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Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsCarcinoma, Basal CellEsophageal NeoplasmsCarcinoma, Renal CellCarcinomaSkin NeoplasmsTongue NeoplasmsLaryngeal NeoplasmsNeoplasms, Squamous CellImmunohistochemistryOropharyngeal NeoplasmsTumor Markers, BiologicalKidney NeoplasmsPrognosisNeoplasm StagingLung NeoplasmsCarcinoma, Transitional CellCarcinoma, HepatocellularCell Line, TumorCarcinoma in SituAdenocarcinomaGene Expression Regulation, NeoplasticNeoplasm InvasivenessCarcinoma, Merkel CellLymphatic MetastasisCarcinoma, Small CellKeratoacanthomaUterine Cervical NeoplasmsMouth MucosaVulvar NeoplasmsHypopharyngeal NeoplasmsCarcinoma, VerrucousPharyngeal NeoplasmsPapillomavirus InfectionsPrecancerous ConditionsKeratosis, ActinicTonsillar NeoplasmsNeoplasm Recurrence, LocalPapillomaviridaeKeratosisTumor Cells, CulturedSurvival RateCisplatinRetrospective StudiesCarcinoma, PapillaryNeoplasm ProteinsImmunoenzyme TechniquesGingival NeoplasmsPenile NeoplasmsSurvival AnalysisCombined Modality TherapyMice, NudeAntineoplastic AgentsNeoplasms, Multiple PrimaryLip NeoplasmsNeck DissectionLeukoplakia, OralCarcinoma, AdenosquamousTumor Suppressor Protein p53Treatment OutcomeNeoplasm MetastasisPapillomaCarcinoma, BasosquamousDNA, NeoplasmAntigens, NeoplasmCarcinoma, Large CellReverse Transcriptase Polymerase Chain ReactionKeratinsAnus NeoplasmsCase-Control StudiesTissue Array AnalysisLiver NeoplasmsGenes, p53Carcinoma, Acinar CellRNA, MessengerUrinary Bladder NeoplasmsCarcinoma, Signet Ring CellDisease ProgressionDisease-Free SurvivalHuman papillomavirus 16Cyclin-Dependent Kinase Inhibitor p16Carcinoma, BronchogenicReceptor, Epidermal Growth FactorEsophagusKeratinocytesCell ProliferationBowen's DiseaseKaplan-Meier EstimateNeoplasm TransplantationLoss of HeterozygosityEsophagectomyEyelid NeoplasmsLeukoplakiaChromosomes, Human, Pair 3Cell Transformation, NeoplasticBiopsySerpinsFollow-Up Studies
SituPatients with Oral Squamous Cell CarcInvasiveTumorsEpithelialExophyticBiopsyLeukoplakiaBuccal mucosaCervixEpitheliumMetastaticAdenocarcinomaCase of verrucousLesionNeoplasmMucosalCancersProliferativeDiagnosisPapillaryLymphomaLymphocytes and plasma cellsInvasionBladderMelanomaUrothelial carcinomaDysplasiaMucinous CarcinomaClinicalStromaOralTissuesMetaplasiaAnalSarcomatoidActinic KeratosisAdenosquamousEpidermalCuniculatumLesions1948
Situ3
Patients with Oral Squamous Cell Carc2
  • Clinicopathologic Characteristics of Young Patients with Oral Squamous Cell Carcinoma. (nih.gov)
  • Panneerselvam K, Rameshkumar A, Rajkumar K, Ramadoss R. Detection of human papilloma virus 16 and 18 in patients with oral squamous cell carcinoma and potentially malignant oral disorders in South Indian population: a pilot study. (edu.in)
Invasive6
  • It does not metastasize, although it may develop foci of invasive squamous cell carcinoma. (medscape.com)
  • The diagnosis of invasive squamous cell carcinoma was established after clinical, radiologic, and biopsy evaluation. (webpathology.com)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
  • An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST. (lookformedical.com)
  • Invasive carcinoma with measured deepest invasion ≥5 mm, limited to the cervix. (mdwiki.org)
  • Whether the carcinoma occur in the upper aerodigestive tract (verrucous carcinoma), on the genitalia (condyloma acuminatum), or on extremities (carcinoma cuniculatum), they are essentially the same neoplasm with slow growing, locally invasive and nonmetastasizing behavior 3 . (ispub.com)
Tumors7
  • they resemble epidermal tumors, with some combination of individual cell keratinization, keratin pearls, and intercellular bridges. (medscape.com)
  • The highest incidence has been seen in areas where schistosomiasis is endemic, notably Sudan and Egypt, where squamous cell carcinoma ranges from two thirds to three quarters of all malignant tumors of the bladder. (medscape.com)
  • More than 9 in 10 oral cavity tumors are squamous cell carcinoma. (ucihealth.org)
  • Other much less common types of oral cancer include salivary gland tumors, including adenoid cystic carcinoma and adenocarcinoma, and lymphoma. (ucihealth.org)
  • Verrucous carcinoma is an uncommon but distinct variety of well differentiated squamous cell carcinoma first delineated by Ackerman in 1948 3 .The term verrucous carcinoma refers to those exophytic mucosal or cutaneous squamous tumors that are heaped above the epithelial surface with a papillary micronodular surface and pushing margins 4 .Predominantly being a squamous mucosal lession, verrucous carcinoma may also be found on cutaneous surfaces. (ispub.com)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
Epithelial7
  • In HHV-1 and HHV-2 oral infections, viral replication within the oral epithelium may cause lysis of epithelial cells, with vesicle formation. (medscape.com)
  • A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
  • A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
  • It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
Exophytic5
  • Verrucous carcinomas an exophytic, well differentiated form of oral cancer. (experts.com)
  • Oral submucous fibrosis with an exophytic, proliferative growth on the right buccal mucosa which proved to be squamous cell carcinoma on histopathological examination. (iarc.fr)
  • Verrucous carcinoma (VC) was first described in 1948 as a slow-growing exophytic and papillary lesion [ 1 ]. (jwmr.org)
  • The fully developed carcinoma in an exophytic gray to red bulky lesion with a rough, shaggy, papillomatous surface 3 . (ispub.com)
  • Note 2:** Verrucous carcinoma (M-8051) is a locally aggressive, exophytic, low grade carcinoma with minimal metastatic potential. (cancer.gov)
Biopsy8
  • Abundant degenerated cells are also seen in biopsy material. (medscape.com)
  • mucinous, villoglandular, endometrioid) Clear cell adenocarcinoma Serous carcinoma Adenosquamous carcinoma Glassy cell carcinoma Adenoid cystic carcinoma Adenoid basal carcinoma Small cell carcinoma Undifferentiated carcinoma Cancers can be histopathologically graded as follows: GX: Grade cannot be assessed G1: Well differentiated G2: Moderately differentiated G3: Poorly or undifferentiated For microinvasive disease, clinicians should collect a specimen using a loop electrosurgical excision procedure (LEEP) or a cone biopsy. (wikipedia.org)
  • Biopsy from the growth revealed verrucous carcinoma. (iarc.fr)
  • Homogeneous leukoplakia (arrow), with a proliferative growth in the center of the lesion (red arrow) that revealed verrucous carcinoma on biopsy. (iarc.fr)
  • Sentinel lymph node biopsy for early squamous cell carcinoma of the lip and oral cavity: Real-world experience in Brazil. (nih.gov)
  • Abnormal cells will appear to glow under the light and can be scraped off and collected for biopsy. (drmarclazare.com)
  • Permanent biopsy revealed that the skin lesion was a PC with basal cells and squamous differentiation. (e-acfs.org)
  • Grocott methenamine silver-stained section of skin biopsy specimen revealing a short chain of lemon-shaped fungal cells connected by thin, tubelike bridges. (cdc.gov)
Leukoplakia4
Buccal mucosa2
  • The most common location for verrucous carcinomas is the buccal mucosa and gingiva. (experts.com)
  • The patient is a 16-year-old Caucasian female with a history of left verrucous squamous cell carcinoma of the buccal mucosa, present for a number of months that was diagnosed in the office after two biopsies. (mtsamples.com)
Cervix6
  • citation needed] The carcinoma is confined to the surface layer (cells lining) of the cervix. (wikipedia.org)
  • The carcinoma has grown into the cervix, but has not spread beyond it (extension to the corpus would be disregarded). (wikipedia.org)
  • Human Papillomavirus (HPV) Infection Human papillomavirus (HPV) can be sexually transmitted and causes changes in cells, which can lead to genital warts or to precancer or cancer of the cervix, vagina, vulva, anus, or throat. (msdmanuals.com)
  • Carcinoma cervix is not the only cancer caused by HPV. (cytojournal.com)
  • The region where there is a transition from squamous to columnar epithelium in cervix is transformation zone. (cytojournal.com)
  • A test in which cells are scraped from a womans cervix and checked for cancer or pre-cancer cells. (jobjaillady.com)
Epithelium4
  • [ 5 , 6 ] In a localized primary infection, the virus penetrates the mucosal epithelium and invades the cells of the basal layer, where the viral DNA inserts into the host DNA. (medscape.com)
  • It can originate from squamous or glandular epithelium. (mdwiki.org)
  • The epithelium was hyperplastic stratified squamous type which was parakeratinised in nature (figure 1). (ispub.com)
  • The endocervix is lined by columnar mucinous epithelium and in continuity with vaginal mucosa, the ectocervix is lined by squamous epithelium. (cytojournal.com)
Metastatic1
  • Other than metastatic foci of gastric cancer cells, some dissected lymph nodes showed destructive architecture with proliferation of small- to medium-sized atypical hematopoietic cells. (bvsalud.org)
Adenocarcinoma2
Case of verrucous3
  • Waltz KM, Helm KF, Billingsley EM: The spectrum of epidermal nevi: a case of verrucous epidermal nevus contiguous with nevus sebaceus. (karger.com)
  • A case of male patient is being presented who was diagnosed as a case of verrucous carcinoma. (ispub.com)
  • The histopathological examination of the tissue biopsied revealed it to be case of verrucous carcinoma with numerous dysplastic features. (ispub.com)
Lesion3
  • Note the 2x1 cm red velvety lesion (yellow arrow) on the left side of the lower labial mucosa with an area of crust formation extending to the vermilion border (red arrow), which on histopathological examination revealed well-differentiated squamous cell carcinoma. (iarc.fr)
  • The lower anogenital squamous terminology (LAST), an acronym for LAST, incorporates the low- and high-grade squamous intraepithelial lesion (HSIL) terminology. (cytojournal.com)
  • No benefit of addition of other biomarkers like p63 or ki67 is found in problem-solving in differentiation of HSIL from mimics or low-grade squamous intraepithelial lesion. (cytojournal.com)
Neoplasm3
  • Squamous cell carcinoma of the urinary bladder is a malignant neoplasm derived from bladder urothelium with pure squamous phenotype. (medscape.com)
  • An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)
  • In 1948, Lauren V. Ackermann first described this neoplasm of the oral mucous membrane, which is now also know as Verrucous Carcinoma of Ackermann or Ackermann's tumor. (ispub.com)
Mucosal1
Cancers2
  • Porocarcinoma (PC) and basal cell carcinoma (BCC) are distinct skin cancers. (e-acfs.org)
  • Note 1:** Over 90% of penile cancers are squamous cell carcinomas arising in the skin. (cancer.gov)
Proliferative1
  • The development of verrucous carcinoma from proliferative lesions makes it likely that the tumor develops from a benign precursor. (ispub.com)
Diagnosis4
  • Because many urothelial carcinomas contain a minor squamous cell component, a diagnosis of squamous cell carcinoma of the bladder should be rendered only when the tumor is solely composed of a squamous cell component in the absence of a conventional urothelial carcinoma component. (medscape.com)
  • Some authors make the diagnosis after a long-term follow-up, observing initial stages until the development of verrucous areas or carcinomas. (bvsalud.org)
  • It was suggested that PVL diagnostic criteria should include the presence of multifocal white lesions with aggressive behavior, long-term evolution, recurrences after any type of treatment, excluding the obligation of verrucous aspect on the time of diagnosis. (bvsalud.org)
  • Since the diagnosis changed to VC, and the resection margin was involved by the carcinoma, the patient underwent an amputation procedure at the proximal phalangeal base. (jwmr.org)
Papillary1
  • The papillary dermis showed chronic inflammatory infiltrates composed predominantly of lymphocytes and plasma cells admixed with few eosinophils ( Figure 2 ). (iranjd.ir)
Lymphoma1
  • HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
Lymphocytes and plasma cells1
  • There was a very dense inflammatory cell infiltrate consisting of lymphocytes and plasma cells (figure 2). (ispub.com)
Invasion2
  • [ 19 ] Keratinization of the cells at the stromal interface is a sign of invasion. (medscape.com)
  • If there is destructive invasion of verrucous carcinoma into structures in T1 or greater, assign the appropriate higher code **Note 4:** Information about involvement of the corpus spongiosum or corpus cavernosum is collected in this field for anatomic staging. (cancer.gov)
Bladder14
  • [ 3 ] Worldwide, however, squamous cell carcinoma is the most common form of bladder cancer, accounting for up to 73% of cases in developing nations, particularly regions with a high prevalence of schistosomiasis (eg, Middle East, Southeast Asia, South America). (medscape.com)
  • For more information, see Bladder Cancer , as well as Pathologic Findings in Small Cell Bladder Carcinoma and Cystoscopy . (medscape.com)
  • Cystoscopically, squamous cell carcinoma appears nodular and has a plaquelike, irregular surface with involvement of multiple bladder sites. (medscape.com)
  • [ 17 ] There is a 21%-42% risk of the development of bladder cancer once squamous metaplasia occurs. (medscape.com)
  • Verrucous squamous cell carcinoma is a rare variant of squamous cell carcinoma of the bladder, accounting for less than 5% of the squamous cell carcinomas. (medscape.com)
  • In the United States, squamous cell carcinoma constitutes around 5% of all urinary bladder carcinomas. (medscape.com)
  • Worldwide, the incidence of squamous cell carcinoma of the bladder varies. (medscape.com)
  • In certain parts of the African continent, the majority of bladder carcinomas are of the squamous cell type. (medscape.com)
  • Having bladder diverticula may increase the likelihood that an individual will develop squamous cell carcinoma. (medscape.com)
  • [ 12 ] Bladder exstrophy has been associated with the development of squamous cell carcinoma at a younger age than usual. (medscape.com)
  • Smoking has a well-recognized role in the development of bladder carcinoma, with smoking duration and intensity directly related to increased risk. (medscape.com)
  • Cyclophosphamide chemotherapy has also been reported to increase the incidence of squamous cell carcinoma of the bladder. (medscape.com)
  • As previously mentioned, schistosomiasis is the major cause of squamous cell carcinoma of the bladder in African countries. (medscape.com)
  • In one study from Egypt, 82% of patients with bladder carcinoma were found to harbor Schistosoma haematobium eggs in the bladder wall. (medscape.com)
Melanoma1
  • Melanoma Melanoma is a skin cancer that begins in the pigment-producing cells of the skin (melanocytes). (msdmanuals.com)
Urothelial carcinoma2
  • this stands in contrast to urothelial carcinoma, which predominantly affects males. (medscape.com)
  • [ 6 , 7 , 8 ] An increase in the prevalence of smoking in Egypt is also believed to have contributed to the shift toward urothelial carcinoma, as that tumor type has a stronger association with smoking. (medscape.com)
Dysplasia2
  • The recurrence rate after treatment of verrucous carcinoma is high due to the dysplasia left close to verrucous carcinoma. (ispub.com)
  • Verrucous carcinoma is a rarely occurring, low-grade variant of squamous cell carcinoma, slow-growing verrucous and with minimal dysplasia. (units.it)
Mucinous Carcinoma1
Clinical1
  • Clinical photograph shows an extensive squamous cell carcinoma (SCC) arising on the distal foot in a patient with a history of previous burn injury. (basicmedicalkey.com)
Stroma1
Oral9
  • HPV infections have received particular attention in recent years, as high-risk strains have been linked to some cases of oral squamous cell carcinoma. (medscape.com)
  • Oral cancer is cancer that starts in cells in the mouth or throat. (ucihealth.org)
  • Squamous cells make up the lining of the oral cavity (the mucosa). (ucihealth.org)
  • The reemergence of lip and oral cavity squamous cell carcinoma after a period of remission. (nih.gov)
  • With respect to the upper aero digestive tract, where the verrucous carcinoma most often arises, the oral cavity, particularly the cheek mucosa, gingivae and retromolar areas, remains the most common site of origin 4 . (ispub.com)
  • Bethel nut chewing, poor dental hygiene and Human Papilloma Virus (HPV) infection have been implicated in the development of oral verrucous carcinoma 4 . (ispub.com)
  • Squamous cell carcinoma, which means the cancer develops in the squamous cells that line the inside of the mouth or throat, is by far the most common type of oral cancer. (msdmanuals.com)
  • Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. (cdc.gov)
  • Role of functional polymorphism of matrix metalloproteinase-2 (-1306 C/T and -168 G/T) and MMP-9 (-1562 C/T) promoter in oral submucous fibrosis and head and neck squamous cell carcinoma in an Indian population. (cdc.gov)
Tissues1
  • when verrucous carcinoma involves the plantar surface of the foot, it is named carcinoma cuniculatum (CC). Metastasis from CC is rare, although it can invade deep into the soft tissues and can extend to tendons, muscles, or bone. (units.it)
Metaplasia2
  • Squamous metaplasia has been seen in 17%-60% of nonendemic cases. (medscape.com)
  • Keratinous squamous metaplasia has been associated with the increased risk of developing squamous cell carcinoma, with approximately one half of the cases arising subsequent to the metaplasia. (medscape.com)
Anal2
Sarcomatoid1
  • Vast majority of them are squamous cell carcinomas (SCC) which include conventional, verrucous, and spindle cell (sarcomatoid) subtypes. (webpathology.com)
Actinic Keratosis2
  • Actinic Keratosis (AK) is also known as Solar Keratosis caused by UV radiation, is the most common precancer which can advance to Squamous Cell Carcinoma. (skcin.org)
  • Actinic keratosis is a precancer which indicates sun damage and can lead to Squamous Cell Carcinoma which if left untreated has the potential to spread to organs and be fatal. (skcin.org)
Adenosquamous1
Epidermal1
  • Epidermal nevi(EN)represent a heterogeneous group of mosaic skin lesions frequently following the lines of Blaschko. (karger.com)
Cuniculatum1
  • Carcinoma Cuniculatum: Usefulness of Radiological Assessment. (units.it)
Lesions2
  • Clinically, all of them showed aggressive and multifocal lesions, varying from homogenous to non homogenous aspect with verrucous surface and erythematous areas. (bvsalud.org)
  • Although the risk of an AK transforming into squamous cell carcinoma (SCC) is very low, the risk increases over time and with larger number of lesions. (skcin.org)
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