• bladder tumor
  • These results suggest that let-7c downregulation and its regulated cell-cycle pathway may play an integral role in governing bladder tumor suppression or collaborative oncogenesis and that Iressa exhibits its preventive efficacy on bladder tumorigenesis by upregulating let-7 and inhibiting the cell cycle. (aacrjournals.org)
  • Cell culture study confirmed that the increased expression of let-7c decreases Iressa-treated bladder tumor cell growth. (aacrjournals.org)
  • epithelial cells
  • Low cuboidal to columnar epithelial cells forming microcysts, sheets, glands, and papillae, often associated with eosinophilic hyaline globules. (brainscape.com)
  • Early changes include disorganization of the epithelial cells, with the superficial cells becoming oriented horizontally with respect to the basal lamina. (nih.gov)
  • atypia
  • If features of atypia are present, it should be should be diagnosed by adding the modifier, "atypical. (nih.gov)
  • tissue
  • Metastasis means that cells spread through the tissue fluid's circulation called the lymphatic system or through the bloodstream where they can then stop off in other tissues or organs where they may grow as metastases or metastatic deposits and can become destructive in these new locations. (emedicinehealth.com)
  • genes
  • Both tumor module and treatment module were enriched for genes involved in cell-cycle processes. (aacrjournals.org)
  • Twenty-four and twenty-one highly connected hub genes likely to be key drivers in cell cycle were identified in the tumor module and treatment module, respectively. (aacrjournals.org)
  • These changes may turn on certain genes, oncogenes, that will tell the cells to grow, divide, and stay alive, or turn off suppressor genes, genes that control the division of cells, repair of mistakes in the DNA, and death of cells. (emedicinehealth.com)
  • tissues
  • Embodiments of the present invention are directed to quantitative analysis of tissues enabling the measurement of objects and parameters of objects found in images of tissues including perimeter, area, and other metrics of such objects. (google.com)
  • layer
  • Successful tumor cell implantation in this model requires disruption of the protective glycosaminoglycan layer, which can be accomplished by physical or chemical means. (jove.com)
  • image
  • May appear grossly as pearly or luminescent cysts with intact surface urothelium (image A) . (auanet.org)
  • Well-defined nests of urothelium with a centrally dilated lumen (like von Brunn's nests but with a hole in the middle) (image B) , (image C) , & (image D) . (auanet.org)
  • surface
  • The recruitment of immune cells from the periphery to the site of inflammation is an essential step in the innate immune response at any mucosal surface. (jove.com)
  • type
  • At termination, interferon gamma (IFN-γ)/interleukin-4 (IL-4) ELISpot analysis for MUC1 specific T-cell immune response and histopathological evaluations of tumor type and grade were performed. (jove.com)