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  • Alzheimer's
  • As the prevalence of Alzheimer's disease (AD), the most common dementia in the elderly, continues to increase, neurologists will encounter a growing number of questions about genetic testing for dementia patients, their relatives, and people concerned about memory or cognitive function who have no apparent risk except advancing age. (medreviews.com)
  • We and others have examined patients with various neurodegenerative and behavioral neurological conditions, such as Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD) and Autistic Spectrum Disorders ([ASD], including Autism, Attention Deficit Disorder, Asperger Syndrome), and found evidence for systemic intracellular bacterial and viral infections in a majority of patients. (townsendletter.com)
  • They include: Alzheimer's disease Acute disseminated encephalomyelitis Viral meningitis Multiple sclerosis Bell's palsy Neuroborreliosis presenting with symptoms consistent with amyotrophic lateral sclerosis has been described. (wikipedia.org)
  • New research from the University of Toronto Mississauga definitively puts to rest a theory that Lyme disease causes Alzheimer's. (iospress.nl)
  • While researching his book " The Alzheimer's Epidemic-Searching for Causes and a Cure " (Emeritus Books), U of T Mississauga Professor Emeritus Danton O'Day was intrigued to discover studies and popular professional opinion supporting a potential link between Lyme disease and Alzheimer's deaths. (iospress.nl)
  • Alzheimer's disease affects 750,000 Canadians. (iospress.nl)
  • Alzheimer's disease causes a similar loss of cognitive ability and, eventually, death. (iospress.nl)
  • Studies suggested a link between the two diseases because earlier research had detected the presence of spirochete bacteria, including B. burgdorferi , in the brains of individuals with Alzheimer's disease. (iospress.nl)
  • In contrast, the causes of Alzheimer's disease remain unknown and there is no cure. (iospress.nl)
  • Together with Andrew Catalano , a recent PhD graduate from O'Day's research group who is now a post-doctoral fellow at City College of New York, O'Day compared data to see if states with high incidences of Lyme disease also showed a high incidence of deaths related to Alzheimer's. (iospress.nl)
  • The pair found, in fact, that the 13 states with the highest incidence of Lyme disease actually reported the lowest number of deaths due to Alzheimer's. (iospress.nl)
  • Furthermore, seven of the states with high incidences of Alzheimer's deaths were among the 13 states with the lowest incidence of Lyme disease. (iospress.nl)
  • Statistical analyses revealed a complete lack of correlation between the two diseases, strongly suggesting that Lyme disease could not be the cause Alzheimer's," O'Day said. (iospress.nl)
  • Because of this growing impact Alzheimer's disease will have in Canada and world-wide, we need to understand the true factors that underlie the disease," said O'Day. (iospress.nl)
  • We need to quickly rule out concerns, like Lyme disease, that unnecessarily cause widespread fear and interfere with attempts to fully understand the causes of Alzheimer's disease. (iospress.nl)
  • The research, which was published in the August 2014 issue of the Journal of Alzheimer's Disease , was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC). (iospress.nl)
  • systemic
  • Patients with neurodegenerative diseases and behavioral disorders often have systemic bacterial, viral, and/or fungal infections that are important in disease progression and severity. (townsendletter.com)
  • However, about 10-15% of patients with Lyme arthritis fail the initial course of antibiotics, and some of those develop a chronic inflammatory arthritis optimally treated with local or systemic immunosuppressive agents. (springer.com)
  • In the first part of this review we considered neurodegenerative and neurobehavioural diseases and the findings that these diseases commonly are associated with systemic and central nervous system bacterial and viral infections. (blogspot.com)
  • antibiotics
  • The importance is that only the spirochete form can be killed by beta lactam antibiotics. (ariplex.com)
  • In the US, neuroborreliosis is typically treated with intravenous antibiotics which cross the blood-brain barrier, such as penicillins, ceftriaxone, or cefotaxime. (wikipedia.org)
  • 11 In contrast, if the SF-36 was used to determine Quality of Life (QOL) in post-Lyme patients, the average SF-36 physical component summary (40±9, range 29-44) and mental component summary (39±14, range 23-46) of the QOL assessment were worse than the general USA population, and they could be significantly improved by anti-Lyme antibiotics (46% versus 18%, p =0.007). (blogspot.com)
  • Lyme disease can be easily detected and cured with antibiotics," O'Day said. (iospress.nl)
  • neuropsychiatric
  • Thus the value of careful evaluation that often includes neuropsychiatric testing, SPECT and MRI brain scans, CSF analysis when appropriate, regular input from Lyme-aware neurologists, pain clinics, and occasionally specialists in psychopharmacology. (ariplex.com)
  • Neurology
  • Pediatr Res, 1993 Jan,33(1Suppl):S90-4 Dept. Neurology, University Pennsylvania School of Medicine In this abstract, Guillain-Barre disease is the topic with Lyme mentioned as well. (borrelioosi.net)
  • neurological
  • 1-5 One of the biochemical changes found in essentially all neurological degenerative diseases is the over-expression of oxidative free radical compounds (oxidative stress) that cause lipid, protein, and genetic structural changes. (townsendletter.com)
  • An attractive model for neurodegeneration resulting in neurological disease involves the action of toxic products produced as a result of chronic bacterial and/or viral infections. (townsendletter.com)
  • Can microbes and immune reactions to them actually contribute to cognitive decline, degenerative neurological disease, developmental disabilities, mental illness, personality changes and, at the most extreme, even violent and criminal behavior? (psychologytoday.com)
  • Although most patients with Lyme/tick-borne disease do not become violent, a small percent of patients who become infected develop a type of neurological dysfunction that can increase their risk of aggressiveness. (psychologytoday.com)
  • ELISA
  • Neuroborreliosis can also be diagnosed serologically to confirm clinical examination via western blot, ELISA, and PCR. (wikipedia.org)
  • The rheumatologist then added a screening test for Lyme disease, either ELISA or an IFA quantitative (titer) test. (medcapsules.com)
  • Recent studies (14) by the group responsible for Lyme disease proficiency testing for the College of American Pathologists (CAP) came to the conclusion that the currently available ELISA assays for Lyme disease do not have adequate sensitivity to meet the two-tiered approach recommended by the CDC/ASPHLD group (7). (medcapsules.com)
  • rash
  • this rash occurs in 75% of patients infected with Lyme disease and tends to resolve from the inside-out, leaving a bull's eye mark on the skin (Frey 2002). (davidson.edu)
  • The patients considered for entry in the study had an EM rash and either arthritis or neuroborreliosis. (medcapsules.com)
  • Africa
  • With so many vectors, the underlying assumption behind this checklist is that Lyme is not rare in North America, Europe, South America, Russia, Africa or Asia. (lymebook.com)
  • The disease is rarely detected in northern Africa and Mediterranean countries ( 3 , 6 , 7 ). (cdc.gov)
  • TBRF
  • In TBRF, the spirochetes are transmitted via the bite of an infected tick, whereas, in LBRF, contact with hemolymph from the human body louse (eg, from scratching-induced louse crushing) is the mode of spirochete transfer. (medscape.com)
  • findings
  • Ocular Lyme disease has also been reported, as has neuroborreliosis affecting the spinal cord, but neither of these findings are common. (wikipedia.org)
  • Findings showed that a group of Lyme patients had both proximal and distal paraspinal denervation on electromyographic testing (EMG) with clearly ALS signs. (borrelioosi.net)
  • The United States is the only source to report location-specific data on the two diseases, but O'Day says that the findings are equally relevant in Canada. (iospress.nl)
  • patients
  • Oral antimicrobials have been shown to be effective in European neuroborreliosis and presumably are equally potent in North American patients. (medreviews.com)
  • We review the neuro-ophthalmic literatureon FAS to alert neurologists to the ocular disease seen in patients with this condition. (medreviews.com)
  • showed that patients with neuroborreliosis demonstrate a blood brain barrier disturbance with 62 % showing an elevated albumin ratio and 60 % revealing an increased IgG index, indicative of intrathecal IgG synthesis. (upmc.edu)
  • It is clear that in the great majority of patients, chronic Lyme is a disease affecting predominantly the nervous system. (ariplex.com)
  • Use of bisphosphonates in patients with conditions or diseases affecting renal function is not recommended. (issuu.com)
  • In working with a number of patients with Lyme/tick-borne diseases it is apparent to many clinicians these conditions can cause reduced frustration tolerance, irritability, depression , cognitive impairments and mood swings, but more significantly, in a few patients, suicidal and aggressive tendencies. (psychologytoday.com)
  • The presence of B.bissettii as a single strain in patients provides strong support of the factthat B. bissettii might be a causative agent of the disease. (borrelioosi.net)
  • immunological
  • 1 In addition to genetic changes and changes in gene expression, it is thought that nutritional deficiencies, head trauma, environmental toxins, chronic bacterial and viral infections, autoimmune immunological responses, vascular diseases, accumulation of fluid in the brain, changes in neurotransmitter concentrations, and other causes are involved in various neurodegenerative diseases. (townsendletter.com)
  • epidemic
  • Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. (springer.com)
  • occur
  • There appears to be a genetic link to neurodegenerative diseases, but the genetic changes that occur and the changes in gene expression that are found in these diseases are complex and not related to simple genetic mutations, deletions, or amplifications. (townsendletter.com)
  • 1975
  • It was first identified in 1975 in the town of Old Lyme, CT after an outbreak of juvenile rheumatoid arthritis. (davidson.edu)
  • Lyme disease was diagnosed as a separate condition for the first time in 1975 in Old Lyme, Connecticut. (wikipedia.org)
  • arthritis
  • Orczyk K, Swidrowska-Jaros J, Smolewska E. When a patient suspected with juvenile idiopathic arthritis turns out to be diagnosed with an infectious disease - a review of Lyme arthritis in children. (springer.com)
  • psychiatric
  • Here to weigh in with some evidence is psychiatrist Robert Bransfield, an expert on the psychiatric manifestions of Lyme disease and founder of the mailing list, Microbes and Mental Illness, where the discussions on such topics are held. (psychologytoday.com)