propagation of a stable genome. (cea.fr)
  • Profiling of KSHV LANA positioning on the host genome and examination of gene expression from promoters bound by KSHV LANA. (nih.gov)
  • We used LTRdigest to annotate the chromosome 4 sequence of Mus musculus (Results). (uni-hamburg.de)
  • The replication terminus region of the E. coli chromosome encodes a locus, dif, that is required for normal chromosome segregation at cell division, dif is a substrate for site-specific recombination catalysed by the related chromosomally encoded recombinases XerC and XerD. (gla.ac.uk)
  • Clonal dissemination is associated with chromosome replication, plasmid conjugation with replicative transfer, and gene migration with replicative transposition ( 1 ). (cdc.gov)
  • Any number of homologous recombination events between linear homologous chromosomes generates linear products that have the same overall structure as their parents. (gla.ac.uk)
  • In contrast, any odd number of homologous exchanges between circular chromosomes generates a fusion of the two circles. (gla.ac.uk)
  • It has been proposed that this recombination converts chromosome multimers formed by homologous recombination back to monomers in order that they can be segregated prior to cell division. (gla.ac.uk)
  • This stable silencing requires components of the small RNA pathway and can silence homologous sequences in trans . (nature.com)
  • In each strain, the resistance gene and associated sequences are recombined into an identical position in a gene homologous to the inv gene of the yersiniae. (oregonstate.edu)
  • Eighty-nine accessions with stable resistance were identified in at least three of the four environments by phenotypic evaluation. (unboundmedicine.com)
  • ASX binds to multiple sites on polytene chromosomes, 70% of which overlap those of Polycomb, polyhomeotic and Polycomblike, and 30% of which are unique. (ox.ac.uk)
  • C) on chromosome 4q25 with atrial fibrillation (AF), but phenotype alterations conferred by this SNP have not been described. (nature.com)
  • Strains mutant in dif, xerC, or xerD, share a characteristic phenotype, containing a variable fraction of filamentous cells with aberrantly positioned and sized nucleoids. (gla.ac.uk)
  • Many strains of Chlamydia suis, a pathogen of pigs, express a stable tetracycline resistance phenotype. (oregonstate.edu)
  • So the companies are forming partnerships and collaborations to maintain a stable market position. (globenewswire.com)
  • Such temporary transgenerational changes could be qualitatively distinct from induced changes that are stable for hundreds of generations. (nature.com)
  • These are some of the most common cytogenetically visible rearrangements in humans - for example , the pericentric inversion of chromosome 9 is found in over. (schleiden-eifel.de)
  • Similarly, the large ribosomal RNA gene clusters that reside on different chromosomes manage to find each other in almost every cell nucleus to form another easily discernable nuclear entity, the nucleolus [ 27 - 29 ]. (biomedcentral.com)
  • a stable nucleus heavier than lead. (cdc.gov)
  • Linear chromosomes, for example those of eukaryotes, have evolved mechanisms to ensure that chromosome ends are protected from exonucleolytic attack and can be replicated completely. (gla.ac.uk)
  • These considerations suggest that other currently unknown factors that recruit or enhance positive feedback mechanisms are crucial for stable epigenetic changes. (nature.com)
  • It is shown that the only DNA sequences required for wild-type dif function in the terminus region of the chromosome are contained within 33 bp known to bind XerC and XerD, and that certain active site residues of the Xer proteins known to be involved in the catalysis of recombination are required for normal chromosome segregation. (gla.ac.uk)
  • Since neither the dif/Xer, nor the loxP/Cie system caused this suppression when located in other positions on the chromosome, close to oriC or within lacZ, this reinforces the idea that site-specific recombination must occur in the terminus region in order to allow normal chromosome segregation. (gla.ac.uk)
  • Dynein is involved in the movement of chromosomes and positioning the mitotic spindles for cell division. (wikipedia.org)
  • Alberts made discoveries in how chromosomes replicate during cell division, is the former editor of Science, and former President of the National Academy of Sciences. (theincidentaleconomist.com)
  • Correspondingly, the lamina mostly recruits TADs of the B compartment, whereas TADs of the A compartment occupy more central nuclear positions in general. (biomedcentral.com)
  • Latency-associated nuclear antigen (LANA), a multifunctional protein expressed by the Kaposi sarcoma-associated herpesvirus (KSHV) in latently-infected cells, is required for stable maintenance of the viral episome. (nih.gov)
  • Man-made radioactive atoms are produced either as a by-product of fission of uranium atoms in a nuclear reactor or by bombarding stable atoms with particles, such as neutrons, directed at the stable atoms with high velocity. (cdc.gov)
  • Some lighter elements such as carbon-14 and tritium (hydrogen-3) primarily emit beta particles as they transform to a more stable atom. (cdc.gov)
  • We demonstrate that this resistance pattern is associated with a resistance gene, tet(C), in the chlamydial chromosome. (oregonstate.edu)
  • One study finds that the loss of the entire Y chromosome in some cells - which occurs naturally as men age - raises the risk of aggressive bladder cancer and could allow bladder tumours to evade detection by the immune system2. (cdc.gov)
  • After regression between infancy and the fifth year of life, the clinical course becomes more stable. (neurology.org)
  • Stable epigenetic changes appear uncommon, suggesting that changes typically dissipate or are repaired. (nature.com)
  • Genomes of individuals strains typically incorporate 45-55 recombinations between parental chromosomes. (nervenet.org)
  • Of 75 clinicopathologic, immune, microbial, and genomic variables in 815 stage II-III patients within two U.S.-wide prospective cohort studies, the BART risk model identified seven stable survival predictors. (cdc.gov)
  • If a normal diploid cell is 2n, the chromosome content of a double tetrasomic cell is designated. (schleiden-eifel.de)
  • The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. (cdc.gov)
  • I hold the Senior Research Chair in Child and Adolescent Psychiatry at the Children's Hospital of Eastern Ontario (Ottawa, ON), among other positions. (theincidentaleconomist.com)
  • Cytoplasmic dynein positions the spindle at the site of cytokinesis by anchoring to the cell cortex and pulling on astral microtubules emanating from centrosome . (wikipedia.org)
  • Please get the latest stable source or binary distribution from the GenomeTools web site. (uni-hamburg.de)
  • The substitution alters the protein structure and leads to a less stable interaction between the two subunits. (medlineplus.gov)
  • However, the technique must invariably deliver a precise result that is stable and safe for the environment and the consumer. (frontiersin.org)
  • Second, the strict correlation between the fate of a motor neuron with respect to its lineage and position in the ventral cord was disrupted, as manifested by the variable expression pattern of motor neuron fate specific markers. (biologists.com)
  • This study reports the isolation of a stable deficiency, Df(3L)CatDH104(75C1-2;75F1), that uncovers the catalase locus and the subsequent isolation of six acatalasemic mutants. (lookformedical.com)