• The mitochondrial sheath (MS), an important organelle in the midpiece of spermatozoa, is crucial to sperm motility. (nih.gov)
  • The genetic quality of sperm, as well as its volume and motility, all typically decrease with age. (wikipedia.org)
  • However, the over production of oxygen free radicals in sperm membrane decreases the antioxidant defense activity thereby leading to low sperm motility and viability, DNA fragmentation and protein denaturation. (scialert.net)
  • knockout male mice showed severe subfertility with a defect in sperm motility as well as a significant disorganization in the fibrous sheath. (biologists.com)
  • Functional assessments on sperm included counting sperm amount and sperm motility, staining F-actin, and quantifying adenosine triphosphate (ATP) content. (biomedcentral.com)
  • Testicular torsion-detorsion significantly decreased the amount of sperm, inhibited the motility, declined the F-actin expression, and reduced the content of ATP in sperm. (biomedcentral.com)
  • Local injection of MSCs improved sperm function, particularly in sperm motility. (biomedcentral.com)
  • Local injection of MSCs into a testis damaged by testicular torsion-detorsion restores sperm function mainly through the improvement of sperm motility and energy. (biomedcentral.com)
  • Vigorous motility is initiated almost instantly upon sperm release from cauda during ejaculation. (bioscientifica.com)
  • The molecular mechanisms that suppress sperm motility but increase cell survival during storage in cauda epididymis are not known. (bioscientifica.com)
  • Intracellular signaling via phosphorylation cascades is quick events that may regulate motility and survival of transcriptionally inactive sperm. (bioscientifica.com)
  • Pathscan intracellular signaling array provided the preliminary picture of cell signaling in quiescent and motile rat sperm, indicating upregulation of cell-survival pathways in quiescent sperm, which were downregulated during motility activation. (bioscientifica.com)
  • Interactome of signaling proteins involved in motility activation was constructed by Search Tool for the Retrieval of Interacting Genes (STRING) software, which identified mitogen activated protein kinase-p38 (MAPK-p38), AKT, mTOR and their downstream target p70S6K as the key kinases regulating sperm function. (bioscientifica.com)
  • Activators of these kinases inhibited sperm motility but increased viability, and vice versa was true for inhibitors, in most of the cases. (bioscientifica.com)
  • Data suggest that sperm motility and survival are inversely complementary and critically regulated by intracellular cell signaling. (bioscientifica.com)
  • Aberrant cell signaling in caudal sperm may affect cell survival (sperm concentration) and motility of ejaculated sperm. (bioscientifica.com)
  • In spermatozoa, several key functions are regulated by cytoplasmic Ca2+ concentration such as sperm capacitation, chemotaxis, hyperactive motility, and acrosome reaction. (123dok.net)
  • and (3) incubating sperm with EVs improved motility, fertilizing capacity of cat spermatozoa and prevented acrosomal exocytosis in vitro . (alphanano.tech)
  • Spermatozoa (singular spermatozoon) are specialized gametic cells possessing own motility. (iasri.res.in)
  • Main and end piece contains axonemal contractile filaments for sperm motility. (iasri.res.in)
  • Motility of sperm is visible under ordinary microscope in diluted semen sample. (iasri.res.in)
  • It is suggested that large-scale deletions of the mtDNA is associated with poor sperm motility and may be a causative factor in the decline of fertility in men. (ijfs.ir)
  • Sperm motility is one of the key indicators of fertility in men. (ijfs.ir)
  • first demonstrated the association of the 4977 bp deletion of mtDNA with low motility of the human spermatozoa. (ijfs.ir)
  • It has been suggested that these mutations cause infertility by affecting sperm motility. (ijfs.ir)
  • The fluids improve the motility of the spermatozoa. (lumenlearning.com)
  • Nineteen patients without children were included with semen abnormalities in concentration, morphology and/or progressive motility detected in 2 semen analyses at the Human Reproduction Laboratory of São Paulo Federal University. (wimbledon-acupuncture.co.uk)
  • By contrast, the kinetics of protein tyrosine phosphorylation and sperm motility are unaltered in mutant sperm relative to wild-type. (biologists.com)
  • sperm count of 14 million/ml with 35% active motility and 100% morphologically abnormal sperm, indicating globozoospermia. (jri.ir)
  • Common problems in male related infertility are sperm count, motility or structural abnormalities. (jri.ir)
  • 50%, or at least 25% of spermatozoa with linear progressive motility and ≥ 30% of morphologically normal spermatozoa. (biochemia-medica.com)
  • However, these criteria can only be applied when sperm analysis is carried out at 37 °C. Sperm motility is highly influenced by temperature and should always be assessed under controlled thermal conditions (5). (biochemia-medica.com)
  • Since, the motility analysis at Andrology Laboratory was performed at room temperature (22 °C), we had to readjust the sperm motility criteria. (biochemia-medica.com)
  • MDA levels were negatively correlated with the sperm motility (MDA = -0.014 x motility + 2.62, p =0.017) and concentration (MDA = -0.0045 x concentration + 2.23, p = 0.0166). (ijbs.com)
  • GPx activities were positively but non-significantly correlated with the sperm concentration and sperm motility. (ijbs.com)
  • Seminal MDA concentrations are negatively correlated with sperm concentration and motility, which might provide a simple and useful tool in predicting sperm parameters. (ijbs.com)
  • Spermatozoa are rendered dysfunctional by lipid peroxidation and altered membrane function, together with impaired metabolism, morphology, and motility [ 2 ]. (ijbs.com)
  • In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. (plos.org)
  • It is involved in flagellar movements and motility, and in cellular events that occur in the sperm head, that will lead to successful interaction with the egg and to fertilization [ 1 , 2 ]. (plos.org)
  • Epididymal spermatozoas are often described as immature, immotile, and infertile sperm cells, yet the epididymis is the organ where spermatozoa mature, acquire motility, and become fully fertile. (encyclopedia.pub)
  • As the spermatozoa move along the epididymis, changes in plasma membrane fluidity take place, as well as the acquisition of motility [ 5 ] [ 6 ] . (encyclopedia.pub)
  • The purpose of this investigation was to examine whether boar spermatozoa possess specific binding sites for relaxin and to examine what effects relaxin actually exerts on their motility characteristics. (go.jp)
  • For the motility characteristics study, cauda epididymal spermatozoa were diluted 300-fold in modified KRB + 2% cauda epididymal fluid (approximately 1 × 10 7 cell/ml). (go.jp)
  • Sperm can modulate their energetics by regulating their flagellar waveform -- how the sperm oscillate their tails -- in order to adapt to varying fluid environments, potentially optimizing their motility and navigation within the reproductive tract, according to new research. (womenshealthdaily.com)
  • Epididymal transit lasts 5-10 days in the mouse [ 4 ] and leads to the acquisition of sperm motility and the ability to recognize and fertilize oocytes [ 5 ]. (oncotarget.com)
  • In mammals, sperm is stored in the epididymis and is released from the penis during ejaculation in a fluid known as semen. (wikipedia.org)
  • Sperm cells are carried out of the male body in a fluid known as semen. (wikipedia.org)
  • Sperm quantity and quality are the main parameters in semen quality, which is a measure of the ability of semen to accomplish fertilization. (wikipedia.org)
  • The morphological assessment of human spermatozoa which includes the evaluation of the percentage of morphologically normal sperm and the determination of the incidence of various morphological abnormalities has always been part if semen analysis in couples consulting for infertility. (myhealth.gov.my)
  • Sperm morphology was assessed in the initial semen analysis using the Kruger-Tygerberg Strict Criteria as outlined by the World Health Organization. (myhealth.gov.my)
  • The process of passage of spermatozoa or semen out of male genital tract is termed as ejaculation. (iasri.res.in)
  • Semen is the term given to secretion of male genital tract and it contains spermatozoa and seminal plasma. (iasri.res.in)
  • Approximately 3.5 ml semen is discharged with every ejaculation and one milliliter of semen contains about 100 millions spermatozoa. (iasri.res.in)
  • On volume basis, sperms constitute just 1% of semen volume. (iasri.res.in)
  • Semen composition is described in terms of volume of ejaculate (i.e. volume of semen discharged per ejaculate) and sperm concentration (i.e. billions of sperms present in one milliliter of semen). (iasri.res.in)
  • Semen is a thick, yellowish white, glairy, opalescent, secretion having a characteristic odour known as seminal odor.It is also called seminal fluid, fluid that is ejaculated from the male reproductive tract and that contains sperm cells, which are capable of fertilizing the female eggs. (forensicsdigest.com)
  • Semen also contains other liquids, known as seminal plasma, which help to keep the sperm cells viable. (forensicsdigest.com)
  • The total volume of semen for each ejaculation of a human male averages between 2 and 5 ml. (forensicsdigest.com)
  • The seminal vesicles produce a yellowish viscous fluid rich in fructose and other substances that makes up about 70% of human semen. (forensicsdigest.com)
  • 1. Testes produce spermatozoa that can be considered as confirmatory evidence for the presence of semen. (forensicsdigest.com)
  • The identification of one or more sperms is a conclusive proof of the presence of semen.However, there are difficulties in the identification of sperms due to several reasons. (forensicsdigest.com)
  • Semen and sperm are then fused together during fertilization, and the result is a child. (fertiligy.com)
  • This study aimed to evaluate the effects of bacteriospermia on sperm parameters and clinical outcomes in semen samples infected with two common bacteria ( Staphylococcus saprophyticus and Escherichia coli ) in northern Iran. (ecerm.org)
  • In washed semen, tight adhesion between the sperm midpiece and S. saprophyticus was observed. (ecerm.org)
  • Therefore, a comparative study of these two bacteria on semen parameters and fertility results of sperm in laboratory conditions would help to better understand the potential effects of bacteria on sperm fertility potential. (ecerm.org)
  • The male reproductive system consists of a pair of testes that produce sperm (or spermatozoa ), ducts that transport the sperm to the penis and glands that add secretions to the sperm to make semen (see diagram 13.2). (wikibooks.org)
  • Type 2 is classified as partial globozoospermia in that the ratio of round-headed spermatozoa is less than 100% (i.e., 20-90%) in a semen sample and acrosomal vesicles are present in the rest of the spermatozoa (3). (jri.ir)
  • The World Health Organization (WHO) has so far published several manuals in order to standardize semen analysis procedures and WHO criteria have become widely accepted in sperm morphology examination at andrology laboratories all over the world (1,2). (biochemia-medica.com)
  • Indications for performing a postcoital test include semen hyperviscosity, increased or decreased semen volume with good sperm density, or unexplained infertility. (medscape.com)
  • Excessive generation of ROS in semen may be associated with reduced sperm fertilizing potentials. (ijbs.com)
  • Excessive generation of ROS in semen, mainly by neutrophils but also by abnormal spermatozoa, could be linked with infertility. (ijbs.com)
  • Moreover, in cats, a species notoriously difficult to collect semen from, epididymal sperm may serve as an extra and easily accessible source of gametes [ 2 ] . (encyclopedia.pub)
  • It is a well-known fact that sperm counts have dropped by half in the last 50 years, and that modern men have 20 percent less semen volume than their fathers (BMJ, 1992, volume 305). (carmk.net)
  • Both unilateral and bilateral cryptorchidism are associated with a decrease in sperm production and semen quality, regardless of the timing of orchidopexy. (medscape.com)
  • The seminal vesicles and prostate gland add fluids to the sperm to create semen. (bccampus.ca)
  • Thus, in humans, it is a measure of fertility in a man. (wikipedia.org)
  • DNA damages present in sperm cells in the period after meiosis but before fertilization may be repaired in the fertilized egg, but if not repaired, can have serious deleterious effects on fertility and the developing embryo. (wikipedia.org)
  • More studies of fertility outcomes in large populations are required to refine the application of CASA to measuring sperm morphology. (myhealth.gov.my)
  • Several studies have also demonstrated that multiple mtDNA deletions are associated with defective sperm function and diminish fertility in men (14, 21-25). (ijfs.ir)
  • Therefore, male fertility may be inhibited by the negative effects of bacteriospermia and leukocytospermia on sperm parameters [ 2 ]. (ecerm.org)
  • However, to the best of our knowledge, no study in the literature has yet investigated the impact of Staphylococcus saprophyticus on sperm quality and male fertility potential during in vitro fertilization (IVF) techniques. (ecerm.org)
  • The minisymposium, organized by Victor D. Vacquier, included the following presentations: "An Hypothesis to Explain the Evolution of Species-Specific Fertilization" by Victor D. Vacquier, "Molecular Biology of the Zona Pellucida: Genetic Mutations and Fertility" by Jurrein Dean, and "Sperm-Egg Membrane Interactions During Fertilizations" by Janice P. Evans. (bioone.org)
  • High lipid peroxidation as represented by MDA levels may cause changes in the sperm and diminish fertility [ 5 ]. (ijbs.com)
  • Why is Glutathione important for Sperm Quality and Fertility? (carmk.net)
  • Using less stringent statistical criteria (uncorrected p -values), also the gene SPATA16 , which has a pivotal role in male fertility and for which episodes of adaptive evolution have been suggested, also displays a putative signal of diversifying selection in the human branch. (biomedcentral.com)
  • The present study was conducted to determine the effect of two human chorionic gonadotropin (hCG) treatments on the fertility of ewes which were estrus-induced and artificially inseminated during the non-breeding season. (go.jp)
  • New research provides rare direct evidence showing that increased homozygosity -- meaning two identical alleles in a genome -- leads to negative effects on fertility in a human population. (womenshealthdaily.com)
  • New research reveals how the bacteria strain Wolbachia pipientis enhances the fertility of the insects it infects, an insight that could help scientists increase the populations of mosquitoes that do not carry human disease. (womenshealthdaily.com)
  • The midpiece has a central filamentous core with many mitochondria spiralled around it, used for ATP production for the journey through the female cervix, uterus, and uterine tubes. (wikipedia.org)
  • Immunofluorescence localized the kinase proteins in the sperm mid-piece region (mitochondria), a known extra-nuclear target for these signaling pathways. (bioscientifica.com)
  • Immediately after the neck is the midpiece, which is where the mitochondria of the cell are located. (lishkolab.org)
  • The mid-piece of sperm contains several mitochondria. (forensicsdigest.com)
  • Figure 346 from Chapter 14 (Sperm Flagellum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Top panel: A cross section of sperm tail of the cecidomyid fly, Diplolaboncus tumorificus shows mitochondria. (cellimagelibrary.org)
  • There are ~22-80 mitochondria in the midpiece of a single mature mammalian spermatozoon (2-4). (ijfs.ir)
  • Propagation of paternal sperm-contributed mitochondrial genes, leading to heteroplasmy, is seldom noticed in mammals attributable to post-fertilization degradation of sperm mitochondria, known as sperm mitophagy. (eqalix.com)
  • Such patterns are according to our earlier commentary of SQSTM1 and VCP associating with sperm mitochondria contained in the porcine zygote. (eqalix.com)
  • Even in an interspecific mobile setting encompassing bull spermatozoa and porcine oocyte extract, ooplasmic SQSTM1 was recruited to heterospecific sperm mitochondria. (eqalix.com)
  • Complementary with the binding of SQSTM1 and VCP to sperm mitochondria, two sperm-borne pro-mitophagy proteins, parkin co-regulated gene product (PACRG) and spermatogenesis related 18, underwent localization modifications after extract coincubation, which had been according to their degradation noticed inside fertilized porcine oocytes. (eqalix.com)
  • The midpiece contains the mitochondria. (ussromantics.com)
  • As a result of spermatogenesis and epididymal maturation, male germ cells differentiate to become fully functional spermatozoa. (biomedcentral.com)
  • Possible cause of male infertility: Gina Esther Merges and Prof. Hubert Schorle study genes involved in sperm maturation. (innovations-report.com)
  • Since it is exclusively made in humans and mice during the maturation of male sperm, it has been postulated that the protein is important for this phase of development," notes corresponding author Prof. Hubert Schorle from the Institute of Pathology at UKB, who is also a member of the Transdisciplinary Research Area (TRA) "Life & Health" at the University of Bonn. (innovations-report.com)
  • It is through their transit in the epididymis that sperms cells complete important maturation steps crucial for fulfilling their functions. (123dok.net)
  • Mammalian sperm must undergo a physiological maturation, termed capacitation, before they are able to fertilize eggs. (biologists.com)
  • A better understanding of the function of this organ and of the chronology of sperm maturation may elucidate the etiological background of many idiopathic subfertilities that are related to disorders in sperm maturation. (encyclopedia.pub)
  • The epididymis is the location of sperm maturation and sperm storage. (oncotarget.com)
  • Several accessory organs and ducts aid the process of sperm maturation and transport the sperm and other seminal components to the penis, which delivers sperm to the female reproductive tract. (bccampus.ca)
  • It contains a fluid called seminal plasma and spermatozoa in varying number (sperm concentration). (iasri.res.in)
  • Infertility in men can result from deficiencies in sperm formation, concentration, or transportation. (medscape.com)
  • Free radicals have beneficial or detrimental effects upon sperm functions, which depend on their nature and concentration. (ijbs.com)
  • Spermatozoa are highly sensitive to injuries caused by high ROS concentration [ 1 ]. (ijbs.com)
  • As in somatic cells, sperm intracellular cAMP concentration is regulated by the opposite action of two enzymes: the adenylyl cyclases (AC), which synthesize cAMP from ATP, and the phosphodiesterases (PDE), which break the phosphodiester bond of cAMP to form 5'-adenosine monophosphate (AMP). (plos.org)
  • A recent report from researchers in Aberdeen presented preliminary data that suggests the sperm concentration of the men seen in their clinic had declined by 29% over the past 14 years. (carmk.net)
  • Infertile men may have deficiencies in sperm formation, concentration (eg, oligospermia [too few sperm], azoospermia [no sperm in the ejaculate]), or transportation. (medscape.com)
  • Researchers have found in a new systematic review that there is a strong association between insecticide exposure and lower sperm concentration in adult men globally. (womenshealthdaily.com)
  • It shows that frequent use of mobile phones is associated with a lower sperm concentration and total sperm count. (womenshealthdaily.com)
  • The morphology of sperm cells is the end result of a highly complex process of cellular modifications occurring during spermiogenesis. (myhealth.gov.my)
  • However, the focus of this article is going to be on the assessment of image analysis to indicate the normal sperm morphology of an ejaculate. (myhealth.gov.my)
  • Assessment of sperm morphology is one of the most important steps in the evaluation of male partner in infertile couples. (biochemia-medica.com)
  • The protamine status, chromatin structure, chromatin condensation, and acrosome reaction of sperm and assisted reproductive outcomes were determined in couples with different male infertility factors. (ecerm.org)
  • In this paper, we describe the capacitation phenotype of sperm lacking the long isoform of β1,4-galactosyltransferase I (GalT I), a sperm surface protein that functions as a receptor for the zona pellucida glycoprotein, ZP3, and as an inducer of the acrosome reaction following ZP3-dependent aggregation. (biologists.com)
  • As expected, wild-type sperm must undergo capacitation in order to bind the zona pellucida and undergo a Ca 2+ ionophore-induced acrosome reaction. (biologists.com)
  • The sperm-specific ion channel CatSper is the principal calcium channel in sperm mediating the calcium influx into the sperm flagellum and acting as an essential modulator of downstream mechanisms involved in fertilization. (123dok.net)
  • Isolated teratozoospermia does not affect in vitro fertilization outcome and is not an indication for intracytoplasmic sperm injection. (myhealth.gov.my)
  • The authors concluded that these findings provide new insights to improve sperm cryopreservation and in vitro fertilization in the domestic and wild felids and human. (alphanano.tech)
  • Spermatozoa require enormous amount of energy for their survival and fast speed of flagella during fertilization (1, 2). (ijfs.ir)
  • Fertilization occurs when a sperm and an oocyte (egg) combine and their nuclei fuse. (lumenlearning.com)
  • During the journey, fluids in the female reproductive tract prepare the sperm for fertilization through a process called capacitation , or priming. (lumenlearning.com)
  • Gamete interaction is a crucial event during fertilization when receptors on sperm bind to ligands on the extracellular coat of the egg, called the zona pellucida in mammals. (biologists.com)
  • post-fertilization sperm mitophagy depend on the ubiquitin -binding autophagy receptor, sequestosome 1 (SQSTM1), and the proteasome-interacting ubiquitin ated protein dislocase, valosin-containing protein (VCP). (eqalix.com)
  • These outcomes reveal that the early developmental occasions of post-fertilization sperm mitophagy noticed in porcine zygote will be reconstituted in a cell-free system, which may grow to be a useful gizmo for figuring out extra molecules that regulate mitochondrial inheritance in mammals. (eqalix.com)
  • At the same time, we found evidence for recent positive directional selection acting on several human testis-enriched genes ( MORC1 , SLC9B1 , ROPN1L , DMRT1 , PLCZ1 , RNF17 , FAM71D and WBP2NL ) that play important roles in human spermatogenesis and fertilization. (biomedcentral.com)
  • At fertilization, the chromosomes in one male gamete, called a sperm (or spermatozoon), combine with the chromosomes in one female gamete, called an oocyte. (bccampus.ca)
  • Hamster sperm fertilizing a hamster oocyte. (cellimagelibrary.org)
  • This scanning electron micrograph shows hamster sperm fertilizing a hamster oocyte. (cellimagelibrary.org)
  • Thus, the race into the uterine tubes, which is the most typical site for sperm to encounter the oocyte, is reduced to a few thousand contenders. (lumenlearning.com)
  • If the sperm do not encounter an oocyte immediately, they can survive in the uterine tubes for another 3-5 days. (lumenlearning.com)
  • Sperm must undergo the process of capacitation in order to have the "capacity" to fertilize an oocyte. (lumenlearning.com)
  • As it is swept along the distal uterine tube, the oocyte encounters the surviving capacitated sperm, which stream toward it in response to chemical attractants released by the cells of the corona radiata. (lumenlearning.com)
  • To reach the oocyte itself, the sperm must penetrate the two protective layers. (lumenlearning.com)
  • These enzymes clear a path through the zona pellucida that allows sperm to reach the oocyte. (lumenlearning.com)
  • The plasma membrane of that sperm then fuses with the oocyte's plasma membrane, and the head and mid-piece of the "winning" sperm enter the oocyte interior. (lumenlearning.com)
  • As you can see, the first sperm to reach the oocyte is never the one to fertilize it. (lumenlearning.com)
  • Rather, hundreds of sperm cells must undergo the acrosomal reaction, each helping to degrade the corona radiata and zona pellucida until a path is created to allow one sperm to contact and fuse with the plasma membrane of the oocyte. (lumenlearning.com)
  • Consequently, we anti cipated that sperm mitophagy may very well be reconstituted in a cell-free system consisting of permeabilized mammalian spermatozoa co-incubated with porcine oocyte extracts. (eqalix.com)
  • We discovered that SQSTM1 was detected within the midpiece/mitochondrial sheath of the sperm tail after, however not earlier than, co-incubation with oocyte extracts. (eqalix.com)
  • As well as, it was noticed that sperm head enlargement mimicked the early levels of paternal pronucleus growth in a zygote throughout extended sperm-oocyte extract co-incubation. (eqalix.com)
  • This case report detailed the course of treatment and protocol of a patient with type 1 globozoospermia using Intracytoplasmic Sperm Injection (ICSI) and oocyte activation by calcium ionophore, which yielded conception and birth of a healthy baby after six previous unsuccessful attempts, using ICSI alone. (jri.ir)
  • The mature and ejaculated spermatozoa are carried to the female tract in seminal plasma, which supports key sperm functions such as interactions with the various environments of the tubular genital tract, with the oocyte and with the female immune system and potentially helps modulate sperm rejection or tolerance [ 2 ]. (biomedcentral.com)
  • After spermiation in the testis, spermatozoa are functionally incompetent and are unable to fertilize an oocyte even though they are morphologically mature. (oncotarget.com)
  • Animals produce motile sperm with a tail known as a flagellum, which are known as spermatozoa, while some red algae and fungi produce non-motile sperm cells, known as spermatia. (wikipedia.org)
  • Flowering plants contain non-motile sperm inside pollen, while some more basal plants like ferns and some gymnosperms have motile sperm. (wikipedia.org)
  • Animals produce motile sperm known as spermatozoa, and some red algae and fungi produce non-motile sperm cells. (fertiligy.com)
  • That's an active, motile sperm - plural spermatozoa, or just plain sperm. (ussromantics.com)
  • The cytoplasmic droplet then becomes known as excess residual cytoplasm, which can impair overall sperm function and produce higher levels of reactive oxygen species, potentially leading to male infertility. (biomedcentral.com)
  • The excessive generation of oxygen free radicals in the form of ROS by abnormal spermatozoa and by contaminating leukocytes has been identified as one of the few defined etiologies for male infertility. (scialert.net)
  • However, low levels of mtDNA deletions have been identified in human spermatozoa and studies have not found a clear relationship between large-scale mtDNA deletions and male infertility. (ijfs.ir)
  • Therefore, the identification of mtDNA mutations in the pathophysiology of human spermatozoa dysfunction is considered to be important better understanding the etiology of idiopathic infertility in men. (ijfs.ir)
  • If you consider the loss of millions of sperm between entry into the vagina and degradation of the zona pellucida, you can understand why a low sperm count can cause male infertility. (lumenlearning.com)
  • Patients sought infertility treatment in the Human Reproductive Division of the Department of Gynecology and Discipline of Urology of the São Paulo Federal University Paulista School of Medicine between January 1999 and September 2000. (wimbledon-acupuncture.co.uk)
  • In addition, the effects of bacteriospermia on sperm quality and assisted reproductive outcomes were studied among couples with different factors of male infertility. (ecerm.org)
  • Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)
  • Other reasons for infertility include congenital factors, and health conditions like prostatitis and diabetes that can affect sperm production. (carmk.net)
  • There is strong clinical evidence to show that men diagnosed with infertility have high levels of oxidative stress that may impair the quality of their sperm. (carmk.net)
  • On the other hand, this lipid membrane makes the sperm cell sensitive to oxidative damage caused by reactive oxygen species (ROS)( 2 2 Sheweita SA, Tilmisany AM, Al-Sawaf H. Mechanisms ofmale infertility: role of antioxidants. (scielo.br)
  • 1. If a criminal is oligospermic , then his ejaculate may contain only a few sperms. (forensicsdigest.com)
  • Once the sperm has matured, they will enter the pelvis and ejaculate. (fertiligy.com)
  • ARMC12 is mainly expressed in the midpiece of elongated and late spermatids in the human testis. (nih.gov)
  • MSCs significantly reversed the imbalance of glycolysis in sperm and testis induced by testicular torsion-detorsion, as evidenced by increasing the expression of phosphoglycerate kinase 2 and glyceraldehyde-3-phosphate dehydrogenase-spermatogenic, activating Akt, and increasing glycogen synthase kinase 3 (GSK3), which led to the increase in glycolysis cascades and ATP production. (biomedcentral.com)
  • Figure 341 from Chapter 14 (Sperm Flagellum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Cross sections of spermatozoa in the testis of a moth. (cellimagelibrary.org)
  • The objective of this study was to identify the PDE10A isoforms expressed in the testis and germ cells, and to determine the presence and localization of PDE10A in mature spermatozoa. (plos.org)
  • Goupil S, Maréchal L, El Hajj H, Tremblay M-È, Richard FJ, Leclerc P (2016) Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. (plos.org)
  • At the exit of the testis, spermatozoa are non-fertile, despite the fact that they are morphologically differentiated. (encyclopedia.pub)
  • Recent human transcriptomic analyses revealed a very large number of testis-enriched genes, many of which are involved in spermatogenesis. (biomedcentral.com)
  • This comprehensive transcriptomic data lead us to the question whether positive selection was a decisive force influencing the evolution and variability of testis-enriched genes in humans. (biomedcentral.com)
  • Episodic diversifying selection, possibly driven by sperm competition, was not an important force driving the evolution of testis-enriched genes in the human lineage. (biomedcentral.com)
  • The primordial germ cells differentiate in the testis, in these seminiferous tubules… But let me first fast forward to the end of the process and describe a complete, mature sperm cell or spermatozoon. (ussromantics.com)
  • Papanicolaou staining, HE staining, immunofluorescent staining, transmission electron microscopy and field emission scanning electron microscopy were employed to observe the morphological and structural defects of the spermatozoa and testes. (nih.gov)
  • Sperm cells form during the process known as spermatogenesis, which in amniotes (reptiles and mammals) takes place in the seminiferous tubules of the testes. (wikipedia.org)
  • 2. Another reason could be the condition of Aspermia where no sperms are produced by the seminiferous tubules of the testes. (forensicsdigest.com)
  • Sperm is created in the testes and move through a coiled tube, called the vas deferens. (fertiligy.com)
  • In many animals (including humans) the testes descend into the scrotal sacs at birth but in some animals they do not descend until sexual maturity and in others they only descend temporarily during the breeding season. (wikibooks.org)
  • The key male reproductive organ in humans is the testes. (biomedcentral.com)
  • The paired testes are a crucial component in this process, as they produce both sperm and androgens, the hormones that support male reproductive physiology. (bccampus.ca)
  • This location is important in sperm production, which occurs within the testes, and proceeds more efficiently when the testes are kept 2 to 4°C below core body temperature. (bccampus.ca)
  • The patients' spermatozoa displayed multiple midpiece defects, including absent MS and central pair, scattered or forked axoneme and incomplete plasma membrane. (nih.gov)
  • Oxygen free radicals are naturally produced by mitochondrial and sperm plasma membrane and have beneficial and detrimental effects that cannot be overlooked. (scialert.net)
  • This unusual structure of sperm membrane is responsible for its flexibility and the functional ability of sperm cells. (scialert.net)
  • Activators and inhibitors also affected sperm mitochondrial membrane potential, ATP content and reactive oxygen species (ROS) levels. (bioscientifica.com)
  • They also deplete cholesterol molecules embedded in the membrane of the head of the sperm, thinning the membrane in such a way that will help facilitate the release of the lysosomal (digestive) enzymes needed for the sperm to penetrate the oocyte's exterior once contact is made. (lumenlearning.com)
  • Finally, a single sperm makes contact with sperm-binding receptors on the oocyte's plasma membrane. (lumenlearning.com)
  • Sperm-egg interactions occur at multiple levels on the egg surface, first with the egg's extracellular matrix and then with the egg's plasma membrane. (bioone.org)
  • Spermatozoa are rich in polyunsaturated fatty acids as well as susceptible to be attacked by ROS or membrane lipid peroxide ion. (ijbs.com)
  • Mammalian spermatozoa are coated by a membrane rich in polyunsaturated fatty acids. (carmk.net)
  • Lipid peroxidation damages the sperm cell membrane. (carmk.net)
  • A decrease in levels of reduced glutathione (GSH) during sperm production is known to disrupt the membrane integrity of spermatozoa due to increased oxidative stress. (carmk.net)
  • The membrane that constitutes the swine sperm is rich in polyunsaturated fatty acids, which is important to maintain sperm fluidity and flexibility( 1 1 Surai, PF. (scielo.br)
  • GPx is part of the membrane defense system, protecting the integrity of the sperm cell from oxidative damage( 3 3 Drevet JR. The antioxidant glutathione peroxidase family andspermatozoa: a complex story. (scielo.br)
  • Special proteins -- known as membrane transporters -- are key to the mobility of sperm cells. (womenshealthdaily.com)
  • Spermatozoa absorbed epididymal exosomes through endocytosis or membrane fusion pathways. (oncotarget.com)
  • Human sperm cells can survive within the female reproductive tract for more than 5 days post coitus. (wikipedia.org)
  • The sperm can survive for up to two days outside the male body and 72 hours in the female reproductive tract. (fertiligy.com)
  • The function of the male reproductive system ( Figure 1 ) is to produce sperm and transfer them to the female reproductive tract. (bccampus.ca)
  • This implies that intracellular targets of albumin, Ca 2+ and/or HCO 3 - may be constitutively active in GalT I-null sperm. (biologists.com)
  • These data suggest that GalT I may function as a negative regulator of capacitation in the sperm head by suppressing intracellular signaling pathways that promote this process. (biologists.com)
  • Sperm intracellular cAMP levels depend on the activity of adenylyl cyclases, mostly SACY, though transmembrane-containing adenylyl cyclases are also present, and on the activity of cyclic nucleotide phosphodiesterases (PDE) whose role is to degrade cAMP into 5'-AMP. (plos.org)
  • It plays a key role during sperm capacitation [ 3 - 6 ] and the acrosomal exocytosis [ 7 - 10 ], where it affects different intracellular signalling pathways. (plos.org)
  • Intracellular glutathione levels of spermatozoa are known to be decreased in certain populations of infertile men. (carmk.net)
  • Further, abnormal configuration of doublet microtubules was observed in the Cabyr -knockout spermatozoa , suggesting that the fibrous sheath is important. (biologists.com)
  • Using this criterion, any subnormally (or borderline forms) classified sperm cells are going to be indicated as abnormal. (myhealth.gov.my)
  • Intracytoplasmic sperm injection was used to treat the patients. (nih.gov)
  • Moreover, two patients were treated with intracytoplasmic sperm injection and achieved good outcomes. (nih.gov)
  • This study was conducted to evaluate in vivo and in vitro development of in vitro-matured equine oocytes fertilized by intracytoplasmic sperm injection. (bioone.org)
  • The Chinese Traditional Medicine acupuncture and moxa techniques significantly increase the percentage of normal-form sperm in infertile patients with oligoastenoteratozoospermia without apparent cause. (wimbledon-acupuncture.co.uk)
  • Because men with high levels of ROS have a seven-fold lower likelihood of inducing a pregnancy than men with lower levels, researchers recommend that treatment for infertile men should include strategies to reduce oxidative stress and improve sperm quality. (carmk.net)
  • For 10 percent of infertile males, little or no sperm are produced. (womenshealthdaily.com)
  • Sperm cells are highly sensitive to reactive oxygen species (ROS), which are produced during cellular oxidation. (mdpi.com)
  • Reactive oxygen species (ROS) induced lipid peroxidation is associated with sperm function. (ijbs.com)
  • Reactive oxygen species (ROS) play an important role in the human reproduction. (ijbs.com)
  • To counteract the negative effects of excess ROS, spermatozoa and seminal plasma have several mechanisms to neutralize free radicals. (scialert.net)
  • To counteract oxidative damage, spermatozoa and seminal plasma have several mechanisms to neutralize free radicals. (scialert.net)
  • The fluid portion is known as seminal plasma and sperms are suspended in it. (iasri.res.in)
  • Seminal plasma also contains some specific bio-molecules that are required for sperm metabolism. (iasri.res.in)
  • Seminal plasma and spermatozoa have several antioxidant enzymes - glutathione peroxidase, glutathione reductase, superoxide dismutase. (carmk.net)
  • We observed that CaMKIIα colocalizes with MUPP1 in the acrosomal region of epididymal spermatozoa where the kinase selectively binds to a region encompassing PDZ domains 10-11 of MUPP1. (biologists.com)
  • Ali Hassan, H. Epididymal Sperm of Canine and Feline. (encyclopedia.pub)
  • Epididymal Sperm of Canine and Feline" Encyclopedia , https://encyclopedia.pub/entry/15218 (accessed November 30, 2023). (encyclopedia.pub)
  • Epididymal spermatozoa remain a kind of enigma. (encyclopedia.pub)
  • However, epididymal spermatozoa are different from ejaculated spermatozoa in certain morphological and functional characteristics. (encyclopedia.pub)
  • For the relaxin binding study, washed cauda epididymal spermatozoa were smeared on glass slides, and specific sites that bind relaxin were identified by sequential application of a biotinylated relaxin probe, antibiotine immunoglobulin G conjugated to 1 nm colloidal gold, and silver for signal amplification. (go.jp)
  • Our aim was to analyze the secretory properties of epididymal exosomes and their ultrastructural interaction with maturing spermatozoa in the Chinese soft-shelled turtle. (oncotarget.com)
  • in spermatozoa , and whether they contribute to the regulation of acrosomal secretion. (biologists.com)
  • The tip of the sperm cell is known as acrosomal cap or acrosomal vesicle. (forensicsdigest.com)
  • Acrosomal vesicle containing hydrolytic enzyme facilitate the penetration of sperm into the egg. (forensicsdigest.com)
  • This initiates a process called the acrosomal reaction in which the enzyme-filled "cap" of the sperm, called the acrosome , releases its stored digestive enzymes. (lumenlearning.com)
  • The appearance of a cross section through the flagellum differs between the principal piece and the midpiece. (lishkolab.org)
  • The principal piece is the part of the flagellum that comes after the midpiece and comprises most of the flagellum. (lishkolab.org)
  • Figures 338 (upper) and 339 (lower) from Chapter 14 (Sperm Flagellum) of 'The Cell, 2nd Ed.' by Don W. Fawcett M.D. Transverse sections through midpiece and principal piece of several sperm from the n. (cellimagelibrary.org)
  • The flagellum on the sperm cell makes it move. (fertiligy.com)
  • clarification needed] The mammalian sperm cell can be divided in 2 parts: Head: contains the nucleus with densely coiled chromatin fibers, surrounded anteriorly by a thin, flattened sac called the acrosome, which contains enzymes used for penetrating the female egg. (wikipedia.org)
  • Transmission electron micrograph of longitudinal section through mouse spermatozoon showing characteristic hooked shape of sperm head and extremely compact DNA-protamine in the nucleus. (cellimagelibrary.org)
  • Sperm consists of several parts, including a head cap that contains the nucleus and a midpiece that contains the genetic material. (fertiligy.com)
  • The CDs of mature non-human mammalian sperm are found at the distal end of the midpiece. (biomedcentral.com)
  • The droplet is located in the proximal region of the midpiece in a caput-spermatozoon and in the distal region of the midpiece in a corpus-spermatozoon [ 3 ] . (encyclopedia.pub)
  • Mature human spermatozoa are similar to that of other mammals in possessing a CD at the midpiece. (biomedcentral.com)
  • We also reveal using a combination of immunological techniques and proteomics analytical tools that the PDE10A isoform X4 is present in the area of the developing acrosome of spermatids and of the acrosome of mature spermatozoa. (plos.org)
  • The glutathione peroxidase/reductase enzymes play a central role in the defense against oxidative damage in human sperm. (carmk.net)
  • Spermiogenesis, the final stage of spermatogenesis, transforms haploid spermatids to free testicular (non-motile) spermatozoa [ 14 ]. (biomedcentral.com)
  • The spermatozoa of animals are produced through spermatogenesis inside the male gonads (testicles) via meiotic division. (wikipedia.org)
  • We previously reported that mesenchymal stem cells (MSCs), through local injection upon testicular torsion-detorsion, restored the spermatogenesis without differentiation into sperm. (biomedcentral.com)
  • Male sperm cells are constantly produced in large quantities in the testicles during so-called spermatogenesis. (innovations-report.com)
  • They have two main functions: the efficient production of sperm (spermatogenesis) over a male's reproductive life span and the synthesis of hormones necessary to develop male sex characteristics. (biomedcentral.com)
  • Human spermatogenesis requires about 70 days for a complete cycle. (biomedcentral.com)
  • It is a familiar element of mammalian spermatozoa, though many studies in the past have focused primarily on CDs in non-human species. (biomedcentral.com)
  • However, controversy exists regarding the role of different types of bacteria in decreasing sperm parameters. (ecerm.org)
  • The differences between human and non-human mammals became apparent once researchers drew attention to human CDs. (biomedcentral.com)
  • In mammals the sperm are placed in the body of the female and the eggs are fertilized internally. (wikibooks.org)
  • The reproductive organs of mammals produce the gametes (sperm and egg cells), help them fertilize and then support the developing embryo. (wikibooks.org)
  • The problem of keeping sperm at a low enough temperature is even greater in birds that have a higher body temperature than mammals. (wikibooks.org)
  • Sperm cells cannot divide and have a limited lifespan, but after fusion with egg cells during fertilisation, a new organism begins developing, starting as a totipotent zygote. (wikipedia.org)
  • This new single cell, called a zygote , contains all of the genetic material needed to form a human-half from the mother and half from the father. (lumenlearning.com)
  • MPVs were previously considered distinct from CDs and characteristic of immature sperm [ 13 ]. (biomedcentral.com)
  • The journey begins after sper- matogenesis has been completed culminating in the formation of highly differentiated spermatozoa that are structurally complete but are still functionally immature. (123dok.net)
  • Spermatozoa from Armc12 -/- mice showed parallel defects in the midpiece. (nih.gov)
  • This explains why the sperm of male mice with a mutated Actl7b gene is not able to develop the characteristic shape. (innovations-report.com)
  • This review aims to provide insights into the structure, localization, and function of the mammalian CatSper channel, primarily human and mice. (123dok.net)
  • Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
  • VCP was distinguished within the sperm mitochondrial sheath each earlier than and after the extract co-incubation and was additionally detected within the acrosome and postacrosomal sheath and the subacrosomal layer of the spermatozoa co-incubated with extraction buffer as management. (eqalix.com)
  • Due to the mitochondrial helix that forms around the core of the axoneme-outer dense fibers complex, the midpiece has a large diameter relative to the rest of the cell [ 10 ]. (biomedcentral.com)
  • Sperm (PL: sperm or sperms) is the male reproductive cell, or gamete, in anisogamous forms of sexual reproduction (forms in which there is a larger, female reproductive cell and a smaller, male one). (wikipedia.org)
  • This process involves the production of several successive sperm cell precursors, starting with spermatogonia, which differentiate into spermatocytes. (wikipedia.org)
  • The human sperm cell is haploid, so that its 23 chromosomes can join the 23 chromosomes of the female egg to form a diploid cell with 46 paired chromosomes. (wikipedia.org)
  • Sperm cell membranes are high in polyunsaturated fatty acids and are sensitive to oxygen free radical induced damage mediated by lipid peroxidation. (scialert.net)
  • Human stem cell factor contributed the activation of Akt/GSK3 axis when sperm suffered from testicular torsion-detorsion-induced germ cell injury. (biomedcentral.com)
  • In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress which threatens sperm biology. (mdpi.com)
  • The spermatozoon is a highly unique and specialized cell. (lishkolab.org)
  • Here we explain all the basics of sperm cell anatomy for those who may not have a background in the subject along with images. (lishkolab.org)
  • The neck is located between the head and the midpiece of the sperm cell. (lishkolab.org)
  • Sperm is the male reproductive cell or gamete of an animal. (fertiligy.com)
  • Sperm is a male reproductive cell that fuses with the egg to create an embryo. (fertiligy.com)
  • Because each of these reproductive cells is a haploid cell containing half of the genetic material needed to form a human being, their combination forms a diploid cell. (lumenlearning.com)
  • Unique for its role in human reproduction, a gamete is a specialized sex cell carrying 23 chromosomes-one half the number in body cells. (bccampus.ca)
  • Before ejaculated sperm can complete any of these steps,they must undergo a series of biochemical, morphological and behavioral changes, collectively called capacitation. (biologists.com)
  • Mammalian sperm cells present highly specific lipidic composition, high content of polyunsaturated fatty acids, plasmalogenes and sphingomyelins. (scialert.net)
  • We found that the splicing factors hnRNPA1/A2, PTBP1/2, and U1-snRNP inhibit ZAPS production and demonstrated the feasibility to modulate the ZAPL/S balance by splice-switching antisense oligonucleotides in human cells. (bvsalud.org)
  • Without ACTL7B, development is blocked, the cells often remain in a roundish shape, usually do not form the elongated, typical sperm shape and die to a large extent ," says first author Gina Esther Merges, a doctoral student in Professor Schorle's laboratory. (innovations-report.com)
  • After being released in the lumen of the seminif- erous tubules, sperm cells have to accomplish several challenging tasks before reaching and fertilizing the egg. (123dok.net)
  • The cytoplasmic droplet is not present in all sperm cells, but it allows us to perform electrophysiology when present. (lishkolab.org)
  • Finding sperm cells in body cavities of a victim of sexual crime is the utmost priority for obvious reasons. (forensicsdigest.com)
  • Sperm and egg cells combine to form a diploid organism with 46 chromosomes. (fertiligy.com)
  • The sperm first burrow through the cells of the corona radiata. (lumenlearning.com)
  • Spermatogonia are undifferentiated male germ cells, or sperm cells. (ussromantics.com)
  • Duration of testicular torsion and the severity of cord twisting are two key prognostic factors for sperm survival and activity. (biomedcentral.com)
  • Testicular sperms are not capable of fertilizing ovum. (iasri.res.in)
  • Now, new research is shedding light on what may be going wrong in the process of sperm formation, leading to potential theories on possible treatments. (womenshealthdaily.com)
  • In this section, we examine each of these different structures, and discuss the process of sperm production and transport. (bccampus.ca)
  • This protease activity has recently been ascribed to serine metalloprotease(s), including pregnancy-associated plasma protein-A (PAPP-A), which was first detected in human follicular fluid nearly 20 yr ago. (bioone.org)
  • Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. (biomedcentral.com)
  • A widespread hypothesis states that sperm evolved rapidly, but there is no direct evidence that sperm evolved at a fast rate or before other male characteristics. (wikipedia.org)
  • The main sperm function is to reach the ovum and fuse with it to deliver two sub-cellular structures: (i) the male pronucleus that contains the genetic material and (ii) the centrioles that are structures that help organize the microtubule cytoskeleton. (wikipedia.org)
  • 2001). Sperm Morphological defects Related to Environment, Lifestyle and Medical History of 1001 male Partners of Pregnant Women from Four European Cities. (myhealth.gov.my)
  • 3. If the criminal has undergone Vasectomy which is the surgical procedure for male sterilization to prevent sperm from entering into the seminal stream. (forensicsdigest.com)
  • Sperm consists of DNA and contains the genetic material of the male. (fertiligy.com)
  • Whether the sperm has a Y or an X chromosome determines whether the child will be male or female. (fertiligy.com)
  • The female lays the eggs and then the male deposits his sperm on or at least near them. (wikibooks.org)
  • In reptiles and birds, eggs are fertilized inside the body when the male deposits the sperm inside the egg duct of the female. (wikibooks.org)
  • In humans, the most important male androgen is testosterone. (bccampus.ca)
  • They produce both sperm and androgens, such as testosterone, and are active throughout the reproductive lifespan of the male. (bccampus.ca)
  • Sperm are flattened almond-shaped and contain genetic substances called chromosomes. (fertiligy.com)
  • For this reason, CDs are not considered detrimental to proper sperm function. (biomedcentral.com)
  • In recent years, the detrimental effects of different types of bacteria strains and/or leukocytes on some sperm parameters were studied [ 3 ]. (ecerm.org)