Spermatids sperm sex chromatin. Medical search. Frequent questions

Here, we show that HSF1 is transiently expressed in meiotic spermatocytes and haploid round spermatids in mouse testis. (abo.fi)
At the completion of meiosis, four haploid gametes, termed round spermatids, result from the division of every spermatocyte. (jci.org)
Immunohistochemistry using two sets of antibodies, one that recognized full-length PRL and N-terminal cleaved PRL and another that recognized full-length PRL and C-terminal cleaved PRL, suggested that intact PRL was localized in the nucleus of round spermatids, while N-terminal cleaved PRL variants were localized in the Golgi apparatus of the sperrmatid nuclei of round spermatids, cytoplasms of elongated spermatids and in the spermatozoa tails. (go.jp)
Histology evaluation: Abnormal spermiogenesis with accumulation of meiotic division-phase spermatocytes and degenerating round spermatids present in multinucleated cell bodies (see 1). (jax.org)

During their passage through the epididymis to the vas deferens, sperm acquire their motility. (jci.org)
sperm count of 14 million/ml with 35% active motility and 100% morphologically abnormal sperm, indicating globozoospermia. (jri.ir)
Common problems in male related infertility are sperm count, motility or structural abnormalities. (jri.ir)
In vitro clinic: Low epididymal sperm concentration, many sperm have abnormally shaped heads, sperm tails are short, no sperm motility, no IVF success. (jax.org)

We find that the rapid evolution of the testis was driven by accelerated fixation rates of gene expression changes, amino acid substitutions and new genes in late spermatogenic stages, probably facilitated by reduced pleiotropic constraints, haploid selection and transcriptionally permissive chromatin. (bvsalud.org)

Each round spermatid then undergoes dramatic changes in its cellular morphology (spermiogenesis) to form first an elongating spermatid and finally a spermatozoon. (jci.org)
As a result, numerous authors have suggested an introduction of sperm DNA damage testing into the andrological laboratory workup as an independent tool as DNA fragmentation apart from normal sperm morphology appears to be a reliable and more robust parameter than conventional semen analysis due to its low biological variability and thus is a useful biomarker that should be implemented in any andrological diagnostic workup [ 19 - 21 ]. (hindawi.com)
Histology evaluation: Abnormal spermiogenesis (see 1) characterized by abnormally shaped sperm heads and abnormal tail morphology. (jax.org)

We examined sperm DNA damage and chromatin condensation and measured plasma levels of leptin, testosterone, cholesterol and triglycerides. (nature.com)

In mitosis prophase chromatin typically condenses progressively into the microscopically visible individual chromosomes, which can be seen in their fully condensed state at metaphase. (biomedcentral.com)
Although sex hormones play a key role in sex differences in susceptibility, severity, outcomes, and response to therapy of different diseases, sex chromosomes are also increasingly recognized as an important factor. (biomedcentral.com)
X-degenerate sequences are single copy and broadly expressed genes which were evolved from ancestral autosomes to generate sex chromosomes. (biomedcentral.com)

It also controls the genome-wide post-meiotic genome reorganization that occurs after histone hyperacetylation in elongating spermatids. (wikipedia.org)
The mechanism of action of JQ1 could be explained by considering Brdt's functions as a driver of testis-specific gene expression and post-meiotic chromatin reorganization. (wikipedia.org)
In addition, our results show that HSF1 localizes to the sex body prior to the meiotic divisions and to the sex chromocenter after completed meiosis. (abo.fi)
Further work identified transcriptomal differences between X- and Y-bearing spermatids and uncovered that meiotic sex-chromosome inactivation (MSCI) also occurs in monotremes and hence is common to mammalian sex-chromosome systems. (bvsalud.org)
Thus, the mechanism of meiotic silencing of unsynapsed chromatin, which underlies MSCI, is an ancestral mammalian feature. (bvsalud.org)
In the male germ line of Drosophila chromatin remains decondensed and highly transcribed during meiotic prophase until it is rapidly compacted. (biomedcentral.com)
During the meiotic prophase some modifications expected in active chromatin are not found or are found at low level. (biomedcentral.com)
During the first meiotic prophase, the chromatin of Drosophila male germ cells displays remarkable differences compared with most other organisms. (biomedcentral.com)
The meiotic prophase in Drosophila is also characterized by a high level of transcriptional activity which ceases shortly before the compaction of the chromatin and the entry into the first meiotic metaphase [ 3 ]. (biomedcentral.com)

Disruption of Hsf1, together with another HSF family member, Hsf2, causes male sterility and complete lack of mature sperm in mice, but the specific role of HSF1 in spermatogenesis has remained unclear. (abo.fi)
Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. (jci.org)
The process of spermatogenesis as the cells progress from spermatogium, to primary spermatocytes, to secondary spermatocytes, to spermatids and to Sperm. (iiab.me)
The release of FSH into the testes will enhance spermatogenesis and lead to the development of sertoli cells , which act as nursing cells where spermatids will go to mature after Meiosis II. (iiab.me)
LH promotes leydig cell secretion of testosterone into the testes and blood, which induce spermatogenesis and aid the formation of secondary sex characteristics. (iiab.me)
Evidence thus implicates participation of orexins in steroidogenesis, spermatogenesis, transportation and maturation of sperm as well as in the control of penile function. (researchgate.net)

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. (axonmedchem.com)
Postmeiotically, we observed a highly complex pattern of the histone modifications until late spermatid nuclear elongation stages. (biomedcentral.com)
This may be in part due to postmeiotic transcription and in part to differential histone replacement during chromatin condensation. (biomedcentral.com)
We also observe that certain histone modifications are specific of spermatid nuclei. (biomedcentral.com)

Condensation and decondensation of chromatin is to a large extent controlled or accompanied by both postranslational modifications of nucleosomal histones and sometimes by DNA methylation. (biomedcentral.com)

We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr −/− .Leiden) mice, and studied the morphological structure of the testes and histologically examined the proportion of Sertoli cells, spermatocytes and spermatids in the seminiferous tubules. (nature.com)
HFD-induced obesity caused high plasma leptin and abnormal testosterone levels and induced an aberrant intra-tubular organisation (ITO) which is associated with an altered spermatids/spermatocytes ratio (2:1 instead of 3:1). (nature.com)

Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries1. (bvsalud.org)
The mPRL was detected in Leydig cells and in round and elongated spermatids of the testes by immunohistochemistry. (go.jp)

We observe preferential methylation of H3K9 in the Y chromosome chromatin whereas H3K27 methylation is more prominent in the X and autosomal chromatin. (biomedcentral.com)
Y chromosome harbors male‑specific genes, which either solely or in cooperation with their X-counterpart, and independent or in conjunction with sex hormones have a considerable impact on basic physiology and disease mechanisms in most or all tissues development. (biomedcentral.com)
Furthermore, loss of Y chromosome and/or aberrant expression of Y chromosome genes cause sex differences in disease mechanisms. (biomedcentral.com)
All mutations were mapped to a chromosome region and all were archived as cryopreserved sperm from heterozygous males. (jax.org)

BET inhibitors such as JQ1 block the region of BRDT responsible for chromatin binding, and cause a reversible reduction of sperm production, sperm quality, and size of the testis in mice. (wikipedia.org)
Immotile sperm flow from the lumen of the seminiferous tubules into the epididymis via the rete testis. (jci.org)
Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)
In both species, we define the somatic cell states present at the time of sex specification, including the bipotent early supporting population that, in males, upregulates the testis-determining factor SRY and sPAX8s, a gonadal lineage located at the gonadal-mesonephric interface. (bvsalud.org)
In vitro clinic: Very low testis weight, no epididymal sperm recovered. (jax.org)
The primordial germ cells differentiate in the testis, in these seminiferous tubules… But let me first fast forward to the end of the process and describe a complete, mature sperm cell or spermatozoon. (ussromantics.com)

The Hsf1(-/-) male mice displayed regions of seminiferous tubules containing only spermatogonia and increased morphological abnormalities in sperm heads. (abo.fi)

Meiosis is a type of cell division which is concerned mainly with the production of sex gametes( sperm and egg cells). (kegrat.online)

The stages VII + VII indicate crucial processes in spermatogenic development like initiation of meiosis, initiation of spermatid elongation, and release of fully matured spermatids. (nature.com)

Given that the sex chromatin mostly is repressed during and after meiosis, it is remarkable that HSF1 directly regulates the transcription of sex-linked multicopy genes during postmeiotic repression. (abo.fi)
To the best of our knowledge, HSF1 is the first known transcription factor found at the repressed sex chromatin during meiosis. (abo.fi)
Each secondary spermatocyte will form two spermatids after Meiosis II. (iiab.me)

The majority of modifications persist until the early spermatid nuclei, and only a minority further persist until the final chromatin compaction stages before individualization of the spermatozoa. (biomedcentral.com)

Among them, the sex chromosomal multicopy genes that are expressed in postmeiotic cells were occupied by HSF1. (abo.fi)
The hypothesis of this research was that cannabis exposure is associated with heritable, but reversible, changes in DNA methylation in sperm at genes important for early life development. (duke.edu)
Lastly, two publicly available datasets were investigated to determine significant overlap between a known list of autism candidate genes and a list of genes with bivalent chromatin, a unique epigenetic feature. (duke.edu)
In the sperm of rats injected with THC and those nicotine-exposed, significant differential methylation at five of seven neurodevelopmentally active genes that were initially identified as significantly altered by oral gavage was identified. (duke.edu)
It was further discovered that autism candidate genes are significantly enriched for genes containing bivalent chromatin. (duke.edu)
Enrichment of both autism candidate genes and genes possessing bivalent chromatin was identified in the human RRBS dataset of genes significantly differentially methylated in sperm of cannabis users. (duke.edu)
The role of MSY genes in important cellular processes such as transcription regulation, translation, and protein stability in males is vital not only in sex determination but also in sex-dependent organ development [ 3 ]. (biomedcentral.com)

Mutagenesis-generated mouse models of human infertility with abnormal sperm. (jax.org)

That's an active, motile sperm - plural spermatozoa, or just plain sperm. (ussromantics.com)

Infertility in men can result from deficiencies in sperm formation, concentration, or transportation. (medscape.com)
Indications for performing a postcoital test include semen hyperviscosity, increased or decreased semen volume with good sperm density, or unexplained infertility. (medscape.com)
Causes of infertility in men can be explained by deficiencies in sperm formation, concentration, or transportation. (medscape.com)
Of the mutant lines established, about 75% exhibited a male infertility phenotype only, almost 10% exhibited female infertility only, and about 15% exhibited infertility of both sexes. (jax.org)
At the level of human exposure, ATZ reduces sperm count and contribute to infertility in men. (frontiersin.org)

This case report detailed the course of treatment and protocol of a patient with type 1 globozoospermia using Intracytoplasmic Sperm Injection (ICSI) and oocyte activation by calcium ionophore, which yielded conception and birth of a healthy baby after six previous unsuccessful attempts, using ICSI alone. (jri.ir)
This study was conducted to evaluate in vivo and in vitro development of in vitro-matured equine oocytes fertilized by intracytoplasmic sperm injection. (bioone.org)

The level of sperm DNA fragmentation may give a sense of guidance as to the appropriate method of ARTs to employ especially between IVF and ICSI [ 17 , 18 ]. (hindawi.com)

Infertile men may have deficiencies in sperm formation, concentration (eg, oligospermia [too few sperm], azoospermia [no sperm in the ejaculate]), or transportation. (medscape.com)

In a pilot study, our group recently demonstrated that cannabis use in humans, and exposure to delta-9-tetrahydrocannabinol (THC, the main psychoactive component of cannabis) in rats, is associated with significantly altered levels of DNA methylation in sperm. (duke.edu)
Broadly, the main objectives of this thesis research were to generate meaningful data to contribute to the gaps in knowledge of how cannabis can impact sperm DNA methylation. (duke.edu)
An initial pilot study from our group used reduced representation bisulfite sequencing (RRBS) to analyze methylation changes in sperm between cannabis users and controls. (duke.edu)
Use of human fetal brain tissues demonstrated that there is a significant, sex-specific, inverse relationship between DNA methylation and gene expression at this locus. (duke.edu)
Bisulfite pyrosequencing identified significant changes in rat sperm DNA methylation at Dlgap2, as well as significant losses of methylation at the same locus in F1 nucleus accumbens (NAc) tissues. (duke.edu)
Bisulfite pyrosequencing of sperm DNA from rats exposed to injected THC or vehicle control was performed to examine methylation at regions identified by RRBS. (duke.edu)

Deletion of RibosomeST in mice causes defective sperm formation, resulting in substantially reduced fertility. (bvsalud.org)

Homozygous mutant males were sub-fertile and both sexes had a decreased number of lumbar and sacral vertebrae. (wikipedia.org)

In hermaphrodite C. elegans , sperm production occurs first and is then stored in the spermatheca. (iiab.me)

Besides affecting fertilization and the outcome of pregnancy, sperm DNA damage has a negative impact on the health of the offspring as uncorrected sperm DNA damage following zygote formation has the potential to create mutations/epimutations in the offspring [ 7 ]. (hindawi.com)

Oocytes were collected from slaughterhouse-derived ovaries, matured in vitro, and injected with frozen-thawed stallion sperm. (bioone.org)

Male germ cell development involves complex translational regulation during sperm formation3. (bvsalud.org)
RibosomeST predominantly cotranslationally regulates the folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm. (bvsalud.org)
Spermatogonia are undifferentiated male germ cells, or sperm cells. (ussromantics.com)

In addition, other corrective measures include sperm separation for assisted reproductive techniques. (hindawi.com)

Taken together, identification of this sperm-specific ribosome should greatly expand our understanding of ribosome function and tissue-specific regulation of protein expression pattern in mammals. (bvsalud.org)

Furthermore, sperm DNA damage appears to be linked to the most important checkpoints of fertility such as reduced fertilization rates, lower embryo quality and pregnancy rates, higher miscarriage rates, malformations, and childhood diseases [ 22 ]. (hindawi.com)

However, it remains unclear whether translation during sperm formation is performed by a specific ribosome. (bvsalud.org)

Here, we generated a comprehensive map of first- and second-trimester human gonads using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays and fluorescent microscopy. (bvsalud.org)

Paternal sperm DNA damage has negative effects on the integrity of early embryonic development as the percentage of good quality embryos as well as implantation rates was significantly reduced in patients exhibiting high DNA damage [ 27 ] and it appears that the second and third mitoses are the sensitive periods [ 28 ]. (hindawi.com)

Quantitative bisulfite pyrosequencing confirmed that an intronic region of DLGAP2 was significantly hypomethylated in the sperm of cannabis exposed men compared to controls. (duke.edu)

There remains an urgent need to investigate the effects of cannabis on the sperm epigenome as use increases across the globe. (duke.edu)

Anatomy4

Chemicals and Drugs1

Phenomena and Processes3

Round spermatids4

Motility4

Haploid1

Morphology3

Examined sperm DNA damage1

Chromosomes3

Meiotic9

Spermatogenesis6

Histone4

Condensation1

Spermatocytes2

Testes2

Chromosome4

Testis6

Seminiferous1

Gametes1

Elongation1

Meiosis3

Nuclei1

Genes7

Abnormal1

Spermatozoa1

Infertility5

Intracytoplasmic2

ICSI1

Ejaculate1

Methylation6

Mice1

Males1

Occurs1

Zygote1

Vitro1

Male3

Separation1

Protein1

Pregnancy1

Formation1

Cell1

Early1

Region1

Remains1