AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
Leishmaniasis, VisceralLeishmaniasis, CutaneousLeishmaniasisSpleenLeishmaniasis, MucocutaneousAntiprotozoal AgentsLeishmaniaLeishmania infantumLeishmania braziliensisLeishmania donovaniPsychodidaeLeishmaniasis, Diffuse CutaneousMeglumineLeishmaniasis VaccinesAntimonyPhlebotomusAntimony Sodium GluconateLeishmania tropicaDog DiseasesLeishmania guyanensisLeishmania majorLeishmania mexicanaAntigens, ProtozoanAntibodies, ProtozoanInsect VectorsEndemic DiseasesOrganometallic CompoundsDNA, ProtozoanParomomycinPhosphorylcholineBrazilDNA, KinetoplastProtozoan VaccinesParasite LoadDogsMice, Inbred BALB CAmphotericin BSudanDisease ReservoirsInsect ControlVenezuelaParasitologyPentamidineIndiaProtozoan ProteinsColombiaInterferon-gammaArgentinaSkin UlcerPolymerase Chain ReactionSensitivity and SpecificityDisease VectorsSkin TestsSerologic TestsSkinNepalEnzyme-Linked Immunosorbent AssayAgglutination TestsZoonosesMacrophagesBoliviaPeruBenzethoniumMice, Inbred C57BLPopulation DensityEuglenozoa InfectionsParasitic Sensitivity TestsTrypanocidal AgentsLymph NodesNeglected DiseasesPanamaMesocricetusGeography, MedicalInterleukin-10Immunoglobulin GImmunochromatographyT-LymphocytesHyraxesAfghanistanSplenomegalyRodentiaSplenectomyTh1 CellsBone MarrowHypersensitivity, DelayedTunisiaSeasonsFluorescent Antibody Technique, IndirectIntradermal TestsDisease Models, AnimalEthiopiaImmunity, CellularIranCytokinesLymphocyte ActivationInterleukin-4Military FacilitiesEcuadorLiverSuriname
VisceralLeishmaniaLiver and spleenMucocutaneous leishmaniasisPrevent leishmaniasisMucosalBoneInfectionSymptomsDifferent forms of leishmaniasisFeverParasitesAreas where leishmaniasisOrgansLymphMucous2023EndemicMillion cases of cutaneousPost kala-azar derAffectsClinicalType of leishmaniasisCases of leishmaniasisDiagnosis of leishmaniasisLesionsSandfliesCentral and SouParasitic disease foundEnlargementSand fliesProtozoanOccurUlcersVector-borneVaccinesDiseaseOccursIndiaFormKalaParasitismAfricaImmuneTreatmentDisfigurementMalariaInfectionsParasite load
Visceral88
Leishmania36
  • Leishmaniasis is caused by a tiny parasite called leishmania protozoa. (medlineplus.gov)
  • Leishmaniasis is caused by Leishmania parasites that are transmitted by the bite of phlebotomine sand flies. (webmd.com)
  • When testing for leishmaniasis, specimens may be taken from your skin sores or bone marrow to be examined for Leishmania parasites. (webmd.com)
  • Leishmania donovani is a species of intracellular parasites belonging to the genus Leishmania, a group of haemoflagellate kinetoplastids that cause the disease leishmaniasis. (wikipedia.org)
  • Leishmaniasis Parasitic Disease - (Alternative - leishmaniosis) - A disease caused by protozoan parasites of the genus Leishmania and spread by the bite of certain types of sandflies. (disabled-world.com)
  • After recovery or successful treatment, cutaneous leishmaniasis induces immunity to reinfection by the species of Leishmania that caused the disease. (medscape.com)
  • Tous les isolats ont été typés comme Leishmania donovani sur la base de l'amplification en chaîne par polymérase (PCR) de l'ADNk du parasite. (who.int)
  • Detection of parasite antigens in Leishmania infantum-infected spleen tissue by monoclonal antibody-, piezoelectric-based immunosensors. (fiocruz.br)
  • Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania . (nimbios.org)
  • Cutaneous leishmaniasis caused by Leishmania braziliensis , Leishmania guyanensis , and Leishmania panamensis [see Clinical Trials ]. (rxlist.com)
  • Leishmaniasis is a vector-borne disease caused by an obligate intracellular protozoa of genus Leishmania and is transmitted by the bite of a female phlebotomine sand fly ( Figure 1 ). (intechopen.com)
  • Leishmaniasis, a neglected tropical disease that is caused by protozoan parasites from the genus Leishmania, is not well understood. (healthinternetwork.org)
  • Different species of Leishmania parasites can cause leishmaniasis. (healthinternetwork.org)
  • Sand flies feed on humans and animals in order to produce eggs, and if the blood drawn contains the Leishmania parasite, the next person or animal bitten will be infected and develop leishmaniasis. (ucsdguardian.org)
  • Leishmaniasis is initiated by the inoculation of Leishmania promastigotes into the skin of a susceptible host during the blood meal of an infected sand fly [ 1 ]. (biomedcentral.com)
  • Leishmaniasis is caused by 20 or more species of the protozoa Leishmania . (msdmanuals.com)
  • Medications used to treat the infection depend on the clinical form of leishmaniasis, the status of the person's immune system, which species of Leishmania is causing the infection, and where the infection was acquired. (msdmanuals.com)
  • Leishmaniasis refers to a vector-borne disease caused by parasites of the Leishmania genus. (imarcgroup.com)
  • Leishmania is an intracellular parasite with different species pathogenic to humans and causing the disease leishmaniasis. (sdsc.edu)
  • It's one of three types of leishmaniases spread by the protozoan parasite, Leishmania . (krwg.org)
  • Leishmaniasis is a widespread vector-borne neglected tropical disease (NTD) caused by a protozoan parasite of the Genus Leishmania spp. (ugr.es)
  • La leishmaniasis es una enfermedad muy extendida, de transmisión vectorial, y carácter tropical y está considerada una enfermedad olvidada (Neglected Tropical Disease) causada por un protozoo parásito del género Leishmania spp. (ugr.es)
  • The potential anti-Leishmania effect of miltefosine + LBSapMPL-vaccine was revealed by a specific immune response activation reflecting in control of spleen parasitism using half the miltefosine treatment time. (bvsalud.org)
  • The diagnosis of lymphatic leishmaniasis was confirmed by the presence of Leishmania donovani bodies in fine needle aspiration cytology, and positive anti-rK39 antibodies. (biomedcentral.com)
  • Leishmaniasis consists of a group of diverse diseases that affect viscera, skin, and/or mucous membranes, with a wide spectrum of clinical activity caused by vector-borne, obligate, intracellular hemoflagellates of the genus Leishmania . (biomedcentral.com)
  • The main difference between Amoeba and Leishmania is that Amoeba causes amoebiasis while Leishmania causes leishmaniasis. (pediaa.com)
  • Leishmania is a parasitic protozoan responsible for the disease leishmaniasis. (pediaa.com)
  • Amoeba causes amebiasis, but Leishmania causes leishmaniasis. (pediaa.com)
  • Leishmaniasis is a disease caused by a single-celled protozoan (parasite) from the genus Leishmania . (environ.news)
  • Canine leishmaniasis is widespread in more than 70 countries but is most common in Mediterranean areas as the Leishmania parasite thrives in warm climates. (environ.news)
  • Kala-azar is a slow progressing indigenous disease caused by a protozoan parasite of genus Leishmania In India Leishmania donovani is the only parasite causing this disease The parasite primarily infects reticuloendothelial system and may be found in abundance in bone marrow, spleen and liver. (firebaseapp.com)
  • Leishmaniasis or Kala-azar_UPSC The leishmaniases are a group of diseases caused by protozoan parasites from more than 20 Leishmania species. (firebaseapp.com)
  • In the present study, liposomes with different sizes (100, 400, 1000nm) containing recombinant major surface glycoprotein of Leishmania (rgp63) were prepared, characterized, and inoculated subcutaneously into BALB/c mice to evaluate the rate of protection and the type of immune response generated against leishmaniasis. (hal.science)
  • The disease has three main clinical forms, including cutaneous leishmaniasis, which is the most common form of the disease, which is caused by any species of Leishmania parasite. (cdc.gov)
  • Treatment of leishmaniasis depends in part on the Leishmania species or strain and the geographic area in which infection was acquired. (cdc.gov)
  • Leishmaniasis is caused by a protozoa parasite from over 20 Leishmania species and is transmitted to humans by the bite of infected female phlebotomine sandflies. (who.int)
Liver and spleen3
  • A 70-year-old male had fever, enlarged liver and spleen, and liver cysts and had tested negative in an infectious disease workup. (genomeweb.com)
  • After the protozoa enter the body through a bite in the skin, they may remain in the skin or spread to the mucous membranes of the nose, mouth, and throat, or to internal organs including the bone marrow, liver, and spleen. (msdmanuals.com)
  • Symptoms of this disease include anemia, enlargement of the liver and spleen, irregular bouts of fever and weight loss. (environ.news)
Mucocutaneous leishmaniasis11
Prevent leishmaniasis5
Mucosal7
Bone10
Infection8
  • An enlarged spleen is found in 50% to 80% of malaria patients ( 1 ), while only 25 cases of splenic rupture have been reported since 1960 (0%-2% in natural occurring infection) ( 5 ). (cdc.gov)
  • Recently, an abscess of the spleen caused by Salmonella enterica serovar Enteritidis has been reported as a complication of P . falciparum malaria ( 4 ) and, to our knowledge, is the only case in the literature definitely related to Plasmodium infection. (cdc.gov)
  • Classified as a neglected tropical disease (NTD), leishmaniasis is an infection spread by phlebotomine sand flies. (webmd.com)
  • This infection is typically more common in rural areas, so be sure to take precautions as needed if you spend a lot of time outdoors in areas where leishmaniasis occurs. (webmd.com)
  • Leishmaniasis is a 'vector-borne' infection, meaning that an insect from another host or 'reservoir' (disease carrier) transmits it. (medicinenet.com)
  • Active cutaneous leishmaniasis lesion with likely secondary infection in a soldier. (medscape.com)
  • Cutaneous leishmaniasis (CL): Some people have a silent infection, without any symptoms or signs, they may have one or more sores on their skin. (gov.sa)
  • Other consequences, which can occur a few months to years after infection, include fever, damage to the spleen and liver, and anemia. (firebaseapp.com)
Symptoms8
  • Contact your provider if you have symptoms of leishmaniasis after visiting an area where the disease is known to occur. (medlineplus.gov)
  • To find out if you have leishmaniasis, you should ask yourself if you've been in a part of the world where leishmaniasis occurs and check if you have any of the symptoms covered above. (webmd.com)
  • The parasite is a protozoan, a single-celled microbe, which causes symptoms ranging from skin sores to a swollen spleen or liver. (sciencedaily.com)
  • Collecting a detailed travel history, particularly when signs and/or symptoms of gastrointestinal infections as mentioned above, mumps, varicella, tuberculosis, malaria, leishmaniasis, hepatitis A, and COVID-19 are present, may help in identifying and taking appropriate action to prevent further spread of these diseases within the United States. (cdc.gov)
  • Aloe vera gel, turmeric and other natural remedies can be used to reduce symptoms of leishmaniasis. (healthinternetwork.org)
  • In accordance with VL symptoms and parasite tropism, we found a greater overlap of perturbed metabolites between spleen and liver compared to spleen and gut, or liver and gut. (sdsc.edu)
  • Even though they're not showing symptoms of leishmaniasis, they may still carry the disease-causing parasite. (krwg.org)
  • The symptoms of the disease include skin ulcers, low red blood cell count, fever, and enlarged spleen and liver. (pediaa.com)
Different forms of leishmaniasis2
Fever5
  • The fight against the deadly tropical disease leishmaniasis, also known as black fever, has been boosted by a new screening system has raised the possibility of new, safer drugs. (sciencedaily.com)
  • The fight against the deadly tropical disease Leishmaniasis, also known as black fever, has been boosted by scientists at the University of Durham, whose new screening system has raised the possibility of new, safer drugs. (sciencedaily.com)
  • It can cause fever, weight loss, enlargement of the spleen and liver, and anemia. (krwg.org)
  • These 5 patients had presented with prolonged fever and/or significant spleen enlargement, reflecting high parasite load. (edu.pl)
  • It is characterized by irregular bouts of fever, weight loss, enlargement of the spleen and liver, and anemia. (biomedcentral.com)
Parasites5
  • He processed the tissue sample of the enlarged spleen using a staining technique (now known as Leishman's stain) which he had just developed, and discovered the protozoan parasites using microscopy. (wikipedia.org)
  • Six parasites ont montré une résistance in vitro au stibogluconate de sodium en utilisant le test de détection des amastigotes dans les macrophages J774 murins. (who.int)
  • In progressive forms of cutaneous leishmaniasis, parasites and parasite molecules are continuously observed in the interior of the mononuclear phagocytes in the skin lesion and in the marginal sinus of the draining lymph nodes, suggesting that these phagocytes continuously transport parasite and parasite molecules [ 4 ]. (biomedcentral.com)
  • Leishmaniasis is caused by protozoan parasites, which are transmitted by the bite of infected female phlebotomine sandflies. (biomedcentral.com)
  • Only a small fraction of those infected by parasites causing leishmaniasis will eventually develop the disease. (biomedcentral.com)
Areas where leishmaniasis3
Organs3
Lymph3
Mucous3
20231
Endemic7
  • ABSTRACT A longitudinal study was done in a leishmaniasis-endemic region in eastern Sudan during the period November 2001-February 2003 to determine the incidence of failure of sodium stibogluconate treat- ment. (who.int)
  • Canine leishmaniasis is an endemic zoonotic disease highly widespread in the Mediterranean basin. (vin.com)
  • This chapter reviews the global perspective of Leishmaniasis with increasing recognition of emerging "Atypical forms" and new surge of disease across the world mainly due to increasing conflicts in endemic areas leading to forced migration among other causes. (intechopen.com)
  • According to the World Health Organization (WHO), leishmaniasis is endemic in 88 countries, with a total of 350 million people at risk. (escholarship.org)
  • Leishmaniasis is endemic in 98 countries, it is estimated that a million of new cases take place annually and it is responsible of 20,000-30,000 deaths each year. (ugr.es)
  • In the clinical evaluation of a patient with isolated lymphadenopathies, leishmaniasis must be considered as a differential diagnosis in immunocompetent subjects in endemic areas for early diagnostic workup and management. (biomedcentral.com)
  • The Centers for Disease Control and Prevention (CDC) has warned that cases of leishmaniasis are growing in the United States , even affecting people who have not traveled to Africa, Asia, Latin America and the Middle East, where this parasitic disease is endemic and more prevalent. (environ.news)
Million cases of cutaneous2
  • It is difficult to pinpoint how many cases occur globally, since most may occur in rural, poor areas without established systems of reporting, but the World Health Organization (WHO) reports over 1 million cases of cutaneous (skin) leishmaniasis in the last five years. (medicinenet.com)
  • Leishmaniases constitute a worldwide public-health problem and 1.5 to 2 million new cases occur every year: 1 to 1.5 million cases of cutaneous forms and 500,000 cases of VL [ 2 ]. (biomedcentral.com)
Post kala-azar der1
  • This young patient has been diagnosed with post-kala azar dermal leishmaniasis, a recurrent but non-fatal form of kala azar that affects 5-10 percent of patients, between six months to three years after cure. (firebaseapp.com)
Affects4
  • Leishmaniasis, a neglected and serious tropical disease, affects many millions around the globe. (healthinternetwork.org)
  • Professor Stäger and her team have demonstrated the effect of this key regulator on the function of monocytes and macrophages during viceral leishmaniasis, the most severe form of a tropical disease that affects millions of people around the world. (inrs.ca)
  • Cutaneous leishmaniasis is the most common type, and it primarily affects the skin, causing ulcers, sores, or nodules at the site of the sandfly bite. (imarcgroup.com)
  • Marcos de Almeida] Leishmaniasis is a disease which affects millions of people, causing hundreds of deaths every year. (cdc.gov)
Clinical5
  • Hematoma or infarction of the spleen might be followed by the development of a splenic abscess, a clinical condition that has been reported in only 1 patient, to our knowledge ( 4 ). (cdc.gov)
  • The broad spectrum of clinical manifestations of cutaneous leishmaniasis often is compared with that of leprosy. (medscape.com)
  • Due to its rarity and its tendency to pose a clinical diagnostic challenge, we decided to report a case of lymphatic leishmaniasis. (biomedcentral.com)
  • The clinical manifestations of leishmaniasis appears to depend on a complex set of factors, including tropism and virulence of the parasite strain, and the susceptibility of the host, which may be genetically determined [ 1 ]. (biomedcentral.com)
  • The goal is to develop laboratory methods that improve the diagnosis (including species identification) and clinical management of leishmaniasis and that thereby improve the patient outcomes. (cdc.gov)
Type of leishmaniasis3
Cases of leishmaniasis2
Diagnosis of leishmaniasis2
Lesions5
Sandflies7
  • You will be asked if you recall being bitten by sandflies or if you've been in an area where leishmaniasis is common. (medlineplus.gov)
  • In the tropical regions Leishmaniasis is transmitted by sandflies but more recently cases have been reported in Europe among intravenous drug users with HIV. (sciencedaily.com)
  • Leishmaniasis can be caused by the biting of infected sandflies. (healthinternetwork.org)
  • The rising prevalence of poor sanitation and inadequate housing conditions that can contribute to the proliferation of sandflies and increase the likelihood of human exposure to infected bites is primarily driving the leishmaniasis market. (imarcgroup.com)
  • Moreover, sandflies that spread leishmaniasis are smaller and around one-fourth of the mosquito. (pediaa.com)
  • However, it uses sandflies as the vector for the disease leishmaniasis. (pediaa.com)
  • Leishmaniasis is transmitted through the bites of infected female phlebotomine sandflies. (who.int)
Central and Sou3
  • Leishmaniasis occurs in several temperate and tropical countries of Central and South America (New World), the Middle East, East Africa, and East Asia (Old World). (medicinenet.com)
  • Cutaneous leishmaniasis is most common in Central and South America, the Middle East, and North and East Africa. (medicinenet.com)
  • New World' (Western hemisphere) leishmaniasis occurs in tropical parts of Mexico and Central and South America. (medicinenet.com)
Parasitic disease found3
  • Leishmaniasis is a parasitic disease found in parts of southern Europe, the tropics, and the subtropics. (webmd.com)
  • Leishmaniasis is a parasitic disease found largely in the tropics which the World Health Organisation has estimated infects 12 million people worldwide each year. (sciencedaily.com)
  • Leishmaniasis is a parasitic disease found in over 90 countries in the tropics, subtropics, and southern Europe. (cdc.gov)
Enlargement1
  • Changes in spleen structure, frequently encountered during malaria, may result either in a simple asymptomatic enlargement or in serious complications such as hematoma, rupture, or infarction ( 1 - 3 ). (cdc.gov)
Sand flies1
  • Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. (gov.sa)
Protozoan1
Occur2
  • Leishmaniasis recidivans may occur years after a localized cutaneous lesion has healed, commonly presenting on the face (see the following image). (medscape.com)
  • According to data from the World Health Organization (WHO), about 95 percent of cutaneous leishmaniasis cases occur in the Americas , Central Asia, the Mediterranean basin and the Middle East. (environ.news)
Ulcers1
  • Cutaneous Leishmaniasis (CL) takes place when a cutaneous ulcer or ulcers appear as a result of the parasite activity in the host skin. (ugr.es)
Vector-borne1
  • Leishmaniasis is a vector-borne tropical/subtropical disease caused by an intracellular parasite transmitted to humans by sand fly bite. (intechopen.com)
Vaccines1
  • Eisai is proactively collaborating with academia and research organizations and has participated in 11 joint research projects to develop new medicines and vaccines for malaria, Chagas disease, leishmaniasis, and filariasis, with the support of the GHIT Fund. (eisai.com)
Disease9
  • Leishmaniasis is an infectious disease spread by the bite of the female sandfly. (medlineplus.gov)
  • If you are in the United States, you should contact the Centers for Disease Control and Prevention (CDC), which can help test you for leishmaniasis. (webmd.com)
  • Prof Nigel Brown, BBSRC Director of Science and Technology commented: "Leishmaniasis is an extremely damaging disease which threatens 350 million people in 88 countries around the world. (sciencedaily.com)
  • The Centers for Disease Control and Prevention (CDC) recommends that clinicians be on alert for cases of measles that meet the case definition , as well as other infectious diseases, including mumps , leishmaniasis , and malaria , among evacuees (including both Afghan nationals and U.S. citizens) from Afghanistan. (cdc.gov)
  • All these challenges related to environment, disease, and vector pose major implications on WHO's leishmaniasis control and elimination plan. (intechopen.com)
  • According to the authors, governments need to invest more in research into leishmaniasis and create new tools for diagnosing and treating the disease. (healthinternetwork.org)
  • Leishmaniasis produces a spectrum of disease. (msdmanuals.com)
  • The disease is transmitted from human to human, but rural or zoonotic leishmaniasis comes from the interaction of man with animals. (escholarship.org)
  • Cutaneous leishmaniasis is the most common form of the disease. (environ.news)
Occurs2
  • Old World' (Eastern hemisphere) leishmaniasis occurs in tropical parts of Asia, the Middle East, East and North Africa, and southern Europe. (medicinenet.com)
  • Leishmaniasis occurs in scattered areas throughout the world. (msdmanuals.com)
India1
Form1
  • Many of the 86 identified cases of the milder form of leishmaniasis were found in Texas, while others were detected in Arizona, Florida and Oklahoma. (environ.news)
Kala1
  • It was found that in mice administered with the vitamin A-vitamin D3 combine, the load of the kala azar parasite reduced by as much as 81 per cent in the liver and 75 per cent in the spleen as compared to the control group. (org.in)
Parasitism1
  • In addition, it was demonstrated that the control of spleen parasitism is related to the generation of a protective Th1 immune response. (bvsalud.org)
Africa1
  • In the Eastern Hemisphere, leishmaniasis is found in some parts of the Middle East, Asia, Africa - especially in the tropical regain and North Africa, and southern Europe. (disabled-world.com)
Immune3
  • The expression of immune-related genes, spleen lymphocyte subsets and liver RNA-seq were employed to reveal possible molecular mechanisms. (bvsalud.org)
  • The role of liposome size on the type of immune response induced in BALB/c mice against leishmaniasis: rgp63 as a model antigen. (hal.science)
  • Epidemics of both main forms of leishmaniasis are often associated with migration and the movement of non-immune people into areas with existing transmission cycles. (who.int)
Treatment7
Disfigurement2
Malaria2
  • Indeed, splenic hematoma or infarction, together with the humoral and cellular immunodepression due to malaria, might well be predisposing factors for bacterial (e.g., salmonellae) colonization of the spleen from the gut, as likely happened in this patient, although cultures of the pus, blood, or intraabdominal fluid were not performed. (cdc.gov)
  • A study of malaria on the Kano Plains, Kisumu District, Kenya : a community study of current knowledge, attitudes and control practices : parasite and spleen rates : mosquito bionomics and the feasability of vector-control at the community level / by Dismas Ongore. (who.int)
Infections1
  • Relapses are quite common because of the strong interaction that leishmaniasis and HIV have," says Dr. Marco Vitoria, medical officer of the Global HIV, Hepatitis and Sexually Transmitted Infections Programmes at WHO in Geneva, Switzerland. (krwg.org)
Parasite load1