• malaria
  • 3. Chloroquine diphosphate can be administered in weekly suppressive doses for at least seven months without undesirable side-effects, even in pregnancy, and is recommended for the treatment of splenomegaly due to chronic malaria. (ajtmh.org)
  • anemia
  • Acquired conditions associated with hemolysis and increased red blood cell turnover that cause splenomegaly include: autoimmune hemolysis, megaloblastic anemia, and paroxysmal nocturnal hemoglobinuria. (psychiatryadvisor.com)
  • Case 27-2001: A 50-Year-Old Man with Marked Splenomegaly and Anemia. (derangedphysiology.com)
  • This process of red blood cells rupturing directly results in varying degrees of anemia (causing a pale appearance and fatigue), high levels of bilirubin in the blood (causing jaundice), and splenomegaly. (wikipedia.org)
  • Splenomegaly can result from antigenic stimulation (e.g., infection), obstruction of blood flow (e.g., portal vein obstruction), underlying functional abnormality (e.g., hemolytic anemia), or infiltration (e.g., leukemia or storage disease, such as Gaucher's disease). (wikipedia.org)
  • syndrome
  • Felty's syndrome, also called Felty syndrome, (FS) is rare autoimmune disease characterized by the triad of rheumatoid arthritis, splenomegaly and neutropenia. (wikipedia.org)
  • cause
  • Congenital conditions associated with hemolysis and increased red blood cell turnover that cause splenomegaly include: hereditary spherocytosis and hemoglobinopathies, especially alpha and beta thalassemias and sickle cell-hemoglobin C (or hemoglobin SC disease). (psychiatryadvisor.com)
  • absence
  • First the presence of gross splenomegaly or profuse fluid in the stomach or colon may lead to the absence of a resonant percussion note on full expiration. (wikipedia.org)