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Novel coronavirus2020ContagiousPandemicInfectionSpeciesProteinsInfectionsCasesVirusIncludesShapeTransmissionStateStudiesHigherCanine coronavirus2019OutbreaksOC43InfectiousProteinPathogenPositive-strandedSARSFIPVHumansGenomesOutbreakRespiratory illnessAntibodiesGenomicBatsVirusesDiseaseResearchersScientistsResponsibleHumanFoundBindGroupDiarrheaAnimalsMoleculesPeopleTime
Novel coronavirus5
  • Years before the novel coronavirus turned into a global pandemic, Susan Daniel was already looking for ways to defeat it. (cornell.edu)
  • The work was scientifically interesting - these viruses have a lot of tricks - but the arrival of the novel coronavirus suddenly put her work at the center of a global crisis. (cornell.edu)
  • The novel coronavirus is far more contagious and deadly than its predecessor, but the two viruses also have much in common. (cornell.edu)
  • The good news for these species is that the novel coronavirus has, on the whole, caused only mild to moderate illness and few deaths. (vin.com)
  • Humans are by far the most susceptible animal to the novel coronavirus. (vin.com)
20203
  • According to a review of the literature on SARS-CoV-2 infections in animals, published in October 2020 in the journal Transboundary and Emerging Diseases, experimental studies had demonstrated infection and transmission in cats, ferrets, hamsters, bats and nonhuman primates. (vin.com)
  • Tracking coronavirus' global spread updated July 30th, 2020 @ 11 a.m. (thenewsblender.com)
  • On July 29th, 2020 the New York Times reported that Vietnam, who had gone months without reporting a single coronavirus death or even a confirmed case of local transmission, has a new outbreak, and it's spreading. (thenewsblender.com)
Contagious1
  • The virus isn't necessarily highly contagious among felines: There have been instances in which only one cat in a multi-cat household tested positive. (vin.com)
Pandemic2
  • Coronavirus cases in Stockport have remained relatively low throughout the pandemic, but concerns have been raised as they're now growing, particularly in young people. (propermanchester.com)
  • Today, two years since Covid-19 was declared a pandemic, the list of nonhuman species that have tested positive for the notorious coronavirus is 19 long. (vin.com)
Infection4
  • Feline enteric coronavirus is responsible for an infection of the mature gastrointestinal epithelial cells (see also enterocytes, brush border, microvilli, villi). (wikipedia.org)
  • Some cats are resistant to the virus and can avoid infection or even becoming carriers, while others may become FECV carriers. (wikipedia.org)
  • These spike proteins reach out to grab nearby cells (Daniel calls it "harpooning"), the first step toward an infection. (cornell.edu)
  • Daniel and colleagues discussed the role of calcium in coronavirus infection in a paper published online April 6 in Antiviral Research . (cornell.edu)
Species1
Proteins5
  • Much of the work in Daniel's lab looks at the pointy projections - called spike proteins - that give coronaviruses their tell-tale appearance. (cornell.edu)
  • If there was a way to stop these spike proteins from doing their job, the virus would be essentially disarmed. (cornell.edu)
  • Daniel and her team believe they may have identified a potential vulnerability in spike proteins. (cornell.edu)
  • Daniel - along with her frequent collaborators Gary Whittaker, professor of virology at the College of Veterinary Medicine, and Nicholas Abbott, the Tisch University Professor of chemical and biomolecular engineering in the College of Engineering - received a $200,000 "rapid" grant from the National Science Foundation in April to study the spike proteins of the new virus. (cornell.edu)
  • COVID-19 virus: Closed (6VXX) and open state (6VYB) of spike proteins (red pyramid shape). (wisc.edu)
Infections2
  • Cats were the first pets in the United States to have confirmed infections, manifesting as mild respiratory illness. (vin.com)
  • Although Vietnam, a nation of 95 million people, remains the largest country in the world to have not confirmed a single fatality from the coronavirus, the mystery surrounding the infections popping up across the country has spooked medical experts and residents alike. (thenewsblender.com)
Cases4
  • Overcrowding increases the risk of mutation and conversion from FECV to FIPV, which constitutes a major risk factor for the development of feline infectious peritonitis (FIP) cases. (wikipedia.org)
  • Similarly, there has been a spike in coronavirus cases in Trafford which is also proportionately higher in younger people. (propermanchester.com)
  • In the week ending July 17th, the number of new coronavirus cases in Trafford was 26, which rose to 77 in the following week. (propermanchester.com)
  • As news that his great economy was not-so great President Whines More than Cat's do at Dinner Time whined that the media wasn't covering other countries spike in coronavirus cases while also questioning the numbers being reported by those other countries. (thenewsblender.com)
Virus10
  • Feline coronavirus (FCoV) is a positive-stranded RNA virus that infects cats worldwide. (wikipedia.org)
  • Cats living in groups can infect each other with different strains of the virus during visits to a communal litter tray. (wikipedia.org)
  • The virus becomes feline infectious peritonitis virus (FIPV) when random errors occur in the virus infecting an enterocyte, causing the virus to mutate from FECV to FIPV. (wikipedia.org)
  • such as younger kittens, old cats, immunosuppression due to viral-FIV (feline immunodeficiency virus) and/or FeLV (feline leukemia virus) and stress, including the stress of separation and adoption. (wikipedia.org)
  • FCoV type II is a recombinant virus type I with spike genes (S protein) replacement from FCoV by the canine coronavirus (CCoV) spikes. (wikipedia.org)
  • Once the spikes have snagged a cell, the virus can deliver its genetic payload, essentially turning the infected cell into a virus factory. (cornell.edu)
  • Studies of the original SARS 1 virus showed that the spikes depend on calcium to effectively do their job. (cornell.edu)
  • Without calcium, the spikes tend to flop, potentially making it more difficult for the virus to infect a cell. (cornell.edu)
  • For molecules, it is demonstrated using the spikes of COVID-19 virus [13] . (wisc.edu)
  • 6JX7 is feline corona virus. (wisc.edu)
Includes1
  • Nixalite Mounting Hardware includes a wide variety of stainless steel or all weather mounting hardware to fasten the Premium Nixalite, E-Spike or Pigeon Spike Stainless bird spike models to nearly any surface. (nixalite.com)
Shape1
  • Fastens the Premium Nixalite, E-Spike and Pigeon Spike Stainless to nearly any surface, shape or material. (nixalite.com)
Transmission1
  • In environments with multiple cats, the transmission rate is much higher compared to single-cat environments. (wikipedia.org)
State1
  • In their pre-domestication natural state, cats are solitary animals and do not share space (hunting areas, rest areas, defecation sites, etc. (wikipedia.org)
Studies2
  • The only known exceptions are on the Falkland Islands and the Galapagos, where studies found no occurrences of FCoV antibodies in cats tested. (wikipedia.org)
  • With a new sense of urgency, Daniel and her team are collaborating with other Cornell researchers to expand their coronavirus studies in an effort that blends engineering with virology and data science. (cornell.edu)
Higher2
  • Domestic cats living in a group therefore have a much higher epidemiological risk of mutation. (wikipedia.org)
  • In a large group of cats, n, the epidemiological risk of mutation (E) is higher and expressed theoretically as: E = n2 −n. (wikipedia.org)
Canine coronavirus2
20196
  • With those two elements, half of them factual, the authors come to the sweeping conclusion that "somebody was entangled with the evolution of 2019-nCoV coronavirus," and "the killer coronavirus probably originated from a laboratory in Wuhan. (snopes.com)
  • The current global pandemic, caused by the coronavirus SARS-CoV-2, emerged in December 2019. (nih.gov)
  • No matter where you go online these days, there's bound to be discussion of coronavirus disease 2019 (COVID-19). (nih.gov)
  • Coronavirus Disease 2019 Transmission: Blood Viremia and Aerosol Generation from Spinal Surgery. (asianspinejournal.org)
  • We reviewed the available evidence to ascertain the presence of coronavirus disease 2019 (COVID-19) blood viremia and the virus' blood transmissibility, as well as evidence of blood-aerosol generation and operating room contamination from spinal surgical procedures. (asianspinejournal.org)
  • Chinese medical researchers suggested the drug had successfully cured coronavirus patients after the December 2019 outbreak. (dailymail.co.uk)
Outbreaks2
  • There are still small outbreaks of this coronavirus (MERS-CoV) today. (nih.gov)
  • The continuous emergence of novel viruses and their diseases are a threat to global public health as there have been three outbreaks of coronaviruses that are highly pathogenic to humans in the span of the last two decades, severe acute respiratory syndrome (SARS)-CoV in 2002, Middle East respiratory syndrome (MERS)-CoV in 2012, and novel SARS-CoV-2 which emerged in 2019. (mdpi.com)
OC432
Infectious7
Protein8
  • Trimers (3 subunits) of the S protein form the characteristic spikes that protrude from the virus membrane. (i-sis.org.uk)
  • The team was able to identify protein features unique to the COVID-19, MERS, and SARS coronaviruses. (nih.gov)
  • The insertions in the spike protein appear to help the viruses penetrate human cells. (nih.gov)
  • The genomic data of the new coronavirus responsible for COVID-19 show that its spike protein contains some unique adaptations. (nih.gov)
  • One of these adaptations provides special ability of this coronavirus to bind to a specific protein on human cells called angiotensin converting enzyme (ACE2). (nih.gov)
  • However, to their surprise, the researchers found that the spike protein of the new coronavirus actually bound far better than computer predictions, likely because of natural selection on ACE2 that enabled the virus to take advantage of a previously unidentified alternate binding site. (nih.gov)
  • In fact, any bioengineer trying to design a coronavirus that threatened human health probably would never have chosen this particular conformation for a spike protein. (nih.gov)
  • The week before most NIH employees and trainees began teleworking full-time, Borgnia's team began to study the protein spikes conferring the corona-like appearance to the SARS-CoV-2 virus. (nih.gov)
Pathogen1
Positive-stranded1
SARS10
  • Research on coronaviruses is an important focus of China's scientific efforts ever since the 2002 SARS epidemic, which was also caused by a coronavirus. (snopes.com)
  • The complete sequence of the SARS virus is now available, confirming it is a new coronavirus unrelated to any previously known. (i-sis.org.uk)
  • Furthermore, the SARS virus can grow in Vero green monkey kidney cells, which no other coronavirus can, with the exception of porcine epidemic diarrhea virus, also in Group 1. (i-sis.org.uk)
  • According to a review of the literature on SARS-CoV-2 infections in animals, published in October 2020 in the journal Transboundary and Emerging Diseases, experimental studies had demonstrated infection and transmission in cats, ferrets, hamsters, bats and nonhuman primates. (vin.com)
  • A genomic analysis may help explain why some coronaviruses, like SARS-CoV-2, can be deadly, while others cause only mild illness. (nih.gov)
  • SARS-CoV-2, the virus that causes COVID-19, isolated from a patient in the U.S. The spikes on the outer edge of the virus particles give coronaviruses their name, which means crown-like. (nih.gov)
  • Researchers are trying to uncover why the coronaviruses responsible for COVID-19, MERS, and SARS cause more severe illness than other coronaviruses. (nih.gov)
  • Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses. (nih.gov)
  • A related coronavirus that causes severe acute respiratory syndrome (SARS) in humans also seeks out ACE2. (nih.gov)
  • Existing computer models predicted that the new coronavirus would not bind to ACE2 as well as the SARS virus. (nih.gov)
FIPV1
Humans4
  • The coronavirus responsible for COVID-19 has deadly adaptations that make it perfect for infecting humans. (snopes.com)
  • The findings could help guide the development of treatments for COVID-19 and identify coronaviruses that might pose a threat to humans in the future. (nih.gov)
  • If the new coronavirus had been manufactured in a lab, scientists most likely would have used the backbones of coronaviruses already known to cause serious diseases in humans. (nih.gov)
  • The second scenario is that the new coronavirus crossed from animals into humans before it became capable of causing human disease. (nih.gov)
Genomes2
  • Known coronaviruses are placed in three groups based on similarities in their genomes. (i-sis.org.uk)
  • The researchers analyzed the complete genomes of all human coronaviruses as well as closely related animal ones. (nih.gov)
Outbreak1
  • Nevertheless, the findings could help prevent a future deadly coronavirus outbreak. (nih.gov)
Respiratory illness2
  • Cats were the first pets in the United States to have confirmed infections, manifesting as mild respiratory illness. (vin.com)
  • Coronaviruses are a large family of viruses that mostly cause respiratory illness. (nih.gov)
Antibodies2
  • The only known exceptions are on the Falkland Islands and the Galapagos, where studies found no occurrences of FCoV antibodies in cats tested. (wikipedia.org)
  • Once he had the spike protein's structure, he began collaborating with researchers who were developing antibodies that would neutralize the spike. (nih.gov)
Genomic2
  • and their colleagues used sophisticated bioinformatic tools to compare publicly available genomic data from several coronaviruses, including the new one that causes COVID-19. (nih.gov)
  • The researchers went on to analyze genomic data related to the overall molecular structure, or backbone, of the new coronavirus. (nih.gov)
Bats1
  • However, they are found in other closely related coronaviruses that infect animals, such as bats. (nih.gov)
Viruses1
  • The researchers determined that the spike insertions may improve the viruses' ability to interact with the receptor on human cells that the viruses use to gain entry. (nih.gov)
Disease1
  • Coronavirus disease 19 (COVID-19) has resulted in an estimated 470,000 deaths worldwide to date. (nih.gov)
Researchers2
  • Researchers now believe it may hold the key to treating COVID-19, the latest strain of coronavirus. (dailymail.co.uk)
  • Essentially, his consortium created a pipeline so researchers could study how the spike behaves when exposed to different molecules. (nih.gov)
Scientists1
  • Drugs used to treat HIV and malaria could be used to tackle the coronavirus , according to scientists in Australia. (dailymail.co.uk)
Responsible2
  • Feline enteric coronavirus is responsible for an infection of the mature gastrointestinal epithelial cells (see also enterocytes, brush border, microvilli, villi). (wikipedia.org)
  • The spikes are responsible for attaching to specific host cell receptors and for causing infected cells to fuse together. (i-sis.org.uk)
Human1
  • These insertions aren't found in the four non-lethal human coronaviruses. (nih.gov)
Found2
Bind1
  • These spikes bind to the surface of cells, the first step before the virus can invade a host cell. (nih.gov)
Group2
  • Domestic cats living in a group therefore have a much higher epidemiological risk of mutation. (wikipedia.org)
  • In a large group of cats, n, the epidemiological risk of mutation (E) is higher and expressed theoretically as: E = n2 −n. (wikipedia.org)
Diarrhea1
  • Cats with Covid may also lose their appetite, become lethargic, vomit and have diarrhea. (vin.com)
Animals1
  • In their pre-domestication natural state, cats are solitary animals and do not share space (hunting areas, rest areas, defecation sites, etc. (wikipedia.org)
Molecules1
  • The resulting images are like CAT scans for molecules. (nih.gov)
People1
Time1
  • Finally, next time you come across something about COVID-19 online that disturbs or puzzles you, I suggest going to FEMA's new Coronavirus Rumor Control web site . (nih.gov)